iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089229

Ensembl Protein ID

ENSOARP00000018601.1

UniProt Accession

W5Q7A9; W5Q7A9_SHEEP

Genbank Protein ID

ENSOARP00000018601

Protein Name

Protein HIRA

Genbank Nucleotide ID

AMGL01040374

Gene Name

HIRA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000017323.1	ENSOART00000018864.1	ENSOARP00000018601.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-15	57.3	233	262

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H + v+c+++ ++  +l+sG+dD+ i+vW 
   Q: 233  HLACVNCVRWsNGgMYLASGGDDKLIMVWK 262
           8899******877899*************7 PP

Organism

Ovis aries

Functional Description
(View)

Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

Protein Sequence
(Fasta)

MSSSPSGCLC VPEPPPPPAA PGVAECGGGG XXXXXXXXXX XXXXXXXXXX SDYPPPVGLR 60
SRRRLRDADG AQLNRSGAGW GVPIAAAPGT GAGRAASQTR PPGGDLGECG VCRPSPWAQD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCAGCT CGCCGTCAGG CTGCTTGTGT GTCCCTGAGC CCCCTCCCCC TCCGGCGGCC 60
CCGGGTGTGG CGGAGTGTGG GGGGGGTGGG ANNNNNNNNN NNNNNNNNNN NNNNNNNNNN 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR031120--HIR1
IPR011494--Hira
IPR019015--HIRA_B_motif
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07569--Hira
PF09453--HIRA_B
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0000790--C:nuclear chromatin
GO:0043234--C:protein complex
GO:0016569--P:covalent chromatin modification
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0007369--P:gastrulation
GO:0042692--P:muscle cell differentiation
GO:0001649--P:osteoblast differentiation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001039	Aegilops tauschii	34.89	2.00e-63	237.00
IUUC-Aml-001723	Ailuropoda melanoleuca	70.77	0.00e+00	1041.00
IUUC-Atr-003132	Amborella trichopoda	26.87	4.00e-39	157.00
IUUC-Apl-003197	Anas platyrhynchos	63.46	0.00e+00	980.00
IUUC-Aca-004733	Anolis carolinensis	62.73	0.00e+00	931.00
IUUC-Aly-005446	Arabidopsis lyrata	26.77	9.00e-37	149.00
IUUC-Ath-007627	Arabidopsis thaliana	28.16	2.00e-39	158.00
IUUC-Ago-007766	Ashbya gossypii	26.56	3.00e-39	157.00
IUUC-Acl-008104	Aspergillus clavatus	28.27	3.00e-42	167.00
IUUC-Afu-008781	Aspergillus fumigatus	29.02	3.00e-42	167.00
IUUC-Ani-009272	Aspergillus nidulans	27.40	6.00e-38	152.00
IUUC-Ang-009655	Aspergillus niger	29.50	1.00e-44	175.00
IUUC-Ate-010530	Aspergillus terreus	27.63	1.00e-36	148.00
IUUC-Ame-011147	Astyanax mexicanus	82.95	7.00e-44	167.00
IUUC-Bgr-012237	Blumeria graminis	29.72	1.00e-43	171.00
IUUC-Bta-013320	Bos taurus	75.66	0.00e+00	1130.00
IUUC-Bci-013795	Botrytis cinerea	26.74	1.00e-46	182.00
IUUC-Bdi-014075	Brachypodium distachyon	30.50	2.00e-39	157.00
IUUC-Bol-016440	Brassica oleracea	27.48	3.00e-40	160.00
IUUC-Bra-016651	Brassica rapa	27.25	3.00e-40	160.00
IUUC-Cel-018692	Caenorhabditis elegans	33.51	9.00e-52	198.00
IUUC-Cja-018987	Callithrix jacchus	68.97	0.00e+00	956.00
IUUC-Cfa-020132	Canis familiaris	70.64	0.00e+00	1036.00
IUUC-Cpo-021484	Cavia porcellus	69.73	0.00e+00	1015.00
IUUC-Cre-022846	Chlamydomonas reinhardtii	40.76	2.00e-24	108.00
IUUC-Csa-023081	Chlorocebus sabaeus	70.54	0.00e+00	1028.00
IUUC-Cin-025182	Ciona intestinalis	47.93	7.00e-116	412.00
IUUC-Csv-026154	Ciona savignyi	49.38	2.00e-114	406.00
IUUC-Cne-026891	Cryptococcus neoformans	35.65	6.00e-59	222.00
IUUC-Cme-027349	Cyanidioschyzon merolae	29.44	7.00e-31	129.00
IUUC-Dre-027655	Danio rerio	65.60	0.00e+00	749.00
IUUC-Dno-029557	Dasypus novemcinctus	76.32	0.00e+00	756.00
IUUC-Dor-030687	Dipodomys ordii	70.42	7.00e-160	558.00
IUUC-Dme-031746	Drosophila melanogaster	49.89	8.00e-121	428.00
IUUC-Ete-032384	Echinops telfairi	63.97	0.00e+00	904.00
IUUC-Eca-033430	Equus caballus	70.24	0.00e+00	1016.00
IUUC-Fca-036121	Felis catus	70.29	0.00e+00	1036.00
IUUC-Fal-036817	Ficedula albicollis	63.08	0.00e+00	976.00
IUUC-Fox-037906	Fusarium oxysporum	27.71	5.00e-37	149.00
IUUC-Gmo-039151	Gadus morhua	74.79	4.00e-158	552.00
IUUC-Gga-040936	Gallus gallus	63.80	0.00e+00	1011.00
IUUC-Gac-041405	Gasterosteus aculeatus	61.14	2.00e-180	626.00
IUUC-Gma-044252	Glycine max	28.70	8.00e-39	155.00
IUUC-Ggo-045430	Gorilla gorilla	70.54	0.00e+00	1030.00
IUUC-Hsa-046442	Homo sapiens	70.10	0.00e+00	1021.00
IUUC-Hvu-047587	Hordeum vulgare	28.98	8.00e-40	159.00
IUUC-Itr-048910	Ictidomys tridecemlineatus	78.41	1.00e-130	458.00
IUUC-Kpa-049145	Komagataella pastoris	27.34	3.00e-42	167.00
IUUC-Lch-050474	Latimeria chalumnae	57.93	0.00e+00	832.00
IUUC-Lpe-051209	Leersia perrieri	25.64	5.00e-35	143.00
IUUC-Loc-052119	Lepisosteus oculatus	56.12	0.00e+00	848.00
IUUC-Lma-053237	Leptosphaeria maculans	29.39	1.00e-45	178.00
IUUC-Laf-053718	Loxodonta africana	70.48	0.00e+00	1035.00
IUUC-Mcc-055621	Macaca mulatta	69.61	0.00e+00	962.00
IUUC-Meu-055914	Macropus eugenii	55.13	4.00e-118	419.00
IUUC-Mtr-057744	Medicago truncatula	29.05	2.00e-39	157.00
IUUC-Mla-058914	Melampsora laricipopulina	35.46	4.00e-56	213.00
IUUC-Mga-060181	Meleagris gallopavo	63.30	0.00e+00	1009.00
IUUC-Mvi-060432	Microbotryum violaceum	32.54	6.00e-52	199.00
IUUC-Mmr-060871	Microcebus murinus	70.73	0.00e+00	1060.00
IUUC-Mdo-062301	Monodelphis domestica	66.45	0.00e+00	958.00
IUUC-Mmu-063888	Mus musculus	69.29	0.00e+00	997.00
IUUC-Mac-065137	Musa acuminata	27.00	2.00e-40	161.00
IUUC-Mpu-066732	Mustela putorius furo	71.10	0.00e+00	1075.00
IUUC-Mlu-067542	Myotis lucifugus	70.10	0.00e+00	995.00
IUUC-Nfi-068396	Neosartorya fischeri	29.14	1.00e-41	165.00
IUUC-Ncr-068842	Neurospora crassa	28.26	6.00e-47	182.00
IUUC-Nle-070156	Nomascus leucogenys	69.96	0.00e+00	1037.00
IUUC-Opr-070808	Ochotona princeps	66.20	0.00e+00	754.00
IUUC-Ont-072105	Oreochromis niloticus	56.20	0.00e+00	809.00
IUUC-Ocu-074962	Oryctolagus cuniculus	70.86	0.00e+00	1033.00
IUUC-Oba-075178	Oryza barthii	30.79	2.00e-39	158.00
IUUC-Obr-076399	Oryza brachyantha	27.86	1.00e-38	155.00
IUUC-Ogu-078797	Oryza glumaepatula	30.79	2.00e-39	158.00
IUUC-Oin-080085	Oryza indica	30.79	2.00e-39	158.00
IUUC-Olo-081048	Oryza longistaminata	30.21	4.00e-39	157.00
IUUC-Ome-081324	Oryza meridionalis	30.79	2.00e-39	158.00
IUUC-Oni-082548	Oryza nivara	30.79	2.00e-39	158.00
IUUC-Opu-084008	Oryza punctata	30.79	1.00e-39	158.00
IUUC-Oru-084339	Oryza rufipogon	30.50	6.00e-39	156.00
IUUC-Osa-085782	Oryza sativa	30.50	6.00e-39	156.00
IUUC-Ola-087302	Oryzias latipes	62.25	0.00e+00	647.00
IUUC-Olu-087611	Ostreococcus lucimarinus	31.63	4.00e-60	226.00
IUUC-Oga-087935	Otolemur garnettii	69.66	0.00e+00	1023.00
IUUC-Ptr-090715	Pan troglodytes	70.21	0.00e+00	1023.00
IUUC-Pan-092318	Papio anubis	70.35	0.00e+00	1034.00
IUUC-Psi-094053	Pelodiscus sinensis	63.93	0.00e+00	973.00
IUUC-Pno-094985	Phaeosphaeria nodorum	29.43	7.00e-41	162.00
IUUC-Ppa-095819	Physcomitrella patens	30.52	1.00e-62	234.00
IUUC-Pfo-096857	Poecilia formosa	64.44	0.00e+00	714.00
IUUC-Pab-098047	Pongo abelii	70.32	0.00e+00	1026.00
IUUC-Pop-099587	Populus trichocarpa	28.87	2.00e-53	204.00
IUUC-Pca-100558	Procavia capensis	95.42	2.00e-89	324.00
IUUC-Ppe-101261	Prunus persica	28.51	9.00e-40	159.00
IUUC-Pva-102683	Pteropus vampyrus	70.48	0.00e+00	1040.00
IUUC-Pgr-103660	Puccinia graminis	34.73	2.00e-50	194.00
IUUC-Ptt-103900	Puccinia triticina	44.44	2.00e-30	127.00
IUUC-Pte-104209	Pyrenophora teres	30.10	6.00e-44	172.00
IUUC-Pyt-104802	Pyrenophora triticirepentis	29.85	8.00e-43	169.00
IUUC-Rno-105137	Rattus norvegicus	69.54	0.00e+00	1019.00
IUUC-Sce-106291	Saccharomyces cerevisiae	29.23	7.00e-43	169.00
IUUC-Sha-107514	Sarcophilus harrisii	70.60	0.00e+00	791.00
IUUC-Sja-107833	Schizosaccharomyces japonicus	33.59	3.00e-53	203.00
IUUC-Spo-108162	Schizosaccharomyces pombe	33.60	7.00e-54	205.00
IUUC-Smo-109186	Selaginella moellendorffii	31.35	4.00e-54	206.00
IUUC-Sit-109980	Setaria italica	31.09	2.00e-41	164.00
IUUC-Sly-111547	Solanum lycopersicum	27.93	6.00e-42	166.00
IUUC-Stu-112705	Solanum tuberosum	29.33	1.00e-39	159.00
IUUC-Sar-113222	Sorex araneus	95.42	2.00e-89	323.00
IUUC-Sbi-114272	Sorghum bicolor	27.88	8.00e-40	159.00
IUUC-Sre-115061	Sporisorium reilianum	27.40	8.00e-50	192.00
IUUC-Ssc-116364	Sus scrofa	70.50	0.00e+00	1110.00
IUUC-Tgu-116645	Taeniopygia guttata	63.47	0.00e+00	996.00
IUUC-Tru-117590	Takifugu rubripes	63.24	0.00e+00	726.00
IUUC-Tsy-119212	Tarsius syrichta	74.24	0.00e+00	760.00
IUUC-Tni-119915	Tetraodon nigroviridis	55.65	0.00e+00	822.00
IUUC-Tca-121765	Theobroma cacao	29.38	1.00e-54	208.00
IUUC-Tvi-122262	Trichoderma virens	34.76	5.00e-24	106.00
IUUC-Tae-123009	Triticum aestivum	48.98	7.00e-34	139.00
IUUC-Tur-126483	Triticum urartu	26.71	2.00e-40	161.00
IUUC-Tme-127202	Tuber melanosporum	27.10	3.00e-37	150.00
IUUC-Tbe-127350	Tupaia belangeri	67.14	5.00e-138	485.00
IUUC-Ttr-129077	Tursiops truncatus	67.44	0.00e+00	1040.00
IUUC-Uma-129465	Ustilago maydis	31.98	4.00e-51	196.00
IUUC-Vvi-131397	Vitis vinifera	29.50	1.00e-55	212.00
IUUC-Xtr-132057	Xenopus tropicalis	69.75	0.00e+00	775.00
IUUC-Xma-134139	Xiphophorus maculatus	61.62	0.00e+00	647.00
IUUC-Yli-134424	Yarrowia lipolytica	29.12	3.00e-47	184.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence