iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mac-065634

Ensembl Protein ID

GSMUA_Achr8P34470_001

UniProt Accession

M0TW49; M0TW49_MUSAM

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
GSMUA_Achr8G34470_001	GSMUA_Achr8T34470_001	GSMUA_Achr8P34470_001

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.70e-46	159.2	313	861
UBD/Alpha-Helix/UBA	1.70e-13	51.1	739	777

Active Site

Position(s)	Description	Evidence
322	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
824	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklnee.npkepkgellkslqklfeel...............w.kskkkavspr 71
           tGl NlgN+CYm S++Q+ + ++ + + + e+++ k++   + ++p+ +l ++l+kl + l               w   k++ v pr
   Q: 313  TGLVNLGNSCYMASTIQVVFTTRAFISRYYEHQSLKMAFAmATSDPTLDLNMQLTKLAHGLlsgkysvpiqeiwsiWsCLKQEGVPPR 400
           7**************************999966655554414578888999999999999977777777777755545556669**** PP
   S: 72   ellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.............................. 129
           ++++++++ ++efs+++qq     +++     + +  + ++ p++ + ++                                      
   Q: 401  MFKTVIAANHPEFSSMRQQLGTGTVRYTERYTQVYH-SVTDGPRTGSLSD-------Rytqakwmvsrcildltlaihlanifcmdal 480
           *******************99998888755555554.3333333333332.......122223468999******************* PP
   S: 130  .........aeekkkkknkslisdlFqgqlksqikclecdnvs.sreepfldlslpvpgkeetkke...................... 185
                     e+ +  k +   s+ F++ ++++++c++ +  + +r +  l+ls+p+++ ++++++                      
   Q: 481  efflhfldqVERVNSGKPELDPSRSFKFIIEERLQCPSGKVAYnKRSDYILSLSIPLHEATNKEQLeafhkmkaerkleakdidrdei 568
           *******8544444444456689**************999888566666777777777777555449********************* PP
   S: 186  .....slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts. 267
                 l+ cL+sf+++ee+++   +y+++ ++k++a k+  + ++P++L+lh+ +f + ee+++++k++ ++++p+ +d++++  + 
   Q: 569  vrprvPLEACLASFSAPEEVHD---FYSTSLNAKTTAIKTANFATFPDYLVLHMRKF-VMEEGWVPKKLDVYIDVPDVIDITHMRGKg 652
           ********************97...********************************.67889*******************999888 PP
   S: 268  ........................................................................................ 267
                                                                                                   
   Q: 653  lqpgeellpetgpdgdvehthlvasedivsklaamgfnylhcqkaaintanagveeamtwllshmndpdiddpishrsdamelqfvde 740
           8888888888888888888888887777777777777777777777777666666666666666666666666666655555555555 PP
   S: 268  ...peekqke..........................................................kkkYeLiavvvHsG.slssG 293
              +     +                                                            +Y+L+a v+H G s+++G
   Q: 741  tsvE-----TlisfgfqedvarkalkasggdiekatdwifshpeasasadtdatssgmqagdpgvpdgIGRYKLMALVSHIGtSTHCG 823
           5550.....055555555555556666666666666666666666677777888888889999999999******************* PP
   S: 294  HYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           HYva+v + +g+W+ f+DskV ++   +  +   + +Y++fY+r
   Q: 824  HYVAHVHK-DGRWVIFNDSKVGAS--VDPPK---DMGYLYFYER 861
           *******9.9************99..57777...99******97 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           de  +e l++ GF ++ a++aL a+++++e A+++++++
   Q: 739  DETSVETLISFGFQEDVARKALKASGGDIEKATDWIFSH 777
           7999*********************************97 PP

Organism

Musa acuminata

Protein Sequence
(Fasta)

MFPSPMELLR SHLSRVRIPE PTNRIYKSEC CISFDTPRSE GGLYVDLSSF LAFGKEYVGW 60
NYEKTGNPVY LRIQQRPKPV PEDRPLKKPT LLAIGVDGGF DYQETDYEET HNIVILPDYV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTCCCCT CTCCAATGGA GCTCCTCCGC TCCCACCTCT CCAGGGTTCG CATCCCCGAG 60
CCCACCAACC GAATCTACAA GAGCGAGTGC TGCATCTCCT TCGACACCCC GGTAATTCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	62.36	0.00e+00	1027.00
IUUC-Aml-002104	Ailuropoda melanoleuca	42.94	0.00e+00	691.00
IUUC-Atr-002580	Amborella trichopoda	67.01	0.00e+00	1174.00
IUUC-Apl-003774	Anas platyrhynchos	43.52	0.00e+00	683.00
IUUC-Aca-005368	Anolis carolinensis	43.82	0.00e+00	712.00
IUUC-Ago-007890	Ashbya gossypii	27.45	3.00e-35	142.00
IUUC-Acl-008057	Aspergillus clavatus	31.88	8.00e-110	390.00
IUUC-Afu-008805	Aspergillus fumigatus	35.25	5.00e-58	218.00
IUUC-Ani-009441	Aspergillus nidulans	34.23	2.00e-80	293.00
IUUC-Ang-009720	Aspergillus niger	36.01	2.00e-55	210.00
IUUC-Ate-010531	Aspergillus terreus	30.65	2.00e-87	316.00
IUUC-Ame-011470	Astyanax mexicanus	38.49	3.00e-173	601.00
IUUC-Bgr-012183	Blumeria graminis	29.29	4.00e-95	342.00
IUUC-Bta-013179	Bos taurus	42.92	0.00e+00	694.00
IUUC-Bci-013858	Botrytis cinerea	30.88	3.00e-106	379.00
IUUC-Bol-015296	Brassica oleracea	66.28	0.00e+00	1149.00
IUUC-Bra-017619	Brassica rapa	64.74	0.00e+00	1138.00
IUUC-Cja-019063	Callithrix jacchus	42.72	0.00e+00	689.00
IUUC-Cfa-020976	Canis familiaris	44.03	0.00e+00	706.00
IUUC-Cpo-022265	Cavia porcellus	43.82	0.00e+00	707.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	37.19	4.00e-102	365.00
IUUC-Csa-024078	Chlorocebus sabaeus	39.78	6.00e-178	617.00
IUUC-Cho-024522	Choloepus hoffmanni	34.48	8.00e-70	258.00
IUUC-Cin-025411	Ciona intestinalis	39.75	4.00e-171	594.00
IUUC-Csv-026347	Ciona savignyi	38.20	1.00e-165	576.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	31.45	2.00e-95	342.00
IUUC-Cne-026831	Cryptococcus neoformans	35.54	8.00e-56	211.00
IUUC-Cme-027335	Cyanidioschyzon merolae	27.94	6.00e-46	179.00
IUUC-Dre-027651	Danio rerio	39.06	0.00e+00	630.00
IUUC-Dno-028975	Dasypus novemcinctus	39.67	4.00e-178	617.00
IUUC-Dor-030130	Dipodomys ordii	35.28	4.00e-81	295.00
IUUC-Dse-031467	Dothistroma septosporum	32.69	3.00e-107	382.00
IUUC-Dme-032075	Drosophila melanogaster	41.76	6.00e-176	610.00
IUUC-Ete-032865	Echinops telfairi	40.37	2.00e-178	619.00
IUUC-Eca-034059	Equus caballus	43.08	0.00e+00	693.00
IUUC-Eeu-035304	Erinaceus europaeus	40.94	3.00e-178	618.00
IUUC-Fca-035515	Felis catus	43.25	0.00e+00	699.00
IUUC-Fal-037271	Ficedula albicollis	44.07	0.00e+00	663.00
IUUC-Fox-037745	Fusarium oxysporum	31.74	3.00e-107	382.00
IUUC-Fso-038158	Fusarium solani	31.42	7.00e-106	377.00
IUUC-Gmo-039071	Gadus morhua	40.76	2.00e-174	605.00
IUUC-Gga-040635	Gallus gallus	43.33	0.00e+00	716.00
IUUC-Gac-042528	Gasterosteus aculeatus	41.25	5.00e-178	617.00
IUUC-Ggo-044602	Gorilla gorilla	43.14	0.00e+00	698.00
IUUC-Hsa-045959	Homo sapiens	43.14	0.00e+00	698.00
IUUC-Hvu-047563	Hordeum vulgare	64.76	0.00e+00	880.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	42.92	0.00e+00	699.00
IUUC-Kpa-049156	Komagataella pastoris	31.57	2.00e-52	199.00
IUUC-Lch-050425	Latimeria chalumnae	39.35	4.00e-180	624.00
IUUC-Lpe-051523	Leersia perrieri	70.63	0.00e+00	631.00
IUUC-Loc-052072	Lepisosteus oculatus	40.18	4.00e-179	621.00
IUUC-Laf-054327	Loxodonta africana	43.14	0.00e+00	701.00
IUUC-Mcc-055443	Macaca mulatta	43.03	0.00e+00	694.00
IUUC-Meu-056298	Macropus eugenii	43.91	6.00e-139	487.00
IUUC-Mor-057106	Magnaporthe oryzae	31.25	1.00e-104	373.00
IUUC-Mla-058903	Melampsora laricipopulina	30.22	8.00e-94	337.00
IUUC-Mga-059669	Meleagris gallopavo	43.12	0.00e+00	671.00
IUUC-Mmr-060575	Microcebus murinus	43.03	0.00e+00	694.00
IUUC-Mdo-062183	Monodelphis domestica	43.53	0.00e+00	706.00
IUUC-Mmu-063592	Mus musculus	43.08	0.00e+00	698.00
IUUC-Mpu-066082	Mustela putorius furo	43.81	0.00e+00	700.00
IUUC-Mlu-067786	Myotis lucifugus	38.56	8.00e-173	600.00
IUUC-Nfi-068558	Neosartorya fischeri	35.15	5.00e-59	222.00
IUUC-Nle-070173	Nomascus leucogenys	44.03	0.00e+00	705.00
IUUC-Opr-070556	Ochotona princeps	43.36	0.00e+00	707.00
IUUC-Ont-071502	Oreochromis niloticus	46.99	3.00e-104	372.00
IUUC-Ocu-074861	Oryctolagus cuniculus	44.03	0.00e+00	711.00
IUUC-Oba-075109	Oryza barthii	72.18	0.00e+00	635.00
IUUC-Obr-076292	Oryza brachyantha	75.54	0.00e+00	681.00
IUUC-Ogl-077065	Oryza glaberrima	75.30	0.00e+00	676.00
IUUC-Ogu-078776	Oryza glumaepatula	72.42	0.00e+00	638.00
IUUC-Oin-080048	Oryza indica	74.82	0.00e+00	673.00
IUUC-Olo-080711	Oryza longistaminata	76.49	4.00e-164	571.00
IUUC-Ome-081506	Oryza meridionalis	76.49	2.00e-164	572.00
IUUC-Oni-082320	Oryza nivara	68.64	1.00e-180	625.00
IUUC-Opu-083801	Oryza punctata	72.66	0.00e+00	637.00
IUUC-Oru-085139	Oryza rufipogon	68.64	0.00e+00	626.00
IUUC-Osa-085713	Oryza sativa	75.54	0.00e+00	679.00
IUUC-Ola-087344	Oryzias latipes	38.67	2.00e-179	622.00
IUUC-Olu-087822	Ostreococcus lucimarinus	37.01	1.00e-149	523.00
IUUC-Oga-088625	Otolemur garnettii	42.70	0.00e+00	688.00
IUUC-Oar-089995	Ovis aries	42.54	0.00e+00	685.00
IUUC-Ptr-090640	Pan troglodytes	42.37	0.00e+00	696.00
IUUC-Pan-091974	Papio anubis	42.72	0.00e+00	690.00
IUUC-Psi-093957	Pelodiscus sinensis	43.18	0.00e+00	721.00
IUUC-Pma-094242	Petromyzon marinus	41.12	4.00e-91	327.00
IUUC-Ppa-095901	Physcomitrella patens	60.57	0.00e+00	1060.00
IUUC-Pfo-096029	Poecilia formosa	40.35	0.00e+00	636.00
IUUC-Pab-098068	Pongo abelii	39.36	2.00e-166	579.00
IUUC-Pca-100738	Procavia capensis	39.46	2.00e-129	455.00
IUUC-Pva-102545	Pteropus vampyrus	36.64	3.00e-155	541.00
IUUC-Pgr-103343	Puccinia graminis	33.33	2.00e-60	226.00
IUUC-Ptt-103928	Puccinia triticina	31.58	1.00e-49	191.00
IUUC-Rno-105801	Rattus norvegicus	43.25	0.00e+00	700.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.68	1.00e-37	150.00
IUUC-Sha-107635	Sarcophilus harrisii	43.86	0.00e+00	701.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	35.32	1.00e-50	194.00
IUUC-Spo-108144	Schizosaccharomyces pombe	36.23	8.00e-59	221.00
IUUC-Smo-108703	Selaginella moellendorffii	56.49	0.00e+00	910.00
IUUC-Sit-110728	Setaria italica	75.48	0.00e+00	674.00
IUUC-Sar-113733	Sorex araneus	42.82	9.00e-84	304.00
IUUC-Sbi-114419	Sorghum bicolor	77.40	0.00e+00	688.00
IUUC-Sre-115225	Sporisorium reilianum	31.15	3.00e-93	335.00
IUUC-Tgu-117346	Taeniopygia guttata	43.50	0.00e+00	697.00
IUUC-Tru-118627	Takifugu rubripes	37.50	6.00e-173	600.00
IUUC-Tsy-119278	Tarsius syrichta	36.77	7.00e-154	537.00
IUUC-Tni-120804	Tetraodon nigroviridis	38.56	1.00e-175	610.00
IUUC-Tca-121585	Theobroma cacao	69.10	0.00e+00	1142.00
IUUC-Tre-122043	Trichoderma reesei	32.11	2.00e-102	366.00
IUUC-Tvi-122303	Trichoderma virens	36.71	4.00e-66	245.00
IUUC-Tae-125686	Triticum aestivum	65.96	0.00e+00	1124.00
IUUC-Tme-126909	Tuber melanosporum	31.31	1.00e-87	317.00
IUUC-Tbe-127261	Tupaia belangeri	41.83	1.00e-84	307.00
IUUC-Ttr-129119	Tursiops truncatus	51.76	1.00e-104	373.00
IUUC-Vda-129688	Verticillium dahliae	31.17	2.00e-98	353.00
IUUC-Vpa-130170	Vicugna pacos	43.60	1.00e-78	287.00
IUUC-Xma-134273	Xiphophorus maculatus	39.59	0.00e+00	643.00
IUUC-Yli-134510	Yarrowia lipolytica	31.10	7.00e-94	337.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence