iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-007992

Ensembl Protein ID

AAS51997

UniProt Accession

Q75A42; Q75A42_ASHGO

Genbank Protein ID

AAS51997.1

Protein Name

Coatomer subunit alpha

Genbank Nucleotide ID

AE016817

Gene Name

AGOS_ADR077C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_ADR077C	AAS51997	AAS51997

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.80e-38	125.1	52	88
UBD/Beta-Prp	5.80e-87	289.6	4	327

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           H+++v++++f ++ +l+vs++dD +ikvW+l+t+++l
   Q: 52   HEGPVRGVDFhPTqPLFVSAGDDYSIKVWSLSTHKCL 88
           9**********888********************998 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfs 103
            t +++++++ ++++f+p++++++++  ++ti++wd+++g ll+++++he++v+ v+f+p+++++v++++D+ ikvw+lst kc+ tl+gh d+v+++ f+
   Q: 4    LTKFESKSTRAKAIAFHPSRPWVLVALFSSTIQLWDYRMGVLLHRFEEHEGPVRGVDFHPTQPLFVSAGDDYSIKVWSLSTHKCLFTLNGHLDYVRTVFFH 104
           678899999******************************************************************************************** PP
   S: 104  psgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl............................ktgkllrtl. 175
            +  +++s+s+d+tir+w+++++ ++  +l+gh+++v+c+++hp+++l+vs+slD+tvr+Wd+                             +g+++ ++ 
   Q: 105  TELPWIISASDDQTIRIWNWQNRREIA-CLTGHNHFVMCAQFHPTEDLVVSASLDETVRIWDIsglrkrhsapgsqsfeeqmitqqnlfdgGFGDCVVKFi 204
           ***************************.************************************************************************* PP
   S: 176  .tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavl 273
            + ght+ v++ sf+++ + +vsgs+d++vklw +++++   v+t++ght+nv sv f+p +++++s+++D +ir+Wdl++++++k++++++++++s+ + 
   Q: 205  lE-GHTRGVNWASFHPTLPLIVSGSDDRQVKLWRMSSTKAweVDTCRGHTNNVDSVIFHPFQNLIISVGEDSTIRVWDLDKRTPVKQFKREQDRFWSIRA- 303
           55.5********************************888889**********************************************************. PP
   S: 274  sfgdnvlvlgse..dskvniwklkkne 298
              ++++ l+++  ds ++++kl++++
   Q: 304  ---HPNVNLFGAahDSGIMVFKLDRER 327
           ...66666666667*********9876 PP

Organism

Ashbya gossypii

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MKMLTKFESK STRAKAIAFH PSRPWVLVAL FSSTIQLWDY RMGVLLHRFE EHEGPVRGVD 60
FHPTQPLFVS AGDDYSIKVW SLSTHKCLFT LNGHLDYVRT VFFHTELPWI ISASDDQTIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGATGC TTACAAAGTT TGAGTCGAAG TCTACCAGGG CGAAGGCAAT TGCATTCCAC 60
CCGTCGCGGC CTTGGGTGCT GGTAGCGCTA TTTTCATCGA CCATCCAGCT GTGGGATTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011044--Quino_amine_DH_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER

KEGG

ago:AGOS_ADR077C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	50.60	0.00e+00	850.00
IUUC-Aml-001758	Ailuropoda melanoleuca	44.52	0.00e+00	1019.00
IUUC-Atr-002493	Amborella trichopoda	49.64	0.00e+00	818.00
IUUC-Apl-003385	Anas platyrhynchos	45.60	7.00e-170	589.00
IUUC-Aca-005154	Anolis carolinensis	63.16	4.00e-82	294.00
IUUC-Aly-006020	Arabidopsis lyrata	49.70	0.00e+00	827.00
IUUC-Ath-007058	Arabidopsis thaliana	49.82	0.00e+00	826.00
IUUC-Acl-008027	Aspergillus clavatus	53.07	0.00e+00	1245.00
IUUC-Afl-008644	Aspergillus flavus	53.21	0.00e+00	1243.00
IUUC-Afu-008964	Aspergillus fumigatus	53.52	0.00e+00	1259.00
IUUC-Ani-009379	Aspergillus nidulans	60.14	0.00e+00	1070.00
IUUC-Ang-009756	Aspergillus niger	53.08	0.00e+00	1243.00
IUUC-Aor-010174	Aspergillus oryzae	53.21	0.00e+00	1243.00
IUUC-Ate-010302	Aspergillus terreus	53.65	0.00e+00	1285.00
IUUC-Ame-011229	Astyanax mexicanus	49.77	0.00e+00	872.00
IUUC-Bgr-012300	Blumeria graminis	49.96	0.00e+00	1151.00
IUUC-Bta-012524	Bos taurus	44.92	0.00e+00	1017.00
IUUC-Bci-013781	Botrytis cinerea	50.66	0.00e+00	1206.00
IUUC-Bdi-014549	Brachypodium distachyon	43.06	0.00e+00	959.00
IUUC-Bol-015925	Brassica oleracea	50.24	0.00e+00	827.00
IUUC-Bra-016978	Brassica rapa	50.30	0.00e+00	825.00
IUUC-Cel-018115	Caenorhabditis elegans	48.71	0.00e+00	805.00
IUUC-Cja-019107	Callithrix jacchus	43.99	0.00e+00	1008.00
IUUC-Cfa-020675	Canis familiaris	44.13	0.00e+00	993.00
IUUC-Cpo-021813	Cavia porcellus	44.60	0.00e+00	1025.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	50.00	0.00e+00	857.00
IUUC-Csa-023523	Chlorocebus sabaeus	44.68	0.00e+00	1029.00
IUUC-Cho-024704	Choloepus hoffmanni	34.72	1.00e-116	412.00
IUUC-Cin-025572	Ciona intestinalis	42.04	0.00e+00	959.00
IUUC-Csv-025864	Ciona savignyi	48.99	0.00e+00	801.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	51.35	0.00e+00	1196.00
IUUC-Cne-027053	Cryptococcus neoformans	47.97	0.00e+00	1034.00
IUUC-Cme-027222	Cyanidioschyzon merolae	36.97	1.00e-117	416.00
IUUC-Dre-027421	Danio rerio	43.96	0.00e+00	1024.00
IUUC-Dno-029303	Dasypus novemcinctus	44.60	0.00e+00	1025.00
IUUC-Dor-030290	Dipodomys ordii	42.88	3.00e-130	457.00
IUUC-Dse-031543	Dothistroma septosporum	51.31	0.00e+00	1155.00
IUUC-Dme-031945	Drosophila melanogaster	49.46	0.00e+00	818.00
IUUC-Ete-032873	Echinops telfairi	42.81	0.00e+00	894.00
IUUC-Eca-033773	Equus caballus	43.62	0.00e+00	986.00
IUUC-Eeu-034874	Erinaceus europaeus	33.45	1.00e-128	452.00
IUUC-Fca-035739	Felis catus	44.05	0.00e+00	1003.00
IUUC-Fal-037263	Ficedula albicollis	40.31	0.00e+00	873.00
IUUC-Fox-037738	Fusarium oxysporum	50.94	0.00e+00	1220.00
IUUC-Fso-038153	Fusarium solani	50.86	0.00e+00	1219.00
IUUC-Gmo-039602	Gadus morhua	41.81	0.00e+00	948.00
IUUC-Ggr-039931	Gaeumannomyces graminis	58.40	0.00e+00	1041.00
IUUC-Gga-040590	Gallus gallus	50.66	0.00e+00	866.00
IUUC-Gac-041318	Gasterosteus aculeatus	44.37	0.00e+00	1022.00
IUUC-Gma-043894	Glycine max	51.27	0.00e+00	824.00
IUUC-Ggo-045029	Gorilla gorilla	44.35	0.00e+00	1020.00
IUUC-Hsa-046078	Homo sapiens	44.44	0.00e+00	1023.00
IUUC-Hvu-047556	Hordeum vulgare	43.55	0.00e+00	971.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	36.69	2.00e-146	511.00
IUUC-Kpa-049256	Komagataella pastoris	59.41	0.00e+00	1474.00
IUUC-Lch-049706	Latimeria chalumnae	44.63	0.00e+00	1014.00
IUUC-Lpe-051316	Leersia perrieri	50.00	0.00e+00	842.00
IUUC-Loc-051867	Lepisosteus oculatus	35.31	0.00e+00	645.00
IUUC-Lma-053138	Leptosphaeria maculans	50.61	0.00e+00	1201.00
IUUC-Laf-053510	Loxodonta africana	44.20	0.00e+00	1022.00
IUUC-Mcc-055836	Macaca mulatta	44.35	0.00e+00	1016.00
IUUC-Meu-056238	Macropus eugenii	48.22	0.00e+00	631.00
IUUC-Mor-057172	Magnaporthe oryzae	50.53	0.00e+00	1212.00
IUUC-Mpo-057300	Magnaporthe poae	50.50	0.00e+00	1184.00
IUUC-Mtr-058248	Medicago truncatula	49.28	0.00e+00	824.00
IUUC-Mla-059019	Melampsora laricipopulina	45.81	0.00e+00	1040.00
IUUC-Mga-059499	Meleagris gallopavo	50.54	0.00e+00	862.00
IUUC-Mvi-060336	Microbotryum violaceum	46.15	0.00e+00	1046.00
IUUC-Mmr-061102	Microcebus murinus	44.35	0.00e+00	1013.00
IUUC-Mdo-062594	Monodelphis domestica	44.68	0.00e+00	1029.00
IUUC-Mmu-063736	Mus musculus	44.35	0.00e+00	1016.00
IUUC-Mac-065398	Musa acuminata	41.39	0.00e+00	847.00
IUUC-Mpu-066701	Mustela putorius furo	44.34	0.00e+00	1018.00
IUUC-Mlu-067392	Myotis lucifugus	44.09	0.00e+00	1017.00
IUUC-Nfi-068270	Neosartorya fischeri	53.57	0.00e+00	1248.00
IUUC-Ncr-068892	Neurospora crassa	49.92	0.00e+00	1185.00
IUUC-Nle-069634	Nomascus leucogenys	54.41	0.00e+00	770.00
IUUC-Opr-070952	Ochotona princeps	33.91	1.00e-124	439.00
IUUC-Ont-072488	Oreochromis niloticus	44.16	0.00e+00	1016.00
IUUC-Oan-073184	Ornithorhynchus anatinus	47.62	2.00e-58	216.00
IUUC-Ocu-074211	Oryctolagus cuniculus	44.52	0.00e+00	1020.00
IUUC-Oba-075761	Oryza barthii	50.12	0.00e+00	844.00
IUUC-Obr-076429	Oryza brachyantha	50.36	0.00e+00	844.00
IUUC-Ogl-077364	Oryza glaberrima	50.12	0.00e+00	844.00
IUUC-Ogu-078257	Oryza glumaepatula	50.00	0.00e+00	840.00
IUUC-Oin-079274	Oryza indica	50.12	0.00e+00	843.00
IUUC-Olo-080466	Oryza longistaminata	50.61	0.00e+00	842.00
IUUC-Ome-081668	Oryza meridionalis	49.93	0.00e+00	714.00
IUUC-Oni-082874	Oryza nivara	50.18	0.00e+00	845.00
IUUC-Opu-083885	Oryza punctata	49.88	0.00e+00	838.00
IUUC-Oru-084274	Oryza rufipogon	50.12	0.00e+00	844.00
IUUC-Osa-085565	Oryza sativa	50.12	0.00e+00	844.00
IUUC-Ola-086921	Oryzias latipes	44.79	0.00e+00	1018.00
IUUC-Olu-087639	Ostreococcus lucimarinus	43.98	0.00e+00	998.00
IUUC-Oga-087991	Otolemur garnettii	42.78	0.00e+00	959.00
IUUC-Oar-089590	Ovis aries	44.92	0.00e+00	1026.00
IUUC-Ptr-090808	Pan troglodytes	44.35	0.00e+00	1021.00
IUUC-Pan-092475	Papio anubis	44.48	0.00e+00	1019.00
IUUC-Psi-093044	Pelodiscus sinensis	46.38	0.00e+00	741.00
IUUC-Pno-094839	Phaeosphaeria nodorum	51.01	0.00e+00	1163.00
IUUC-Ppa-095785	Physcomitrella patens	44.25	0.00e+00	994.00
IUUC-Pfo-097493	Poecilia formosa	44.78	0.00e+00	1022.00
IUUC-Pab-098497	Pongo abelii	44.60	0.00e+00	1029.00
IUUC-Pop-099992	Populus trichocarpa	50.06	0.00e+00	820.00
IUUC-Pca-100413	Procavia capensis	48.65	1.00e-157	548.00
IUUC-Ppe-101392	Prunus persica	43.01	0.00e+00	947.00
IUUC-Pva-102126	Pteropus vampyrus	43.00	0.00e+00	964.00
IUUC-Pgr-103376	Puccinia graminis	46.33	0.00e+00	1055.00
IUUC-Ptt-103978	Puccinia triticina	41.38	0.00e+00	855.00
IUUC-Pte-104126	Pyrenophora teres	56.90	0.00e+00	989.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	43.62	0.00e+00	810.00
IUUC-Rno-105428	Rattus norvegicus	44.76	0.00e+00	1023.00
IUUC-Sce-106464	Saccharomyces cerevisiae	68.93	0.00e+00	1702.00
IUUC-Sha-107301	Sarcophilus harrisii	44.16	0.00e+00	1001.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	46.10	0.00e+00	1064.00
IUUC-Spo-108217	Schizosaccharomyces pombe	47.06	0.00e+00	1088.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	50.53	0.00e+00	1202.00
IUUC-Smo-109582	Selaginella moellendorffii	51.23	0.00e+00	874.00
IUUC-Sit-109697	Setaria italica	49.76	0.00e+00	837.00
IUUC-Sly-111447	Solanum lycopersicum	42.74	0.00e+00	946.00
IUUC-Stu-112564	Solanum tuberosum	49.82	0.00e+00	827.00
IUUC-Sar-113313	Sorex araneus	33.84	3.00e-121	427.00
IUUC-Sbi-114388	Sorghum bicolor	50.00	0.00e+00	840.00
IUUC-Sre-115209	Sporisorium reilianum	53.26	0.00e+00	920.00
IUUC-Ssc-115933	Sus scrofa	44.76	0.00e+00	1026.00
IUUC-Tgu-117109	Taeniopygia guttata	37.11	3.00e-71	260.00
IUUC-Tru-117772	Takifugu rubripes	43.54	0.00e+00	1001.00
IUUC-Tsy-119105	Tarsius syrichta	41.75	0.00e+00	759.00
IUUC-Tni-120556	Tetraodon nigroviridis	33.92	0.00e+00	636.00
IUUC-Tca-121046	Theobroma cacao	42.63	0.00e+00	965.00
IUUC-Tre-121951	Trichoderma reesei	50.20	0.00e+00	1182.00
IUUC-Tvi-122359	Trichoderma virens	50.45	0.00e+00	1196.00
IUUC-Tae-123611	Triticum aestivum	50.60	0.00e+00	850.00
IUUC-Tur-126754	Triticum urartu	50.36	0.00e+00	847.00
IUUC-Tme-127170	Tuber melanosporum	53.92	0.00e+00	1294.00
IUUC-Tbe-127882	Tupaia belangeri	41.01	1.00e-125	442.00
IUUC-Ttr-128217	Tursiops truncatus	42.98	0.00e+00	964.00
IUUC-Uma-129337	Ustilago maydis	53.26	0.00e+00	920.00
IUUC-Vda-129828	Verticillium dahliae	48.82	0.00e+00	1156.00
IUUC-Vpa-130537	Vicugna pacos	44.11	0.00e+00	1004.00
IUUC-Vvi-130958	Vitis vinifera	49.94	0.00e+00	833.00
IUUC-Xtr-132857	Xenopus tropicalis	42.83	0.00e+00	942.00
IUUC-Xma-133138	Xiphophorus maculatus	44.78	0.00e+00	1023.00
IUUC-Yli-134399	Yarrowia lipolytica	58.05	0.00e+00	1023.00
IUUC-Zma-135612	Zea mays	42.85	0.00e+00	956.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence