iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gga-041072

Ensembl Protein ID

ENSGALP00000024119.4

UniProt Accession

E1C2F6; E1C2F6_CHICK

Genbank Protein ID

ENSGALP00000024119

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AADN04000161

Gene Name

FRK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000014979.5	ENSGALT00000024165.5	ENSGALP00000024119.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.40e-12	46.5	74	138

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvk........elegkrGlfPenFvekle 63
           k+ +l++yea ++d+L++++Gd+++v+  +   egW++++           ++ +G +P+n+++ ++
   Q: 74   KFVALFNYEARTEDDLSFQAGDKLEVL--DASHEGWWYAKLllpegsvcPGRKLQGYIPANYIAAVQ 138
           789************************..88899*****889**99988888999********9987 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MGNFCQKYCT CLEPCIPCLF SGKEGEREED VGQVFANPAV VRIDSQAGEK DKVNKTKGKP 60
LPALPGQHLM NTCKFVALFN YEARTEDDLS FQAGDKLEVL DASHEGWWYA KLLLPEGSVC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAAACT TCTGTCAGAA ATACTGCACC TGTTTGGAGC CCTGTATTCC TTGCTTATTC 60
TCAGGGAAAG AAGGTGAGCG GGAAGAGGAT GTTGGCCAGG TCTTTGCCAA CCCTGCTGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

gga:421747

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000140	Aegilops tauschii	31.54	6.00e-24	106.00
IUUC-Apl-003394	Anas platyrhynchos	77.46	0.00e+00	847.00
IUUC-Aca-004553	Anolis carolinensis	67.54	0.00e+00	738.00
IUUC-Bdi-014122	Brachypodium distachyon	30.74	6.00e-23	102.00
IUUC-Cja-019885	Callithrix jacchus	68.10	0.00e+00	744.00
IUUC-Cre-022669	Chlamydomonas reinhardtii	30.64	5.00e-23	101.00
IUUC-Dre-028274	Danio rerio	57.36	4.00e-172	597.00
IUUC-Dno-029689	Dasypus novemcinctus	69.27	0.00e+00	740.00
IUUC-Dme-031976	Drosophila melanogaster	60.98	9.00e-172	596.00
IUUC-Eeu-034770	Erinaceus europaeus	55.93	1.00e-147	516.00
IUUC-Fal-036892	Ficedula albicollis	79.73	0.00e+00	870.00
IUUC-Hvu-047855	Hordeum vulgare	31.92	5.00e-24	105.00
IUUC-Loc-052913	Lepisosteus oculatus	61.30	3.00e-180	624.00
IUUC-Mga-059456	Meleagris gallopavo	93.25	0.00e+00	1001.00
IUUC-Mmr-061480	Microcebus murinus	66.73	0.00e+00	710.00
IUUC-Mac-065247	Musa acuminata	30.18	6.00e-24	105.00
IUUC-Mlu-067167	Myotis lucifugus	67.17	0.00e+00	726.00
IUUC-Nle-069786	Nomascus leucogenys	67.35	0.00e+00	738.00
IUUC-Ont-072417	Oreochromis niloticus	58.40	1.00e-179	622.00
IUUC-Obr-076765	Oryza brachyantha	29.96	2.00e-22	100.00
IUUC-Ogl-077139	Oryza glaberrima	30.38	4.00e-22	100.00
IUUC-Ogu-078229	Oryza glumaepatula	30.38	8.00e-22	100.00
IUUC-Olo-080876	Oryza longistaminata	31.01	3.00e-22	100.00
IUUC-Ome-081722	Oryza meridionalis	29.96	3.00e-22	100.00
IUUC-Oni-082868	Oryza nivara	30.38	4.00e-22	99.80
IUUC-Opu-083800	Oryza punctata	30.38	5.00e-22	100.00
IUUC-Oru-084784	Oryza rufipogon	30.38	3.00e-22	100.00
IUUC-Osa-086140	Oryza sativa	30.38	2.00e-22	100.00
IUUC-Ola-086419	Oryzias latipes	62.45	5.00e-174	603.00
IUUC-Pan-092732	Papio anubis	67.23	0.00e+00	735.00
IUUC-Psi-093899	Pelodiscus sinensis	73.60	0.00e+00	797.00
IUUC-Pma-094230	Petromyzon marinus	59.61	5.00e-166	577.00
IUUC-Pfo-096035	Poecilia formosa	60.76	1.00e-171	595.00
IUUC-Pva-103122	Pteropus vampyrus	49.44	2.00e-138	485.00
IUUC-Rno-105269	Rattus norvegicus	68.32	0.00e+00	724.00
IUUC-Sit-109712	Setaria italica	30.98	1.00e-21	98.60
IUUC-Sbi-113999	Sorghum bicolor	31.86	4.00e-20	93.20
IUUC-Tgu-116491	Taeniopygia guttata	83.20	0.00e+00	841.00
IUUC-Tru-117795	Takifugu rubripes	58.17	1.00e-156	546.00
IUUC-Tni-120512	Tetraodon nigroviridis	60.24	4.00e-178	617.00
IUUC-Tae-123192	Triticum aestivum	31.54	4.00e-24	106.00
IUUC-Tur-126022	Triticum urartu	31.13	2.00e-23	103.00
IUUC-Ttr-128817	Tursiops truncatus	68.25	0.00e+00	734.00
IUUC-Vpa-130389	Vicugna pacos	64.12	0.00e+00	668.00
IUUC-Xtr-132360	Xenopus tropicalis	58.96	0.00e+00	651.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence