iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040235

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

WD repeat-containing protein 1

Genbank Nucleotide ID

AADN04000083

Gene Name

WDR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000014957.6	ENSGALT00000024124.4	ENSGALP00000024078.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-39	133.1	235	265
UBD/Beta-Prp	5.20e-63	213.3	57	282

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H ++++++++ +d   l+s+s+D+t k+WD+
   Q: 235  HDGGIYAISWsPDsSQLLSASGDKTAKIWDV 265
           99*********9999***************8 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlk 91
           ++h +++ + k++p++ ++a+g  +g++++wd+t++  l ++  +   ++++++ + +d+k ++ ++e   ++  v+  ++g+ v  ++
   Q: 57   TEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYeyQPFAGKIKDLAWTEDSKRIAVVGEGreKFGAVFLWDSGSSVGEIT 145
           4566667778*************************998777742334567***********99999999887777777789******** PP
   S: 92   ghedsvlslsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tg 177
           gh++ + s+++ +++ ++l++Gs+d+ +  ++ +  +    tls h+++vncv+++pdgn ++++s+D+++ ++d ktg+ +  l   +
   Q: 146  GHNKVINSVDIKQTRpYRLATGSDDNCAAFFEGPPFKFKF-TLSDHTRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALggGK 233
           *************999*******************99999.********************************************9955 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvk 226
           +h++ +y +s+++++ +l+s+s d+t k+wd+ ++++v t+n  ++   
   Q: 234  AHDGGIYAISWSPDSSQLLSASGDKTAKIWDVGANSVVSTFNMGSNVLD 282
           6***************************************997665443 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MRMPYEIKKV FASLPQVERG VSKIIGGDPK GNNFLYTNGK CVVIRNIDNP AIADIYTEHA 60
HQVVVAKYAP SGFYIASGDV SGKLRIWDTT QKEHLLKYEY QPFAGKIKDL AWTEDSKRIA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGACTATA TATGGTCAAA GGCAGGGGAG AGCGGCGGGC CGCGCGGGCG CTTCCTGCTT 60
CGTGCCGCTG GGCGCCGTGG GGCTGAAGCG GCGGGGAGCA GAGCGCAGCG GCGGCCGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR020472--G-protein_beta_WD-40_rep
IPR011045--N2O_reductase_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0030043--P:actin filament fragmentation
GO:0043297--P:apical junction assembly
GO:0030865--P:cortical cytoskeleton organization
GO:0042247--P:establishment of planar polarity of follicular epithelium
GO:0045199--P:maintenance of epithelial cell apical/basal polarity
GO:0002446--P:neutrophil mediated immunity
GO:1990266--P:neutrophil migration
GO:0030220--P:platelet formation
GO:0030836--P:positive regulation of actin filament depolymerization
GO:0008360--P:regulation of cell shape
GO:0060307--P:regulation of ventricular cardiac muscle cell membrane repolarization
GO:0045214--P:sarcomere organization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000457	Aegilops tauschii	35.80	3.00e-84	305.00
IUUC-Aml-002368	Ailuropoda melanoleuca	89.02	0.00e+00	1109.00
IUUC-Atr-003160	Amborella trichopoda	37.72	3.00e-116	412.00
IUUC-Apl-004012	Anas platyrhynchos	96.54	0.00e+00	1168.00
IUUC-Aca-004707	Anolis carolinensis	84.84	0.00e+00	1075.00
IUUC-Aly-006465	Arabidopsis lyrata	39.02	3.00e-115	409.00
IUUC-Ath-006740	Arabidopsis thaliana	38.86	7.00e-114	404.00
IUUC-Ago-007920	Ashbya gossypii	28.00	2.00e-75	276.00
IUUC-Acl-008262	Aspergillus clavatus	36.60	7.00e-109	387.00
IUUC-Afl-008471	Aspergillus flavus	32.99	3.00e-79	289.00
IUUC-Afu-008989	Aspergillus fumigatus	38.56	3.00e-98	352.00
IUUC-Ani-009167	Aspergillus nidulans	37.64	8.00e-116	410.00
IUUC-Ang-009595	Aspergillus niger	38.49	4.00e-104	371.00
IUUC-Aor-009908	Aspergillus oryzae	36.19	5.00e-103	368.00
IUUC-Ate-010580	Aspergillus terreus	37.69	8.00e-109	389.00
IUUC-Ame-011269	Astyanax mexicanus	61.25	3.00e-135	474.00
IUUC-Bgr-011996	Blumeria graminis	34.31	5.00e-106	378.00
IUUC-Bta-013278	Bos taurus	89.77	0.00e+00	1151.00
IUUC-Bci-013925	Botrytis cinerea	35.93	5.00e-110	391.00
IUUC-Bdi-014659	Brachypodium distachyon	35.80	4.00e-106	378.00
IUUC-Bol-016043	Brassica oleracea	36.93	7.00e-112	397.00
IUUC-Bra-017139	Brassica rapa	37.68	4.00e-112	398.00
IUUC-Cel-018417	Caenorhabditis elegans	40.50	3.00e-122	432.00
IUUC-Cja-019952	Callithrix jacchus	88.14	0.00e+00	1093.00
IUUC-Cfa-020225	Canis familiaris	89.27	0.00e+00	1122.00
IUUC-Cpo-021900	Cavia porcellus	88.02	0.00e+00	1106.00
IUUC-Csa-023028	Chlorocebus sabaeus	88.94	0.00e+00	1100.00
IUUC-Cho-025030	Choloepus hoffmanni	64.50	0.00e+00	713.00
IUUC-Cin-025152	Ciona intestinalis	54.86	3.00e-81	294.00
IUUC-Csv-025986	Ciona savignyi	37.63	6.00e-94	337.00
IUUC-Cgl-026597	Colletotrichum gloeosporioides	38.44	2.00e-115	409.00
IUUC-Cne-026814	Cryptococcus neoformans	35.38	5.00e-99	354.00
IUUC-Dre-027498	Danio rerio	81.03	1.00e-96	345.00
IUUC-Dno-029383	Dasypus novemcinctus	88.28	0.00e+00	1084.00
IUUC-Dor-030633	Dipodomys ordii	86.79	0.00e+00	1019.00
IUUC-Dse-031526	Dothistroma septosporum	38.45	1.00e-116	413.00
IUUC-Dme-031597	Drosophila melanogaster	48.01	4.00e-170	591.00
IUUC-Ete-032780	Echinops telfairi	80.36	0.00e+00	1003.00
IUUC-Eca-034306	Equus caballus	87.35	0.00e+00	1078.00
IUUC-Eeu-034531	Erinaceus europaeus	70.09	4.00e-129	454.00
IUUC-Fca-036301	Felis catus	89.02	0.00e+00	1132.00
IUUC-Fal-037361	Ficedula albicollis	95.54	0.00e+00	1207.00
IUUC-Fox-037924	Fusarium oxysporum	35.96	7.00e-104	371.00
IUUC-Fso-038199	Fusarium solani	35.14	1.00e-99	356.00
IUUC-Gmo-039238	Gadus morhua	72.49	0.00e+00	902.00
IUUC-Ggr-039830	Gaeumannomyces graminis	35.61	8.00e-98	350.00
IUUC-Gac-042363	Gasterosteus aculeatus	71.99	0.00e+00	935.00
IUUC-Gma-044189	Glycine max	37.38	7.00e-115	407.00
IUUC-Ggo-044632	Gorilla gorilla	86.82	0.00e+00	1065.00
IUUC-Hsa-045792	Homo sapiens	88.61	0.00e+00	1115.00
IUUC-Hvu-047517	Hordeum vulgare	35.95	4.00e-110	391.00
IUUC-Itr-048076	Ictidomys tridecemlineatus	88.85	0.00e+00	1107.00
IUUC-Kpa-049183	Komagataella pastoris	33.88	2.00e-89	323.00
IUUC-Lch-050428	Latimeria chalumnae	77.96	0.00e+00	1018.00
IUUC-Lpe-051306	Leersia perrieri	36.66	6.00e-112	397.00
IUUC-Loc-052096	Lepisosteus oculatus	73.26	0.00e+00	914.00
IUUC-Lma-053313	Leptosphaeria maculans	38.95	5.00e-117	417.00
IUUC-Laf-054060	Loxodonta africana	86.99	0.00e+00	1087.00
IUUC-Mcc-055619	Macaca mulatta	86.91	0.00e+00	1071.00
IUUC-Meu-056689	Macropus eugenii	77.89	0.00e+00	634.00
IUUC-Mor-056940	Magnaporthe oryzae	36.79	3.00e-99	355.00
IUUC-Mpo-057557	Magnaporthe poae	30.96	5.00e-71	261.00
IUUC-Mtr-057922	Medicago truncatula	35.89	1.00e-112	399.00
IUUC-Mla-059103	Melampsora laricipopulina	33.63	4.00e-77	281.00
IUUC-Mga-060150	Meleagris gallopavo	98.68	0.00e+00	1197.00
IUUC-Mvi-060448	Microbotryum violaceum	31.45	1.00e-77	283.00
IUUC-Mmr-061226	Microcebus murinus	87.95	0.00e+00	1092.00
IUUC-Mdo-062674	Monodelphis domestica	89.93	0.00e+00	1137.00
IUUC-Mmu-064170	Mus musculus	88.78	0.00e+00	1120.00
IUUC-Mac-065124	Musa acuminata	38.79	4.00e-116	411.00
IUUC-Mpu-066001	Mustela putorius furo	85.53	0.00e+00	1099.00
IUUC-Mlu-067253	Myotis lucifugus	88.85	0.00e+00	1112.00
IUUC-Nfi-068550	Neosartorya fischeri	38.25	4.00e-112	398.00
IUUC-Ncr-068948	Neurospora crassa	37.14	2.00e-115	409.00
IUUC-Nle-070115	Nomascus leucogenys	85.79	0.00e+00	993.00
IUUC-Opr-070254	Ochotona princeps	86.00	0.00e+00	1042.00
IUUC-Ont-071666	Oreochromis niloticus	76.24	0.00e+00	972.00
IUUC-Oan-073594	Ornithorhynchus anatinus	87.43	1.00e-160	558.00
IUUC-Ocu-074824	Oryctolagus cuniculus	86.80	0.00e+00	1069.00
IUUC-Oba-075010	Oryza barthii	36.33	9.00e-112	397.00
IUUC-Obr-076364	Oryza brachyantha	38.50	1.00e-114	406.00
IUUC-Ogl-077019	Oryza glaberrima	36.33	9.00e-112	397.00
IUUC-Ogu-078496	Oryza glumaepatula	36.33	9.00e-112	397.00
IUUC-Oin-080116	Oryza indica	36.50	8.00e-112	397.00
IUUC-Olo-080290	Oryza longistaminata	36.33	1.00e-111	396.00
IUUC-Ome-081969	Oryza meridionalis	36.33	1.00e-111	397.00
IUUC-Oni-082075	Oryza nivara	36.33	8.00e-112	397.00
IUUC-Opu-083959	Oryza punctata	36.66	2.00e-112	399.00
IUUC-Oru-084711	Oryza rufipogon	36.33	9.00e-112	397.00
IUUC-Osa-085958	Oryza sativa	36.50	8.00e-112	397.00
IUUC-Ola-086968	Oryzias latipes	76.11	0.00e+00	979.00
IUUC-Oga-089108	Otolemur garnettii	88.40	0.00e+00	1143.00
IUUC-Oar-089986	Ovis aries	83.61	0.00e+00	1051.00
IUUC-Ptr-091281	Pan troglodytes	88.67	0.00e+00	1105.00
IUUC-Pan-092585	Papio anubis	88.94	0.00e+00	1098.00
IUUC-Psi-093811	Pelodiscus sinensis	91.20	0.00e+00	1164.00
IUUC-Pma-094542	Petromyzon marinus	70.35	0.00e+00	900.00
IUUC-Pno-095086	Phaeosphaeria nodorum	37.30	1.00e-110	393.00
IUUC-Ppa-095876	Physcomitrella patens	36.17	9.00e-113	400.00
IUUC-Pfo-096973	Poecilia formosa	76.57	0.00e+00	1011.00
IUUC-Pab-098391	Pongo abelii	88.45	0.00e+00	1095.00
IUUC-Pop-098850	Populus trichocarpa	37.91	1.00e-115	410.00
IUUC-Pca-100257	Procavia capensis	56.57	4.00e-84	305.00
IUUC-Ppe-101578	Prunus persica	38.40	9.00e-116	410.00
IUUC-Pva-102872	Pteropus vampyrus	84.02	0.00e+00	1069.00
IUUC-Pgr-103593	Puccinia graminis	33.06	4.00e-81	295.00
IUUC-Pte-104365	Pyrenophora teres	38.35	2.00e-111	395.00
IUUC-Pyt-104689	Pyrenophora triticirepentis	38.03	4.00e-114	404.00
IUUC-Rno-105737	Rattus norvegicus	89.11	0.00e+00	1146.00
IUUC-Sce-106383	Saccharomyces cerevisiae	29.54	9.00e-71	261.00
IUUC-Sha-107084	Sarcophilus harrisii	87.17	0.00e+00	983.00
IUUC-Sja-107688	Schizosaccharomyces japonicus	35.36	3.00e-112	398.00
IUUC-Spo-108309	Schizosaccharomyces pombe	33.22	3.00e-96	345.00
IUUC-Ssl-108408	Sclerotinia sclerotiorum	36.10	2.00e-110	392.00
IUUC-Smo-109255	Selaginella moellendorffii	36.95	2.00e-104	372.00
IUUC-Sit-109962	Setaria italica	37.21	3.00e-114	405.00
IUUC-Sly-110897	Solanum lycopersicum	38.83	2.00e-117	416.00
IUUC-Stu-111971	Solanum tuberosum	38.50	3.00e-116	412.00
IUUC-Sar-113415	Sorex araneus	71.59	5.00e-108	384.00
IUUC-Sbi-114857	Sorghum bicolor	36.66	7.00e-112	397.00
IUUC-Sre-114900	Sporisorium reilianum	35.28	7.00e-94	337.00
IUUC-Tgu-117256	Taeniopygia guttata	96.35	0.00e+00	1211.00
IUUC-Tru-117871	Takifugu rubripes	71.40	0.00e+00	910.00
IUUC-Tsy-119172	Tarsius syrichta	92.50	3.00e-134	471.00
IUUC-Tni-120339	Tetraodon nigroviridis	71.12	0.00e+00	937.00
IUUC-Tca-121609	Theobroma cacao	37.77	7.00e-114	404.00
IUUC-Tre-122076	Trichoderma reesei	36.12	6.00e-98	351.00
IUUC-Tvi-122528	Trichoderma virens	34.92	3.00e-99	355.00
IUUC-Tae-124549	Triticum aestivum	35.62	2.00e-110	392.00
IUUC-Tur-126845	Triticum urartu	35.38	2.00e-82	300.00
IUUC-Tme-127217	Tuber melanosporum	35.96	1.00e-106	380.00
IUUC-Tbe-127526	Tupaia belangeri	86.30	0.00e+00	1085.00
IUUC-Ttr-128898	Tursiops truncatus	81.22	0.00e+00	1031.00
IUUC-Uma-129631	Ustilago maydis	33.33	7.00e-96	344.00
IUUC-Vda-129732	Verticillium dahliae	34.98	7.00e-95	341.00
IUUC-Vvi-131217	Vitis vinifera	38.05	8.00e-114	404.00
IUUC-Xtr-132860	Xenopus tropicalis	74.72	0.00e+00	963.00
IUUC-Xma-133830	Xiphophorus maculatus	76.57	0.00e+00	1011.00
IUUC-Yli-134335	Yarrowia lipolytica	32.68	5.00e-73	268.00
IUUC-Zma-135907	Zea mays	36.50	3.00e-112	398.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence