iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO
Protein-protein Interaction
HINT
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	dbPTM
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.10e-40	133.1	161	197
UBD/Beta-Prp	3.40e-62	208.4	164	451

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gH ++v+c++  ++   +++G++D tik+WDl +gvl
   Q: 161  GHLGWVRCVDVePGnQWFCTGAGDRTIKIWDLASGVL 197
           8***********77799****************9997 PP

UBD/Beta-Prp

   S: 11   svitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsf 102
           + ++cv++ p+++++ tg  d+tik+wd+ +g l  +l gh a+v+ +  sp+ ++l +++eD+++k wdl+t+k +++++gh + v++l++
   Q: 164  GWVRCVDVEPGNQWFCTGAGDRTIKIWDLASGVLKLTLTGHIATVRGLAVSPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYALKL 255
           56899*************************************************************************************** PP
   S: 103  spsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngke 194
           +p+ d+lv++++d ++rvwd++t+q ++ +lsgh+++v +++v++++  +v+Gs D+t+rlWdl+ gk l+tlt  h++ v+ ls++++ + 
   Q: 256  HPTLDVLVTAGRDAVARVWDMRTRQNVH-VLSGHKSTVASLAVQEFDPQVVTGSMDSTIRLWDLAAGKTLTTLTH-HKKTVRALSLHPDEFT 345
           ****************************.*********************************************9.**************** PP
   S: 195  lvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn.....ssvisvav..lsfgdnv 279
           ++sgs d+ +k w + +g  +  ++gh++ v+ +     d+ + sg++ gs  +Wd +sg   + lq        +s   + +  ++ ++  
   Q: 346  FASGSSDN-IKHWKFPEGAFMGNFEGHNAIVNTLSIN-SDNVMFSGADNGSMCFWDWKSGHKYQELQSVVqpgslDSEAGIFAssFDKTGLR 435
           ******96.*************************999.9************************99998778888855555555345677999 PP
   S: 280  lvlgsedskvniwklk 295
           l+++++d++v+i+k+ 
   Q: 436  LITCEADKSVKIYKQV 451
           9************975 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Required for both cell cycle progression at G2/M and pre-mRNA splicing. Interacts genetically with the PRP4 kinase.

Protein Sequence
(Fasta)

MTEAKNISDD TDVLSLTTNS LRTSKTLFGA EFGSVTSFDD TVAQNLKRTY KEHLEYGSVL 60
GGTVGKRKNR HYEEDTIGSN ALTVRADSEN PSSQVITKFS DPNKKIAGQV SMQSLEKIKG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCGCTAATG TTCGTGGATT ATGATGCTTC AAATAAGTCA GTCCAACTGC CATCTACCTA 60
CAAATCCTCT ACCAAAAATT TAACAGATTT ATGACAGAAG CAAAAAACAT ATCGGATGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0071014--C:post-mRNA release spliceosomal complex
GO:0071011--C:precatalytic spliceosome
GO:0000974--C:Prp19 complex
GO:0005681--C:spliceosomal complex
GO:0045292--P:mRNA cis splicing, via spliceosome

KEGG

spo:SPBP22H7.07

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000084	Aegilops tauschii	55.56	2.00e-127	446.00
IUUC-Aml-001605	Ailuropoda melanoleuca	62.61	1.00e-141	494.00
IUUC-Atr-002757	Amborella trichopoda	52.65	1.00e-129	454.00
IUUC-Apl-003198	Anas platyrhynchos	59.54	9.00e-142	494.00
IUUC-Aca-004683	Anolis carolinensis	49.51	4.00e-142	495.00
IUUC-Aly-005775	Arabidopsis lyrata	62.17	2.00e-132	463.00
IUUC-Ath-007460	Arabidopsis thaliana	61.88	1.00e-131	461.00
IUUC-Ago-007884	Ashbya gossypii	51.03	4.00e-121	426.00
IUUC-Acl-008153	Aspergillus clavatus	71.76	2.00e-149	520.00
IUUC-Afl-008384	Aspergillus flavus	68.58	4.00e-150	522.00
IUUC-Afu-009045	Aspergillus fumigatus	71.76	2.00e-149	520.00
IUUC-Ani-009229	Aspergillus nidulans	72.35	1.00e-148	517.00
IUUC-Ang-009812	Aspergillus niger	73.27	3.00e-140	488.00
IUUC-Aor-010059	Aspergillus oryzae	68.58	4.00e-150	522.00
IUUC-Ate-010351	Aspergillus terreus	71.47	2.00e-155	539.00
IUUC-Ame-011613	Astyanax mexicanus	42.00	8.00e-73	265.00
IUUC-Bgr-012042	Blumeria graminis	74.39	1.00e-155	540.00
IUUC-Bta-012406	Bos taurus	64.60	2.00e-141	493.00
IUUC-Bci-013760	Botrytis cinerea	75.29	9.00e-156	541.00
IUUC-Bdi-014776	Brachypodium distachyon	57.14	2.00e-129	453.00
IUUC-Bol-016189	Brassica oleracea	51.93	1.00e-131	461.00
IUUC-Bra-018044	Brassica rapa	51.93	2.00e-131	460.00
IUUC-Cel-018651	Caenorhabditis elegans	51.78	6.00e-141	491.00
IUUC-Cja-019974	Callithrix jacchus	64.31	3.00e-141	493.00
IUUC-Cfa-021085	Canis familiaris	62.61	1.00e-141	494.00
IUUC-Cpo-021458	Cavia porcellus	62.32	4.00e-141	492.00
IUUC-Cre-022880	Chlamydomonas reinhardtii	62.39	4.00e-133	465.00
IUUC-Csa-023883	Chlorocebus sabaeus	62.54	3.00e-141	493.00
IUUC-Cho-024623	Choloepus hoffmanni	66.36	8.00e-137	478.00
IUUC-Cin-025190	Ciona intestinalis	50.71	1.00e-138	484.00
IUUC-Csv-026367	Ciona savignyi	65.44	1.00e-138	484.00
IUUC-Cgl-026499	Colletotrichum gloeosporioides	73.29	1.00e-158	550.00
IUUC-Cne-027069	Cryptococcus neoformans	68.54	6.00e-140	488.00
IUUC-Cme-027233	Cyanidioschyzon merolae	29.46	1.00e-34	139.00
IUUC-Dre-028260	Danio rerio	65.24	1.00e-142	497.00
IUUC-Dno-029112	Dasypus novemcinctus	64.31	4.00e-141	492.00
IUUC-Dor-031118	Dipodomys ordii	63.72	2.00e-139	486.00
IUUC-Dse-031493	Dothistroma septosporum	69.62	9.00e-145	504.00
IUUC-Dme-032138	Drosophila melanogaster	66.36	6.00e-140	488.00
IUUC-Ete-032411	Echinops telfairi	44.42	1.00e-116	410.00
IUUC-Eca-033521	Equus caballus	64.01	1.00e-140	491.00
IUUC-Eeu-035249	Erinaceus europaeus	55.16	3.00e-112	396.00
IUUC-Fca-036358	Felis catus	62.32	6.00e-141	492.00
IUUC-Fal-036933	Ficedula albicollis	62.89	2.00e-141	493.00
IUUC-Fox-037713	Fusarium oxysporum	65.99	2.00e-158	550.00
IUUC-Fso-038380	Fusarium solani	74.85	9.00e-158	547.00
IUUC-Gmo-039133	Gadus morhua	64.84	3.00e-141	493.00
IUUC-Ggr-039915	Gaeumannomyces graminis	75.00	2.00e-148	516.00
IUUC-Gga-041176	Gallus gallus	63.74	4.00e-142	496.00
IUUC-Gac-042344	Gasterosteus aculeatus	64.83	1.00e-140	490.00
IUUC-Gma-042892	Glycine max	52.14	9.00e-133	464.00
IUUC-Ggo-044478	Gorilla gorilla	62.54	4.00e-141	492.00
IUUC-Hsa-046037	Homo sapiens	62.54	4.00e-141	492.00
IUUC-Hvu-047349	Hordeum vulgare	60.51	6.00e-131	458.00
IUUC-Itr-048390	Ictidomys tridecemlineatus	64.31	4.00e-141	492.00
IUUC-Kpa-049343	Komagataella pastoris	58.95	2.00e-125	439.00
IUUC-Lch-049830	Latimeria chalumnae	64.24	4.00e-142	496.00
IUUC-Lpe-051442	Leersia perrieri	56.81	4.00e-130	456.00
IUUC-Loc-051794	Lepisosteus oculatus	66.46	4.00e-137	479.00
IUUC-Lma-053137	Leptosphaeria maculans	59.08	1.00e-141	494.00
IUUC-Laf-053471	Loxodonta africana	64.31	3.00e-141	493.00
IUUC-Mcc-055627	Macaca mulatta	62.54	3.00e-141	493.00
IUUC-Meu-056148	Macropus eugenii	50.84	2.00e-136	476.00
IUUC-Mor-056960	Magnaporthe oryzae	73.87	4.00e-155	539.00
IUUC-Mtr-057816	Medicago truncatula	51.35	2.00e-131	460.00
IUUC-Mla-059031	Melampsora laricipopulina	63.71	6.00e-141	491.00
IUUC-Mga-059337	Meleagris gallopavo	63.74	7.00e-142	495.00
IUUC-Mvi-060217	Microbotryum violaceum	70.53	2.00e-142	496.00
IUUC-Mmr-061018	Microcebus murinus	62.54	4.00e-141	492.00
IUUC-Mdo-062863	Monodelphis domestica	66.15	3.00e-139	486.00
IUUC-Mmu-063988	Mus musculus	64.01	7.00e-140	488.00
IUUC-Mac-064459	Musa acuminata	63.21	2.00e-123	434.00
IUUC-Mpu-066559	Mustela putorius furo	62.61	1.00e-141	494.00
IUUC-Mlu-067361	Myotis lucifugus	64.31	6.00e-141	492.00
IUUC-Nfi-068492	Neosartorya fischeri	72.06	1.00e-149	520.00
IUUC-Ncr-068808	Neurospora crassa	72.35	3.00e-155	539.00
IUUC-Nle-069875	Nomascus leucogenys	62.54	4.00e-141	492.00
IUUC-Opr-070462	Ochotona princeps	66.17	8.00e-113	398.00
IUUC-Ont-071365	Oreochromis niloticus	65.31	1.00e-140	490.00
IUUC-Oan-072708	Ornithorhynchus anatinus	62.32	7.00e-141	491.00
IUUC-Ocu-074594	Oryctolagus cuniculus	64.31	5.00e-141	492.00
IUUC-Oba-075570	Oryza barthii	59.66	2.00e-129	453.00
IUUC-Obr-076366	Oryza brachyantha	65.25	6.00e-94	334.00
IUUC-Ogl-077153	Oryza glaberrima	59.38	3.00e-128	449.00
IUUC-Ogu-078540	Oryza glumaepatula	59.66	2.00e-129	453.00
IUUC-Oin-079612	Oryza indica	58.82	2.00e-127	447.00
IUUC-Olo-081077	Oryza longistaminata	58.82	2.00e-127	447.00
IUUC-Ome-081236	Oryza meridionalis	59.10	2.00e-127	447.00
IUUC-Oni-082499	Oryza nivara	59.66	2.00e-129	453.00
IUUC-Opu-083499	Oryza punctata	58.82	2.00e-127	446.00
IUUC-Oru-084276	Oryza rufipogon	59.66	2.00e-129	453.00
IUUC-Osa-085849	Oryza sativa	59.66	2.00e-129	453.00
IUUC-Ola-086655	Oryzias latipes	50.00	2.00e-140	490.00
IUUC-Olu-087637	Ostreococcus lucimarinus	63.53	1.00e-132	464.00
IUUC-Oga-087934	Otolemur garnettii	59.95	4.00e-142	495.00
IUUC-Oar-090185	Ovis aries	64.60	3.00e-141	493.00
IUUC-Ptr-091198	Pan troglodytes	62.54	4.00e-141	492.00
IUUC-Pan-092622	Papio anubis	62.54	3.00e-141	493.00
IUUC-Psi-093320	Pelodiscus sinensis	49.02	8.00e-142	494.00
IUUC-Pma-094638	Petromyzon marinus	63.56	4.00e-140	489.00
IUUC-Pno-094826	Phaeosphaeria nodorum	58.24	2.00e-120	423.00
IUUC-Ppa-095576	Physcomitrella patens	67.09	8.00e-130	454.00
IUUC-Pfo-096894	Poecilia formosa	65.89	2.00e-141	493.00
IUUC-Pab-098020	Pongo abelii	62.54	3.00e-141	493.00
IUUC-Pop-099180	Populus trichocarpa	49.25	2.00e-125	440.00
IUUC-Pca-100909	Procavia capensis	67.42	2.00e-113	400.00
IUUC-Ppe-101346	Prunus persica	50.00	3.00e-132	463.00
IUUC-Pva-102167	Pteropus vampyrus	52.97	9.00e-113	398.00
IUUC-Pgr-103516	Puccinia graminis	69.91	2.00e-139	487.00
IUUC-Ptt-103738	Puccinia triticina	68.48	2.00e-139	486.00
IUUC-Pte-104352	Pyrenophora teres	66.18	2.00e-147	513.00
IUUC-Pyt-104632	Pyrenophora triticirepentis	67.06	9.00e-149	518.00
IUUC-Rno-105291	Rattus norvegicus	63.72	7.00e-140	488.00
IUUC-Sce-106204	Saccharomyces cerevisiae	55.08	9.00e-119	418.00
IUUC-Sha-106943	Sarcophilus harrisii	48.62	6.00e-136	475.00
IUUC-Sja-107659	Schizosaccharomyces japonicus	73.96	0.00e+00	675.00
IUUC-Smo-109043	Selaginella moellendorffii	62.83	4.00e-133	465.00
IUUC-Sit-110431	Setaria italica	60.23	5.00e-131	458.00
IUUC-Sly-111391	Solanum lycopersicum	64.56	4.00e-126	442.00
IUUC-Stu-112364	Solanum tuberosum	57.24	5.00e-99	352.00
IUUC-Sar-113450	Sorex araneus	64.01	7.00e-140	488.00
IUUC-Sbi-113829	Sorghum bicolor	57.41	1.00e-129	454.00
IUUC-Sre-115153	Sporisorium reilianum	65.02	5.00e-130	456.00
IUUC-Ssc-116274	Sus scrofa	64.31	6.00e-141	492.00
IUUC-Tgu-117417	Taeniopygia guttata	62.89	2.00e-141	493.00
IUUC-Tru-117615	Takifugu rubripes	55.88	3.00e-134	469.00
IUUC-Tsy-119480	Tarsius syrichta	64.31	4.00e-141	492.00
IUUC-Tni-119847	Tetraodon nigroviridis	56.59	1.00e-140	490.00
IUUC-Tca-121287	Theobroma cacao	49.22	1.00e-127	447.00
IUUC-Tre-122010	Trichoderma reesei	74.62	1.00e-158	550.00
IUUC-Tvi-122475	Trichoderma virens	74.02	3.00e-158	549.00
IUUC-Tae-124397	Triticum aestivum	60.28	3.00e-131	459.00
IUUC-Tur-126116	Triticum urartu	49.72	3.00e-96	343.00
IUUC-Tme-126992	Tuber melanosporum	73.39	2.00e-159	553.00
IUUC-Tbe-127803	Tupaia belangeri	65.44	8.00e-111	391.00
IUUC-Ttr-128933	Tursiops truncatus	64.31	4.00e-141	492.00
IUUC-Uma-129447	Ustilago maydis	62.31	4.00e-126	442.00
IUUC-Vda-129780	Verticillium dahliae	68.77	2.00e-159	553.00
IUUC-Vpa-130557	Vicugna pacos	42.50	8.00e-46	176.00
IUUC-Vvi-130918	Vitis vinifera	50.23	2.00e-125	440.00
IUUC-Xtr-132409	Xenopus tropicalis	62.04	5.00e-140	489.00
IUUC-Xma-133420	Xiphophorus maculatus	65.60	1.00e-141	494.00
IUUC-Yli-134362	Yarrowia lipolytica	54.44	3.00e-140	489.00
IUUC-Zma-135804	Zea mays	57.70	4.00e-126	442.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence