iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107175

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01018824

Gene Name

ITCH

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000017423.1	ENSSHAT00000020711.1	ENSSHAP00000020547.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.20e-137	456.9	539	871

Active Site

Position(s)	Description	Evidence
840	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 539  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 626
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee+gl++ fsv++eilge+k++eLkp+G+ni Vt+eNkeeY++ v+e
   Q: 627  GFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHELKPNGSNILVTEENKEEYIRMVAE 712
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 713  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YTRTSKQIMWFWQFVKEIDNEKRMRLLQFV 800
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 801  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 871
           *********************************************************************96 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MSGSSSRSGS VGGLTMKSQL QIIVISAKLK ENKKNWFGPS PYVEVSVDGQ SKKTEKCSNT 60
NSPKWKQPLT VIVTPISKLN FRVWSHQTLK SDVLLGSAAL DIHETLKSNN LKLDEVIVTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCCATAGTC CAGTTGGTGG CATGTCTGGC AGTAGTTCAC GGTCAGGGTC TGTGGGGGGA 60
TTGACCATGA AATCACAACT TCAGATCATT GGTAAGTCTT TGATAAGATA GTCATTTATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

KEGG

shr:100926872

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	89.42	0.00e+00	1498.00
IUUC-Apl-003752	Anas platyrhynchos	86.13	0.00e+00	1484.00
IUUC-Aca-005338	Anolis carolinensis	84.62	0.00e+00	1440.00
IUUC-Ago-007742	Ashbya gossypii	48.71	8.00e-162	564.00
IUUC-Ame-010601	Astyanax mexicanus	86.42	0.00e+00	1123.00
IUUC-Bta-012782	Bos taurus	87.92	0.00e+00	1469.00
IUUC-Cja-018899	Callithrix jacchus	84.56	0.00e+00	1460.00
IUUC-Cfa-020648	Canis familiaris	88.18	0.00e+00	1462.00
IUUC-Cpo-022073	Cavia porcellus	88.15	0.00e+00	1511.00
IUUC-Csa-023252	Chlorocebus sabaeus	87.46	0.00e+00	1500.00
IUUC-Cho-024695	Choloepus hoffmanni	82.15	0.00e+00	1457.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	47.37	4.00e-155	541.00
IUUC-Cne-026849	Cryptococcus neoformans	47.63	1.00e-158	553.00
IUUC-Dre-028451	Danio rerio	75.09	0.00e+00	1293.00
IUUC-Dno-029884	Dasypus novemcinctus	88.50	0.00e+00	1506.00
IUUC-Eca-033793	Equus caballus	89.08	0.00e+00	1495.00
IUUC-Eeu-034716	Erinaceus europaeus	92.14	0.00e+00	882.00
IUUC-Fca-035605	Felis catus	89.42	0.00e+00	1518.00
IUUC-Fal-037126	Ficedula albicollis	86.39	0.00e+00	1477.00
IUUC-Fso-038393	Fusarium solani	46.70	6.00e-153	534.00
IUUC-Gmo-038596	Gadus morhua	80.07	0.00e+00	1005.00
IUUC-Gga-040832	Gallus gallus	86.74	0.00e+00	1504.00
IUUC-Gac-041658	Gasterosteus aculeatus	85.88	0.00e+00	1126.00
IUUC-Ggo-044535	Gorilla gorilla	85.13	0.00e+00	1477.00
IUUC-Hsa-046564	Homo sapiens	84.37	0.00e+00	1494.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	87.69	0.00e+00	1470.00
IUUC-Kpa-049273	Komagataella pastoris	48.71	1.00e-162	566.00
IUUC-Lch-050454	Latimeria chalumnae	80.41	0.00e+00	1406.00
IUUC-Loc-052647	Lepisosteus oculatus	74.40	0.00e+00	1342.00
IUUC-Laf-054383	Loxodonta africana	88.85	0.00e+00	1516.00
IUUC-Mcc-055532	Macaca mulatta	87.46	0.00e+00	1502.00
IUUC-Mga-059661	Meleagris gallopavo	86.74	0.00e+00	1489.00
IUUC-Mmr-061135	Microcebus murinus	88.26	0.00e+00	1524.00
IUUC-Mdo-062505	Monodelphis domestica	96.39	0.00e+00	1603.00
IUUC-Mmu-063375	Mus musculus	88.53	0.00e+00	1493.00
IUUC-Mpu-066203	Mustela putorius furo	89.77	0.00e+00	1501.00
IUUC-Mlu-067837	Myotis lucifugus	89.20	0.00e+00	1491.00
IUUC-Nle-069244	Nomascus leucogenys	87.91	0.00e+00	1492.00
IUUC-Opr-070585	Ochotona princeps	82.57	0.00e+00	1456.00
IUUC-Ont-071798	Oreochromis niloticus	90.71	0.00e+00	1142.00
IUUC-Oan-073679	Ornithorhynchus anatinus	67.68	0.00e+00	988.00
IUUC-Ocu-074298	Oryctolagus cuniculus	89.11	0.00e+00	1513.00
IUUC-Ola-086526	Oryzias latipes	83.41	0.00e+00	1115.00
IUUC-Oga-088167	Otolemur garnettii	82.10	0.00e+00	1382.00
IUUC-Oar-090316	Ovis aries	72.33	0.00e+00	1107.00
IUUC-Ptr-090819	Pan troglodytes	83.68	0.00e+00	1455.00
IUUC-Pan-092454	Papio anubis	87.46	0.00e+00	1501.00
IUUC-Psi-093319	Pelodiscus sinensis	84.16	0.00e+00	1442.00
IUUC-Pfo-097346	Poecilia formosa	82.21	0.00e+00	1102.00
IUUC-Pab-097580	Pongo abelii	77.94	0.00e+00	1338.00
IUUC-Pca-100923	Procavia capensis	76.59	0.00e+00	1226.00
IUUC-Pva-103209	Pteropus vampyrus	87.79	0.00e+00	1444.00
IUUC-Rno-104924	Rattus norvegicus	87.83	0.00e+00	1489.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	46.84	8.00e-159	553.00
IUUC-Spo-108171	Schizosaccharomyces pombe	50.35	4.00e-162	565.00
IUUC-Sar-113761	Sorex araneus	90.57	0.00e+00	1202.00
IUUC-Sre-114929	Sporisorium reilianum	46.74	3.00e-154	538.00
IUUC-Tgu-116632	Taeniopygia guttata	80.02	0.00e+00	1337.00
IUUC-Tru-118442	Takifugu rubripes	88.58	0.00e+00	1119.00
IUUC-Tsy-119198	Tarsius syrichta	82.11	0.00e+00	1365.00
IUUC-Tni-120168	Tetraodon nigroviridis	84.31	0.00e+00	1056.00
IUUC-Tbe-127756	Tupaia belangeri	70.37	0.00e+00	1154.00
IUUC-Ttr-128504	Tursiops truncatus	81.32	0.00e+00	1046.00
IUUC-Vpa-130103	Vicugna pacos	74.42	0.00e+00	1247.00
IUUC-Xtr-132885	Xenopus tropicalis	76.85	0.00e+00	1390.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence