iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-106058

Ensembl Protein ID

ENSRNOP00000049523.3

UniProt Accession

Q6AXU0; BPI_RAT

Genbank Protein ID

AAH79318.1

Protein Name

Bactericidal permeability-increasing protein

Genbank Nucleotide ID

BC079318

Gene Name

Bpi

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000034195.4	ENSRNOT00000039994.4	ENSRNOP00000049523.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	31.25	1.30e-01	32.30	IUUC-Spo-108230

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

Protein Sequence
(Fasta)

MAWGPDNVRK WSSLALLAIV GTALTAATDP GFVARISQKG LDFVCQESMV ELQKELLAIS 60
IPDFSGDFKI KHLGKGTYEF YSMAVEGFHI PDPQIKLLPS DGLQLSITSA SIKISGRWKY 120

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Nucleotide Sequence
(Fasta)

CTCGCACAGA CCTCTAGGCT CCACTGGGGC AGCCCCTGGA CTGGTCCCCA ACGTTGATGG 60
GGAACCGCAG CTGCCCTCCC CCTCCCGCCC CCACGGTTGC CTTCCTCCTT CCTCTTTCTA 120

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Sequence Source

Ensembl

Keyword

KW-0044--Antibiotic
KW-0929--Antimicrobial
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0472--Membrane
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal

Interpro

IPR017943--Bactericidal_perm-incr_a/b_dom
IPR030181--BPI
IPR030675--BPI/LBP
IPR032942--BPI/LBP/Plunc
IPR001124--Lipid-bd_serum_glycop_C
IPR017942--Lipid-bd_serum_glycop_N

Pfam

PF01273--LBP_BPI_CETP
PF02886--LBP_BPI_CETP_C

SMART

SM00328--BPI1
SM00329--BPI2

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0016020--C:membrane
GO:0008289--F:lipid binding
GO:0001530--F:lipopolysaccharide binding
GO:0042742--P:defense response to bacterium
GO:0050829--P:defense response to Gram-negative bacterium
GO:0006955--P:immune response
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032717--P:negative regulation of interleukin-8 production
GO:0043031--P:negative regulation of macrophage activation
GO:0032720--P:negative regulation of tumor necrosis factor production

KEGG

rno:296321

Orthology

iUUCD ID

Species

Identity

E-value

Score

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence