iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ang-009873

Ensembl Protein ID

CAK39617

UniProt Accession

A2QP30; LIS1_ASPNC

Genbank Protein ID

CAK39617.1

Protein Name

Nuclear distribution protein nudF; Lissencephaly-1 homolog

Genbank Nucleotide ID

AM270140

Gene Name

nudF; lis1; An07g08010

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
An07g08010	CAK39617	CAK39617

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.80e-48	158.8	112	147
UBD/Beta-Prp	3.40e-64	216.4	109	442

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           H d vtc+af +  t l+sGs D+tik+WD+  g l
   Q: 112  HRDAVTCVAFhPVfTSLASGSEDCTIKIWDWELGEL 147
           99********988899**************876665 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfs 103
           +++h + +tcv+f+p  + la+gs+d tik+wd++ g l r+l+gh  +v++++f  ++   il+++s+D  ik+wd++ ++  v+tl+gh++sv +++f 
   Q: 109  FESHRDAVTCVAFHPVFTSLASGSEDCTIKIWDWELGELERTLKGHMRPVSDLDFGGQKGhtILASCSSDLQIKLWDPNkDYANVRTLSGHDHSVSAVRFL 209
           5677778899*********************************************9887788**************9987899****************** PP
   S: 104  psg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng........... 192
           +++ + l+s+s+d tir+wd++tg+c++ + + + +++n v+ + dg+ lv+G+ D++ ++W ++++k +  l g h++ +++  f + +           
   Q: 210  RQTdNILISASRDATIRIWDVSTGYCVK-VIDSQGSWINDVSPSFDGKWLVTGGRDQAAMVWEVASAKSVASLIG-HENFIECCVFAPPSsykhlaaiagl 308
           *55499**********************.9999999**************************************9.*********8888888888888888 PP
   S: 193  ..........kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrs.gdllktlqlhn.................. 264
                     +++++g++d+t+klw+  +g+ ++tl gh+++v+ + f+p +++l+s+++D++ir+Wdl + g l+kt++ h                   
   Q: 309  ktappassssEFIATGARDKTIKLWES-RGRLIKTLVGHDNWVRGLLFHPGGKYLISVADDKTIRCWDLSQgGRLVKTINAHGhfvscirwgpvpvsdvpv 408
           8888888888****************8.8899************************************977257899999999444444444444444444 PP
   S: 265  .....ssvisvavlsfg.dnvlvlgsedskvniw 292
                +++++++ +++g + v+++gs+ds+v+i+
   Q: 409  etsesTKSSKSDSVKPGfQCVIATGSADSSVRIF 442
           444433333333366666667799999****998 PP

Organism

Aspergillus niger

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.

Protein Sequence
(Fasta)

MTKILTSSQA EELHKSIIAY LSSINASRSC EVLREELQVD SSFDDALCRK YEGLLEKKWT 60
GIARLQKKIL DLESKLAGLQ TELDTISPTA RSTGKDPINW LPTSSRHTFE SHRDAVTCVA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCAAGA TATTGACCTC CAGCCAAGCT GAGGAACTGT GAGTATATTT ATGCCATGGC 60
CTGCCGTACC TTGCTTGCGC GCTTATACGC AACCCAGGCA TAAGTCGATA ATCGCCTACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

KEGG

ang:ANI_1_996064

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	44.68	2.00e-92	330.00
IUUC-Apl-004024	Anas platyrhynchos	44.84	4.00e-95	340.00
IUUC-Aca-004564	Anolis carolinensis	44.56	4.00e-93	332.00
IUUC-Ago-007862	Ashbya gossypii	28.31	2.00e-34	137.00
IUUC-Acl-008360	Aspergillus clavatus	56.99	1.00e-148	517.00
IUUC-Afl-008502	Aspergillus flavus	53.88	8.00e-143	498.00
IUUC-Afu-008848	Aspergillus fumigatus	58.28	3.00e-158	549.00
IUUC-Ani-009173	Aspergillus nidulans	72.65	0.00e+00	667.00
IUUC-Aor-009973	Aspergillus oryzae	52.32	3.00e-139	486.00
IUUC-Ate-010523	Aspergillus terreus	74.16	0.00e+00	680.00
IUUC-Ame-011154	Astyanax mexicanus	45.06	2.00e-95	340.00
IUUC-Bgr-011972	Blumeria graminis	59.91	2.00e-163	566.00
IUUC-Bta-013106	Bos taurus	44.56	4.00e-95	339.00
IUUC-Bci-013615	Botrytis cinerea	61.39	7.00e-171	591.00
IUUC-Cel-018459	Caenorhabditis elegans	42.42	5.00e-84	302.00
IUUC-Cja-018755	Callithrix jacchus	44.68	1.00e-92	331.00
IUUC-Cfa-020749	Canis familiaris	44.56	4.00e-95	339.00
IUUC-Cpo-022371	Cavia porcellus	44.56	4.00e-95	339.00
IUUC-Csa-023524	Chlorocebus sabaeus	44.98	7.00e-79	285.00
IUUC-Cho-024764	Choloepus hoffmanni	41.53	4.00e-77	280.00
IUUC-Cin-025753	Ciona intestinalis	41.62	3.00e-84	303.00
IUUC-Csv-025817	Ciona savignyi	42.13	8.00e-89	318.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	57.95	2.00e-152	530.00
IUUC-Cne-027087	Cryptococcus neoformans	47.98	6.00e-101	358.00
IUUC-Dre-027554	Danio rerio	44.33	2.00e-93	334.00
IUUC-Dno-029050	Dasypus novemcinctus	44.56	3.00e-95	340.00
IUUC-Dor-030222	Dipodomys ordii	41.12	1.00e-85	308.00
IUUC-Dse-031164	Dothistroma septosporum	55.77	5.00e-150	522.00
IUUC-Dme-031745	Drosophila melanogaster	42.96	2.00e-82	297.00
IUUC-Ete-032508	Echinops telfairi	46.33	3.00e-64	237.00
IUUC-Eca-034288	Equus caballus	44.16	3.00e-91	327.00
IUUC-Eeu-034984	Erinaceus europaeus	40.86	2.00e-84	304.00
IUUC-Fca-036498	Felis catus	44.56	4.00e-95	339.00
IUUC-Fal-036920	Ficedula albicollis	44.84	4.00e-95	340.00
IUUC-Fox-037996	Fusarium oxysporum	57.70	9.00e-157	544.00
IUUC-Fso-038160	Fusarium solani	55.65	9.00e-149	518.00
IUUC-Gmo-038983	Gadus morhua	44.05	1.00e-93	334.00
IUUC-Ggr-040051	Gaeumannomyces graminis	54.13	1.00e-146	511.00
IUUC-Gga-040623	Gallus gallus	44.84	4.00e-95	340.00
IUUC-Gac-041613	Gasterosteus aculeatus	45.06	5.00e-94	336.00
IUUC-Ggo-045410	Gorilla gorilla	41.95	4.00e-81	293.00
IUUC-Hsa-046358	Homo sapiens	44.56	5.00e-95	339.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	44.56	4.00e-95	339.00
IUUC-Kpa-049351	Komagataella pastoris	29.30	5.00e-41	160.00
IUUC-Lch-049936	Latimeria chalumnae	44.81	1.00e-94	337.00
IUUC-Loc-052476	Lepisosteus oculatus	44.94	4.00e-92	330.00
IUUC-Lma-053170	Leptosphaeria maculans	60.96	3.00e-160	556.00
IUUC-Laf-053713	Loxodonta africana	44.50	2.00e-93	334.00
IUUC-Mcc-054628	Macaca mulatta	44.30	1.00e-94	338.00
IUUC-Meu-055927	Macropus eugenii	38.91	5.00e-47	179.00
IUUC-Mor-056962	Magnaporthe oryzae	55.77	2.00e-149	520.00
IUUC-Mpo-057583	Magnaporthe poae	54.78	6.00e-141	492.00
IUUC-Mla-058819	Melampsora laricipopulina	42.95	2.00e-96	344.00
IUUC-Mga-059945	Meleagris gallopavo	44.84	4.00e-95	339.00
IUUC-Mvi-060403	Microbotryum violaceum	46.59	3.00e-113	400.00
IUUC-Mmr-061289	Microcebus murinus	44.68	2.00e-92	330.00
IUUC-Mdo-061912	Monodelphis domestica	44.30	3.00e-94	337.00
IUUC-Mmu-063253	Mus musculus	44.56	4.00e-95	339.00
IUUC-Mpu-066638	Mustela putorius furo	44.56	4.00e-95	339.00
IUUC-Mlu-067267	Myotis lucifugus	43.91	2.00e-92	330.00
IUUC-Nfi-068571	Neosartorya fischeri	54.74	3.00e-145	506.00
IUUC-Ncr-068895	Neurospora crassa	58.94	7.00e-154	535.00
IUUC-Nle-069087	Nomascus leucogenys	41.69	1.00e-73	268.00
IUUC-Opr-070579	Ochotona princeps	44.56	3.00e-95	340.00
IUUC-Ont-072432	Oreochromis niloticus	44.33	3.00e-94	336.00
IUUC-Oan-073072	Ornithorhynchus anatinus	44.56	4.00e-95	339.00
IUUC-Ocu-074180	Oryctolagus cuniculus	44.56	3.00e-95	340.00
IUUC-Ola-086772	Oryzias latipes	44.81	8.00e-94	335.00
IUUC-Oga-088219	Otolemur garnettii	43.69	3.00e-93	333.00
IUUC-Oar-090394	Ovis aries	44.56	4.00e-95	339.00
IUUC-Ptr-091517	Pan troglodytes	44.56	4.00e-95	339.00
IUUC-Pan-092421	Papio anubis	44.30	1.00e-94	338.00
IUUC-Psi-093370	Pelodiscus sinensis	44.56	8.00e-95	338.00
IUUC-Pma-094319	Petromyzon marinus	42.60	1.00e-74	271.00
IUUC-Pno-094815	Phaeosphaeria nodorum	58.91	6.00e-162	561.00
IUUC-Pfo-097089	Poecilia formosa	44.56	2.00e-94	337.00
IUUC-Pab-098421	Pongo abelii	44.56	4.00e-95	339.00
IUUC-Pca-100120	Procavia capensis	34.42	8.00e-50	189.00
IUUC-Pva-102960	Pteropus vampyrus	44.30	9.00e-94	335.00
IUUC-Pgr-103538	Puccinia graminis	44.42	1.00e-105	374.00
IUUC-Ptt-103990	Puccinia triticina	41.50	6.00e-39	154.00
IUUC-Pte-104261	Pyrenophora teres	59.91	1.00e-164	570.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	59.69	2.00e-164	569.00
IUUC-Rno-105123	Rattus norvegicus	44.56	4.00e-95	339.00
IUUC-Sce-106208	Saccharomyces cerevisiae	26.17	6.00e-36	143.00
IUUC-Sha-107010	Sarcophilus harrisii	44.30	2.00e-94	337.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	35.31	9.00e-71	258.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	64.83	2.00e-167	580.00
IUUC-Sar-113309	Sorex araneus	43.90	1.00e-89	321.00
IUUC-Sre-115003	Sporisorium reilianum	47.20	1.00e-114	404.00
IUUC-Ssc-116148	Sus scrofa	44.56	4.00e-95	339.00
IUUC-Tgu-117299	Taeniopygia guttata	44.58	2.00e-94	337.00
IUUC-Tru-117721	Takifugu rubripes	43.80	3.00e-93	333.00
IUUC-Tsy-119493	Tarsius syrichta	44.56	5.00e-94	336.00
IUUC-Tni-120355	Tetraodon nigroviridis	44.05	3.00e-92	330.00
IUUC-Tre-121977	Trichoderma reesei	55.58	8.00e-144	501.00
IUUC-Tvi-122661	Trichoderma virens	56.13	4.00e-144	502.00
IUUC-Tme-127031	Tuber melanosporum	58.47	1.00e-149	521.00
IUUC-Tbe-127492	Tupaia belangeri	37.07	5.00e-44	169.00
IUUC-Ttr-128929	Tursiops truncatus	44.56	7.00e-95	338.00
IUUC-Uma-129347	Ustilago maydis	47.78	4.00e-115	406.00
IUUC-Vda-129837	Verticillium dahliae	55.63	2.00e-141	493.00
IUUC-Vpa-130532	Vicugna pacos	37.82	9.00e-75	271.00
IUUC-Xtr-131985	Xenopus tropicalis	44.56	6.00e-95	339.00
IUUC-Xma-133314	Xiphophorus maculatus	44.81	1.00e-94	338.00
IUUC-Yli-134403	Yarrowia lipolytica	37.71	8.00e-88	315.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence