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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064328
UUCD1 version UUC-MuM-00787
Ensembl Protein ID ENSMUSP00000025421.7
UniProt Accession Q8R2U0; Q3TLC9; Q3UP79; Q9D0K7; SEH1_MOUSE
Genbank Protein ID BAB27549.1; BAC40603.1; BAE25518.1; BAE38863.1; BAE41000.1; BAE41135.1; BAE41899.1; EDL09627.1; EDL09628.1; AAH27244.1
Protein Name Nucleoporin SEH1; Nup107-160 subcomplex subunit SEH1
Genbank Nucleotide ID AK011330; AK088835; AK143727; AK166573; AK169231; AK169388; AK170591; CH466528; CH466528; BC027244
Gene Name Seh1l
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000079614.3 ENSMUST00000025421.7 ENSMUSP00000025421.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.10e-22 78.8 11 40
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWD 29
           H+d +++++f  ++++++++s D ++kvWD
   Q: 11   HKDLIHDVSFdfHGRRMATCSSDQSVKVWD 40
           9*********976599************** PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3.
 As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3.
Protein Sequence
(Fasta)
MFVARSIAAD HKDLIHDVSF DFHGRRMATC SSDQSVKVWD KSESGDWHCT ASWKTHSGSV 60
WRVTWAHPEF GQVLASCSFD RTAAVWEEIV GESNDKLRGQ SHWVKRTTLV DSRTSVTDVK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064328|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGGCGTGGC GCGCCGGGGC CGACGCGGGC GGGCAGGCGA GGGCCGACGT GCCGTACGTG 60
CCTCCGCGGT GGTCCGGGGG CTGCGGGCCG CACCGCCGCC CTCTCGGAGG CGGGCCCGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064328|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0995--Kinetochore
KW-0498--Mitosis
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0061700--C:GATOR2 complex
GO:0031080--C:nuclear pore outer ring
GO:0051315--P:attachment of mitotic spindle microtubules to kinetochore
GO:0051301--P:cell division
GO:0034629--P:cellular protein complex localization
GO:0034198--P:cellular response to amino acid starvation
GO:0002534--P:cytokine production involved in inflammatory response
GO:0050830--P:defense response to Gram-positive bacterium
GO:0007080--P:mitotic metaphase plate congression
GO:0051028--P:mRNA transport
GO:0006999--P:nuclear pore organization
GO:0032008--P:positive regulation of TOR signaling
GO:1904263--P:positive regulation of TORC1 signaling
GO:0015031--P:protein transport
KEGG mmu:72124
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001926 Ailuropoda melanoleuca 97.50 0.00e+00 625.00
IUUC-Apl-003654 Anas platyrhynchos 92.81 3.00e-169 587.00
IUUC-Aca-004378 Anolis carolinensis 89.72 3.00e-165 574.00
IUUC-Ago-007816 Ashbya gossypii 34.50 1.00e-49 189.00
IUUC-Ame-011945 Astyanax mexicanus 84.12 1.00e-172 598.00
IUUC-Bta-013306 Bos taurus 95.83 0.00e+00 652.00
IUUC-Cel-018235 Caenorhabditis elegans 42.31 1.00e-74 273.00
IUUC-Cja-018849 Callithrix jacchus 96.09 0.00e+00 641.00
IUUC-Cfa-020841 Canis familiaris 96.78 3.00e-178 620.00
IUUC-Cpo-021379 Cavia porcellus 95.83 0.00e+00 648.00
IUUC-Csa-023900 Chlorocebus sabaeus 96.36 0.00e+00 646.00
IUUC-Cho-024660 Choloepus hoffmanni 94.97 1.00e-175 608.00
IUUC-Cin-025471 Ciona intestinalis 56.48 6.00e-103 367.00
IUUC-Csv-026242 Ciona savignyi 59.36 6.00e-88 317.00
IUUC-Dre-028068 Danio rerio 83.01 0.00e+00 626.00
IUUC-Dno-029981 Dasypus novemcinctus 89.16 8.00e-171 593.00
IUUC-Dme-031763 Drosophila melanogaster 57.62 3.00e-111 394.00
IUUC-Ete-032243 Echinops telfairi 62.25 1.00e-116 413.00
IUUC-Eca-033425 Equus caballus 95.67 7.00e-166 576.00
IUUC-Eeu-035119 Erinaceus europaeus 75.91 6.00e-116 410.00
IUUC-Fca-036520 Felis catus 96.51 0.00e+00 669.00
IUUC-Fal-037234 Ficedula albicollis 92.83 1.00e-172 601.00
IUUC-Gmo-039013 Gadus morhua 85.47 3.00e-176 610.00
IUUC-Gga-041059 Gallus gallus 93.56 0.00e+00 664.00
IUUC-Gac-041337 Gasterosteus aculeatus 84.36 1.00e-171 595.00
IUUC-Ggo-044944 Gorilla gorilla 96.36 0.00e+00 691.00
IUUC-Hsa-046038 Homo sapiens 96.08 0.00e+00 690.00
IUUC-Hvu-047455 Hordeum vulgare 31.01 6.00e-35 141.00
IUUC-Itr-048858 Ictidomys tridecemlineatus 96.25 6.00e-165 573.00
IUUC-Kpa-049201 Komagataella pastoris 35.62 9.00e-50 190.00
IUUC-Lch-050466 Latimeria chalumnae 78.52 9.00e-176 609.00
IUUC-Lpe-051064 Leersia perrieri 31.25 2.00e-35 142.00
IUUC-Loc-052773 Lepisosteus oculatus 74.64 4.00e-168 584.00
IUUC-Laf-053409 Loxodonta africana 96.11 0.00e+00 653.00
IUUC-Meu-055958 Macropus eugenii 69.78 4.00e-122 431.00
IUUC-Mga-059348 Meleagris gallopavo 92.59 1.00e-170 592.00
IUUC-Mmr-060977 Microcebus murinus 97.12 5.00e-134 469.00
IUUC-Mdo-061806 Monodelphis domestica 94.74 0.00e+00 682.00
IUUC-Mpu-066873 Mustela putorius furo 97.19 1.00e-180 625.00
IUUC-Mlu-067563 Myotis lucifugus 89.44 0.00e+00 640.00
IUUC-Nle-068977 Nomascus leucogenys 96.11 0.00e+00 644.00
IUUC-Opr-070773 Ochotona princeps 63.61 5.00e-87 314.00
IUUC-Ont-072644 Oreochromis niloticus 85.20 5.00e-176 610.00
IUUC-Oan-073098 Ornithorhynchus anatinus 94.15 2.00e-165 575.00
IUUC-Ocu-073911 Oryctolagus cuniculus 96.64 0.00e+00 693.00
IUUC-Ola-087096 Oryzias latipes 84.31 4.00e-171 594.00
IUUC-Oga-088798 Otolemur garnettii 96.08 0.00e+00 692.00
IUUC-Oar-090298 Ovis aries 94.72 5.00e-165 577.00
IUUC-Ptr-091074 Pan troglodytes 96.11 0.00e+00 698.00
IUUC-Pan-092013 Papio anubis 97.24 5.00e-141 493.00
IUUC-Psi-093508 Pelodiscus sinensis 90.71 3.00e-169 587.00
IUUC-Pma-094288 Petromyzon marinus 84.29 9.00e-104 369.00
IUUC-Ppa-095228 Physcomitrella patens 32.39 4.00e-37 148.00
IUUC-Pfo-096384 Poecilia formosa 84.64 1.00e-174 605.00
IUUC-Pab-098629 Pongo abelii 96.39 0.00e+00 699.00
IUUC-Pca-100322 Procavia capensis 72.50 5.00e-111 394.00
IUUC-Pva-102861 Pteropus vampyrus 95.80 0.00e+00 644.00
IUUC-Rno-104895 Rattus norvegicus 90.78 0.00e+00 673.00
IUUC-Sce-106420 Saccharomyces cerevisiae 34.76 8.00e-55 207.00
IUUC-Sha-106829 Sarcophilus harrisii 89.26 0.00e+00 632.00
IUUC-Sja-107923 Schizosaccharomyces japonicus 38.32 4.00e-66 244.00
IUUC-Spo-108184 Schizosaccharomyces pombe 37.86 8.00e-64 237.00
IUUC-Smo-109282 Selaginella moellendorffii 34.08 4.00e-37 148.00
IUUC-Sit-110393 Setaria italica 30.82 1.00e-33 136.00
IUUC-Sar-113279 Sorex araneus 95.62 1.00e-163 569.00
IUUC-Sbi-114110 Sorghum bicolor 31.58 2.00e-36 145.00
IUUC-Ssc-115589 Sus scrofa 95.06 6.00e-178 616.00
IUUC-Tgu-117523 Taeniopygia guttata 93.28 0.00e+00 663.00
IUUC-Tru-117985 Takifugu rubripes 81.49 7.00e-156 545.00
IUUC-Tsy-118913 Tarsius syrichta 95.38 2.00e-164 572.00
IUUC-Tni-120670 Tetraodon nigroviridis 85.00 8.00e-176 609.00
IUUC-Tae-122796 Triticum aestivum 31.01 1.00e-34 139.00
IUUC-Tme-126885 Tuber melanosporum 35.80 1.00e-54 207.00
IUUC-Tbe-127344 Tupaia belangeri 77.03 2.00e-135 475.00
IUUC-Ttr-128347 Tursiops truncatus 96.25 2.00e-164 572.00
IUUC-Vpa-130656 Vicugna pacos 97.53 5.00e-159 553.00
IUUC-Vvi-131103 Vitis vinifera 28.53 4.00e-35 141.00
IUUC-Xtr-132736 Xenopus tropicalis 89.66 0.00e+00 642.00
IUUC-Xma-133678 Xiphophorus maculatus 84.64 2.00e-174 605.00
IUUC-Yli-134659 Yarrowia lipolytica 40.19 2.00e-62 232.00
IUUC-Zma-135774 Zea mays 30.72 1.00e-34 140.00
Created Date 25-Jun-2017

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