iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	12724408; 15791259; 18082611
E3 adaptor/Cullin RING/APC_C/CDC20	CDC20	12724408; 15791259; 18082611

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.00e-31	103.1	373	403
E3 adaptor/Cullin RING/APC_C/CDC20	2.90e-145	481.3	238	540

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H  +v++l++ s+ +ll+sG++D+ ++vWD 
   Q: 373  HRQEVCGLEWnSNeNLLASGGNDNALMVWDK 403
           999*******9667****************6 PP

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladleekdlvtsvswieegtllavGtkkgeveiyDveekkkvrtl 92
           p++vldap l+ dfylnLldW++ n+lavaL+s+vylws  +++v+ ++++ ++d+vts++w+++gt+lavGt++g+vei+D++++kk+rt+
   Q: 238  PYRVLDAPGLAGDFYLNLLDWGQCNMLAVALASRVYLWSGISSEVTVMHNFYPTDTVTSLRWVQRGTHLAVGTHNGSVEIWDAATCKKTRTM 329
           79****************************************************************************************** PP
   S: 93   tghsarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfkehkaavka 184
           +gh++rvgaLsWn++vlssG+rd++ilhrdvr++e+ +++l+ah+qevCGl+wn++++lLasGGnDn+++vwd+ +++Pl++f++h aavka
   Q: 330  SGHTERVGALSWNDHVLSSGGRDNHILHRDVRAPEHYFRVLTAHRQEVCGLEWNSNENLLASGGNDNALMVWDKFEEKPLYSFHNHIAAVKA 421
           ******************************************************************************************** PP
   S: 185  iawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvlslals 276
           i+wsP+q+++LasGGGtaDr+ik+wnt++g++l++idtgsqvc+llwsk+++e++sthGf+en+++lw+yps+s+v +lkgh+ Rvl+la+s
   Q: 422  ITWSPHQRGILASGGGTADRTIKLWNTQRGSMLHNIDTGSQVCNLLWSKQTNEFISTHGFMENEVALWNYPSVSRVGTLKGHTDRVLYLAMS 513
           ******************************************************************************************** PP
   S: 277  pdgeaivtaagDetlrfwklfdkkkak 303
           p+ge+ivt+a+Detlrfwklfd+k+++
   Q: 514  PNGENIVTGAADETLRFWKLFDSKSKH 540
           **********************99875 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Has a role in cell differentiation and cell cycling by negatively regulating cig2 and cdc12-associated cdc2. Down-regulates the level of cdc13, particularly in a nitrogen deprived environment. Regulator of cell cycle G1 phase progression. Prevents onset of mitosis during the pre-Start G1 period. Required for degradation of cdc13 mitotic cyclin B during G1 arrest but not during mitotic exit.

Protein Sequence
(Fasta)

MDEFDGFTRP TSSNSSANRN SNNSMNRVEN NNSNSDSANT VDSRGDAHTR MRQGFEKSFP 60
SSPNKKRPRT NEGDRFIPSR DASTELWTGF TKVEGPLTPV KKKQSVADRN FTTLLRSELF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACATGTT AGCTTTAGCA TTTACTAACT GTTGCTTCCG AAGTTTGTTT GAAGTTTGAA 60
TTTATTGCTT CTAAATGTCA ATGAGTCCAA ACGTATATGT TATAATGATC ATGTCAATAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:1990757--F:ubiquitin ligase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0071851--P:mitotic G1 cell cycle arrest in response to nitrogen starvation
GO:1904668--P:positive regulation of ubiquitin protein ligase activity

KEGG

spo:SPAC144.13c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000670	Aegilops tauschii	53.77	4.00e-98	350.00
IUUC-Atr-002753	Amborella trichopoda	52.80	1.00e-105	374.00
IUUC-Aly-005442	Arabidopsis lyrata	43.97	5.00e-110	389.00
IUUC-Ath-006938	Arabidopsis thaliana	44.01	7.00e-111	392.00
IUUC-Ago-007784	Ashbya gossypii	44.00	2.00e-106	377.00
IUUC-Acl-008269	Aspergillus clavatus	48.91	7.00e-133	465.00
IUUC-Afl-008432	Aspergillus flavus	48.80	2.00e-135	474.00
IUUC-Afu-008829	Aspergillus fumigatus	47.91	5.00e-132	462.00
IUUC-Ani-009471	Aspergillus nidulans	49.01	7.00e-134	468.00
IUUC-Ang-009711	Aspergillus niger	48.38	2.00e-129	454.00
IUUC-Aor-010118	Aspergillus oryzae	48.80	2.00e-135	474.00
IUUC-Ate-010534	Aspergillus terreus	48.52	4.00e-133	466.00
IUUC-Bgr-012013	Blumeria graminis	45.38	4.00e-126	442.00
IUUC-Bci-013807	Botrytis cinerea	48.32	5.00e-120	422.00
IUUC-Bdi-014981	Brachypodium distachyon	57.76	1.00e-108	384.00
IUUC-Bol-016301	Brassica oleracea	52.51	1.00e-109	387.00
IUUC-Bra-017453	Brassica rapa	52.51	1.00e-109	388.00
IUUC-Cho-024920	Choloepus hoffmanni	50.89	9.00e-35	139.00
IUUC-Cgl-026631	Colletotrichum gloeosporioides	47.93	1.00e-132	464.00
IUUC-Cne-026933	Cryptococcus neoformans	51.33	7.00e-113	399.00
IUUC-Cme-027143	Cyanidioschyzon merolae	54.52	1.00e-98	352.00
IUUC-Dno-029629	Dasypus novemcinctus	50.73	8.00e-99	352.00
IUUC-Dse-031502	Dothistroma septosporum	45.73	5.00e-118	416.00
IUUC-Ete-032562	Echinops telfairi	39.56	3.00e-89	320.00
IUUC-Fox-037814	Fusarium oxysporum	58.65	1.00e-114	404.00
IUUC-Fso-038420	Fusarium solani	48.10	5.00e-129	452.00
IUUC-Ggr-039774	Gaeumannomyces graminis	48.12	3.00e-129	453.00
IUUC-Gma-042657	Glycine max	44.72	1.00e-107	381.00
IUUC-Hvu-047486	Hordeum vulgare	56.20	6.00e-96	341.00
IUUC-Kpa-049239	Komagataella pastoris	47.28	1.00e-127	448.00
IUUC-Lpe-051568	Leersia perrieri	52.88	6.00e-96	342.00
IUUC-Meu-056276	Macropus eugenii	51.78	4.00e-102	362.00
IUUC-Mor-057113	Magnaporthe oryzae	46.85	4.00e-128	449.00
IUUC-Mpo-057599	Magnaporthe poae	48.51	1.00e-129	455.00
IUUC-Mtr-057689	Medicago truncatula	45.74	1.00e-109	387.00
IUUC-Mvi-060465	Microbotryum violaceum	45.96	8.00e-123	431.00
IUUC-Mac-064942	Musa acuminata	43.12	3.00e-111	393.00
IUUC-Nfi-068536	Neosartorya fischeri	48.51	7.00e-133	465.00
IUUC-Ncr-068734	Neurospora crassa	46.08	2.00e-125	440.00
IUUC-Oan-073634	Ornithorhynchus anatinus	54.61	2.00e-93	333.00
IUUC-Oba-075417	Oryza barthii	52.88	5.00e-96	342.00
IUUC-Obr-076033	Oryza brachyantha	56.61	8.00e-106	375.00
IUUC-Ogl-077441	Oryza glaberrima	55.59	2.00e-104	370.00
IUUC-Ogu-077996	Oryza glumaepatula	53.41	1.00e-104	371.00
IUUC-Oin-080172	Oryza indica	53.41	1.00e-104	371.00
IUUC-Olo-081068	Oryza longistaminata	53.41	1.00e-104	370.00
IUUC-Ome-081250	Oryza meridionalis	53.41	9.00e-105	371.00
IUUC-Oni-083048	Oryza nivara	53.41	9.00e-105	371.00
IUUC-Opu-083333	Oryza punctata	53.41	9.00e-105	372.00
IUUC-Oru-085001	Oryza rufipogon	53.41	9.00e-105	371.00
IUUC-Osa-085451	Oryza sativa	55.59	2.00e-104	370.00
IUUC-Olu-087647	Ostreococcus lucimarinus	50.00	8.00e-96	342.00
IUUC-Pno-095139	Phaeosphaeria nodorum	54.04	2.00e-104	371.00
IUUC-Ppa-095366	Physcomitrella patens	46.06	3.00e-117	413.00
IUUC-Pop-099953	Populus trichocarpa	54.36	6.00e-103	365.00
IUUC-Ppe-101924	Prunus persica	44.19	1.00e-106	378.00
IUUC-Pte-104097	Pyrenophora teres	43.63	3.00e-120	423.00
IUUC-Pyt-104445	Pyrenophora triticirepentis	40.45	3.00e-106	376.00
IUUC-Sce-106240	Saccharomyces cerevisiae	40.89	1.00e-102	365.00
IUUC-Sja-107785	Schizosaccharomyces japonicus	54.11	1.00e-162	564.00
IUUC-Ssl-108391	Sclerotinia sclerotiorum	48.32	3.00e-124	436.00
IUUC-Smo-108878	Selaginella moellendorffii	45.66	2.00e-117	414.00
IUUC-Sly-111446	Solanum lycopersicum	43.43	5.00e-109	385.00
IUUC-Stu-112491	Solanum tuberosum	43.43	2.00e-108	384.00
IUUC-Sre-115222	Sporisorium reilianum	44.07	2.00e-122	430.00
IUUC-Tre-122249	Trichoderma reesei	48.90	6.00e-130	455.00
IUUC-Tvi-122675	Trichoderma virens	48.30	3.00e-131	459.00
IUUC-Tae-124272	Triticum aestivum	54.30	4.00e-110	389.00
IUUC-Tur-126545	Triticum urartu	51.61	3.00e-93	332.00
IUUC-Tme-127151	Tuber melanosporum	48.83	2.00e-136	476.00
IUUC-Tbe-128056	Tupaia belangeri	50.16	6.00e-87	311.00
IUUC-Vda-130027	Verticillium dahliae	49.21	7.00e-130	455.00
IUUC-Vvi-131749	Vitis vinifera	43.15	2.00e-106	377.00
IUUC-Yli-134584	Yarrowia lipolytica	47.21	1.00e-122	431.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence