iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108065

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable ubiquitin carboxyl-terminal hydrolase 4; Deubiquitinating enzyme 4; Ubiquitin thioesterase 4; Ubiquitin-specific-processing protease 4

Genbank Nucleotide ID

CU329671

Gene Name

ubp4; SPBC18H10.08c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC18H10.08c	SPBC18H10.08c.1	SPBC18H10.08c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.60e-81	270.1	228	572

Active Site

Position(s)	Description	Evidence
236	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
530	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           Gl+NlgNtCYmN+vLQcL+++++l+  +l+     +++n +np ++ g++++++ +l+++++ ++ ++++spr++l++++++++ fs   
   Q: 228  GLTNLGNTCYMNCVLQCLFACKDLTIPMLQgrGLLQNINTKNPLGTGGKITSAFFSLLQSVLlNHGQRSISPRNFLEIVQSLNRDFSIDG 317
           9*****************************99899**************************9999************************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.........aeekkkkknkslisdlFqgqlksqikclecdnvssreepf 169
           q DaqEfl+f+ld+l+e+l+++++ +      ed+ ++ +e         +++ + ++nks+++++F gql s+++c +c+++s+++ pf
   Q: 318  QCDAQEFLNFFLDKLHEDLNSNASRSPIAPLTEDQLSAREElplshfshiEWNLHLRSNKSIVVNNFVGQLCSRTQCMTCGRTSTTFAPF 407
           *******************9955554444444444444444577788888**************************************** PP
   S: 170  ldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleL 259
           ++l +p+ + +  +  slq+cL +f+++e l+g++ ++c+ ck ++ a+k ++++klPe+Li++++Rf+ s   + r+ki++ + +   L
   Q: 408  TSLAIPIDDVS--HVVSLQECLLKFSAPELLQGHDGWHCPVCKVQRSAKKVIMISKLPEYLIIQIQRFKISV--MGRKKIDTPLGLS--L 491
           *******9999..678****************************************************7755..7899999999976..6 PP
   S: 260  dlspfctspeekqke....kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           ++ + +  p + q+     + +Y+L+a ++H+G+l++GHY+++v   +++W+++dDs V++v   + l+e  s+ Y+lfYkr
   Q: 492  QIPSKMLVPPSFQSGigyiPSNYNLFAFICHYGQLENGHYISDVLF-NNEWCHIDDSIVRTVGGITDLREDFSSSYILFYKR 572
           6655444444444446788**************************9.899************9766666677********98 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Acts late in the proteolytic pathway in conjunction with the 26S proteasome. Plays a role in avoiding DNA overreplication (By similarity).

Protein Sequence
(Fasta)

MSDDYFDRLF ELAFVYINED ETIQSCSFRG QRWLEEAQTL EQKNSLLKAY YYYLKALKLA 60
YEIPCRFEIS VKSTHYGEFK QFQKLAIQAV SKAFTIKSKL AVKHYLPVIQ ISDALSLSKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTATAACTAA AGTAATCAAT CCATGATCAC TGGGCAAGGA TAAGAAAATC TCATTTCTTG 60
CCTCTCTGGT ACTAGTTAAT AAAGATGTTT ACATTAACTA ACCCACAGCT AACCTGCTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0032153--C:cell division site
GO:0005737--C:cytoplasm
GO:0005768--C:endosome
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

spo:SPBC18H10.08c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007959	Ashbya gossypii	32.10	8.00e-52	196.00
IUUC-Acl-008102	Aspergillus clavatus	33.51	3.00e-48	185.00
IUUC-Afl-008604	Aspergillus flavus	34.86	5.00e-50	190.00
IUUC-Afu-009001	Aspergillus fumigatus	34.43	1.00e-47	183.00
IUUC-Ani-009291	Aspergillus nidulans	32.71	8.00e-46	177.00
IUUC-Ang-009844	Aspergillus niger	34.25	3.00e-49	187.00
IUUC-Aor-010098	Aspergillus oryzae	34.86	2.00e-50	192.00
IUUC-Ate-010585	Aspergillus terreus	33.70	8.00e-48	183.00
IUUC-Ame-011102	Astyanax mexicanus	32.56	2.00e-37	147.00
IUUC-Cel-018482	Caenorhabditis elegans	30.00	2.00e-33	135.00
IUUC-Csv-026253	Ciona savignyi	34.02	1.00e-34	139.00
IUUC-Cne-026821	Cryptococcus neoformans	34.70	1.00e-52	199.00
IUUC-Dor-031053	Dipodomys ordii	29.41	4.00e-35	140.00
IUUC-Dse-031463	Dothistroma septosporum	30.79	2.00e-41	162.00
IUUC-Dme-032208	Drosophila melanogaster	31.65	4.00e-34	138.00
IUUC-Gac-042475	Gasterosteus aculeatus	33.96	1.00e-39	155.00
IUUC-Kpa-049321	Komagataella pastoris	35.85	3.00e-59	221.00
IUUC-Lma-053021	Leptosphaeria maculans	33.25	6.00e-49	187.00
IUUC-Meu-056279	Macropus eugenii	29.09	6.00e-35	140.00
IUUC-Mvi-060559	Microbotryum violaceum	37.60	3.00e-54	205.00
IUUC-Nfi-068410	Neosartorya fischeri	34.15	8.00e-48	184.00
IUUC-Opr-071096	Ochotona princeps	29.69	6.00e-36	143.00
IUUC-Psi-093216	Pelodiscus sinensis	30.48	5.00e-34	137.00
IUUC-Pma-094626	Petromyzon marinus	36.78	1.00e-46	178.00
IUUC-Pno-094986	Phaeosphaeria nodorum	31.94	2.00e-39	155.00
IUUC-Pgr-103408	Puccinia graminis	31.31	6.00e-28	118.00
IUUC-Ptt-103699	Puccinia triticina	39.16	9.00e-40	157.00
IUUC-Pte-104348	Pyrenophora teres	33.13	1.00e-41	163.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	34.73	3.00e-49	188.00
IUUC-Sce-106166	Saccharomyces cerevisiae	33.51	1.00e-47	183.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	44.50	5.00e-145	505.00
IUUC-Smo-108711	Selaginella moellendorffii	28.69	5.00e-31	126.00
IUUC-Sre-115031	Sporisorium reilianum	37.09	7.00e-57	214.00
IUUC-Tme-127144	Tuber melanosporum	37.30	6.00e-60	224.00
IUUC-Uma-129340	Ustilago maydis	36.26	8.00e-54	203.00
IUUC-Yli-134561	Yarrowia lipolytica	35.83	1.00e-50	192.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence