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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-031585
UUCD1 version UUC-DrM-00045
Ensembl Protein ID FBpp0070117
UniProt Accession Q9W5E1; O77429; RBX1A_DROME
Genbank Protein ID AAF45536.1; CAA20888.1; AAM51125.1
Protein Name RING-box protein 1A; Regulator of cullins 1a; dRbx1
Genbank Nucleotide ID AE014298; AL031581; AY119265
Gene Name Roc1a; CG16982
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0025638 FBtr0308651 FBpp0300874
FBgn0025638 FBtr0070122 FBpp0070117
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18698375
Classification
Family E-value Score Start End
E3 activity/RING/RING 5.30e-09 36.5 42 97
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplv..................lpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+++++d +++                  + C+H+fh++C+ +w       ++++ CPl+
   Q: 42   CAICRNHIMD-LCIecqanqasatseectvawGVCNHAFHFHCISRW------LKTRQVCPLD 97
           ********66.55333444444433333333488*************......********97 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex (PubMed:12062088). During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larval ddaC dendrites and mushroom body axons (PubMed:24068890). The SCF-slmb complex also regulates asymmetrical division of neuroblasts and inhibits ectopic neuroblast formation partly through SAK and Akt1 (PubMed:24413555). Also part of an SCF complex required for caspase activation during sperm differentiation (Probable).
 Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex (PubMed:12062088). During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larval ddaC dendrites and mushroom body axons (PubMed:24068890). The SCF-slmb complex also regulates asymmetrical division of neuroblasts and inhibits ectopic neuroblast formation partly through SAK and Akt1 (PubMed:24413555). Also part of an SCF complex required for caspase activation during sperm differentiation (Probable).
Protein Sequence
(Fasta)
MEVDEDGYEV PSSSSKGDKK RFEVKKWNAV ALWAWDIVVD NCAICRNHIM DLCIECQANQ 60
ASATSEECTV AWGVCNHAFH FHCISRWLKT RQVCPLDNRE WDFQKYGH 108
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Protein Fasta Sequence


>IUUC-Dme-031585|E3,RING|Drosophila melanogaster
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Nucleotide Sequence
(Fasta)
GCGGTCACAC TGCTTGAGCC TCACTGCGAG TGGTTTTCTA TTAAAACGAA AAGGATAGGG 60
ACAGAAAAGC CAAAACTACG TTAGTTGTGA AAATTGCATT TGTGTTGCGA GAGTTTTGTC 120
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Nucleotide Fasta Sequence


>IUUC-Dme-031585|E3,RING|Drosophila melanogaster
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR024766--Znf_RING_H2
PROSITE

PS50089--ZF_RING_2
Pfam

PF12678--zf-rbx1
Gene Ontology

GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:0019915--P:lipid storage
GO:0030178--P:negative regulation of Wnt signaling pathway
GO:0022008--P:neurogenesis
GO:0016322--P:neuron remodeling
GO:0016567--P:protein ubiquitination
GO:0006508--P:proteolysis
GO:0007224--P:smoothened signaling pathway
KEGG dme:Dmel_CG16982
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001798 Ailuropoda melanoleuca 91.09 6.00e-52 194.00
IUUC-Atr-002900 Amborella trichopoda 88.89 1.00e-50 190.00
IUUC-Apl-003762 Anas platyrhynchos 98.72 1.00e-42 162.00
IUUC-Aca-005328 Anolis carolinensis 91.09 1.00e-51 193.00
IUUC-Aly-005923 Arabidopsis lyrata 95.45 4.00e-48 182.00
IUUC-Ath-007535 Arabidopsis thaliana 93.26 2.00e-46 176.00
IUUC-Ago-007991 Ashbya gossypii 60.55 5.00e-38 148.00
IUUC-Acl-008332 Aspergillus clavatus 92.13 1.00e-47 180.00
IUUC-Afl-008537 Aspergillus flavus 93.02 3.00e-46 175.00
IUUC-Afu-008985 Aspergillus fumigatus 92.13 1.00e-47 180.00
IUUC-Ani-009342 Aspergillus nidulans 87.23 1.00e-47 180.00
IUUC-Ang-009778 Aspergillus niger 93.02 3.00e-46 175.00
IUUC-Aor-009918 Aspergillus oryzae 93.02 3.00e-46 175.00
IUUC-Ame-010814 Astyanax mexicanus 98.21 1.00e-29 119.00
IUUC-Bgr-012224 Blumeria graminis 92.22 1.00e-48 183.00
IUUC-Bta-012426 Bos taurus 91.09 5.00e-52 194.00
IUUC-Bci-013839 Botrytis cinerea 96.55 4.00e-48 181.00
IUUC-Bdi-014575 Brachypodium distachyon 92.47 3.00e-49 186.00
IUUC-Bol-015671 Brassica oleracea 96.63 4.00e-49 185.00
IUUC-Bra-017034 Brassica rapa 96.63 4.00e-49 185.00
IUUC-Cel-018195 Caenorhabditis elegans 80.00 2.00e-48 182.00
IUUC-Cja-018788 Callithrix jacchus 90.82 9.00e-50 187.00
IUUC-Cpo-021365 Cavia porcellus 91.09 5.00e-52 194.00
IUUC-Cre-022904 Chlamydomonas reinhardtii 53.12 8.00e-27 111.00
IUUC-Csa-024198 Chlorocebus sabaeus 91.09 5.00e-52 194.00
IUUC-Cho-024344 Choloepus hoffmanni 98.18 3.00e-29 118.00
IUUC-Cin-025449 Ciona intestinalis 87.85 6.00e-52 194.00
IUUC-Cgl-026522 Colletotrichum gloeosporioides 83.96 2.00e-49 186.00
IUUC-Cne-027067 Cryptococcus neoformans 70.65 2.00e-36 143.00
IUUC-Cme-027268 Cyanidioschyzon merolae 62.86 2.00e-37 146.00
IUUC-Dre-027434 Danio rerio 91.09 5.00e-52 194.00
IUUC-Dno-029252 Dasypus novemcinctus 89.80 5.00e-49 184.00
IUUC-Dor-030861 Dipodomys ordii 65.98 3.00e-32 129.00
IUUC-Dse-031355 Dothistroma septosporum 92.31 1.00e-48 183.00
IUUC-Ete-032747 Echinops telfairi 47.52 7.00e-17 77.80
IUUC-Eca-033758 Equus caballus 91.09 5.00e-52 194.00
IUUC-Fca-035586 Felis catus 91.09 5.00e-52 194.00
IUUC-Fal-037097 Ficedula albicollis 97.53 2.00e-44 168.00
IUUC-Fox-037881 Fusarium oxysporum 93.83 4.00e-43 165.00
IUUC-Fso-038373 Fusarium solani 86.14 1.00e-48 183.00
IUUC-Gmo-039457 Gadus morhua 90.72 4.00e-49 184.00
IUUC-Ggr-039970 Gaeumannomyces graminis 94.25 7.00e-47 177.00
IUUC-Gga-040328 Gallus gallus 91.09 5.00e-52 194.00
IUUC-Gac-041578 Gasterosteus aculeatus 91.09 5.00e-52 194.00
IUUC-Gma-042692 Glycine max 96.59 1.00e-48 183.00
IUUC-Ggo-045249 Gorilla gorilla 62.39 3.00e-31 125.00
IUUC-Hsa-046279 Homo sapiens 91.09 5.00e-52 194.00
IUUC-Hvu-047597 Hordeum vulgare 96.63 6.00e-49 184.00
IUUC-Itr-048174 Ictidomys tridecemlineatus 91.09 5.00e-52 194.00
IUUC-Kpa-049330 Komagataella pastoris 66.32 7.00e-37 144.00
IUUC-Lch-049667 Latimeria chalumnae 92.08 2.00e-52 195.00
IUUC-Lma-053052 Leptosphaeria maculans 94.57 7.00e-50 187.00
IUUC-Laf-053827 Loxodonta africana 89.90 6.00e-50 187.00
IUUC-Mcc-055208 Macaca mulatta 91.09 5.00e-52 194.00
IUUC-Meu-056143 Macropus eugenii 98.78 1.00e-45 172.00
IUUC-Mor-057158 Magnaporthe oryzae 95.40 2.00e-47 179.00
IUUC-Mpo-057409 Magnaporthe poae 94.25 8.00e-47 177.00
IUUC-Mtr-058505 Medicago truncatula 96.59 1.00e-48 184.00
IUUC-Mla-059071 Melampsora laricipopulina 74.59 1.00e-46 177.00
IUUC-Mga-059797 Meleagris gallopavo 91.09 5.00e-52 194.00
IUUC-Mvi-060401 Microbotryum violaceum 81.55 3.00e-48 182.00
IUUC-Mmr-061077 Microcebus murinus 91.09 5.00e-52 194.00
IUUC-Mdo-062218 Monodelphis domestica 91.09 5.00e-52 194.00
IUUC-Mmu-064224 Mus musculus 91.09 5.00e-52 194.00
IUUC-Mac-064505 Musa acuminata 96.59 2.00e-48 182.00
IUUC-Mpu-066572 Mustela putorius furo 91.09 5.00e-52 194.00
IUUC-Mlu-067821 Myotis lucifugus 91.09 5.00e-52 194.00
IUUC-Nfi-068412 Neosartorya fischeri 92.13 1.00e-47 180.00
IUUC-Nle-069309 Nomascus leucogenys 91.09 5.00e-52 194.00
IUUC-Opr-070307 Ochotona princeps 91.09 5.00e-52 194.00
IUUC-Ont-071677 Oreochromis niloticus 91.00 8.00e-53 197.00
IUUC-Oan-072926 Ornithorhynchus anatinus 98.75 4.00e-44 167.00
IUUC-Oba-075405 Oryza barthii 92.47 3.00e-49 185.00
IUUC-Obr-076843 Oryza brachyantha 92.47 2.00e-49 187.00
IUUC-Ogl-077608 Oryza glaberrima 92.47 3.00e-49 185.00
IUUC-Ogu-078316 Oryza glumaepatula 92.47 3.00e-49 185.00
IUUC-Oin-079918 Oryza indica 64.62 1.00e-42 164.00
IUUC-Olo-080968 Oryza longistaminata 96.23 1.00e-26 109.00
IUUC-Ome-081246 Oryza meridionalis 95.45 3.00e-48 182.00
IUUC-Oni-082052 Oryza nivara 92.47 3.00e-49 185.00
IUUC-Opu-084035 Oryza punctata 91.84 1.00e-50 189.00
IUUC-Oru-084941 Oryza rufipogon 92.47 3.00e-49 185.00
IUUC-Osa-085800 Oryza sativa 92.47 3.00e-49 185.00
IUUC-Ola-087352 Oryzias latipes 91.09 5.00e-52 194.00
IUUC-Olu-087676 Ostreococcus lucimarinus 52.33 2.00e-25 106.00
IUUC-Oga-088880 Otolemur garnettii 91.09 5.00e-52 194.00
IUUC-Oar-089286 Ovis aries 91.09 6.00e-52 194.00
IUUC-Ptr-091402 Pan troglodytes 91.09 5.00e-52 194.00
IUUC-Pan-091687 Papio anubis 85.19 5.00e-51 191.00
IUUC-Psi-093640 Pelodiscus sinensis 91.09 8.00e-52 194.00
IUUC-Pma-094723 Petromyzon marinus 97.59 8.00e-46 173.00
IUUC-Pno-094822 Phaeosphaeria nodorum 92.71 2.00e-51 192.00
IUUC-Ppa-095730 Physcomitrella patens 95.51 9.00e-49 184.00
IUUC-Pfo-096055 Poecilia formosa 91.09 4.00e-52 194.00
IUUC-Pab-098577 Pongo abelii 91.09 5.00e-52 194.00
IUUC-Pop-099697 Populus trichocarpa 92.78 4.00e-51 191.00
IUUC-Pca-100719 Procavia capensis 91.09 5.00e-52 194.00
IUUC-Ppe-101429 Prunus persica 82.46 1.00e-50 190.00
IUUC-Pva-102885 Pteropus vampyrus 61.47 9.00e-32 127.00
IUUC-Pgr-103470 Puccinia graminis 79.63 3.00e-49 185.00
IUUC-Ptt-103909 Puccinia triticina 74.03 4.00e-30 122.00
IUUC-Pte-104144 Pyrenophora teres 91.49 1.00e-47 180.00
IUUC-Pyt-104533 Pyrenophora triticirepentis 92.71 5.00e-51 191.00
IUUC-Rno-105912 Rattus norvegicus 91.09 5.00e-52 194.00
IUUC-Sce-106407 Saccharomyces cerevisiae 57.52 9.00e-35 137.00
IUUC-Sha-107549 Sarcophilus harrisii 91.09 5.00e-52 194.00
IUUC-Sja-108003 Schizosaccharomyces japonicus 79.63 1.00e-48 183.00
IUUC-Spo-108091 Schizosaccharomyces pombe 73.15 5.00e-45 171.00
IUUC-Ssl-108634 Sclerotinia sclerotiorum 96.55 4.00e-48 181.00
IUUC-Smo-109406 Selaginella moellendorffii 96.51 3.00e-47 179.00
IUUC-Sit-110419 Setaria italica 94.38 4.00e-48 181.00
IUUC-Sly-111256 Solanum lycopersicum 95.45 1.00e-48 184.00
IUUC-Stu-112567 Solanum tuberosum 79.82 2.00e-50 189.00
IUUC-Sar-113409 Sorex araneus 62.39 5.00e-32 128.00
IUUC-Sbi-113799 Sorghum bicolor 91.58 6.00e-50 188.00
IUUC-Sre-115142 Sporisorium reilianum 84.85 9.00e-47 177.00
IUUC-Tgu-116923 Taeniopygia guttata 97.47 7.00e-43 163.00
IUUC-Tru-117710 Takifugu rubripes 91.67 9.00e-51 190.00
IUUC-Tni-119934 Tetraodon nigroviridis 90.10 3.00e-52 195.00
IUUC-Tca-121820 Theobroma cacao 95.51 9.00e-49 184.00
IUUC-Tre-122212 Trichoderma reesei 93.83 1.00e-43 166.00
IUUC-Tvi-122357 Trichoderma virens 89.47 4.00e-49 185.00
IUUC-Tae-125834 Triticum aestivum 92.71 1.00e-50 190.00
IUUC-Tur-125958 Triticum urartu 96.59 3.00e-48 182.00
IUUC-Tme-126940 Tuber melanosporum 88.42 3.00e-48 182.00
IUUC-Tbe-127918 Tupaia belangeri 98.78 1.00e-45 172.00
IUUC-Ttr-128306 Tursiops truncatus 98.78 1.00e-45 172.00
IUUC-Uma-129482 Ustilago maydis 74.77 7.00e-45 171.00
IUUC-Vda-129917 Verticillium dahliae 88.12 7.00e-50 187.00
IUUC-Vpa-130142 Vicugna pacos 87.63 9.00e-46 173.00
IUUC-Vvi-130957 Vitis vinifera 96.59 1.00e-48 183.00
IUUC-Xma-133061 Xiphophorus maculatus 91.09 4.00e-52 194.00
IUUC-Yli-134542 Yarrowia lipolytica 62.16 4.00e-37 145.00
IUUC-Zma-135466 Zea mays 92.47 3.00e-49 185.00
Created Date 25-Jun-2017

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