iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096467

Ensembl Protein ID

ENSPFOP00000007693.1

UniProt Accession

A0A087XPJ0; A0A087XPJ0_POEFO

Genbank Protein ID

ENSPFOP00000007693

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AYCK01005505

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000007599.1	ENSPFOT00000007705.1	ENSPFOP00000007693.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.20e-115	386.7	12	527

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe+l++a+v+l++a+++G+E+lKnLvl G+g +t+vD++tv  ++++++F+++  ++gk++A++a e l+eln+dv+
   Q: 12   YDRQLRLWGDHGQEALENAHVCLINATATGTEILKNLVLPGIGAFTIVDGHTVAGEDVGNNFFLSSNSIGKNRAQAATELLQELNSDVS 100
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrear.rkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPf 173
           + ++ees+++l ++++ Ff +f++V+  + ++++  +++ +++++a+vp + ++t+Gl+G++r +++++t+++s++d   +++++++Pf
   Q: 101  GNFVEESPDKLLDNDPeFFHRFTIVIGVQLPESSTcLRLGSVLWSASVPYLVCKTYGLIGYMRLVVQEHTVIESHPDnalEDLRLDQPF 189
           ******************************99887369*************************************************** PP
   S: 174  ctlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafak 247
            ++k+++n         +++++++w+ +++k+l+ +  e++++++++++eke++++ +++++ +      edeenf+eai+++++a+++
   Q: 190  DEFKNHINsydltsmekKDHSHTPWIIIVAKYLDRWLNEHDGQPPKNYKEKESFRQMIREGILKnlngvpEDEENFDEAIKNVNTALNP 278
           ******99999999998************************************************************************ PP
   S: 248  ttins.ikqllksfecdivtkskspfwv............................................................. 274
           t i+s +++l++s +c+++t ++++fwv                                                             
   Q: 279  TKIPSaVEDLFSSEQCNNITAQSPSFWVmlrgvkefvhsegsgnlpvrgtipdmiadsqkfinlqniyrekalqdaaavtkhvenllqs 367
           ***************************************************************************************** PP
   S: 275  ..............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkp..gelsfekddds 331
                          fc+na+ l+v            ++v+kde+++ +++p     +yl+lra++rf++ ++r+p  g+ ++++++d 
   Q: 368  vgkpaesiserdikLFCKNAAFLRVVccrslaeeyhvDSVNKDEITSCMDSPdsemvFYLMLRAVDRFHQLHSRYPvkGVYNYQVEED- 455
           ************************5566666666666999999999999999999********************9445678888888. PP
   S: 332  avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           + +l+  + +l  ++++++ +++dd+i+e++++++++ +t++a++gG aaqE+iK++s++f+p++n+f+++a+
   Q: 456  ISKLKLCVNSLL-QEYNLNVNIKDDYIHEFCRYGAAEPHTVSAFLGGSAAQEAIKIISHQFVPFNNTFIYNAM 527
           888888888877.*********************************************************997 PP

Organism

Poecilia formosa

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAATKGSKEQ KYDRQLRLWG DHGQEALENA HVCLINATAT GTEILKNLVL PGIGAFTIVD 60
GHTVAGEDVG NNFFLSSNSI GKNRAQAATE LLQELNSDVS GNFVEESPDK LLDNDPEFFH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATTTTTTTA TCGAAAGTGC ACATGCGGAT CATCGCGCCG CCACATTCGT GTCGAATCTG 60
ACGTCGCGGA AGTAAAACTA GAGCCATTAA CGTAAGTTAT TTTAAAGCTA TCATGGCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	40.82	2.00e-118	419.00
IUUC-Aml-002333	Ailuropoda melanoleuca	72.69	0.00e+00	833.00
IUUC-Atr-002644	Amborella trichopoda	39.35	2.00e-106	379.00
IUUC-Apl-003446	Anas platyrhynchos	71.26	0.00e+00	786.00
IUUC-Aca-004450	Anolis carolinensis	71.46	0.00e+00	805.00
IUUC-Aly-006187	Arabidopsis lyrata	40.23	3.00e-120	425.00
IUUC-Ath-007600	Arabidopsis thaliana	40.61	1.00e-121	430.00
IUUC-Ago-007900	Ashbya gossypii	26.62	4.00e-38	152.00
IUUC-Acl-008333	Aspergillus clavatus	35.47	4.00e-84	305.00
IUUC-Afl-008529	Aspergillus flavus	35.97	3.00e-87	316.00
IUUC-Afu-009071	Aspergillus fumigatus	34.83	2.00e-84	306.00
IUUC-Ani-009443	Aspergillus nidulans	33.63	2.00e-77	283.00
IUUC-Ang-009669	Aspergillus niger	33.81	3.00e-84	306.00
IUUC-Aor-009914	Aspergillus oryzae	36.01	3.00e-86	312.00
IUUC-Ate-010450	Aspergillus terreus	34.17	4.00e-83	302.00
IUUC-Ame-011183	Astyanax mexicanus	80.60	0.00e+00	931.00
IUUC-Bgr-012111	Blumeria graminis	31.37	5.00e-62	232.00
IUUC-Bta-012583	Bos taurus	72.78	0.00e+00	834.00
IUUC-Bci-013892	Botrytis cinerea	31.93	3.00e-60	226.00
IUUC-Bdi-014592	Brachypodium distachyon	41.78	2.00e-123	436.00
IUUC-Bol-016399	Brassica oleracea	40.83	2.00e-122	433.00
IUUC-Bra-017506	Brassica rapa	39.62	5.00e-117	414.00
IUUC-Cel-018456	Caenorhabditis elegans	35.62	5.00e-90	325.00
IUUC-Cja-020007	Callithrix jacchus	72.18	0.00e+00	827.00
IUUC-Cfa-020324	Canis familiaris	72.78	0.00e+00	835.00
IUUC-Cpo-022248	Cavia porcellus	62.00	1.00e-128	453.00
IUUC-Csa-023149	Chlorocebus sabaeus	68.57	0.00e+00	698.00
IUUC-Cho-024537	Choloepus hoffmanni	60.99	3.00e-171	594.00
IUUC-Cin-025763	Ciona intestinalis	47.75	1.00e-149	523.00
IUUC-Csv-026113	Ciona savignyi	45.40	1.00e-143	503.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	34.40	2.00e-68	253.00
IUUC-Cne-026884	Cryptococcus neoformans	29.07	3.00e-68	253.00
IUUC-Cme-027210	Cyanidioschyzon merolae	24.68	2.00e-16	80.90
IUUC-Dre-028140	Danio rerio	82.28	0.00e+00	939.00
IUUC-Dno-030033	Dasypus novemcinctus	71.70	0.00e+00	723.00
IUUC-Dor-030513	Dipodomys ordii	49.21	2.00e-79	290.00
IUUC-Dse-031536	Dothistroma septosporum	32.51	4.00e-78	285.00
IUUC-Dme-031683	Drosophila melanogaster	43.84	9.00e-127	447.00
IUUC-Ete-032420	Echinops telfairi	62.24	0.00e+00	676.00
IUUC-Eca-033992	Equus caballus	70.92	0.00e+00	684.00
IUUC-Eeu-034713	Erinaceus europaeus	58.20	2.00e-86	313.00
IUUC-Fca-036548	Felis catus	71.64	0.00e+00	821.00
IUUC-Fal-037600	Ficedula albicollis	69.90	0.00e+00	769.00
IUUC-Fox-038037	Fusarium oxysporum	35.40	5.00e-62	232.00
IUUC-Fso-038387	Fusarium solani	33.52	3.00e-70	259.00
IUUC-Gmo-038562	Gadus morhua	84.20	0.00e+00	951.00
IUUC-Ggr-040005	Gaeumannomyces graminis	33.52	7.00e-70	258.00
IUUC-Gga-041129	Gallus gallus	71.27	0.00e+00	796.00
IUUC-Gac-042558	Gasterosteus aculeatus	87.36	0.00e+00	982.00
IUUC-Gma-043610	Glycine max	39.32	3.00e-113	402.00
IUUC-Ggo-045611	Gorilla gorilla	72.18	0.00e+00	829.00
IUUC-Hsa-046563	Homo sapiens	72.40	0.00e+00	833.00
IUUC-Hvu-047790	Hordeum vulgare	36.84	2.00e-74	273.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	72.40	0.00e+00	825.00
IUUC-Kpa-049309	Komagataella pastoris	32.77	1.00e-76	280.00
IUUC-Lch-050038	Latimeria chalumnae	72.63	0.00e+00	834.00
IUUC-Lpe-051535	Leersia perrieri	41.04	7.00e-106	377.00
IUUC-Loc-051917	Lepisosteus oculatus	75.46	0.00e+00	842.00
IUUC-Lma-053112	Leptosphaeria maculans	33.45	8.00e-86	311.00
IUUC-Laf-053690	Loxodonta africana	72.56	0.00e+00	836.00
IUUC-Mcc-055117	Macaca mulatta	70.92	0.00e+00	815.00
IUUC-Meu-056761	Macropus eugenii	60.34	0.00e+00	657.00
IUUC-Mor-057230	Magnaporthe oryzae	33.63	3.00e-75	276.00
IUUC-Mpo-057514	Magnaporthe poae	33.03	2.00e-68	253.00
IUUC-Mtr-058551	Medicago truncatula	38.89	7.00e-111	394.00
IUUC-Mla-059183	Melampsora laricipopulina	35.73	8.00e-97	347.00
IUUC-Mga-060144	Meleagris gallopavo	70.21	0.00e+00	777.00
IUUC-Mvi-060221	Microbotryum violaceum	34.20	5.00e-78	285.00
IUUC-Mmr-061325	Microcebus murinus	71.43	0.00e+00	817.00
IUUC-Mdo-062532	Monodelphis domestica	73.50	0.00e+00	838.00
IUUC-Mmu-063956	Mus musculus	73.16	0.00e+00	836.00
IUUC-Mac-064521	Musa acuminata	39.29	5.00e-115	408.00
IUUC-Mpu-066716	Mustela putorius furo	71.83	0.00e+00	779.00
IUUC-Mlu-067459	Myotis lucifugus	71.62	0.00e+00	826.00
IUUC-Nfi-068245	Neosartorya fischeri	35.19	3.00e-85	309.00
IUUC-Ncr-068910	Neurospora crassa	33.21	1.00e-73	271.00
IUUC-Nle-070034	Nomascus leucogenys	69.89	0.00e+00	798.00
IUUC-Opr-070552	Ochotona princeps	67.74	0.00e+00	686.00
IUUC-Ont-071426	Oreochromis niloticus	90.49	0.00e+00	1015.00
IUUC-Oan-073389	Ornithorhynchus anatinus	69.35	0.00e+00	644.00
IUUC-Ocu-074911	Oryctolagus cuniculus	72.97	0.00e+00	833.00
IUUC-Oba-075437	Oryza barthii	41.18	3.00e-111	395.00
IUUC-Obr-076684	Oryza brachyantha	41.43	1.00e-107	384.00
IUUC-Ogl-077170	Oryza glaberrima	41.18	3.00e-111	395.00
IUUC-Ogu-078844	Oryza glumaepatula	41.58	6.00e-104	371.00
IUUC-Oin-079105	Oryza indica	41.18	1.00e-110	394.00
IUUC-Olo-080943	Oryza longistaminata	38.84	5.00e-99	355.00
IUUC-Oni-082891	Oryza nivara	38.33	1.00e-104	374.00
IUUC-Opu-083457	Oryza punctata	41.18	8.00e-111	394.00
IUUC-Oru-084960	Oryza rufipogon	38.67	3.00e-100	358.00
IUUC-Osa-085358	Oryza sativa	41.37	1.00e-111	397.00
IUUC-Ola-086420	Oryzias latipes	85.87	0.00e+00	674.00
IUUC-Olu-087625	Ostreococcus lucimarinus	29.22	4.00e-61	229.00
IUUC-Oga-088810	Otolemur garnettii	72.78	0.00e+00	833.00
IUUC-Oar-089196	Ovis aries	72.56	0.00e+00	829.00
IUUC-Ptr-090617	Pan troglodytes	72.59	0.00e+00	834.00
IUUC-Pan-092761	Papio anubis	72.40	0.00e+00	832.00
IUUC-Psi-093191	Pelodiscus sinensis	71.92	0.00e+00	813.00
IUUC-Pma-094380	Petromyzon marinus	61.49	0.00e+00	656.00
IUUC-Pno-095084	Phaeosphaeria nodorum	33.76	3.00e-75	277.00
IUUC-Ppa-095875	Physcomitrella patens	39.59	5.00e-114	404.00
IUUC-Pab-098255	Pongo abelii	71.92	0.00e+00	689.00
IUUC-Pop-099722	Populus trichocarpa	40.23	1.00e-118	420.00
IUUC-Pca-100807	Procavia capensis	61.65	3.00e-92	332.00
IUUC-Ppe-101280	Prunus persica	39.51	4.00e-117	415.00
IUUC-Pva-102333	Pteropus vampyrus	70.49	0.00e+00	791.00
IUUC-Pgr-103401	Puccinia graminis	30.69	8.00e-77	281.00
IUUC-Ptt-103889	Puccinia triticina	27.27	1.00e-56	214.00
IUUC-Pte-104355	Pyrenophora teres	34.52	1.00e-86	314.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	34.28	7.00e-87	315.00
IUUC-Rno-105810	Rattus norvegicus	72.97	0.00e+00	827.00
IUUC-Sce-106397	Saccharomyces cerevisiae	25.32	5.00e-28	119.00
IUUC-Sha-106770	Sarcophilus harrisii	75.99	2.00e-128	451.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.20	7.00e-75	274.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.71	2.00e-78	286.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	34.06	2.00e-64	240.00
IUUC-Smo-109296	Selaginella moellendorffii	40.68	3.00e-117	415.00
IUUC-Sit-110157	Setaria italica	41.42	1.00e-124	439.00
IUUC-Sly-111105	Solanum lycopersicum	38.81	3.00e-116	412.00
IUUC-Stu-112469	Solanum tuberosum	38.81	3.00e-116	412.00
IUUC-Sar-113083	Sorex araneus	54.34	1.00e-166	579.00
IUUC-Sbi-113813	Sorghum bicolor	42.12	1.00e-123	436.00
IUUC-Sre-115058	Sporisorium reilianum	36.50	2.00e-77	283.00
IUUC-Tgu-116772	Taeniopygia guttata	70.00	0.00e+00	776.00
IUUC-Tru-118686	Takifugu rubripes	85.07	0.00e+00	968.00
IUUC-Tsy-119111	Tarsius syrichta	70.29	2.00e-114	406.00
IUUC-Tni-120231	Tetraodon nigroviridis	78.85	0.00e+00	875.00
IUUC-Tca-121491	Theobroma cacao	39.17	7.00e-112	397.00
IUUC-Tre-122103	Trichoderma reesei	35.24	8.00e-79	288.00
IUUC-Tvi-122672	Trichoderma virens	34.92	3.00e-73	269.00
IUUC-Tae-125316	Triticum aestivum	41.40	9.00e-121	427.00
IUUC-Tur-126487	Triticum urartu	40.08	2.00e-114	406.00
IUUC-Tme-127097	Tuber melanosporum	36.23	4.00e-89	322.00
IUUC-Ttr-128465	Tursiops truncatus	68.23	0.00e+00	766.00
IUUC-Uma-129645	Ustilago maydis	33.06	4.00e-83	302.00
IUUC-Vda-129989	Verticillium dahliae	31.55	1.00e-55	210.00
IUUC-Vpa-130529	Vicugna pacos	69.74	0.00e+00	785.00
IUUC-Vvi-131059	Vitis vinifera	40.26	4.00e-117	415.00
IUUC-Xtr-132002	Xenopus tropicalis	71.83	0.00e+00	820.00
IUUC-Xma-133930	Xiphophorus maculatus	97.95	0.00e+00	1086.00
IUUC-Yli-134505	Yarrowia lipolytica	32.07	8.00e-82	298.00
IUUC-Zma-135895	Zea mays	41.78	7.00e-122	431.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence