iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	PINA	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	3.30e-21	76.5	37	101
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	1.30e-07	30.9	137	166

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           +Dv+l+vg+e f++h++vLaasS++F alf+++++es  k+ v+i +v+++ f+ ll+F+Ytg ++
   Q: 37   CDVQLQVGKETFQVHRLVLAASSPYFAALFTGGMKESS-KDVVQILGVEAGIFQLLLDFIYTGVVN 101
           8************************************7.************************875 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhF 31
            Nc+g+++f+++  c+dL ++ +++i+ hF
   Q: 137  QNCIGLFQFSEQIACHDLLEFTENYIHVHF 166
           6****************************9 PP

Organism

Mus musculus

Functional Description
(View)

Expression seems confined to tissues derived from trophectoderm and primitive endoderm.

Protein Sequence
(Fasta)

MSKEECPKAA DNSFSSDKHA QLILAQMNKM RSGQHFCDVQ LQVGKETFQV HRLVLAASSP 60
YFAALFTGGM KESSKDVVQI LGVEAGIFQL LLDFIYTGVV NIAVTNVQEL IVAADMLQLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCACTCGCA GTCACCTGTC ACCAAAGACT GTCCCCGCCC CCTCCGCTGC CTGCCTGCGC 60
GCGCAGAGCA CCGGAGGGCG CCGGCGGGAA GGGACGCGGC GGGTAAGCGA GGCCTGCGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR030104--IPP
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0016567--P:protein ubiquitination

KEGG

mmu:16351

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001672	Ailuropoda melanoleuca	94.18	0.00e+00	1165.00
IUUC-Apl-003849	Anas platyrhynchos	84.89	0.00e+00	1027.00
IUUC-Aca-004563	Anolis carolinensis	79.57	0.00e+00	910.00
IUUC-Ang-009864	Aspergillus niger	30.85	5.00e-07	48.10
IUUC-Ame-010887	Astyanax mexicanus	65.49	1.00e-106	379.00
IUUC-Bta-013512	Bos taurus	93.84	0.00e+00	1157.00
IUUC-Cja-018771	Callithrix jacchus	93.32	0.00e+00	1150.00
IUUC-Cfa-020097	Canis familiaris	92.64	0.00e+00	1096.00
IUUC-Cpo-022161	Cavia porcellus	92.98	0.00e+00	1154.00
IUUC-Csa-024249	Chlorocebus sabaeus	94.18	0.00e+00	1161.00
IUUC-Dno-029046	Dasypus novemcinctus	94.35	0.00e+00	1162.00
IUUC-Dor-030510	Dipodomys ordii	93.16	0.00e+00	769.00
IUUC-Dme-031884	Drosophila melanogaster	36.16	1.00e-109	390.00
IUUC-Ete-032968	Echinops telfairi	84.42	0.00e+00	1025.00
IUUC-Eca-033203	Equus caballus	87.86	0.00e+00	1069.00
IUUC-Fca-036451	Felis catus	93.84	0.00e+00	1162.00
IUUC-Fal-036931	Ficedula albicollis	82.92	0.00e+00	1003.00
IUUC-Fox-037735	Fusarium oxysporum	25.77	9.00e-06	43.50
IUUC-Gmo-039098	Gadus morhua	68.00	0.00e+00	822.00
IUUC-Gga-040552	Gallus gallus	85.24	0.00e+00	1030.00
IUUC-Gac-041995	Gasterosteus aculeatus	71.43	0.00e+00	871.00
IUUC-Ggo-045305	Gorilla gorilla	85.80	0.00e+00	929.00
IUUC-Hsa-045757	Homo sapiens	93.49	0.00e+00	1159.00
IUUC-Itr-048686	Ictidomys tridecemlineatus	94.52	0.00e+00	1165.00
IUUC-Lch-049691	Latimeria chalumnae	66.43	2.00e-166	578.00
IUUC-Loc-052552	Lepisosteus oculatus	74.30	0.00e+00	892.00
IUUC-Laf-053779	Loxodonta africana	89.42	0.00e+00	1103.00
IUUC-Mcc-054862	Macaca mulatta	93.69	0.00e+00	1099.00
IUUC-Mga-060083	Meleagris gallopavo	85.94	0.00e+00	1039.00
IUUC-Mmr-061303	Microcebus murinus	87.32	0.00e+00	994.00
IUUC-Mdo-062064	Monodelphis domestica	87.67	0.00e+00	1077.00
IUUC-Mpu-066841	Mustela putorius furo	93.64	0.00e+00	1095.00
IUUC-Mlu-067053	Myotis lucifugus	86.01	0.00e+00	1015.00
IUUC-Ncr-068938	Neurospora crassa	24.31	4.00e-09	56.60
IUUC-Nle-070066	Nomascus leucogenys	91.83	0.00e+00	1005.00
IUUC-Ont-072640	Oreochromis niloticus	72.68	0.00e+00	885.00
IUUC-Oan-073110	Ornithorhynchus anatinus	89.64	0.00e+00	1098.00
IUUC-Ocu-073916	Oryctolagus cuniculus	84.79	0.00e+00	1034.00
IUUC-Ola-086579	Oryzias latipes	63.77	0.00e+00	779.00
IUUC-Oga-088373	Otolemur garnettii	93.32	0.00e+00	1148.00
IUUC-Oar-089314	Ovis aries	94.01	0.00e+00	1163.00
IUUC-Ptr-090515	Pan troglodytes	92.93	0.00e+00	1089.00
IUUC-Pan-092367	Papio anubis	94.18	0.00e+00	1161.00
IUUC-Psi-093109	Pelodiscus sinensis	87.39	0.00e+00	1073.00
IUUC-Pma-094467	Petromyzon marinus	45.30	8.00e-129	454.00
IUUC-Pfo-096194	Poecilia formosa	73.38	0.00e+00	870.00
IUUC-Pab-098529	Pongo abelii	84.06	0.00e+00	948.00
IUUC-Pca-100654	Procavia capensis	95.36	4.00e-113	402.00
IUUC-Pva-102519	Pteropus vampyrus	87.59	0.00e+00	750.00
IUUC-Pte-104061	Pyrenophora teres	29.76	5.00e-06	44.70
IUUC-Rno-105294	Rattus norvegicus	97.26	0.00e+00	1159.00
IUUC-Sha-106587	Sarcophilus harrisii	86.69	0.00e+00	1065.00
IUUC-Ssl-108429	Sclerotinia sclerotiorum	29.57	7.00e-09	54.70
IUUC-Sar-113688	Sorex araneus	93.32	0.00e+00	1150.00
IUUC-Tgu-117449	Taeniopygia guttata	83.51	0.00e+00	1010.00
IUUC-Tru-118138	Takifugu rubripes	72.49	0.00e+00	880.00
IUUC-Tsy-118868	Tarsius syrichta	79.24	0.00e+00	637.00
IUUC-Tni-120684	Tetraodon nigroviridis	72.49	0.00e+00	904.00
IUUC-Ttr-128460	Tursiops truncatus	97.08	0.00e+00	710.00
IUUC-Vpa-130752	Vicugna pacos	92.81	0.00e+00	1139.00
IUUC-Xtr-131890	Xenopus tropicalis	71.65	0.00e+00	880.00
IUUC-Xma-133979	Xiphophorus maculatus	73.71	0.00e+00	844.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence