iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bra-018095

Ensembl Protein ID

Bra006306.1-P

UniProt Accession

M4CQ17; M4CQ17_BRARP

Protein Name

Ribosome biogenesis protein WDR12 homolog

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bra006306	Bra006306.1	Bra006306.1-P

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-29	101.5	352	386
UBD/Beta-Prp	5.60e-41	141.7	110	299

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtg 33
           H+++++++++  s+  +l+s+s+Dg+i++WDlrt 
   Q: 352  HSSWISACKWhkSSwFHLLSASYDGKIMLWDLRTA 386
           ***********977688***************986 PP

UBD/Beta-Prp

   S: 14   tcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk....ilvtgseDrtikvwdls.........tgkcvhtlkgheds 96
           ++v+   + ++++tg++dg  ++w+  +g++ + l+gh+++++++ f +++     + +t+s+Drt++++ ++               +l+gh++s
   Q: 110  SAVDG-SSPRFVLTGCYDGLGRLWSS-PGSCTHILEGHTGAISSIAFANSEGaegvTVATASKDRTLRLFKVDtaesgdtttRLGAYKILRGHKAS 203
           55555.456789************85.66999*****************9989999**************777556555443334456677***** PP
   S: 97   vlslsfspsgdklvsGshdrtirvwdletgqclee.......................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktg 169
           v s++ +++g+k+ sGs+d ti+vwd+++ +   +                       tl gh++ v++vv+++  +++ s+s D  vr Wd++tg
   Q: 204  VSSVTAQKYGSKVCSGSWDCTINVWDTNESTSELSvpgkkrkgnnqaeepqlegeaetTLVGHTQCVSSVVWPE-HDVIYSCSWDHSVRRWDVETG 298
           ***************************999999999************************************99.8999***************99 PP
   S: 170  k 170
           k
   Q: 299  K 299
           7 PP

Organism

Brassica rapa

Functional Description
(View)

Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.

Protein Sequence
(Fasta)

MNGEGDDASK VIHVKFLTKL DSPFKVPVTS VVIPSSVTRL GLSSIVNSLL TLEKAEAFDF 60
LIDGELIRMS LEQFLLAKGI SAERTLEIEY IRAVAPRKEE KPSLHDDWVS AVDGSSPRFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATGGCG AAGGAGACGA TGCATCCAAA GTAATTCACG TGAAGTTCTT GACGAAGCTT 60
GACTCTCCGT TCAAAGTTCC GGTCACCTCC GTCGTTATCC CTTCCAGTGT CACTCGTCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007864	Ashbya gossypii	32.39	2.00e-49	189.00
IUUC-Ame-011432	Astyanax mexicanus	33.02	3.00e-63	235.00
IUUC-Bgr-012218	Blumeria graminis	29.80	2.00e-38	152.00
IUUC-Bol-016190	Brassica oleracea	96.03	0.00e+00	806.00
IUUC-Cel-018569	Caenorhabditis elegans	23.92	8.00e-25	107.00
IUUC-Cja-019468	Callithrix jacchus	33.50	3.00e-52	199.00
IUUC-Cho-024426	Choloepus hoffmanni	31.95	4.00e-42	165.00
IUUC-Cin-025789	Ciona intestinalis	30.63	8.00e-48	184.00
IUUC-Dor-031082	Dipodomys ordii	30.96	5.00e-24	105.00
IUUC-Dme-032189	Drosophila melanogaster	29.98	5.00e-47	181.00
IUUC-Ete-032247	Echinops telfairi	31.22	8.00e-47	180.00
IUUC-Gmo-039040	Gadus morhua	34.98	2.00e-65	242.00
IUUC-Gac-042117	Gasterosteus aculeatus	33.57	3.00e-63	235.00
IUUC-Lch-050655	Latimeria chalumnae	32.38	2.00e-43	169.00
IUUC-Laf-053993	Loxodonta africana	33.17	6.00e-54	204.00
IUUC-Mcc-055128	Macaca mulatta	28.00	2.00e-33	135.00
IUUC-Ont-071646	Oreochromis niloticus	32.69	5.00e-59	221.00
IUUC-Ola-087420	Oryzias latipes	33.18	4.00e-61	228.00
IUUC-Olu-087740	Ostreococcus lucimarinus	34.87	9.00e-63	233.00
IUUC-Pfo-096337	Poecilia formosa	32.29	7.00e-62	230.00
IUUC-Pca-100394	Procavia capensis	31.46	3.00e-45	175.00
IUUC-Rno-105114	Rattus norvegicus	33.74	6.00e-56	211.00
IUUC-Spo-108134	Schizosaccharomyces pombe	28.97	3.00e-36	145.00
IUUC-Smo-108720	Selaginella moellendorffii	48.80	1.00e-115	409.00
IUUC-Sre-115002	Sporisorium reilianum	31.84	7.00e-20	91.70
IUUC-Tni-119820	Tetraodon nigroviridis	33.73	2.00e-59	222.00
IUUC-Uma-129628	Ustilago maydis	30.58	8.00e-12	65.10
IUUC-Xtr-132083	Xenopus tropicalis	33.33	5.00e-56	211.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence