iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-091140

Ensembl Protein ID

ENSPTRP00000026520.3

UniProt Accession

H2QND4; H2QND4_PANTR

Genbank Protein ID

JAA10174.1; JAA13158.1; JAA28007.1; JAA41571.1

Protein Name

Phosphoinositide-3-kinase, regulatory subunit 4

Genbank Nucleotide ID

AACZ03028670; GABF01008987; GABD01005093; GABE01003168

Gene Name

PIK3R4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000015388.4	ENSPTRT00000028739.3	ENSPTRP00000026520.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.70e-17	61.8	992	1021

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H++ v+ ++  ++  l++++s+Dgt+k+W+
   Q: 992  HKSAVNRIRVsDEhSLFATCSNDGTVKIWN 1021
           9999999999544788*************9 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60
TLPLTSYKQE LEELKIRLNS AQNCLPFQKA SEKASEKAAM LFRQYVRDNL YDRISTRPFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTCCGCTC GGCGACAGGA AGTGAGGTCA GACCGGTTGC TTTCCCGGGA GTTCGGCGTT 60
TGCTGGGGCT GCAGCAGCTG AAGTGTAGTG TTTTGTTGGG ACTGGCGGTC TGCACTTCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0418--Kinase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0853--WD repeat

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR021133--HEAT_type_2
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50077--HEAT_REPEAT
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00069--Pkinase
PF00400--WD40

SMART

SM00220--S_TKc
SM00320--WD40

Gene Ontology

GO:0005930--C:axoneme
GO:0005770--C:late endosome
GO:0015630--C:microtubule cytoskeleton
GO:0005643--C:nuclear pore
GO:0071561--C:nucleus-vacuole junction
GO:0034271--C:phosphatidylinositol 3-kinase complex, class III, type I
GO:0034272--C:phosphatidylinositol 3-kinase complex, class III, type II
GO:0005524--F:ATP binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0042149--P:cellular response to glucose starvation
GO:0045324--P:late endosome to vacuole transport
GO:0016236--P:macroautophagy
GO:0030242--P:pexophagy
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0006468--P:protein phosphorylation
GO:0006623--P:protein targeting to vacuole
GO:0032801--P:receptor catabolic process
GO:0032465--P:regulation of cytokinesis

KEGG

ptr:460692

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000213	Aegilops tauschii	31.87	3.00e-43	171.00
IUUC-Aml-001659	Ailuropoda melanoleuca	98.01	0.00e+00	2714.00
IUUC-Atr-002968	Amborella trichopoda	40.06	8.00e-48	186.00
IUUC-Apl-003418	Anas platyrhynchos	91.79	0.00e+00	2603.00
IUUC-Aca-004344	Anolis carolinensis	90.88	0.00e+00	2315.00
IUUC-Aly-006107	Arabidopsis lyrata	46.67	3.00e-71	264.00
IUUC-Ath-007260	Arabidopsis thaliana	46.97	7.00e-72	266.00
IUUC-Ago-007721	Ashbya gossypii	39.05	7.00e-57	216.00
IUUC-Acl-008378	Aspergillus clavatus	37.33	8.00e-149	521.00
IUUC-Afl-008632	Aspergillus flavus	36.05	2.00e-142	500.00
IUUC-Afu-009020	Aspergillus fumigatus	36.45	3.00e-142	500.00
IUUC-Ani-009204	Aspergillus nidulans	35.51	3.00e-132	466.00
IUUC-Ang-009811	Aspergillus niger	35.30	2.00e-140	493.00
IUUC-Aor-010168	Aspergillus oryzae	36.05	2.00e-142	500.00
IUUC-Ate-010556	Aspergillus terreus	35.61	3.00e-140	493.00
IUUC-Ame-011955	Astyanax mexicanus	81.02	0.00e+00	1825.00
IUUC-Bgr-012050	Blumeria graminis	36.53	1.00e-140	494.00
IUUC-Bta-012432	Bos taurus	96.69	0.00e+00	2722.00
IUUC-Bci-013846	Botrytis cinerea	34.57	9.00e-143	501.00
IUUC-Bdi-015072	Brachypodium distachyon	42.98	9.00e-67	249.00
IUUC-Bol-015314	Brassica oleracea	46.97	5.00e-72	266.00
IUUC-Bra-017476	Brassica rapa	46.97	6.00e-72	266.00
IUUC-Cel-018550	Caenorhabditis elegans	31.98	7.00e-85	309.00
IUUC-Cja-019538	Callithrix jacchus	98.82	0.00e+00	2772.00
IUUC-Cfa-020483	Canis familiaris	97.86	0.00e+00	2723.00
IUUC-Cpo-021392	Cavia porcellus	97.28	0.00e+00	2730.00
IUUC-Csa-024112	Chlorocebus sabaeus	99.56	0.00e+00	2786.00
IUUC-Cho-025015	Choloepus hoffmanni	90.53	0.00e+00	950.00
IUUC-Cin-025209	Ciona intestinalis	41.52	0.00e+00	1085.00
IUUC-Csv-026334	Ciona savignyi	41.86	0.00e+00	894.00
IUUC-Cgl-026447	Colletotrichum gloeosporioides	35.92	2.00e-144	508.00
IUUC-Cne-026999	Cryptococcus neoformans	39.83	8.00e-117	415.00
IUUC-Dre-028662	Danio rerio	81.51	0.00e+00	2315.00
IUUC-Dno-029545	Dasypus novemcinctus	95.66	0.00e+00	2667.00
IUUC-Dor-030941	Dipodomys ordii	66.44	0.00e+00	717.00
IUUC-Dse-031455	Dothistroma septosporum	36.53	1.00e-137	484.00
IUUC-Dme-031726	Drosophila melanogaster	40.72	0.00e+00	1001.00
IUUC-Ete-033147	Echinops telfairi	94.69	0.00e+00	1013.00
IUUC-Eca-034025	Equus caballus	98.23	0.00e+00	2749.00
IUUC-Eeu-034480	Erinaceus europaeus	90.28	0.00e+00	1524.00
IUUC-Fca-035741	Felis catus	97.35	0.00e+00	2713.00
IUUC-Fal-037666	Ficedula albicollis	90.76	0.00e+00	2578.00
IUUC-Fox-037818	Fusarium oxysporum	33.98	5.00e-128	452.00
IUUC-Fso-038086	Fusarium solani	34.26	1.00e-130	461.00
IUUC-Gmo-038804	Gadus morhua	81.18	0.00e+00	743.00
IUUC-Ggr-039800	Gaeumannomyces graminis	35.83	4.00e-135	476.00
IUUC-Gga-041251	Gallus gallus	90.37	0.00e+00	2020.00
IUUC-Gac-042376	Gasterosteus aculeatus	79.23	0.00e+00	2247.00
IUUC-Gma-044095	Glycine max	45.86	5.00e-74	273.00
IUUC-Ggo-044506	Gorilla gorilla	99.34	0.00e+00	2783.00
IUUC-Hsa-045871	Homo sapiens	99.93	0.00e+00	2796.00
IUUC-Hvu-047648	Hordeum vulgare	31.01	1.00e-44	175.00
IUUC-Itr-048082	Ictidomys tridecemlineatus	98.84	0.00e+00	1218.00
IUUC-Kpa-049390	Komagataella pastoris	32.68	2.00e-127	451.00
IUUC-Lch-050284	Latimeria chalumnae	85.74	0.00e+00	2353.00
IUUC-Lpe-050880	Leersia perrieri	41.76	2.00e-64	241.00
IUUC-Loc-052815	Lepisosteus oculatus	82.26	0.00e+00	2328.00
IUUC-Lma-053324	Leptosphaeria maculans	36.62	9.00e-147	515.00
IUUC-Laf-054204	Loxodonta africana	86.10	0.00e+00	2326.00
IUUC-Mcc-054612	Macaca mulatta	99.63	0.00e+00	2786.00
IUUC-Meu-056227	Macropus eugenii	85.91	0.00e+00	851.00
IUUC-Mor-057094	Magnaporthe oryzae	36.51	2.00e-135	477.00
IUUC-Mtr-058550	Medicago truncatula	43.92	5.00e-73	270.00
IUUC-Mla-058893	Melampsora laricipopulina	34.93	4.00e-130	459.00
IUUC-Mga-059474	Meleagris gallopavo	90.68	0.00e+00	2442.00
IUUC-Mvi-060227	Microbotryum violaceum	45.01	5.00e-85	310.00
IUUC-Mmr-061543	Microcebus murinus	90.50	0.00e+00	2450.00
IUUC-Mdo-062129	Monodelphis domestica	93.90	0.00e+00	2558.00
IUUC-Mmu-064381	Mus musculus	95.95	0.00e+00	2696.00
IUUC-Mac-064455	Musa acuminata	38.36	2.00e-123	437.00
IUUC-Mpu-066151	Mustela putorius furo	98.55	0.00e+00	988.00
IUUC-Mlu-067824	Myotis lucifugus	98.09	0.00e+00	2741.00
IUUC-Nfi-068241	Neosartorya fischeri	37.63	1.00e-145	511.00
IUUC-Ncr-068964	Neurospora crassa	36.32	1.00e-140	494.00
IUUC-Nle-069152	Nomascus leucogenys	99.71	0.00e+00	2787.00
IUUC-Opr-070870	Ochotona princeps	85.55	0.00e+00	1450.00
IUUC-Ont-071293	Oreochromis niloticus	80.73	0.00e+00	2295.00
IUUC-Oan-072852	Ornithorhynchus anatinus	88.06	0.00e+00	2442.00
IUUC-Ocu-074727	Oryctolagus cuniculus	97.86	0.00e+00	2709.00
IUUC-Oba-075932	Oryza barthii	39.69	3.00e-64	241.00
IUUC-Obr-076424	Oryza brachyantha	46.64	2.00e-61	231.00
IUUC-Ogl-077491	Oryza glaberrima	39.69	3.00e-64	241.00
IUUC-Ogu-078933	Oryza glumaepatula	33.87	8.00e-99	355.00
IUUC-Oin-079604	Oryza indica	44.13	8.00e-70	259.00
IUUC-Olo-080850	Oryza longistaminata	36.07	4.00e-116	412.00
IUUC-Ome-081860	Oryza meridionalis	44.13	9.00e-70	259.00
IUUC-Oni-082895	Oryza nivara	39.69	7.00e-64	239.00
IUUC-Opu-083741	Oryza punctata	43.84	2.00e-68	254.00
IUUC-Oru-084616	Oryza rufipogon	39.39	1.00e-63	238.00
IUUC-Osa-085941	Oryza sativa	28.74	2.00e-36	146.00
IUUC-Ola-087357	Oryzias latipes	86.22	5.00e-160	556.00
IUUC-Olu-087659	Ostreococcus lucimarinus	30.59	9.00e-89	322.00
IUUC-Oga-088555	Otolemur garnettii	98.38	0.00e+00	2729.00
IUUC-Oar-089304	Ovis aries	96.17	0.00e+00	1327.00
IUUC-Pan-092413	Papio anubis	99.31	0.00e+00	2677.00
IUUC-Psi-093210	Pelodiscus sinensis	91.62	0.00e+00	2598.00
IUUC-Pma-094674	Petromyzon marinus	56.18	0.00e+00	735.00
IUUC-Pno-094969	Phaeosphaeria nodorum	31.51	6.00e-146	512.00
IUUC-Ppa-096017	Physcomitrella patens	46.42	4.00e-77	284.00
IUUC-Pfo-096077	Poecilia formosa	80.56	0.00e+00	2247.00
IUUC-Pab-098269	Pongo abelii	98.82	0.00e+00	2771.00
IUUC-Pop-100052	Populus trichocarpa	44.20	8.00e-65	243.00
IUUC-Pca-100377	Procavia capensis	92.10	0.00e+00	2472.00
IUUC-Ppe-101445	Prunus persica	46.69	3.00e-73	270.00
IUUC-Pva-102198	Pteropus vampyrus	98.24	0.00e+00	1809.00
IUUC-Pgr-103544	Puccinia graminis	47.80	8.00e-82	299.00
IUUC-Ptt-103964	Puccinia triticina	47.48	1.00e-78	288.00
IUUC-Pte-104196	Pyrenophora teres	36.94	9.00e-139	488.00
IUUC-Pyt-104544	Pyrenophora triticirepentis	37.50	2.00e-137	483.00
IUUC-Rno-105256	Rattus norvegicus	95.80	0.00e+00	2692.00
IUUC-Sce-106295	Saccharomyces cerevisiae	33.50	1.00e-114	408.00
IUUC-Sha-107597	Sarcophilus harrisii	92.96	0.00e+00	2590.00
IUUC-Sja-107781	Schizosaccharomyces japonicus	34.23	3.00e-106	380.00
IUUC-Spo-108031	Schizosaccharomyces pombe	44.14	2.00e-73	271.00
IUUC-Ssl-108579	Sclerotinia sclerotiorum	35.64	5.00e-137	483.00
IUUC-Smo-108679	Selaginella moellendorffii	44.85	2.00e-79	291.00
IUUC-Sit-110765	Setaria italica	41.55	6.00e-64	239.00
IUUC-Sly-111527	Solanum lycopersicum	44.20	1.00e-73	272.00
IUUC-Stu-112899	Solanum tuberosum	44.20	8.00e-74	272.00
IUUC-Sar-112986	Sorex araneus	96.98	0.00e+00	2712.00
IUUC-Sbi-114604	Sorghum bicolor	41.02	6.00e-67	249.00
IUUC-Sre-115191	Sporisorium reilianum	44.00	4.00e-67	250.00
IUUC-Ssc-115440	Sus scrofa	96.10	0.00e+00	2690.00
IUUC-Tgu-116633	Taeniopygia guttata	90.90	0.00e+00	2581.00
IUUC-Tru-118439	Takifugu rubripes	78.81	0.00e+00	2253.00
IUUC-Tsy-119472	Tarsius syrichta	90.60	0.00e+00	1445.00
IUUC-Tni-119808	Tetraodon nigroviridis	74.80	0.00e+00	2055.00
IUUC-Tca-121648	Theobroma cacao	47.59	1.00e-74	275.00
IUUC-Tre-122161	Trichoderma reesei	34.35	2.00e-123	437.00
IUUC-Tvi-122575	Trichoderma virens	33.26	5.00e-115	409.00
IUUC-Tae-123381	Triticum aestivum	46.62	5.00e-67	250.00
IUUC-Tur-126291	Triticum urartu	44.13	1.00e-67	252.00
IUUC-Tme-126979	Tuber melanosporum	37.47	2.00e-150	527.00
IUUC-Tbe-127576	Tupaia belangeri	81.74	0.00e+00	942.00
IUUC-Ttr-129106	Tursiops truncatus	98.33	0.00e+00	1322.00
IUUC-Uma-129633	Ustilago maydis	43.17	1.00e-75	279.00
IUUC-Vda-130001	Verticillium dahliae	34.89	2.00e-130	461.00
IUUC-Vpa-130733	Vicugna pacos	89.62	0.00e+00	1315.00
IUUC-Vvi-131318	Vitis vinifera	44.60	2.00e-71	264.00
IUUC-Xtr-131908	Xenopus tropicalis	86.16	0.00e+00	2462.00
IUUC-Xma-133331	Xiphophorus maculatus	80.41	0.00e+00	2260.00
IUUC-Yli-134651	Yarrowia lipolytica	37.21	1.00e-121	431.00
IUUC-Zma-135850	Zea mays	40.75	6.00e-68	253.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence