iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ola-086566

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

BAAF04079440

Gene Name

prp19; prpf19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000004666.1	ENSORLT00000005874.1	ENSORLP00000005873.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.10e-13	51.3	3	61
E3 adaptor/Cullin RING/DCX/DWD	4.40e-32	109.0	394	427
UBD/Beta-Prp	9.10e-51	173.1	232	508

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrl 64
           ++C+I +e++++P+++p s+++++r+ Iek++a++g+ +P+++qpl+ee+lv+ ++ + +
   Q: 3    LVCAICNEVPEHPCISPvSNHVFERRLIEKYIAENGT-DPMNGQPLSEEQLVDIKVTHPI 61
           68**********************************9.**************99987765 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           gH+++vt++af  ++ +l++G+ D ++k+WDlr+
   Q: 394  GHSGPVTSIAFseNGYYLATGAQDSSLKLWDLRK 427
           8**********976699**************986 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgd 107
             d++ ++tg++d+ + v+d ++++ +++l+gh+++vt+v ++p++++  ++s D ti+vw++  g cv+++++he+ v+ ls++++gd
   Q: 232  PSDTNKVLTGGADKNVVVFDKSEEQIVATLKGHTKKVTSVIYHPSQSVVFSASPDTTIRVWSVTGGNCVQVVRAHEAGVTGLSLHATGD 320
           568899*********************************************************************************** PP
   S: 108  klvsGshdrtirvwdletgqclee....tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng 192
           +l+s s+d++    d++tg++l +         + + +c+++hpdg ++ +G++D+++++Wdlk  + +  + g h ++v+s++f++ng
   Q: 321  YLLSSSEDQYWAFSDIQTGKVLTKvtdeSAGCGSTALTCAQFHPDGLIFGTGTADSQIKIWDLKERTNVANFPG-HSGPVTSIAFSENG 408
           **********************9965542222355899***********************************9.************** PP
   S: 193  kelvsgsldgtvklwdlqtgec...........................................vrtlnghtdnvksvrfspnderlv 238
            +l++g++d+++klwdl++ +                                              t+++ht  v+ v+f ++ ++l 
   Q: 409  YYLATGAQDSSLKLWDLRKLKNfktitldnnyevkslvfdqsgtylavagtdirvyickqwsevlNFTVIDHTGLVTGVAFGEHAKFLT 497
           ******************65551112222222333333333333344444444444444444444444444444444444444444444 PP
   S: 239  sgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniw 292
           s+++                                           d +++++
   Q: 498  SAGM-------------------------------------------DRSLRFY 508
           4444...........................................5555444 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

MSLVCAICNE VPEHPCISPV SNHVFERRLI EKYIAENGTD PMNGQPLSEE QLVDIKVTHP 60
IRPKAPSATS IPAILKSLQD EWDAVMLHSF TLRQQLQTTR QELSHALYQH DAACRVIARL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTATGAAA GGGCATAGCT TTTCTTAGTT TCAATTCAGT CATTATCGGT GCACACTAGC 60
GAAACACAAG GTTGGAGTAA GCATATATTA CTTTCCAGAG GAGACTATTT ACACAGCGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013915--Pre-mRNA_splic_Prp19
IPR000772--Ricin_B_lectin
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50231--RICIN_B_LECTIN
PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08606--Prp19
PF04564--U-box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000488	Aegilops tauschii	40.15	7.00e-100	358.00
IUUC-Aml-001230	Ailuropoda melanoleuca	81.98	0.00e+00	849.00
IUUC-Atr-002594	Amborella trichopoda	43.88	2.00e-119	422.00
IUUC-Apl-003686	Anas platyrhynchos	76.57	0.00e+00	652.00
IUUC-Aca-005272	Anolis carolinensis	84.71	0.00e+00	895.00
IUUC-Aly-005586	Arabidopsis lyrata	43.57	4.00e-117	414.00
IUUC-Ath-007696	Arabidopsis thaliana	43.10	7.00e-115	407.00
IUUC-Acl-008335	Aspergillus clavatus	37.29	2.00e-69	256.00
IUUC-Afl-008527	Aspergillus flavus	38.05	5.00e-73	268.00
IUUC-Afu-008957	Aspergillus fumigatus	38.59	4.00e-80	291.00
IUUC-Ani-009280	Aspergillus nidulans	37.89	4.00e-68	252.00
IUUC-Ang-009746	Aspergillus niger	37.32	1.00e-68	253.00
IUUC-Aor-009905	Aspergillus oryzae	37.84	9.00e-77	280.00
IUUC-Ate-010412	Aspergillus terreus	36.61	2.00e-64	239.00
IUUC-Ame-011561	Astyanax mexicanus	89.63	8.00e-115	405.00
IUUC-Bgr-012283	Blumeria graminis	32.78	2.00e-57	216.00
IUUC-Bta-013242	Bos taurus	84.12	0.00e+00	895.00
IUUC-Bci-013901	Botrytis cinerea	34.06	7.00e-68	251.00
IUUC-Bdi-014277	Brachypodium distachyon	44.27	5.00e-125	441.00
IUUC-Bol-016207	Brassica oleracea	44.51	1.00e-117	416.00
IUUC-Bra-017650	Brassica rapa	44.32	2.00e-118	419.00
IUUC-Cel-018271	Caenorhabditis elegans	52.25	2.00e-152	531.00
IUUC-Cja-019879	Callithrix jacchus	83.76	0.00e+00	888.00
IUUC-Cfa-020175	Canis familiaris	84.12	0.00e+00	894.00
IUUC-Cpo-022379	Cavia porcellus	84.31	0.00e+00	894.00
IUUC-Cre-022993	Chlamydomonas reinhardtii	39.88	3.00e-97	348.00
IUUC-Csa-023500	Chlorocebus sabaeus	84.12	0.00e+00	895.00
IUUC-Cho-025065	Choloepus hoffmanni	74.68	3.00e-130	457.00
IUUC-Cin-025699	Ciona intestinalis	68.24	2.00e-174	604.00
IUUC-Csv-026128	Ciona savignyi	65.90	0.00e+00	693.00
IUUC-Cgl-026507	Colletotrichum gloeosporioides	33.27	2.00e-63	236.00
IUUC-Cne-026860	Cryptococcus neoformans	37.62	1.00e-94	339.00
IUUC-Dre-028187	Danio rerio	91.37	0.00e+00	905.00
IUUC-Dno-029453	Dasypus novemcinctus	84.12	0.00e+00	894.00
IUUC-Dor-030150	Dipodomys ordii	85.36	7.00e-113	400.00
IUUC-Dse-031220	Dothistroma septosporum	31.88	2.00e-57	216.00
IUUC-Dme-031906	Drosophila melanogaster	65.63	0.00e+00	660.00
IUUC-Ete-033035	Echinops telfairi	73.14	0.00e+00	747.00
IUUC-Eca-033478	Equus caballus	83.92	0.00e+00	892.00
IUUC-Eeu-034974	Erinaceus europaeus	82.63	3.00e-171	594.00
IUUC-Fca-036194	Felis catus	83.66	0.00e+00	885.00
IUUC-Fal-037417	Ficedula albicollis	83.53	0.00e+00	886.00
IUUC-Fox-037922	Fusarium oxysporum	32.06	7.00e-62	231.00
IUUC-Fso-038256	Fusarium solani	33.60	4.00e-66	245.00
IUUC-Gmo-038713	Gadus morhua	94.31	0.00e+00	934.00
IUUC-Ggr-039854	Gaeumannomyces graminis	32.04	1.00e-51	197.00
IUUC-Gga-041143	Gallus gallus	83.73	0.00e+00	889.00
IUUC-Gac-042129	Gasterosteus aculeatus	94.31	0.00e+00	957.00
IUUC-Gma-044273	Glycine max	44.36	1.00e-121	430.00
IUUC-Ggo-045262	Gorilla gorilla	84.12	0.00e+00	895.00
IUUC-Hsa-046036	Homo sapiens	84.12	0.00e+00	895.00
IUUC-Hvu-047442	Hordeum vulgare	43.85	3.00e-66	244.00
IUUC-Itr-048169	Ictidomys tridecemlineatus	83.33	0.00e+00	858.00
IUUC-Lch-050105	Latimeria chalumnae	83.92	0.00e+00	885.00
IUUC-Lpe-050976	Leersia perrieri	44.23	4.00e-120	424.00
IUUC-Loc-052042	Lepisosteus oculatus	78.53	0.00e+00	689.00
IUUC-Lma-053143	Leptosphaeria maculans	34.52	5.00e-66	246.00
IUUC-Laf-053451	Loxodonta africana	81.02	0.00e+00	882.00
IUUC-Mcc-055786	Macaca mulatta	84.12	0.00e+00	895.00
IUUC-Meu-056161	Macropus eugenii	84.02	4.00e-124	438.00
IUUC-Mor-057215	Magnaporthe oryzae	34.43	2.00e-52	199.00
IUUC-Mpo-057419	Magnaporthe poae	31.20	3.00e-48	186.00
IUUC-Mtr-057756	Medicago truncatula	43.77	9.00e-116	410.00
IUUC-Mla-059085	Melampsora laricipopulina	39.42	3.00e-88	318.00
IUUC-Mga-060158	Meleagris gallopavo	79.01	0.00e+00	792.00
IUUC-Mvi-060441	Microbotryum violaceum	39.17	7.00e-82	297.00
IUUC-Mmr-061085	Microcebus murinus	84.12	0.00e+00	895.00
IUUC-Mdo-061804	Monodelphis domestica	84.12	0.00e+00	894.00
IUUC-Mmu-063608	Mus musculus	81.10	0.00e+00	880.00
IUUC-Mac-064972	Musa acuminata	44.53	6.00e-119	421.00
IUUC-Mpu-065700	Mustela putorius furo	84.12	0.00e+00	894.00
IUUC-Mlu-068223	Myotis lucifugus	81.52	0.00e+00	882.00
IUUC-Nfi-068504	Neosartorya fischeri	37.97	1.00e-78	286.00
IUUC-Ncr-068729	Neurospora crassa	34.72	3.00e-61	229.00
IUUC-Nle-069754	Nomascus leucogenys	84.12	0.00e+00	895.00
IUUC-Opr-070621	Ochotona princeps	81.67	0.00e+00	843.00
IUUC-Ont-071377	Oreochromis niloticus	95.49	0.00e+00	940.00
IUUC-Oan-073498	Ornithorhynchus anatinus	62.88	1.00e-106	379.00
IUUC-Ocu-074182	Oryctolagus cuniculus	80.79	0.00e+00	881.00
IUUC-Oba-075509	Oryza barthii	44.08	4.00e-123	434.00
IUUC-Obr-076480	Oryza brachyantha	44.47	2.00e-123	435.00
IUUC-Ogl-077052	Oryza glaberrima	44.08	4.00e-123	434.00
IUUC-Ogu-078919	Oryza glumaepatula	44.08	4.00e-123	434.00
IUUC-Oin-079357	Oryza indica	42.99	4.00e-116	411.00
IUUC-Olo-080376	Oryza longistaminata	43.79	4.00e-111	395.00
IUUC-Ome-081973	Oryza meridionalis	43.58	5.00e-111	394.00
IUUC-Oni-082849	Oryza nivara	44.27	1.00e-123	436.00
IUUC-Opu-083243	Oryza punctata	43.89	3.00e-122	432.00
IUUC-Oru-084613	Oryza rufipogon	44.08	9.00e-123	433.00
IUUC-Osa-085407	Oryza sativa	44.06	1.00e-122	432.00
IUUC-Olu-087757	Ostreococcus lucimarinus	37.67	1.00e-88	320.00
IUUC-Oga-089010	Otolemur garnettii	81.18	0.00e+00	848.00
IUUC-Oar-089638	Ovis aries	84.12	0.00e+00	895.00
IUUC-Ptr-091141	Pan troglodytes	84.12	0.00e+00	895.00
IUUC-Pan-092662	Papio anubis	84.12	0.00e+00	895.00
IUUC-Psi-093777	Pelodiscus sinensis	83.06	0.00e+00	723.00
IUUC-Pno-095115	Phaeosphaeria nodorum	35.55	1.00e-69	256.00
IUUC-Ppa-095841	Physcomitrella patens	45.09	4.00e-122	431.00
IUUC-Pfo-096390	Poecilia formosa	96.08	0.00e+00	952.00
IUUC-Pab-098250	Pongo abelii	84.27	0.00e+00	843.00
IUUC-Pop-099854	Populus trichocarpa	44.34	2.00e-119	422.00
IUUC-Pca-100553	Procavia capensis	83.53	0.00e+00	884.00
IUUC-Ppe-101383	Prunus persica	44.34	3.00e-116	412.00
IUUC-Pva-102189	Pteropus vampyrus	84.12	0.00e+00	894.00
IUUC-Pgr-103304	Puccinia graminis	36.26	2.00e-84	306.00
IUUC-Ptt-103984	Puccinia triticina	37.20	4.00e-89	322.00
IUUC-Pte-104385	Pyrenophora teres	33.96	1.00e-72	266.00
IUUC-Pyt-104697	Pyrenophora triticirepentis	33.96	9.00e-73	267.00
IUUC-Rno-105581	Rattus norvegicus	84.12	0.00e+00	893.00
IUUC-Sha-107071	Sarcophilus harrisii	80.64	0.00e+00	880.00
IUUC-Sja-107697	Schizosaccharomyces japonicus	29.90	4.00e-36	145.00
IUUC-Spo-108315	Schizosaccharomyces pombe	30.73	2.00e-41	163.00
IUUC-Ssl-108628	Sclerotinia sclerotiorum	34.06	7.00e-66	244.00
IUUC-Smo-109648	Selaginella moellendorffii	45.30	3.00e-123	435.00
IUUC-Sit-109873	Setaria italica	43.76	3.00e-120	426.00
IUUC-Sly-111673	Solanum lycopersicum	44.17	2.00e-111	395.00
IUUC-Stu-112125	Solanum tuberosum	43.57	4.00e-110	391.00
IUUC-Sbi-114696	Sorghum bicolor	41.08	2.00e-108	386.00
IUUC-Sre-115134	Sporisorium reilianum	32.21	5.00e-71	261.00
IUUC-Ssc-116260	Sus scrofa	83.92	0.00e+00	893.00
IUUC-Tgu-116533	Taeniopygia guttata	83.73	0.00e+00	888.00
IUUC-Tru-117800	Takifugu rubripes	93.73	0.00e+00	970.00
IUUC-Tsy-118980	Tarsius syrichta	79.60	0.00e+00	807.00
IUUC-Tni-120334	Tetraodon nigroviridis	92.90	0.00e+00	648.00
IUUC-Tca-121807	Theobroma cacao	43.85	4.00e-120	424.00
IUUC-Tre-121920	Trichoderma reesei	33.33	1.00e-61	230.00
IUUC-Tvi-122294	Trichoderma virens	32.85	3.00e-54	206.00
IUUC-Tae-125713	Triticum aestivum	45.12	4.00e-125	441.00
IUUC-Tur-126664	Triticum urartu	40.63	9.00e-115	407.00
IUUC-Tme-127026	Tuber melanosporum	33.20	1.00e-71	263.00
IUUC-Tbe-127582	Tupaia belangeri	82.63	4.00e-171	593.00
IUUC-Ttr-128313	Tursiops truncatus	83.73	0.00e+00	884.00
IUUC-Uma-129626	Ustilago maydis	32.97	2.00e-73	270.00
IUUC-Vda-129699	Verticillium dahliae	32.87	2.00e-65	243.00
IUUC-Vpa-130593	Vicugna pacos	85.12	0.00e+00	806.00
IUUC-Vvi-131668	Vitis vinifera	44.17	6.00e-121	427.00
IUUC-Xtr-132186	Xenopus tropicalis	80.14	0.00e+00	719.00
IUUC-Xma-133212	Xiphophorus maculatus	96.27	0.00e+00	947.00
IUUC-Yli-134607	Yarrowia lipolytica	53.79	9.00e-40	155.00
IUUC-Zma-135662	Zea mays	44.36	1.00e-122	433.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence