iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bra-017576

Ensembl Protein ID

Bra021150.1-P

UniProt Accession

M4DXA4; M4DXA4_BRARP

Protein Name

Coatomer subunit beta'

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bra021150	Bra021150.1	Bra021150.1-P

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.70e-33	113.5	252	292
UBD/Beta-Prp	6.70e-65	220.2	79	357

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+ +v+c+++    d ++l++GsdD+t kvWD+ t  ++++
   Q: 252  HQKGVNCVDYftgGDkPYLITGSDDHTAKVWDYQTKSCVQT 292
           9999****966*9778*******************999986 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlsls 101
           ++++++++++v+ +p +++++++ + gt+ +w+++t+   +s++  + +v++ kf+p++++ v g++D +i+v++++t + v ++++h d++++++
   Q: 79   FAQRSERVKSVDLHPTEPWILASLYAGTVCIWNYQTQVITKSFEVTDVPVRSAKFIPRKQWVVAGADDLHIRVYNYNTMDKVKVFEAHADYIRCVA 174
           66788899**************************************************************************************** PP
   S: 102  fspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvysls..fdsngke 194
           ++p+  +++s s+d  i++wd+e+g+   ++++gh++ v+ vv++p++ n ++s+slDr +++W+l + +   tl   h++ v++++     ++++
   Q: 175  VHPTLPYVLSSSDDMLIKLWDWENGWACTQIFEGHSHYVMQVVFNPKDtNTFASASLDRSIKIWNLGSPDPNFTLDA-HQKGVNCVDyfTGGDKPY 269
           **************************9999*********************************************98.*********6444555** PP
   S: 195  lvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvl 282
           l++gs+d t k+wd+qt++cv+tl ght nv+ v f+p+  ++++g++Dg++riW  ++  l +tl+++ ++v+++ +++ +++v++ 
   Q: 270  LITGSDDHTAKVWDYQTKSCVQTLDGHTHNVSAVCFHPELPIILTGTEDGTVRIWHATTYRLENTLNYSLDRVWAIGYIKSSRRVVIG 357
           ****************************************************************************997777777654 PP

Organism

Brassica rapa

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

Protein Sequence
(Fasta)

MVRPQISLCY FRFLSPRSQS NPLAMRSRSL NPKSTSPFRD VAIGCSFHEI EFFKALYVVT 60
DYMLSFSQQP LSLDIKRKFA QRSERVKSVD LHPTEPWILA SLYAGTVCIW NYQTQVITKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGAGAC CTCAAATCTC TCTATGTTAT TTCCGTTTCC TCTCTCCCAG ATCTCAATCG 60
AACCCGCTTG CGATGCGATC TAGATCATTG AATCCGAAAT CAACATCTCC GTTTCGTGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR006692--Coatomer_WD-assoc_reg
IPR016453--COPB2
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030663--C:COPI-coated vesicle membrane
GO:0000139--C:Golgi membrane
GO:0030117--C:membrane coat
GO:0005198--F:structural molecule activity
GO:0006886--P:intracellular protein transport
GO:0016192--P:vesicle-mediated transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005853	Arabidopsis lyrata	92.44	0.00e+00	1696.00
IUUC-Bol-016338	Brassica oleracea	95.85	0.00e+00	1744.00
IUUC-Spo-108299	Schizosaccharomyces pombe	46.72	0.00e+00	796.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence