iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ate-010336

Ensembl Protein ID

CADATEAP00000562

UniProt Accession

Q0CY32; SCONB_ASPTN

Genbank Protein ID

EAU38159.1

Protein Name

Probable E3 ubiquitin ligase complex SCF subunit sconB; Sulfur controller B; Sulfur metabolite repression control protein B

Genbank Nucleotide ID

CH476595

Gene Name

ATEG_01402; sconB

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADATEAG00000562	CADATEAT00000562	CADATEAP00000562

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.30e-55	181.2	382	418
E3 adaptor/Cullin RING/SCF/F-box	8.40e-06	25.0	166	210
UBD/Beta-Prp	8.10e-76	254.1	340	672

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsdtllvsGsdDgtikvWDlrtgvllk 37
           gH+++++cl+f+dt l+sGs D ++kvW++rtg ++ 
   Q: 382  GHESGIRCLQFDDTKLISGSMDRSLKVWNWRTGECIS 418
           8**********66*********************975 PP

E3 adaptor/Cullin RING/SCF/F-box

   S: 102  lldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
            l+ lp ei ++il +ld+++l++aa+v+rrw+ la+++ +w+++
   Q: 166  FLTALPPEISFKILCYLDTTSLCKAAQVSRRWRALADDDVVWHRM 210
           5678*********************************9****987 PP

UBD/Beta-Prp

   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           +kgh  +v+ c++f  ++++latgs+d+tik+wd++tg  lr+l+ghe+++++++f+++   l++gs Dr +kvw+ +tg+c++t++gh   v
   Q: 340  FKGHTNGVM-CLQF--EDNILATGSYDATIKIWDTETGEELRTLYGHESGIRCLQFDDT--KLISGSMDRSLKVWNWRTGECISTYTGHRGGV 427
           455555555.5***..*******************************************..6******************************* PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls... 187
             l+f++    l+s+s d+t+++w+ e ++    +l+gh+++vn v+v+ +++ ++s+s+D tvrlWdl t++++rt+ g h ++v+ ++   
   Q: 428  IGLHFDA--TILASASVDKTVKIWNFEDKSTC--LLRGHTDWVNAVRVDTTSRTVFSASDDCTVRLWDLDTKQCIRTFHG-HVGQVQQVIplp 515
           *******..*****************999988..59*******************************************9.*********999 PP
   S: 188  .......fdsng..................................................kelvsgsldgtvklwdlqtgecvrtlnghtd 223
                                                                         +++v+ +ld+t++lw+  tg+c+rt+ gh +
   Q: 516  refefeeH---DaecendnvstvsddpgspapqttfgvssiepasqssmfgpsfdngrpappRYIVTSALDSTIRLWETTTGRCLRTFFGHLE 605
           99776550...24555555666666667888888888888888999999999999999*********************************** PP
   S: 224  nvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
            v+ + ++  + r+vsg++D+ ++iWd r+g++ +t+++h     +v+++++gd+ +++gsed++v++++++
   Q: 606  GVWALGAD--TLRIVSGAEDRMVKIWDPRTGKCERTFTGHS---GPVTCIGLGDSRFATGSEDCEVRMYSFQ 672
           ***88888..*****************************88...55555666*****************996 PP

Organism

Aspergillus terreus

Functional Description
(View)

Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.

Protein Sequence
(Fasta)

MDSTQVSFKS IFGGTPEPTD EVDAEPDPTQ HGPHSFNNVT TTSAKLADEN VAPFLAKHIP 60
EQYAPLGSRT GKPEDLSSAN SKYCYRHRPD LKCRRQADEP SMDKLQRDLE TLPQSDQQGI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATTCCA CCCAGGTCTC CTTCAAATCC ATCTTCGGTG GCACACCCGA GCCCACTGAT 60
GAGGTTGATG CCGAGCCCGA TCCTACCCAG CATGGGCCCC ACAGTTTCAA CAACGTAACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0043224--C:nuclear SCF ubiquitin ligase complex
GO:0071276--P:cellular response to cadmium ion
GO:0006270--P:DNA replication initiation
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030174--P:regulation of DNA-dependent DNA replication initiation
GO:0000083--P:regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0046685--P:response to arsenic-containing substance
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007794	Ashbya gossypii	42.07	1.00e-133	468.00
IUUC-Acl-008078	Aspergillus clavatus	82.02	0.00e+00	1131.00
IUUC-Afl-008744	Aspergillus flavus	84.33	0.00e+00	1098.00
IUUC-Afu-008939	Aspergillus fumigatus	80.69	0.00e+00	1109.00
IUUC-Ani-009383	Aspergillus nidulans	81.51	0.00e+00	1089.00
IUUC-Ang-009570	Aspergillus niger	83.03	0.00e+00	1102.00
IUUC-Aor-010217	Aspergillus oryzae	84.53	0.00e+00	1078.00
IUUC-Bgr-012225	Blumeria graminis	57.95	0.00e+00	743.00
IUUC-Bci-013916	Botrytis cinerea	65.05	0.00e+00	851.00
IUUC-Cgl-026550	Colletotrichum gloeosporioides	52.98	0.00e+00	667.00
IUUC-Cne-026800	Cryptococcus neoformans	35.87	4.00e-123	434.00
IUUC-Dse-031413	Dothistroma septosporum	59.15	0.00e+00	733.00
IUUC-Fox-037683	Fusarium oxysporum	51.09	0.00e+00	650.00
IUUC-Fso-038092	Fusarium solani	56.66	0.00e+00	742.00
IUUC-Ggr-039842	Gaeumannomyces graminis	54.49	0.00e+00	716.00
IUUC-Kpa-049101	Komagataella pastoris	44.99	1.00e-161	561.00
IUUC-Lma-053200	Leptosphaeria maculans	56.35	0.00e+00	780.00
IUUC-Mor-057039	Magnaporthe oryzae	53.42	0.00e+00	701.00
IUUC-Mpo-057381	Magnaporthe poae	52.81	0.00e+00	688.00
IUUC-Mla-059099	Melampsora laricipopulina	38.89	1.00e-121	428.00
IUUC-Mvi-060426	Microbotryum violaceum	40.17	2.00e-54	206.00
IUUC-Nfi-068464	Neosartorya fischeri	80.09	0.00e+00	1091.00
IUUC-Ncr-068962	Neurospora crassa	51.46	0.00e+00	706.00
IUUC-Pno-095133	Phaeosphaeria nodorum	51.82	5.00e-159	552.00
IUUC-Pgr-103527	Puccinia graminis	40.06	5.00e-66	243.00
IUUC-Ptt-103819	Puccinia triticina	34.48	1.00e-55	208.00
IUUC-Pte-104035	Pyrenophora teres	55.83	0.00e+00	702.00
IUUC-Pyt-104799	Pyrenophora triticirepentis	56.00	0.00e+00	705.00
IUUC-Sce-106343	Saccharomyces cerevisiae	40.58	3.00e-135	474.00
IUUC-Sja-107945	Schizosaccharomyces japonicus	38.45	3.00e-121	427.00
IUUC-Spo-108115	Schizosaccharomyces pombe	40.56	5.00e-126	442.00
IUUC-Sre-115173	Sporisorium reilianum	41.12	2.00e-103	369.00
IUUC-Tre-122126	Trichoderma reesei	55.76	0.00e+00	738.00
IUUC-Tvi-122482	Trichoderma virens	57.37	0.00e+00	751.00
IUUC-Tme-127212	Tuber melanosporum	55.94	0.00e+00	743.00
IUUC-Uma-129406	Ustilago maydis	40.77	3.00e-103	368.00
IUUC-Vda-129799	Verticillium dahliae	54.24	0.00e+00	705.00
IUUC-Yli-134408	Yarrowia lipolytica	45.53	5.00e-168	582.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence