iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046278

UUCD1 version

UUC-HoS-01138

Ensembl Protein ID

ENSP00000343535.4

UniProt Accession

Q93009; A6NMY8; B7Z815; H0Y3G8; UBP7_HUMAN

Genbank Protein ID

CAA96580.1; BAH13801.1; EAW85194.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 7; Deubiquitinating enzyme 7; Herpesvirus-associated ubiquitin-specific protease; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7

Genbank Nucleotide ID

Z72499; AK302771; AC022167

Gene Name

USP7; HAUSP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000187555.14	ENST00000344836.8	ENSP00000343535.4
ENSG00000187555.14	ENST00000563961.5	ENSP00000454362.1
ENSG00000187555.14	ENST00000381886.8	ENSP00000371310.4
ENSG00000187555.14	ENST00000565455.5	ENSP00000456258.1
ENSG00000187555.14	ENST00000563043.1	ENSP00000459594.1
ENSG00000187555.14	ENST00000567692.1	ENSP00000458027.1
ENSG00000187555.14	ENST00000542333.5	ENSP00000439272.1
ENSG00000187555.14	ENST00000566273.5	ENSP00000455719.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD	CARLSBAD	PDTD	Manually
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	15933713; 20153724; 20800574; 17442268; 21268065; 21258371; 18410486
UBD/Other/Other	UBD/Other/Other	12507430; 21981925

Classification

Family	E-value	Score	Start	End
DUB/USP	3.80e-68	231.8	214	520

Active Site

Position(s)	Description	Evidence
223	Nucleophile	{ECO:0000269\|PubMed:12507430, ECO:0000305\|PubMed:11923872, ECO:0000305\|PubMed:15053880, ECO:0000305\|PubMed:16964248, ECO:0000305\|PubMed:18716620, ECO:0000305\|PubMed:21745816, ECO:0000305\|PubMed:22411829}
464	Proton acceptor	{ECO:0000305\|PubMed:12507430}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDa 92
           +GlkN+g+tCYmNS+LQ+L+++++lr+++    + +      +++++++  +lq++f el ++++k v +++l+k++++e   +++++q+D+
   Q: 214  VGLKNQGATCYMNSLLQTLFFTNQLRKAVYM-MPTEG-----DDSSKSVPLALQRVFYEL-QHSDKPVGTKKLTKSFGWET--LDSFMQHDV 296
           6******************************.44433.....466889************.88889************887..67******* PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkk 184
           qE++++lld++e+++                          k +  + +i +lF+g++ s i+c+e d +s r+e+ +d++l+++gk+    
   Q: 297  QELCRVLLDNVENKM--------------------------KGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKK---- 358
           ***************..........................789********************************************.... PP
   S: 185  eslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekk 276
            ++ +++ ++++ e+l+g+nky   +  ++qeaek +k+ +lP+vL+l+L+Rf ++ ++++++kin+++efp++L l++f+++++ k+  + 
   Q: 359  -NIFESFVDYVAVEQLDGDNKYDAGEH-GLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKD--PA 446
           .9*********************9996.7******************************************************88777..** PP
   S: 277  kYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg............staYvlfYkr 337
           +Y L+av+vHsG  ++GHYv+y +   +gkW++fdD+ V+ +++ee  e +             ++aY+l+Y r
   Q: 447  NYILHAVLVHSGDNHGGHYVVYLNPkGDGKWCKFDDDVVSRCTKEEAIEHNYgghdddlsvrhcTNAYMLVYIR 520
           ***********************9834566************86666664446*******************87 PP

Organism

Homo sapiens

Functional Description
(View)

(Microbial infection) Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.

Protein Sequence
(Fasta)

MNHQQQQQQQ KAGEQQLSEP EDMEMEAGDT DDPPRITQNP VINGNVALSD GHNTAEEDME 60
DDTSWRSEAT FQFTVERFSR LSESVLSPPC FVRNLPWKIM VMPRFYPDRP HQKSVGFFLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTGCGCCC CGCCTGGGGT TGCTCTTGAG GAGCCAAACT TTGCCAGATT AGGCTGACAG 60
TGAGAAAATA AATTCTTCCA CGGTAGATAC TGGGTGAAAA AGTGCACGTC AGCGGGCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0945--Host-virus interaction
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR002083--MATH/TRAF_dom
IPR001394--Peptidase_C19_UCH
IPR008974--TRAF-like
IPR024729--USP7_ICP0-binding_dom
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50144--MATH
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00917--MATH
PF00443--UCH
PF14533--USP7_C2
PF12436--USP7_ICP0_bdg

SMART

SM00061--MATH

Gene Ontology

GO:0005694--C:chromosome
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0004197--F:cysteine-type endopeptidase activity
GO:0002039--F:p53 binding
GO:0008022--F:protein C-terminus binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008134--F:transcription factor binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0010216--P:maintenance of DNA methylation
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0007275--P:multicellular organism development
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0016579--P:protein deubiquitination
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:0051090--P:regulation of sequence-specific DNA binding transcription factor activity
GO:1904353--P:regulation of telomere capping
GO:0006283--P:transcription-coupled nucleotide-excision repair
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016032--P:viral process

KEGG

hsa:7874

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000761	Aegilops tauschii	33.21	6.00e-143	502.00
IUUC-Aml-002408	Ailuropoda melanoleuca	99.72	0.00e+00	2222.00
IUUC-Atr-003067	Amborella trichopoda	36.73	7.00e-123	435.00
IUUC-Apl-003558	Anas platyrhynchos	96.75	0.00e+00	2199.00
IUUC-Aca-004518	Anolis carolinensis	91.06	0.00e+00	2059.00
IUUC-Aly-006427	Arabidopsis lyrata	35.80	2.00e-157	550.00
IUUC-Ath-006591	Arabidopsis thaliana	35.65	5.00e-157	549.00
IUUC-Ago-007849	Ashbya gossypii	32.88	2.00e-139	490.00
IUUC-Acl-008327	Aspergillus clavatus	33.92	6.00e-170	592.00
IUUC-Afl-008491	Aspergillus flavus	34.57	4.00e-164	572.00
IUUC-Afu-008804	Aspergillus fumigatus	34.94	4.00e-161	562.00
IUUC-Ang-009776	Aspergillus niger	34.69	3.00e-161	562.00
IUUC-Aor-009998	Aspergillus oryzae	33.83	8.00e-156	545.00
IUUC-Ate-010428	Aspergillus terreus	34.51	8.00e-164	571.00
IUUC-Ame-010903	Astyanax mexicanus	93.45	0.00e+00	2157.00
IUUC-Bgr-012132	Blumeria graminis	32.10	6.00e-144	505.00
IUUC-Bta-013192	Bos taurus	98.70	0.00e+00	2207.00
IUUC-Bci-013924	Botrytis cinerea	33.94	3.00e-150	526.00
IUUC-Bdi-014920	Brachypodium distachyon	35.73	7.00e-157	548.00
IUUC-Bol-015224	Brassica oleracea	36.68	3.00e-157	549.00
IUUC-Bra-017448	Brassica rapa	36.46	1.00e-156	547.00
IUUC-Cel-018219	Caenorhabditis elegans	33.95	2.00e-155	543.00
IUUC-Cja-019006	Callithrix jacchus	98.42	0.00e+00	2187.00
IUUC-Cfa-020361	Canis familiaris	98.63	0.00e+00	2221.00
IUUC-Cpo-022320	Cavia porcellus	99.44	0.00e+00	2216.00
IUUC-Cre-022708	Chlamydomonas reinhardtii	43.84	1.00e-91	330.00
IUUC-Csa-024050	Chlorocebus sabaeus	99.82	0.00e+00	2256.00
IUUC-Cho-024434	Choloepus hoffmanni	90.55	0.00e+00	1438.00
IUUC-Cin-025689	Ciona intestinalis	54.17	0.00e+00	1215.00
IUUC-Csv-025963	Ciona savignyi	52.41	0.00e+00	1165.00
IUUC-Cgl-026650	Colletotrichum gloeosporioides	33.24	8.00e-151	528.00
IUUC-Cne-026968	Cryptococcus neoformans	36.57	1.00e-180	627.00
IUUC-Cme-027103	Cyanidioschyzon merolae	35.69	3.00e-115	410.00
IUUC-Dre-028510	Danio rerio	93.60	0.00e+00	2147.00
IUUC-Dno-029696	Dasypus novemcinctus	99.44	0.00e+00	2211.00
IUUC-Dor-030611	Dipodomys ordii	84.35	0.00e+00	962.00
IUUC-Dse-031433	Dothistroma septosporum	34.00	9.00e-147	514.00
IUUC-Dme-031583	Drosophila melanogaster	48.58	0.00e+00	1043.00
IUUC-Ete-033191	Echinops telfairi	97.21	0.00e+00	2166.00
IUUC-Eca-034122	Equus caballus	99.35	0.00e+00	2219.00
IUUC-Eeu-035292	Erinaceus europaeus	84.54	0.00e+00	680.00
IUUC-Fca-036377	Felis catus	99.44	0.00e+00	2214.00
IUUC-Fal-036964	Ficedula albicollis	96.87	0.00e+00	2157.00
IUUC-Fox-037695	Fusarium oxysporum	32.39	8.00e-159	555.00
IUUC-Fso-038084	Fusarium solani	33.36	3.00e-158	553.00
IUUC-Gmo-038644	Gadus morhua	93.13	0.00e+00	2150.00
IUUC-Ggr-040029	Gaeumannomyces graminis	33.67	4.00e-157	549.00
IUUC-Gga-040944	Gallus gallus	96.73	0.00e+00	2199.00
IUUC-Gac-041740	Gasterosteus aculeatus	93.37	0.00e+00	2162.00
IUUC-Gma-043300	Glycine max	36.54	4.00e-168	585.00
IUUC-Ggo-044947	Gorilla gorilla	99.63	0.00e+00	2224.00
IUUC-Hvu-047749	Hordeum vulgare	37.01	7.00e-142	498.00
IUUC-Itr-047904	Ictidomys tridecemlineatus	99.36	0.00e+00	1907.00
IUUC-Kpa-049121	Komagataella pastoris	30.64	1.00e-126	447.00
IUUC-Lch-049847	Latimeria chalumnae	96.22	0.00e+00	2194.00
IUUC-Lpe-051505	Leersia perrieri	35.49	5.00e-143	502.00
IUUC-Loc-052234	Lepisosteus oculatus	93.27	0.00e+00	1447.00
IUUC-Lma-053169	Leptosphaeria maculans	36.66	2.00e-167	583.00
IUUC-Laf-053566	Loxodonta africana	99.26	0.00e+00	2218.00
IUUC-Mcc-055549	Macaca mulatta	99.17	0.00e+00	2218.00
IUUC-Meu-056887	Macropus eugenii	88.25	0.00e+00	1281.00
IUUC-Mor-057149	Magnaporthe oryzae	34.60	2.00e-158	553.00
IUUC-Mpo-057536	Magnaporthe poae	33.51	1.00e-157	551.00
IUUC-Mtr-058583	Medicago truncatula	36.75	3.00e-164	572.00
IUUC-Mla-058899	Melampsora laricipopulina	37.14	2.00e-171	596.00
IUUC-Mga-060148	Meleagris gallopavo	96.93	0.00e+00	2201.00
IUUC-Mvi-060207	Microbotryum violaceum	37.62	0.00e+00	632.00
IUUC-Mmr-060946	Microcebus murinus	99.08	0.00e+00	2237.00
IUUC-Mdo-062079	Monodelphis domestica	90.39	0.00e+00	1974.00
IUUC-Mmu-063678	Mus musculus	98.80	0.00e+00	2209.00
IUUC-Mac-065416	Musa acuminata	36.75	2.00e-157	550.00
IUUC-Mpu-066744	Mustela putorius furo	99.34	0.00e+00	2170.00
IUUC-Mlu-067949	Myotis lucifugus	97.62	0.00e+00	2192.00
IUUC-Nfi-068342	Neosartorya fischeri	35.28	3.00e-161	563.00
IUUC-Ncr-068818	Neurospora crassa	34.42	4.00e-162	565.00
IUUC-Nle-070064	Nomascus leucogenys	99.82	0.00e+00	2254.00
IUUC-Opr-071001	Ochotona princeps	97.60	0.00e+00	1824.00
IUUC-Ont-072095	Oreochromis niloticus	93.27	0.00e+00	2155.00
IUUC-Oan-073483	Ornithorhynchus anatinus	97.82	0.00e+00	2143.00
IUUC-Ocu-073967	Oryctolagus cuniculus	98.66	0.00e+00	2128.00
IUUC-Oba-075811	Oryza barthii	33.79	3.00e-141	496.00
IUUC-Obr-076514	Oryza brachyantha	36.50	6.00e-156	545.00
IUUC-Ogl-077038	Oryza glaberrima	35.70	3.00e-150	526.00
IUUC-Ogu-078265	Oryza glumaepatula	34.10	3.00e-136	479.00
IUUC-Oin-079513	Oryza indica	34.86	4.00e-142	499.00
IUUC-Olo-081067	Oryza longistaminata	33.73	2.00e-139	490.00
IUUC-Ome-081879	Oryza meridionalis	35.93	7.00e-152	531.00
IUUC-Oni-082409	Oryza nivara	33.46	3.00e-140	493.00
IUUC-Opu-083199	Oryza punctata	35.26	2.00e-147	517.00
IUUC-Oru-085109	Oryza rufipogon	35.33	1.00e-146	514.00
IUUC-Osa-085418	Oryza sativa	37.24	8.00e-131	461.00
IUUC-Ola-086640	Oryzias latipes	93.38	0.00e+00	2155.00
IUUC-Olu-087874	Ostreococcus lucimarinus	33.73	2.00e-143	504.00
IUUC-Oga-089059	Otolemur garnettii	92.27	0.00e+00	2019.00
IUUC-Oar-089710	Ovis aries	98.98	0.00e+00	2207.00
IUUC-Ptr-091334	Pan troglodytes	99.63	0.00e+00	2224.00
IUUC-Pan-091717	Papio anubis	100.00	0.00e+00	2157.00
IUUC-Psi-093933	Pelodiscus sinensis	96.44	0.00e+00	2226.00
IUUC-Pma-094648	Petromyzon marinus	83.49	0.00e+00	1724.00
IUUC-Pno-095020	Phaeosphaeria nodorum	35.16	5.00e-150	525.00
IUUC-Ppa-096020	Physcomitrella patens	34.71	4.00e-162	565.00
IUUC-Pfo-096181	Poecilia formosa	93.14	0.00e+00	2142.00
IUUC-Pab-098231	Pongo abelii	97.04	0.00e+00	2151.00
IUUC-Pop-099680	Populus trichocarpa	37.36	9.00e-160	558.00
IUUC-Pca-100543	Procavia capensis	81.67	0.00e+00	1012.00
IUUC-Ppe-101523	Prunus persica	35.95	1.00e-154	540.00
IUUC-Pva-102472	Pteropus vampyrus	97.16	0.00e+00	2166.00
IUUC-Pgr-103463	Puccinia graminis	36.00	9.00e-171	594.00
IUUC-Ptt-103716	Puccinia triticina	37.85	1.00e-167	583.00
IUUC-Pte-104360	Pyrenophora teres	36.13	5.00e-151	529.00
IUUC-Pyt-104581	Pyrenophora triticirepentis	35.75	2.00e-149	523.00
IUUC-Rno-105816	Rattus norvegicus	99.18	0.00e+00	2245.00
IUUC-Sce-106230	Saccharomyces cerevisiae	30.02	5.00e-123	436.00
IUUC-Sha-107439	Sarcophilus harrisii	97.95	0.00e+00	2186.00
IUUC-Sja-107690	Schizosaccharomyces japonicus	33.09	9.00e-139	488.00
IUUC-Spo-108019	Schizosaccharomyces pombe	34.45	5.00e-144	505.00
IUUC-Smo-109308	Selaginella moellendorffii	35.95	4.00e-152	532.00
IUUC-Sit-110367	Setaria italica	36.25	8.00e-158	551.00
IUUC-Sly-111337	Solanum lycopersicum	37.87	1.00e-165	577.00
IUUC-Stu-112387	Solanum tuberosum	36.75	5.00e-166	578.00
IUUC-Sar-113685	Sorex araneus	98.24	0.00e+00	2187.00
IUUC-Sbi-114037	Sorghum bicolor	36.61	1.00e-158	554.00
IUUC-Sre-115156	Sporisorium reilianum	36.68	0.00e+00	632.00
IUUC-Ssc-116297	Sus scrofa	99.18	0.00e+00	2245.00
IUUC-Tgu-116767	Taeniopygia guttata	96.71	0.00e+00	2226.00
IUUC-Tru-118208	Takifugu rubripes	93.32	0.00e+00	2126.00
IUUC-Tsy-119277	Tarsius syrichta	89.28	0.00e+00	711.00
IUUC-Tni-119890	Tetraodon nigroviridis	93.50	0.00e+00	2131.00
IUUC-Tca-121501	Theobroma cacao	35.82	2.00e-158	553.00
IUUC-Tre-122169	Trichoderma reesei	33.36	1.00e-152	534.00
IUUC-Tvi-122600	Trichoderma virens	34.15	6.00e-160	558.00
IUUC-Tae-125264	Triticum aestivum	35.93	7.00e-156	545.00
IUUC-Tur-126287	Triticum urartu	35.22	2.00e-149	523.00
IUUC-Tme-127045	Tuber melanosporum	35.35	2.00e-166	579.00
IUUC-Tbe-127696	Tupaia belangeri	88.60	1.00e-160	560.00
IUUC-Ttr-129161	Tursiops truncatus	99.26	0.00e+00	2206.00
IUUC-Uma-129535	Ustilago maydis	36.84	0.00e+00	643.00
IUUC-Vda-129708	Verticillium dahliae	32.81	3.00e-158	553.00
IUUC-Vvi-131048	Vitis vinifera	35.79	9.00e-159	554.00
IUUC-Xtr-132073	Xenopus tropicalis	91.56	0.00e+00	2075.00
IUUC-Xma-133949	Xiphophorus maculatus	92.86	0.00e+00	2134.00
IUUC-Yli-134527	Yarrowia lipolytica	32.80	4.00e-139	489.00
IUUC-Zma-135550	Zea mays	35.07	1.00e-147	518.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence