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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046186
UUCD1 version UUC-HoS-00102
Ensembl Protein ID ENSP00000252457.5
UniProt Accession Q13042; A2A365; Q5T8C8; Q7Z651; Q96AE6; Q9Y564; CDC16_HUMAN
Genbank Protein ID AAC50200.1; AAD45156.1; AAS94323.1; CAI15810.1; CAM22287.1; EAX09237.1; EAX09244.1; EAX09245.1; AAH10875.1; AAH17244.1
Protein Name Cell division cycle protein 16 homolog; Anaphase-promoting complex subunit 6; CDC16 homolog; Cyclosome subunit 6
Genbank Nucleotide ID U18291; AF164598; AY599074; AL160396; AL160396; CH471085; CH471085; CH471085; BC010875; BC017244
Gene Name CDC16; ANAPC6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000130177.14 ENST00000356221.7 ENSP00000348554.3
ENSG00000130177.14 ENST00000252457.9 ENSP00000252457.5
ENSG00000130177.14 ENST00000252458.6 ENSP00000252458.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/APC_C/APC_C APC_C 21107322; 16763193
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 32.65 1.00e-75 278.00 IUUC-Sce-106205
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Protein Sequence
(Fasta)
MNLERLRKRV RQYLDQQQYQ SALFWADKVA SLSREPQDIY WLAQCLYLTA QYHRAAHALR 60
SRKLDKLYEA CRYLAARCHY AAKEHQQALD VLDMEEPINK RLFEKYLKDE SGFKDPSSDW 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046186|E3,APC_C|Homo sapiens
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Nucleotide Sequence
(Fasta)
GAGCCTGGGC AGTGCACGGG GCCTGGGTGG GGGGTGCGGG TGTGGGTGGG GACCTGCGGC 60
CTTCGAGTCC GCGGCCTTCG AGTCCTGGGG CGGCGGCGGC GGCTGCAGGC ACGGGCACGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046186|E3,APC_C|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
PROSITE

PS50005--TPR
PS50293--TPR_REGION
SMART

SM00028--TPR
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005819--C:spindle
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0008283--P:cell proliferation
GO:0007067--P:mitotic nuclear division
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0007088--P:regulation of mitotic nuclear division
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
KEGG hsa:8881
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000117 Aegilops tauschii 37.03 2.00e-76 280.00
IUUC-Aml-001382 Ailuropoda melanoleuca 96.08 0.00e+00 1201.00
IUUC-Atr-002720 Amborella trichopoda 42.03 5.00e-110 391.00
IUUC-Apl-003937 Anas platyrhynchos 92.18 0.00e+00 1102.00
IUUC-Aca-004235 Anolis carolinensis 85.44 0.00e+00 1105.00
IUUC-Aly-005937 Arabidopsis lyrata 42.45 4.00e-103 369.00
IUUC-Ath-006890 Arabidopsis thaliana 42.26 2.00e-100 359.00
IUUC-Ago-007821 Ashbya gossypii 35.95 4.00e-82 299.00
IUUC-Acl-008251 Aspergillus clavatus 31.60 3.00e-64 240.00
IUUC-Afl-008584 Aspergillus flavus 29.04 6.00e-50 192.00
IUUC-Afu-009095 Aspergillus fumigatus 30.65 3.00e-61 229.00
IUUC-Ani-009178 Aspergillus nidulans 31.71 7.00e-59 222.00
IUUC-Ang-009647 Aspergillus niger 32.59 1.00e-63 238.00
IUUC-Aor-010061 Aspergillus oryzae 29.85 2.00e-56 214.00
IUUC-Ate-010558 Aspergillus terreus 29.66 4.00e-55 209.00
IUUC-Ame-011880 Astyanax mexicanus 78.94 0.00e+00 1002.00
IUUC-Bgr-012022 Blumeria graminis 32.55 2.00e-78 286.00
IUUC-Bta-012343 Bos taurus 97.58 0.00e+00 1262.00
IUUC-Bci-013719 Botrytis cinerea 31.88 5.00e-76 278.00
IUUC-Bdi-014012 Brachypodium distachyon 41.92 1.00e-104 374.00
IUUC-Bol-015750 Brassica oleracea 41.17 4.00e-100 358.00
IUUC-Bra-017378 Brassica rapa 41.35 3.00e-101 362.00
IUUC-Cel-018178 Caenorhabditis elegans 28.71 7.00e-42 165.00
IUUC-Cja-019645 Callithrix jacchus 99.03 0.00e+00 1278.00
IUUC-Cfa-021173 Canis familiaris 97.74 0.00e+00 1236.00
IUUC-Cpo-022175 Cavia porcellus 97.26 0.00e+00 1193.00
IUUC-Csa-023470 Chlorocebus sabaeus 99.52 0.00e+00 1255.00
IUUC-Cho-024406 Choloepus hoffmanni 74.47 8.00e-180 623.00
IUUC-Cin-025267 Ciona intestinalis 59.95 8.00e-144 503.00
IUUC-Cgl-026539 Colletotrichum gloeosporioides 32.30 1.00e-75 277.00
IUUC-Cne-026856 Cryptococcus neoformans 30.54 1.00e-68 254.00
IUUC-Cme-027272 Cyanidioschyzon merolae 26.00 2.00e-27 117.00
IUUC-Dre-027977 Danio rerio 78.40 0.00e+00 974.00
IUUC-Dno-029872 Dasypus novemcinctus 86.71 0.00e+00 849.00
IUUC-Dor-030233 Dipodomys ordii 93.84 0.00e+00 658.00
IUUC-Dse-031306 Dothistroma septosporum 29.55 2.00e-70 260.00
IUUC-Dme-031877 Drosophila melanogaster 50.31 2.00e-92 333.00
IUUC-Ete-032688 Echinops telfairi 74.77 1.00e-139 490.00
IUUC-Eca-033845 Equus caballus 98.02 0.00e+00 1211.00
IUUC-Eeu-034744 Erinaceus europaeus 84.18 3.00e-92 332.00
IUUC-Fca-036291 Felis catus 97.58 0.00e+00 1236.00
IUUC-Fal-036779 Ficedula albicollis 91.48 0.00e+00 1183.00
IUUC-Fox-037869 Fusarium oxysporum 32.84 4.00e-75 275.00
IUUC-Fso-038267 Fusarium solani 33.33 3.00e-79 290.00
IUUC-Gmo-039534 Gadus morhua 77.90 0.00e+00 999.00
IUUC-Ggr-039826 Gaeumannomyces graminis 30.66 3.00e-72 266.00
IUUC-Gga-040228 Gallus gallus 90.69 0.00e+00 1175.00
IUUC-Gac-041593 Gasterosteus aculeatus 77.37 0.00e+00 980.00
IUUC-Gma-043291 Glycine max 40.82 2.00e-102 366.00
IUUC-Ggo-044491 Gorilla gorilla 99.68 0.00e+00 1257.00
IUUC-Hvu-047156 Hordeum vulgare 36.58 6.00e-40 157.00
IUUC-Itr-048812 Ictidomys tridecemlineatus 96.60 0.00e+00 1214.00
IUUC-Kpa-049186 Komagataella pastoris 31.39 2.00e-74 273.00
IUUC-Lch-050215 Latimeria chalumnae 81.83 0.00e+00 926.00
IUUC-Lpe-051395 Leersia perrieri 38.42 1.00e-86 315.00
IUUC-Loc-052340 Lepisosteus oculatus 73.13 0.00e+00 894.00
IUUC-Lma-053003 Leptosphaeria maculans 31.05 2.00e-73 270.00
IUUC-Laf-054125 Loxodonta africana 96.31 0.00e+00 1166.00
IUUC-Mcc-054598 Macaca mulatta 99.19 0.00e+00 1250.00
IUUC-Meu-056839 Macropus eugenii 76.02 0.00e+00 853.00
IUUC-Mor-056916 Magnaporthe oryzae 31.20 3.00e-78 286.00
IUUC-Mtr-057912 Medicago truncatula 40.67 8.00e-105 374.00
IUUC-Mla-058971 Melampsora laricipopulina 27.98 6.00e-64 239.00
IUUC-Mga-059655 Meleagris gallopavo 90.79 0.00e+00 1148.00
IUUC-Mvi-060246 Microbotryum violaceum 32.89 3.00e-74 273.00
IUUC-Mmr-060691 Microcebus murinus 92.10 0.00e+00 1139.00
IUUC-Mdo-061872 Monodelphis domestica 94.86 0.00e+00 1208.00
IUUC-Mmu-063256 Mus musculus 95.32 0.00e+00 1242.00
IUUC-Mac-064797 Musa acuminata 38.20 1.00e-95 343.00
IUUC-Mpu-066773 Mustela putorius furo 97.35 0.00e+00 1199.00
IUUC-Mlu-067237 Myotis lucifugus 97.26 0.00e+00 1230.00
IUUC-Nfi-068499 Neosartorya fischeri 30.83 1.00e-59 224.00
IUUC-Ncr-068893 Neurospora crassa 33.09 2.00e-81 296.00
IUUC-Nle-070117 Nomascus leucogenys 99.03 0.00e+00 1247.00
IUUC-Opr-070994 Ochotona princeps 97.03 0.00e+00 697.00
IUUC-Ont-072034 Oreochromis niloticus 78.46 0.00e+00 986.00
IUUC-Oan-072989 Ornithorhynchus anatinus 92.01 9.00e-177 612.00
IUUC-Ocu-074107 Oryctolagus cuniculus 89.71 0.00e+00 1121.00
IUUC-Oba-074985 Oryza barthii 41.33 4.00e-99 355.00
IUUC-Obr-076412 Oryza brachyantha 41.13 3.00e-96 346.00
IUUC-Ogl-077693 Oryza glaberrima 41.33 3.00e-99 356.00
IUUC-Ogu-078411 Oryza glumaepatula 41.40 9.00e-100 358.00
IUUC-Oin-079841 Oryza indica 41.07 1.00e-93 338.00
IUUC-Olo-080560 Oryza longistaminata 40.91 6.00e-92 331.00
IUUC-Ome-081660 Oryza meridionalis 41.40 2.00e-99 357.00
IUUC-Oni-082141 Oryza nivara 41.33 4.00e-99 355.00
IUUC-Opu-083634 Oryza punctata 41.14 3.00e-99 356.00
IUUC-Oru-084291 Oryza rufipogon 41.33 4.00e-99 355.00
IUUC-Osa-085547 Oryza sativa 41.40 5.00e-100 358.00
IUUC-Ola-086854 Oryzias latipes 76.75 0.00e+00 970.00
IUUC-Olu-087784 Ostreococcus lucimarinus 34.44 2.00e-68 253.00
IUUC-Oga-088800 Otolemur garnettii 98.55 0.00e+00 1143.00
IUUC-Oar-089669 Ovis aries 97.83 0.00e+00 1192.00
IUUC-Ptr-091251 Pan troglodytes 99.84 0.00e+00 1259.00
IUUC-Pan-092320 Papio anubis 95.65 0.00e+00 1195.00
IUUC-Psi-093847 Pelodiscus sinensis 91.49 0.00e+00 1174.00
IUUC-Pno-094804 Phaeosphaeria nodorum 32.91 5.00e-79 288.00
IUUC-Ppa-095889 Physcomitrella patens 41.96 2.00e-102 366.00
IUUC-Pfo-096273 Poecilia formosa 77.96 0.00e+00 986.00
IUUC-Pab-098108 Pongo abelii 91.94 0.00e+00 1135.00
IUUC-Pop-099818 Populus trichocarpa 41.19 5.00e-105 375.00
IUUC-Pca-100859 Procavia capensis 86.14 3.00e-102 365.00
IUUC-Pva-102413 Pteropus vampyrus 98.06 0.00e+00 1241.00
IUUC-Pgr-103689 Puccinia graminis 33.09 2.00e-51 197.00
IUUC-Ptt-103799 Puccinia triticina 32.20 4.00e-47 182.00
IUUC-Pte-104162 Pyrenophora teres 33.39 2.00e-76 280.00
IUUC-Pyt-104476 Pyrenophora triticirepentis 33.94 1.00e-78 287.00
IUUC-Rno-105403 Rattus norvegicus 95.81 0.00e+00 1220.00
IUUC-Sce-106205 Saccharomyces cerevisiae 32.65 2.00e-83 303.00
IUUC-Sha-107183 Sarcophilus harrisii 94.86 0.00e+00 1236.00
IUUC-Sja-107827 Schizosaccharomyces japonicus 37.48 1.00e-93 337.00
IUUC-Spo-108188 Schizosaccharomyces pombe 36.22 1.00e-86 314.00
IUUC-Ssl-108522 Sclerotinia sclerotiorum 35.66 2.00e-39 155.00
IUUC-Smo-109302 Selaginella moellendorffii 41.25 2.00e-100 360.00
IUUC-Sit-110486 Setaria italica 41.54 1.00e-101 364.00
IUUC-Sly-111083 Solanum lycopersicum 41.56 4.00e-105 375.00
IUUC-Sar-113712 Sorex araneus 93.78 0.00e+00 793.00
IUUC-Sbi-114145 Sorghum bicolor 40.75 7.00e-97 348.00
IUUC-Sre-115016 Sporisorium reilianum 31.26 3.00e-55 210.00
IUUC-Ssc-115757 Sus scrofa 96.60 0.00e+00 1209.00
IUUC-Tgu-116718 Taeniopygia guttata 91.65 0.00e+00 1187.00
IUUC-Tru-118018 Takifugu rubripes 77.42 0.00e+00 961.00
IUUC-Tsy-118804 Tarsius syrichta 97.65 0.00e+00 1103.00
IUUC-Tni-119767 Tetraodon nigroviridis 75.96 0.00e+00 961.00
IUUC-Tca-121364 Theobroma cacao 40.75 9.00e-104 370.00
IUUC-Tre-122067 Trichoderma reesei 33.21 2.00e-82 300.00
IUUC-Tvi-122461 Trichoderma virens 32.78 2.00e-78 287.00
IUUC-Tae-123368 Triticum aestivum 41.24 3.00e-109 389.00
IUUC-Tur-126602 Triticum urartu 44.13 3.00e-79 289.00
IUUC-Tme-126892 Tuber melanosporum 32.90 5.00e-80 292.00
IUUC-Tbe-127430 Tupaia belangeri 78.39 0.00e+00 929.00
IUUC-Ttr-128535 Tursiops truncatus 97.26 0.00e+00 1228.00
IUUC-Uma-129584 Ustilago maydis 31.26 1.00e-57 219.00
IUUC-Vda-129823 Verticillium dahliae 31.66 2.00e-83 303.00
IUUC-Vpa-130167 Vicugna pacos 90.52 0.00e+00 786.00
IUUC-Vvi-131646 Vitis vinifera 40.67 2.00e-98 352.00
IUUC-Xtr-131785 Xenopus tropicalis 87.74 0.00e+00 690.00
IUUC-Xma-133644 Xiphophorus maculatus 78.12 0.00e+00 988.00
IUUC-Yli-134405 Yarrowia lipolytica 34.86 4.00e-89 322.00
IUUC-Zma-135969 Zea mays 40.98 5.00e-101 362.00
Created Date 25-Jun-2017

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