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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064181
Ensembl Protein ID ENSMUSP00000039301.7
UniProt Accession Q8VE19; E9QM00; MIO_MOUSE
Genbank Protein ID AAH20002.1
Protein Name WD repeat-containing protein mio
Genbank Nucleotide ID AC158661
Gene Name Mios
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000042447.13 ENSMUST00000040017.7 ENSMUSP00000039301.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACmiRNAMap
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.40e-07 30.2 270 298
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 6    vtclaf.sd..tllvsGsdDgt.ikvWDl 30
            t +a+ ++  +ll++ ++D + i+++D+
   Q: 270  LTKVAWcPTrtGLLATLTRDSNiIRLYDM 298
           6789***444699*******88899***6 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3.
 As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3.
Protein Sequence
(Fasta)
MSGTKPDILW APHQVDRFVV CDSELSLYHV ESAVNSELKA GSLRLSEDSA ATLLSINSDT 60
PYMKCVAWYL NYDPECLLAV GQANGRVVLT SLGQDHNSKF KDLIGKEFVP KHARQCNTLA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064181|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGGGGAAGG CGGGGCTCGC GGCGAGGAGG TCTGCTTCGG AGGCGGCAGG GTGGTTTGGT 60
CGGGGGCCCA GCGGGTGGCC CGGGTCACCG CCCGTGCTTC GGCGGCCATC TTGCCCGCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064181|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR031488--Zn_ribbon_mio
IPR013083--Znf_RING/FYVE/PHD
Pfam

PF17034--zinc_ribbon_16
SMART

SM00320--WD40
Gene Ontology

GO:0061700--C:GATOR2 complex
GO:0005765--C:lysosomal membrane
GO:0034629--P:cellular protein complex localization
GO:0034198--P:cellular response to amino acid starvation
GO:0032008--P:positive regulation of TOR signaling
KEGG mmu:252875
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001544 Ailuropoda melanoleuca 98.40 0.00e+00 1803.00
IUUC-Apl-003888 Anas platyrhynchos 91.34 0.00e+00 1674.00
IUUC-Aca-004555 Anolis carolinensis 89.77 0.00e+00 1648.00
IUUC-Acl-008325 Aspergillus clavatus 29.53 1.00e-44 175.00
IUUC-Afl-008515 Aspergillus flavus 27.11 2.00e-47 184.00
IUUC-Afu-008938 Aspergillus fumigatus 27.60 2.00e-50 194.00
IUUC-Ani-009434 Aspergillus nidulans 27.52 7.00e-44 172.00
IUUC-Ang-009607 Aspergillus niger 27.69 7.00e-47 182.00
IUUC-Ate-010488 Aspergillus terreus 25.50 2.00e-45 177.00
IUUC-Ame-011575 Astyanax mexicanus 81.09 0.00e+00 1497.00
IUUC-Bta-012439 Bos taurus 97.60 0.00e+00 1796.00
IUUC-Cja-019416 Callithrix jacchus 97.94 0.00e+00 1797.00
IUUC-Cfa-020502 Canis familiaris 98.51 0.00e+00 1808.00
IUUC-Cpo-021505 Cavia porcellus 98.40 0.00e+00 1805.00
IUUC-Csa-023741 Chlorocebus sabaeus 98.17 0.00e+00 1804.00
IUUC-Cho-024318 Choloepus hoffmanni 92.74 0.00e+00 1129.00
IUUC-Cne-026795 Cryptococcus neoformans 27.87 9.00e-08 52.80
IUUC-Dre-028717 Danio rerio 79.65 0.00e+00 1233.00
IUUC-Dno-029671 Dasypus novemcinctus 97.71 0.00e+00 1794.00
IUUC-Dor-030959 Dipodomys ordii 98.51 0.00e+00 1806.00
IUUC-Dme-031859 Drosophila melanogaster 31.42 2.00e-113 403.00
IUUC-Ete-032566 Echinops telfairi 96.47 0.00e+00 1770.00
IUUC-Eca-033468 Equus caballus 98.29 0.00e+00 1800.00
IUUC-Eeu-034980 Erinaceus europaeus 93.94 0.00e+00 1703.00
IUUC-Fca-035591 Felis catus 98.63 0.00e+00 1809.00
IUUC-Fal-036655 Ficedula albicollis 91.70 0.00e+00 1683.00
IUUC-Gmo-039467 Gadus morhua 76.11 0.00e+00 1385.00
IUUC-Gac-041898 Gasterosteus aculeatus 79.84 0.00e+00 1454.00
IUUC-Ggo-045602 Gorilla gorilla 98.17 0.00e+00 1805.00
IUUC-Hsa-045989 Homo sapiens 98.17 0.00e+00 1804.00
IUUC-Itr-048336 Ictidomys tridecemlineatus 98.63 0.00e+00 1809.00
IUUC-Lch-049432 Latimeria chalumnae 87.79 0.00e+00 1615.00
IUUC-Loc-051863 Lepisosteus oculatus 83.49 0.00e+00 1506.00
IUUC-Laf-053630 Loxodonta africana 98.17 0.00e+00 1803.00
IUUC-Mcc-054913 Macaca mulatta 96.58 0.00e+00 1768.00
IUUC-Mla-058875 Melampsora laricipopulina 27.70 3.00e-30 127.00
IUUC-Mga-059331 Meleagris gallopavo 91.46 0.00e+00 1677.00
IUUC-Mvi-060377 Microbotryum violaceum 28.92 2.00e-42 168.00
IUUC-Mmr-061068 Microcebus murinus 97.95 0.00e+00 1795.00
IUUC-Mpu-065818 Mustela putorius furo 97.72 0.00e+00 1791.00
IUUC-Mlu-067027 Myotis lucifugus 97.72 0.00e+00 1793.00
IUUC-Nfi-068460 Neosartorya fischeri 27.80 4.00e-50 193.00
IUUC-Nle-069884 Nomascus leucogenys 97.94 0.00e+00 1800.00
IUUC-Opr-070764 Ochotona princeps 88.57 0.00e+00 1598.00
IUUC-Ont-071473 Oreochromis niloticus 80.16 0.00e+00 1459.00
IUUC-Ocu-074541 Oryctolagus cuniculus 97.71 0.00e+00 1788.00
IUUC-Ola-086342 Oryzias latipes 78.52 0.00e+00 1388.00
IUUC-Oga-089081 Otolemur garnettii 98.74 0.00e+00 1809.00
IUUC-Oar-089969 Ovis aries 97.94 0.00e+00 1798.00
IUUC-Ptr-091278 Pan troglodytes 98.17 0.00e+00 1804.00
IUUC-Pan-092315 Papio anubis 88.03 0.00e+00 1721.00
IUUC-Psi-093799 Pelodiscus sinensis 91.33 0.00e+00 1680.00
IUUC-Pno-094978 Phaeosphaeria nodorum 25.45 2.00e-22 101.00
IUUC-Pfo-096693 Poecilia formosa 80.30 0.00e+00 1452.00
IUUC-Pab-097903 Pongo abelii 98.17 0.00e+00 1804.00
IUUC-Pca-100325 Procavia capensis 98.03 0.00e+00 1028.00
IUUC-Pgr-103692 Puccinia graminis 27.37 3.00e-23 104.00
IUUC-Ptt-103704 Puccinia triticina 25.43 2.00e-08 54.70
IUUC-Rno-105936 Rattus norvegicus 99.43 0.00e+00 1819.00
IUUC-Spo-108350 Schizosaccharomyces pombe 33.58 2.00e-48 187.00
IUUC-Sar-113246 Sorex araneus 97.38 0.00e+00 1786.00
IUUC-Ssc-115759 Sus scrofa 98.13 0.00e+00 1643.00
IUUC-Tgu-116985 Taeniopygia guttata 91.24 0.00e+00 1671.00
IUUC-Tru-118524 Takifugu rubripes 79.84 0.00e+00 1463.00
IUUC-Tsy-119545 Tarsius syrichta 98.29 0.00e+00 1803.00
IUUC-Tni-120566 Tetraodon nigroviridis 78.56 0.00e+00 1437.00
IUUC-Tbe-127649 Tupaia belangeri 91.22 0.00e+00 1652.00
IUUC-Ttr-128308 Tursiops truncatus 98.28 0.00e+00 950.00
IUUC-Xtr-132955 Xenopus tropicalis 86.04 0.00e+00 1580.00
IUUC-Xma-133519 Xiphophorus maculatus 80.18 0.00e+00 1447.00
Created Date 25-Jun-2017

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