iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091536

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AACZ03034163

Gene Name

UCHL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000016009.4	ENSPTRT00000029855.3	ENSPTRP00000027549.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	8.30e-64	216.0	2	222

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvi 95
           ++ ++e +P++   +++++gv +++++ ++ +L++e+lg+++ p ++llllF+++ ++e++rk+q++    e +++++  +++f+kq+i
   Q: 2    QLKPMEINPEVSARVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIE----ELKGQEVSPKVYFMKQTI 86
           5789*************************************************************99....99**************** PP
   S: 96   gNsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           gNsC+t++l+++++n++dkl ++ G+ l++++++t+++spe++a++++++++++++h+++a++++++ +          +k +fhf+++
   Q: 87   GNSCGTIGLIHAVANNQDKLgFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVD----------DKVNFHFILF 165
           *******************************************************************99..........5679****** PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivad 244
            n++g+lyeldg++pfP+++g+++e++ lkd++kv+r+f+er    e++e+rf+++a++++
   Q: 166  NNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTER----EQGEVRFSAVALCKA 222
           ******************************************....************987 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MQLKPMEINP EVSARVLSRL GVAGQWRFVD VLGLEEESLG SVPAPACALL LLFPLTAQHE 60
NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLGFED GSVLKQFLSE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAGCTCA AGCCGATGGA GATCAACCCC GAGGTGAGCG CCAGGTGCAC CGCTACCCGG 60
AGAGCGCGAG GCCGAGGGAG GGGGAGCCGA GTCGCTGATC GGTTCGGTTT TGCCTTTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0044306--C:neuron projection terminus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0016874--F:ligase activity
GO:0008242--F:omega peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007628--P:adult walking behavior
GO:0007412--P:axon target recognition
GO:0019896--P:axonal transport of mitochondrion
GO:0008283--P:cell proliferation
GO:0042755--P:eating behavior
GO:0048747--P:muscle fiber development
GO:0043407--P:negative regulation of MAP kinase activity
GO:0050905--P:neuromuscular process
GO:0016579--P:protein deubiquitination
GO:0002931--P:response to ischemia
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000360	Aegilops tauschii	38.86	1.00e-43	169.00
IUUC-Aml-001376	Ailuropoda melanoleuca	78.52	3.00e-110	390.00
IUUC-Atr-002931	Amborella trichopoda	44.28	4.00e-40	157.00
IUUC-Apl-003693	Anas platyrhynchos	67.86	5.00e-89	320.00
IUUC-Aca-004716	Anolis carolinensis	75.89	1.00e-100	358.00
IUUC-Aly-005939	Arabidopsis lyrata	42.66	3.00e-46	178.00
IUUC-Ath-006827	Arabidopsis thaliana	43.58	4.00e-48	184.00
IUUC-Ago-007950	Ashbya gossypii	32.67	2.00e-15	75.90
IUUC-Acl-008305	Aspergillus clavatus	35.87	9.00e-30	123.00
IUUC-Afl-008611	Aspergillus flavus	37.39	1.00e-32	132.00
IUUC-Afu-008945	Aspergillus fumigatus	36.96	2.00e-31	129.00
IUUC-Ani-009339	Aspergillus nidulans	36.09	2.00e-31	129.00
IUUC-Ang-009691	Aspergillus niger	35.65	2.00e-31	128.00
IUUC-Aor-009961	Aspergillus oryzae	37.39	2.00e-32	132.00
IUUC-Ate-010316	Aspergillus terreus	36.52	7.00e-33	133.00
IUUC-Ame-011806	Astyanax mexicanus	66.37	1.00e-83	301.00
IUUC-Bgr-012125	Blumeria graminis	34.89	1.00e-30	126.00
IUUC-Bta-013521	Bos taurus	80.16	3.00e-112	397.00
IUUC-Bci-013734	Botrytis cinerea	36.21	7.00e-34	137.00
IUUC-Bdi-014330	Brachypodium distachyon	42.27	5.00e-46	177.00
IUUC-Bol-015214	Brassica oleracea	43.12	4.00e-48	184.00
IUUC-Bra-017721	Brassica rapa	43.58	1.00e-48	185.00
IUUC-Cel-018302	Caenorhabditis elegans	37.67	1.00e-33	135.00
IUUC-Cja-018752	Callithrix jacchus	96.88	2.00e-117	414.00
IUUC-Cfa-020442	Canis familiaris	93.75	2.00e-114	404.00
IUUC-Cpo-021723	Cavia porcellus	96.99	2.00e-94	337.00
IUUC-Cre-022599	Chlamydomonas reinhardtii	40.28	1.00e-32	132.00
IUUC-Csa-023626	Chlorocebus sabaeus	97.31	2.00e-118	417.00
IUUC-Cho-024548	Choloepus hoffmanni	85.19	2.00e-40	158.00
IUUC-Cin-025545	Ciona intestinalis	47.56	2.00e-56	211.00
IUUC-Cgl-026409	Colletotrichum gloeosporioides	32.77	7.00e-26	110.00
IUUC-Cne-026914	Cryptococcus neoformans	33.63	4.00e-24	104.00
IUUC-Cme-027216	Cyanidioschyzon merolae	32.89	2.00e-18	85.90
IUUC-Dre-027854	Danio rerio	64.29	4.00e-82	296.00
IUUC-Dno-029325	Dasypus novemcinctus	94.17	1.00e-115	408.00
IUUC-Dor-030114	Dipodomys ordii	92.83	3.00e-124	437.00
IUUC-Dse-031461	Dothistroma septosporum	33.91	2.00e-27	115.00
IUUC-Dme-032146	Drosophila melanogaster	44.69	5.00e-53	200.00
IUUC-Ete-033092	Echinops telfairi	75.78	9.00e-95	338.00
IUUC-Eca-033854	Equus caballus	96.48	2.00e-79	286.00
IUUC-Eeu-034493	Erinaceus europaeus	91.48	3.00e-111	393.00
IUUC-Fca-036421	Felis catus	55.16	1.00e-72	265.00
IUUC-Fal-036693	Ficedula albicollis	74.29	1.00e-92	332.00
IUUC-Fox-037830	Fusarium oxysporum	36.12	4.00e-32	131.00
IUUC-Fso-038259	Fusarium solani	33.92	8.00e-30	125.00
IUUC-Gmo-038848	Gadus morhua	59.43	2.00e-72	264.00
IUUC-Ggr-039832	Gaeumannomyces graminis	34.93	5.00e-26	110.00
IUUC-Gga-041078	Gallus gallus	73.21	4.00e-99	353.00
IUUC-Gac-042064	Gasterosteus aculeatus	60.45	2.00e-75	275.00
IUUC-Gma-043057	Glycine max	43.64	2.00e-42	165.00
IUUC-Ggo-044827	Gorilla gorilla	98.21	1.00e-119	421.00
IUUC-Hsa-045820	Homo sapiens	98.21	1.00e-119	421.00
IUUC-Hvu-047176	Hordeum vulgare	34.38	2.00e-35	142.00
IUUC-Itr-048496	Ictidomys tridecemlineatus	94.17	7.00e-115	405.00
IUUC-Kpa-049123	Komagataella pastoris	30.05	3.00e-21	95.10
IUUC-Lch-050121	Latimeria chalumnae	74.32	2.00e-98	351.00
IUUC-Lpe-051377	Leersia perrieri	43.08	7.00e-40	156.00
IUUC-Loc-052342	Lepisosteus oculatus	68.58	6.00e-90	323.00
IUUC-Lma-053316	Leptosphaeria maculans	36.80	7.00e-34	137.00
IUUC-Laf-053916	Loxodonta africana	92.44	2.00e-113	400.00
IUUC-Mcc-054838	Macaca mulatta	97.31	2.00e-118	417.00
IUUC-Meu-056478	Macropus eugenii	87.44	5.00e-119	419.00
IUUC-Mor-057271	Magnaporthe oryzae	34.93	1.00e-31	129.00
IUUC-Mpo-057343	Magnaporthe poae	32.48	5.00e-19	87.00
IUUC-Mtr-057713	Medicago truncatula	42.27	5.00e-43	167.00
IUUC-Mla-058942	Melampsora laricipopulina	35.34	6.00e-35	140.00
IUUC-Mga-059878	Meleagris gallopavo	73.27	2.00e-94	337.00
IUUC-Mvi-060249	Microbotryum violaceum	35.14	6.00e-25	107.00
IUUC-Mmr-061284	Microcebus murinus	55.03	7.00e-46	177.00
IUUC-Mdo-062544	Monodelphis domestica	86.10	1.00e-107	381.00
IUUC-Mmu-063300	Mus musculus	93.72	5.00e-125	439.00
IUUC-Mac-065075	Musa acuminata	40.72	2.00e-42	165.00
IUUC-Mpu-066128	Mustela putorius furo	93.00	7.00e-101	359.00
IUUC-Mlu-067778	Myotis lucifugus	92.38	3.00e-123	433.00
IUUC-Nfi-068320	Neosartorya fischeri	36.96	2.00e-31	129.00
IUUC-Ncr-068673	Neurospora crassa	34.06	3.00e-32	131.00
IUUC-Nle-069686	Nomascus leucogenys	97.76	2.00e-119	420.00
IUUC-Opr-070535	Ochotona princeps	76.68	7.00e-97	346.00
IUUC-Ont-071510	Oreochromis niloticus	60.81	2.00e-77	281.00
IUUC-Oan-073247	Ornithorhynchus anatinus	54.72	4.00e-29	119.00
IUUC-Ocu-074590	Oryctolagus cuniculus	94.62	5.00e-116	409.00
IUUC-Oba-075098	Oryza barthii	38.25	1.00e-42	166.00
IUUC-Obr-076041	Oryza brachyantha	41.18	1.00e-44	172.00
IUUC-Ogl-076980	Oryza glaberrima	41.63	2.00e-44	172.00
IUUC-Ogu-078978	Oryza glumaepatula	36.18	7.00e-41	160.00
IUUC-Oin-079285	Oryza indica	37.79	4.00e-42	164.00
IUUC-Olo-080671	Oryza longistaminata	37.79	2.00e-41	162.00
IUUC-Ome-081428	Oryza meridionalis	36.87	6.00e-40	157.00
IUUC-Oni-082406	Oryza nivara	38.25	1.00e-42	166.00
IUUC-Opu-083305	Oryza punctata	36.87	5.00e-41	160.00
IUUC-Oru-084969	Oryza rufipogon	38.25	1.00e-42	166.00
IUUC-Osa-085830	Oryza sativa	41.63	2.00e-44	172.00
IUUC-Ola-086893	Oryzias latipes	58.56	2.00e-66	244.00
IUUC-Olu-087858	Ostreococcus lucimarinus	35.91	9.00e-36	142.00
IUUC-Oga-089013	Otolemur garnettii	80.56	3.00e-111	394.00
IUUC-Oar-089861	Ovis aries	80.16	3.00e-112	397.00
IUUC-Pan-092909	Papio anubis	97.31	2.00e-118	417.00
IUUC-Psi-093818	Pelodiscus sinensis	78.12	3.00e-102	363.00
IUUC-Pma-094412	Petromyzon marinus	51.33	4.00e-40	156.00
IUUC-Pno-094997	Phaeosphaeria nodorum	34.13	3.00e-25	108.00
IUUC-Ppa-095519	Physcomitrella patens	42.15	3.00e-45	174.00
IUUC-Pfo-097335	Poecilia formosa	58.67	6.00e-77	280.00
IUUC-Pab-098048	Pongo abelii	98.21	1.00e-119	421.00
IUUC-Pop-099282	Populus trichocarpa	42.73	2.00e-43	168.00
IUUC-Pca-100818	Procavia capensis	70.26	3.00e-64	237.00
IUUC-Ppe-101332	Prunus persica	41.82	7.00e-45	173.00
IUUC-Pva-102954	Pteropus vampyrus	93.27	1.00e-110	391.00
IUUC-Pgr-103430	Puccinia graminis	38.02	6.00e-35	140.00
IUUC-Ptt-103955	Puccinia triticina	39.83	2.00e-35	142.00
IUUC-Pte-104414	Pyrenophora teres	33.62	5.00e-30	124.00
IUUC-Pyt-104587	Pyrenophora triticirepentis	35.59	4.00e-31	127.00
IUUC-Rno-105966	Rattus norvegicus	93.72	5.00e-125	439.00
IUUC-Sce-106412	Saccharomyces cerevisiae	31.52	4.00e-19	87.80
IUUC-Sha-107111	Sarcophilus harrisii	87.27	2.00e-87	314.00
IUUC-Sja-107753	Schizosaccharomyces japonicus	29.60	1.00e-17	82.80
IUUC-Spo-108322	Schizosaccharomyces pombe	33.19	3.00e-23	101.00
IUUC-Ssl-108641	Sclerotinia sclerotiorum	35.74	8.00e-32	130.00
IUUC-Smo-108914	Selaginella moellendorffii	40.35	1.00e-40	159.00
IUUC-Sit-110163	Setaria italica	40.72	6.00e-45	174.00
IUUC-Sly-111832	Solanum lycopersicum	45.41	2.00e-48	185.00
IUUC-Stu-112526	Solanum tuberosum	45.41	1.00e-48	186.00
IUUC-Sar-113190	Sorex araneus	74.56	2.00e-38	150.00
IUUC-Sbi-114545	Sorghum bicolor	40.99	3.00e-43	167.00
IUUC-Sre-114961	Sporisorium reilianum	32.03	6.00e-23	100.00
IUUC-Ssc-115908	Sus scrofa	77.78	2.00e-98	351.00
IUUC-Tgu-117465	Taeniopygia guttata	70.14	2.00e-86	311.00
IUUC-Tru-118565	Takifugu rubripes	60.78	5.00e-70	256.00
IUUC-Tsy-119561	Tarsius syrichta	75.78	4.00e-94	337.00
IUUC-Tni-120042	Tetraodon nigroviridis	52.54	2.00e-50	193.00
IUUC-Tca-120976	Theobroma cacao	43.12	7.00e-46	176.00
IUUC-Tre-122149	Trichoderma reesei	37.44	2.00e-34	138.00
IUUC-Tvi-122450	Trichoderma virens	36.56	2.00e-34	139.00
IUUC-Tae-122693	Triticum aestivum	40.27	6.00e-45	174.00
IUUC-Tur-126250	Triticum urartu	38.86	4.00e-43	167.00
IUUC-Tme-126961	Tuber melanosporum	37.77	7.00e-31	127.00
IUUC-Tbe-128048	Tupaia belangeri	95.15	1.00e-92	331.00
IUUC-Ttr-128494	Tursiops truncatus	95.05	2.00e-114	404.00
IUUC-Uma-129382	Ustilago maydis	32.62	3.00e-28	118.00
IUUC-Vda-129850	Verticillium dahliae	34.20	6.00e-28	117.00
IUUC-Vpa-130783	Vicugna pacos	58.04	4.00e-35	141.00
IUUC-Vvi-131661	Vitis vinifera	40.37	1.00e-44	172.00
IUUC-Xtr-132286	Xenopus tropicalis	68.16	3.00e-90	324.00
IUUC-Xma-133019	Xiphophorus maculatus	58.74	1.00e-76	278.00
IUUC-Yli-134570	Yarrowia lipolytica	34.63	5.00e-30	124.00
IUUC-Zma-134740	Zea mays	40.54	3.00e-43	168.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence