iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/SH3	SH3	17244534

Classification

Family	E-value	Score	Start	End
UBD/SH3	5.40e-42	140.1	354	414

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           sk++ +v+yd++a+++deLt+k+Gd+v+++ +++++++W++++  ++gk+Gl+P++F+e ++
   Q: 354  SKKRGIVQYDFMAESQDELTIKSGDKVYIL-DDKKSKDWWMCQLVDSGKSGLVPAQFIEPVR 414
           78999*************************.****************************997 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.

Protein Sequence
(Fasta)

MTVFLGIYRA VYAYEPQTPE ELAIQEDDLL YLLQKSDIDD WWTVKKRVIG SDSEEPVGLV 60
PSTYIEEAPV LKKVRAIYDY EQVQNADEEL TFHENDVFDV FDDKDADWLL VKSTVSNEFG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACTGTGT TTCTGGGCAT CTATAGGGCC GTCTATGCCT ATGAGCCGCA GACACCAGAA 60
GAACTGGCCA TCCAAGAAGA CGATCTGTTG TACCTCTTAC AGAAGTCAGA CATTGACGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0009--Actin-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0967--Endosome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0832--Ubl conjugation

Interpro

IPR013761--SAM/pointed
IPR001452--SH3_domain
IPR007131--SHD1
IPR029922--Sla1

PROSITE

PS50002--SH3

Pfam

PF00018--SH3_1
PF14604--SH3_9
PF03983--SHD1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0030479--C:actin cortical patch
GO:0005938--C:cell cortex
GO:0010008--C:endosome membrane
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0042802--F:identical protein binding
GO:0030674--F:protein binding, bridging
GO:0043130--F:ubiquitin binding
GO:0000147--P:actin cortical patch assembly
GO:0030041--P:actin filament polymerization
GO:0006897--P:endocytosis

KEGG

sce:YBL007C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007979	Ashbya gossypii	44.07	8.00e-93	333.00
IUUC-Acl-008300	Aspergillus clavatus	37.92	6.00e-54	204.00
IUUC-Afl-008694	Aspergillus flavus	38.53	2.00e-39	156.00
IUUC-Afu-008881	Aspergillus fumigatus	35.74	5.00e-51	194.00
IUUC-Ani-009274	Aspergillus nidulans	36.10	6.00e-44	171.00
IUUC-Ang-009534	Aspergillus niger	33.19	3.00e-71	261.00
IUUC-Aor-010097	Aspergillus oryzae	33.12	3.00e-62	232.00
IUUC-Ate-010495	Aspergillus terreus	36.65	3.00e-41	162.00
IUUC-Bgr-012294	Blumeria graminis	44.44	1.00e-28	120.00
IUUC-Bci-013990	Botrytis cinerea	30.77	6.00e-31	127.00
IUUC-Bol-016323	Brassica oleracea	26.03	1.00e-02	31.20
IUUC-Cel-018144	Caenorhabditis elegans	36.84	8.00e-09	52.80
IUUC-Cgl-026697	Colletotrichum gloeosporioides	54.55	2.00e-21	96.30
IUUC-Cne-026842	Cryptococcus neoformans	30.13	9.00e-31	127.00
IUUC-Dse-031496	Dothistroma septosporum	35.24	1.00e-46	180.00
IUUC-Fso-038358	Fusarium solani	31.33	8.00e-38	150.00
IUUC-Ggr-040032	Gaeumannomyces graminis	42.35	3.00e-24	105.00
IUUC-Kpa-049118	Komagataella pastoris	36.52	4.00e-68	251.00
IUUC-Lma-053236	Leptosphaeria maculans	35.95	4.00e-44	171.00
IUUC-Mor-056954	Magnaporthe oryzae	38.87	1.00e-50	193.00
IUUC-Mpo-057576	Magnaporthe poae	43.02	9.00e-28	117.00
IUUC-Mla-059035	Melampsora laricipopulina	27.78	5.00e-18	85.10
IUUC-Mvi-060454	Microbotryum violaceum	42.06	2.00e-20	92.80
IUUC-Nfi-068406	Neosartorya fischeri	35.71	1.00e-50	192.00
IUUC-Ncr-068902	Neurospora crassa	37.95	4.00e-25	108.00
IUUC-Obr-076697	Oryza brachyantha	31.82	5.00e-03	31.60
IUUC-Pno-094774	Phaeosphaeria nodorum	57.81	1.00e-20	94.00
IUUC-Pgr-103396	Puccinia graminis	50.79	4.00e-20	92.00
IUUC-Ptt-103751	Puccinia triticina	52.38	7.00e-21	94.40
IUUC-Pte-104349	Pyrenophora teres	50.79	3.00e-27	115.00
IUUC-Pyt-104695	Pyrenophora triticirepentis	50.00	6.00e-27	114.00
IUUC-Sja-107962	Schizosaccharomyces japonicus	31.72	5.00e-44	171.00
IUUC-Spo-108375	Schizosaccharomyces pombe	30.10	1.00e-24	107.00
IUUC-Ssl-108553	Sclerotinia sclerotiorum	34.16	7.00e-24	104.00
IUUC-Sit-110611	Setaria italica	40.00	5.80e-02	29.60
IUUC-Stu-112077	Solanum tuberosum	31.48	1.60e-02	32.00
IUUC-Sre-115072	Sporisorium reilianum	38.68	2.00e-20	93.20
IUUC-Tre-121912	Trichoderma reesei	37.02	4.00e-34	138.00
IUUC-Tvi-122336	Trichoderma virens	34.38	9.00e-35	140.00
IUUC-Tme-127017	Tuber melanosporum	40.00	4.00e-31	127.00
IUUC-Tbe-128089	Tupaia belangeri	35.48	1.00e-07	47.80
IUUC-Uma-129502	Ustilago maydis	53.85	8.00e-20	90.90
IUUC-Vda-129879	Verticillium dahliae	39.41	2.00e-28	119.00
IUUC-Yli-134528	Yarrowia lipolytica	44.79	2.00e-39	155.00
IUUC-Zma-135724	Zea mays	32.50	9.00e-02	28.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence