iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108279

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase brl1; BRE1-like protein 1; RING finger protein 2; RING-type E3 ubiquitin transferase brl1

Genbank Nucleotide ID

CU329672

Gene Name

brl1; rfp2; SPCC1919.15; SPCC790.01

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPCC1919.15	SPCC1919.15.1	SPCC1919.15.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17363370

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.013	14.2	639	678

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkd.gplvlp.CgHvfhadClqkwpglknssskefrCPlC 45
           C++C   f++   ++ p CgH+f+ +C + +   +  + k+ +CP C
   Q: 639  CSVC--NFSNwKSKLIPnCGHAFCSNCMEPF---Y--EHKTSTCPQC 678
           7788..664401334556*********9666...3..889999**99 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.

Protein Sequence
(Fasta)

MSVVNESRKR RRLIHSEKET RRLDLGEEDD LELFQKEAAW RRSREYEHLT VLEKKLYEYW 60
ESLVLKLDHY VAAALENHEQ SFEELEKITA SLYQPDDNLQ TLDLSLAEFS LIKDAQNYLN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTGACTCAC TAACGAGACA TGACTACCAT GTACAGATAA CCTGAAAAAA CTCATTAACC 60
GTAGGAATTG GCTTAGTGAA TGTTAATGAG CACATATTTT GATCCTAAGT ACTTTATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR013956--E3_ubiquit_lig_BRE1
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF08647--BRE1
PF00097--zf-C3HC4

SMART

SM00184--RING

Gene Ontology

GO:0033503--C:HULC complex
GO:0031618--C:nuclear pericentric heterochromatin
GO:0005634--C:nucleus
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0031497--P:chromatin assembly
GO:0006342--P:chromatin silencing
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0071894--P:histone H2B conserved C-terminal lysine ubiquitination
GO:0051569--P:regulation of histone H3-K4 methylation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

KEGG

spo:SPCC1919.15

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Afl-008679	Aspergillus flavus	26.33	1.00e-12	66.20
IUUC-Afu-008884	Aspergillus fumigatus	28.70	1.00e-11	63.50
IUUC-Ani-009487	Aspergillus nidulans	27.59	2.00e-15	75.50
IUUC-Bci-013926	Botrytis cinerea	26.61	9.00e-23	100.00
IUUC-Cin-025174	Ciona intestinalis	25.76	5.00e-19	88.20
IUUC-Csv-025830	Ciona savignyi	26.91	5.00e-16	78.20
IUUC-Fox-038017	Fusarium oxysporum	21.97	6.00e-14	70.90
IUUC-Nfi-068269	Neosartorya fischeri	28.70	9.00e-12	63.50
IUUC-Sja-108010	Schizosaccharomyces japonicus	33.89	8.00e-65	239.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence