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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046782
Ensembl Protein ID ENSP00000288828.4
UniProt Accession Q9Y4P8; B3KNC2; Q5MNZ8; Q6FI96; Q75L50; Q96IE4; Q9Y364; WIPI2_HUMAN
Genbank Protein ID AAV80761.1; AAV80762.1; AAD34045.1; CAB45746.1; CAG38561.1; BAG51284.1; AAQ96865.1; AAQ96866.1; AAQ96867.1; EAW87328.1; AAH04116.1; AAH07596.1; AAH21200.1
Protein Name WD repeat domain phosphoinositide-interacting protein 2; WIPI49-like protein 2
Genbank Nucleotide ID AY691425; AY691426; AF151808; AL080155; CR533530; AK024279; AC093376; AC093376; AC093376; CH471144; BC004116; BC007596; BC021068
Gene Name WIPI2; CGI-50
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000157954.14 ENST00000288828.8 ENSP00000288828.4
ENSG00000157954.14 ENST00000401525.7 ENSP00000384945.3
ENSG00000157954.14 ENST00000404704.7 ENSP00000385297.3
ENSG00000157954.14 ENST00000382384.6 ENSP00000371821.2
ENSG00000157954.14 ENST00000484262.1 ENSP00000429654.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.10e-07 31.0 201 235
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgt.ikvWDlrtg 33
           H ++  +laf  s+t l+++s  gt i+v+++ +g
   Q: 201  HDSPLAALAFdaSGTKLATASEKGTvIRVFSIPEG 235
           9999999***9877***********9999987665 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Isoform 4: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.
 Isoform 4: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.
Protein Sequence
(Fasta)
MNLASQSGEA GAGQLLFANF NQDNTEVKGA SRAAGLGRRA VVWSLAVGSK SGYKFFSLSS 60
VDKLEQIYEC TDTEDVCIVE RLFSSSLVAI VSLKAPRKLK VCHFKKGTEI CNYSYSNTIL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046782|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGCGCCGCTC GAGGCCGTGC GTCGCGGGGG CGGGGCCGCG CAGGCGTACC GGGTGCCCCG 60
GCTCTGGAGC ATAAACAAGA GCGGGGACGG GATGAGGCGG CGGTTGATCC CAGGGTGGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046782|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR032911--WIPI2
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0000407--C:pre-autophagosomal structure
GO:0034045--C:pre-autophagosomal structure membrane
GO:0043234--C:protein complex
GO:0080025--F:phosphatidylinositol-3,5-bisphosphate binding
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0010314--F:phosphatidylinositol-5-phosphate binding
GO:0000045--P:autophagosome assembly
GO:0016236--P:macroautophagy
KEGG hsa:26100
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001842 Ailuropoda melanoleuca 95.13 0.00e+00 776.00
IUUC-Apl-003390 Anas platyrhynchos 92.77 0.00e+00 822.00
IUUC-Aca-004975 Anolis carolinensis 90.97 0.00e+00 847.00
IUUC-Ago-007768 Ashbya gossypii 27.61 4.00e-26 112.00
IUUC-Acl-008148 Aspergillus clavatus 43.92 3.00e-52 199.00
IUUC-Afl-008562 Aspergillus flavus 44.31 6.00e-53 201.00
IUUC-Afu-008936 Aspergillus fumigatus 34.87 3.00e-55 209.00
IUUC-Ani-009254 Aspergillus nidulans 44.31 4.00e-53 202.00
IUUC-Ang-009798 Aspergillus niger 35.29 4.00e-60 225.00
IUUC-Aor-010066 Aspergillus oryzae 44.31 6.00e-53 201.00
IUUC-Ate-010266 Aspergillus terreus 43.92 9.00e-53 201.00
IUUC-Ame-010727 Astyanax mexicanus 83.04 0.00e+00 776.00
IUUC-Bta-012655 Bos taurus 90.31 0.00e+00 818.00
IUUC-Bci-013627 Botrytis cinerea 34.20 1.00e-59 223.00
IUUC-Cel-018503 Caenorhabditis elegans 43.90 2.00e-81 296.00
IUUC-Cja-018829 Callithrix jacchus 96.48 0.00e+00 869.00
IUUC-Cfa-020858 Canis familiaris 92.58 0.00e+00 833.00
IUUC-Cpo-022235 Cavia porcellus 93.17 0.00e+00 835.00
IUUC-Csa-023963 Chlorocebus sabaeus 96.04 0.00e+00 837.00
IUUC-Cho-024328 Choloepus hoffmanni 75.06 0.00e+00 666.00
IUUC-Cin-025343 Ciona intestinalis 56.50 2.00e-135 475.00
IUUC-Csv-025920 Ciona savignyi 66.67 2.00e-147 514.00
IUUC-Cgl-026425 Colletotrichum gloeosporioides 46.45 2.00e-29 123.00
IUUC-Cne-026947 Cryptococcus neoformans 35.33 9.00e-59 220.00
IUUC-Dre-027490 Danio rerio 82.60 0.00e+00 772.00
IUUC-Dno-030057 Dasypus novemcinctus 88.35 0.00e+00 774.00
IUUC-Dor-030472 Dipodomys ordii 90.31 0.00e+00 814.00
IUUC-Dse-031215 Dothistroma septosporum 30.41 2.00e-49 190.00
IUUC-Ete-032362 Echinops telfairi 82.34 0.00e+00 759.00
IUUC-Eca-034362 Equus caballus 93.57 0.00e+00 810.00
IUUC-Fca-036230 Felis catus 93.68 0.00e+00 771.00
IUUC-Fal-036782 Ficedula albicollis 95.62 0.00e+00 821.00
IUUC-Fox-037797 Fusarium oxysporum 39.65 1.00e-49 191.00
IUUC-Fso-038174 Fusarium solani 40.35 7.00e-51 194.00
IUUC-Gmo-039706 Gadus morhua 55.46 2.00e-132 465.00
IUUC-Ggr-040113 Gaeumannomyces graminis 39.79 8.00e-50 191.00
IUUC-Gga-040690 Gallus gallus 91.19 0.00e+00 853.00
IUUC-Gac-041360 Gasterosteus aculeatus 83.04 0.00e+00 753.00
IUUC-Gma-043876 Glycine max 32.48 9.00e-36 144.00
IUUC-Itr-048693 Ictidomys tridecemlineatus 96.26 0.00e+00 878.00
IUUC-Kpa-049378 Komagataella pastoris 39.75 9.00e-52 197.00
IUUC-Lch-050413 Latimeria chalumnae 82.54 0.00e+00 723.00
IUUC-Lma-052948 Leptosphaeria maculans 32.75 3.00e-58 219.00
IUUC-Laf-054007 Loxodonta africana 90.71 0.00e+00 857.00
IUUC-Mor-057125 Magnaporthe oryzae 41.57 1.00e-48 187.00
IUUC-Mga-059795 Meleagris gallopavo 94.95 0.00e+00 822.00
IUUC-Mvi-060219 Microbotryum violaceum 37.54 1.00e-42 167.00
IUUC-Mmr-061096 Microcebus murinus 93.61 0.00e+00 863.00
IUUC-Mdo-061815 Monodelphis domestica 91.89 0.00e+00 860.00
IUUC-Mmu-063787 Mus musculus 91.36 0.00e+00 869.00
IUUC-Mpu-066019 Mustela putorius furo 89.44 0.00e+00 779.00
IUUC-Mlu-068016 Myotis lucifugus 90.97 0.00e+00 824.00
IUUC-Nfi-068424 Neosartorya fischeri 34.89 4.00e-56 212.00
IUUC-Ncr-068833 Neurospora crassa 33.41 9.00e-58 217.00
IUUC-Opr-070933 Ochotona princeps 79.74 0.00e+00 647.00
IUUC-Ont-072495 Oreochromis niloticus 82.07 0.00e+00 743.00
IUUC-Oan-073084 Ornithorhynchus anatinus 86.07 0.00e+00 769.00
IUUC-Ocu-074689 Oryctolagus cuniculus 92.41 0.00e+00 819.00
IUUC-Oga-088894 Otolemur garnettii 94.38 0.00e+00 797.00
IUUC-Oar-089850 Ovis aries 92.69 0.00e+00 816.00
IUUC-Ptr-090456 Pan troglodytes 97.36 0.00e+00 849.00
IUUC-Pan-092111 Papio anubis 93.09 0.00e+00 843.00
IUUC-Psi-094095 Pelodiscus sinensis 95.62 0.00e+00 820.00
IUUC-Pno-095015 Phaeosphaeria nodorum 32.80 8.00e-51 194.00
IUUC-Pfo-096987 Poecilia formosa 82.24 0.00e+00 740.00
IUUC-Pab-097754 Pongo abelii 99.30 0.00e+00 824.00
IUUC-Pva-103047 Pteropus vampyrus 83.92 0.00e+00 773.00
IUUC-Pte-104139 Pyrenophora teres 33.19 3.00e-53 202.00
IUUC-Pyt-104488 Pyrenophora triticirepentis 32.82 2.00e-53 203.00
IUUC-Rno-105990 Rattus norvegicus 91.79 0.00e+00 873.00
IUUC-Sha-106581 Sarcophilus harrisii 94.40 0.00e+00 812.00
IUUC-Sja-107913 Schizosaccharomyces japonicus 35.41 1.00e-49 190.00
IUUC-Spo-108068 Schizosaccharomyces pombe 37.95 1.00e-49 190.00
IUUC-Ssl-108418 Sclerotinia sclerotiorum 35.45 3.00e-64 239.00
IUUC-Sre-115219 Sporisorium reilianum 39.93 5.00e-46 178.00
IUUC-Ssc-116360 Sus scrofa 90.97 0.00e+00 802.00
IUUC-Tgu-116951 Taeniopygia guttata 93.56 0.00e+00 815.00
IUUC-Tru-117889 Takifugu rubripes 83.70 0.00e+00 766.00
IUUC-Tre-121895 Trichoderma reesei 39.30 4.00e-53 202.00
IUUC-Tvi-122311 Trichoderma virens 38.95 3.00e-53 202.00
IUUC-Uma-129438 Ustilago maydis 41.92 9.00e-41 161.00
IUUC-Vda-129782 Verticillium dahliae 46.28 7.00e-38 151.00
IUUC-Xma-133370 Xiphophorus maculatus 82.24 0.00e+00 740.00
IUUC-Yli-134337 Yarrowia lipolytica 37.02 2.00e-52 200.00
Created Date 25-Jun-2017

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