iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007499

UUCD1 version

UUC-ArT-01657

Ensembl Protein ID

AT5G45900.1

UniProt Accession

Q94CD5; Q9FJ46; ATG7_ARATH

Genbank Protein ID

AAM70190.1; BAB88385.1; BAB09318.1; AED95313.1; AAK59451.1; AAN12897.1

Protein Name

Ubiquitin-like modifier-activating enzyme atg7; ATG12-activating enzyme E1 atg7; Autophagy-related protein 7; Protein PEROXISOME UNUSUAL POSITIONING 4

Genbank Nucleotide ID

AF492761; AB073173; AB016870; CP002688; AY034945; AY150456

Gene Name

ATG7; APG7; PEUP4; At5g45900; K15I22.10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT5G45900	AT5G45900.1	AT5G45900.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E1	38.51	1.00e-103	372.00	IUUC-Sce-106413

Active Site

Position(s)	Description	Evidence
558	Glycyl thioester intermediate	{ECO:0000250}

Organism

Arabidopsis thaliana

Functional Description
(View)

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes. Involved in the senescence process (PubMed:12070171). Involved in the degradation of damaged peroxisomes (PubMed:24368788). Involved in the non-selective degradation of chlorophylls and photosynthetic proteins during stress-induced leaf yellowing (PubMed:24510943).

Protein Sequence
(Fasta)

MAEKETPAII LQFAPLNSSV DEGFWHSFSS LKLDKLGIDD SPISITGFYG PCGHPQVSNH 60
LTLLSESLPL DEQSLIASTS HGNRNKCPVP GILYNTNTVE SFNKLDKQSL LKAEANKIWE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGGATTGAC CATGTTCCTT GCACGACTCC TTTTTCTCAC CGTTCTCCGT CATCGTCTTC 60
TTCTTTCTCA CATTCATTGA CTCTCCTCCA TAATAAACAT TGCAATCTCT CAGAAAGATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0346--Stress response
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR006285--Atg7
IPR032197--Atg7_N
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF16420--ATG7_N
PF00899--ThiF

Gene Ontology

GO:0005829--C:cytosol
GO:0019779--F:Atg8 activating enzyme activity
GO:0006914--P:autophagy
GO:0050832--P:defense response to fungus
GO:0010150--P:leaf senescence
GO:0006497--P:protein lipidation
GO:0015031--P:protein transport

KEGG

ath:AT5G45900

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000588	Aegilops tauschii	47.06	5.00e-167	581.00
IUUC-Aml-002316	Ailuropoda melanoleuca	47.09	1.00e-150	526.00
IUUC-Atr-002579	Amborella trichopoda	63.00	0.00e+00	892.00
IUUC-Apl-003805	Anas platyrhynchos	45.83	2.00e-166	578.00
IUUC-Aca-004618	Anolis carolinensis	46.76	1.00e-138	486.00
IUUC-Aly-005670	Arabidopsis lyrata	97.80	0.00e+00	1215.00
IUUC-Ago-007838	Ashbya gossypii	39.00	3.00e-108	385.00
IUUC-Acl-008093	Aspergillus clavatus	39.83	5.00e-134	471.00
IUUC-Afl-008663	Aspergillus flavus	41.37	3.00e-128	451.00
IUUC-Afu-008926	Aspergillus fumigatus	38.04	4.00e-131	461.00
IUUC-Ani-009156	Aspergillus nidulans	41.07	8.00e-137	480.00
IUUC-Ang-009853	Aspergillus niger	48.97	4.00e-57	213.00
IUUC-Aor-010055	Aspergillus oryzae	37.86	4.00e-135	474.00
IUUC-Ate-010281	Aspergillus terreus	41.96	1.00e-98	353.00
IUUC-Ame-010939	Astyanax mexicanus	45.31	3.00e-165	574.00
IUUC-Bgr-012006	Blumeria graminis	40.17	1.00e-137	482.00
IUUC-Bta-012336	Bos taurus	45.60	1.00e-155	542.00
IUUC-Bci-013598	Botrytis cinerea	40.03	2.00e-137	482.00
IUUC-Bdi-014170	Brachypodium distachyon	49.78	7.00e-173	600.00
IUUC-Bol-015357	Brassica oleracea	90.36	0.00e+00	1169.00
IUUC-Bra-016835	Brassica rapa	90.27	0.00e+00	1167.00
IUUC-Cel-018172	Caenorhabditis elegans	36.15	7.00e-114	404.00
IUUC-Cja-019544	Callithrix jacchus	45.54	5.00e-163	567.00
IUUC-Cfa-021043	Canis familiaris	45.24	3.00e-160	558.00
IUUC-Cpo-022366	Cavia porcellus	45.02	2.00e-160	558.00
IUUC-Cre-022945	Chlamydomonas reinhardtii	41.50	4.00e-101	361.00
IUUC-Csa-023373	Chlorocebus sabaeus	45.97	1.00e-164	572.00
IUUC-Cho-024965	Choloepus hoffmanni	51.16	8.00e-45	174.00
IUUC-Cin-025710	Ciona intestinalis	45.28	3.00e-155	541.00
IUUC-Cgl-026542	Colletotrichum gloeosporioides	41.55	2.00e-148	518.00
IUUC-Cne-027083	Cryptococcus neoformans	41.54	1.00e-135	476.00
IUUC-Dre-028740	Danio rerio	42.38	4.00e-148	517.00
IUUC-Dno-029637	Dasypus novemcinctus	47.73	3.00e-154	537.00
IUUC-Dor-030492	Dipodomys ordii	45.82	8.00e-164	570.00
IUUC-Dse-031267	Dothistroma septosporum	41.75	7.00e-111	394.00
IUUC-Dme-032084	Drosophila melanogaster	41.75	8.00e-138	483.00
IUUC-Ete-032616	Echinops telfairi	42.92	5.00e-145	507.00
IUUC-Eca-033991	Equus caballus	45.45	1.00e-162	565.00
IUUC-Eeu-035126	Erinaceus europaeus	50.63	6.00e-60	224.00
IUUC-Fca-035472	Felis catus	45.53	2.00e-160	558.00
IUUC-Fal-037178	Ficedula albicollis	45.94	5.00e-165	573.00
IUUC-Fox-037901	Fusarium oxysporum	40.63	3.00e-142	498.00
IUUC-Fso-038279	Fusarium solani	40.92	1.00e-145	509.00
IUUC-Gmo-039329	Gadus morhua	44.54	6.00e-155	540.00
IUUC-Ggr-040061	Gaeumannomyces graminis	40.99	2.00e-137	482.00
IUUC-Gga-040244	Gallus gallus	45.78	5.00e-166	577.00
IUUC-Gac-041880	Gasterosteus aculeatus	42.74	2.00e-145	508.00
IUUC-Gma-043235	Glycine max	70.41	0.00e+00	936.00
IUUC-Ggo-045428	Gorilla gorilla	46.25	2.00e-163	568.00
IUUC-Hsa-046183	Homo sapiens	46.25	3.00e-164	571.00
IUUC-Hvu-047509	Hordeum vulgare	48.24	1.00e-162	566.00
IUUC-Itr-048165	Ictidomys tridecemlineatus	46.78	2.00e-157	548.00
IUUC-Kpa-049142	Komagataella pastoris	39.64	4.00e-124	438.00
IUUC-Lch-049601	Latimeria chalumnae	39.38	4.00e-115	407.00
IUUC-Lpe-051496	Leersia perrieri	48.16	4.00e-164	571.00
IUUC-Loc-051751	Lepisosteus oculatus	45.67	2.00e-169	588.00
IUUC-Lma-053203	Leptosphaeria maculans	40.59	9.00e-108	383.00
IUUC-Laf-053424	Loxodonta africana	45.97	2.00e-163	568.00
IUUC-Mcc-054633	Macaca mulatta	46.11	3.00e-165	574.00
IUUC-Meu-056523	Macropus eugenii	41.91	2.00e-136	478.00
IUUC-Mor-056983	Magnaporthe oryzae	39.61	2.00e-139	489.00
IUUC-Mpo-057615	Magnaporthe poae	41.08	1.00e-144	506.00
IUUC-Mtr-058366	Medicago truncatula	68.72	0.00e+00	921.00
IUUC-Mla-058826	Melampsora laricipopulina	42.61	4.00e-144	504.00
IUUC-Mga-059447	Meleagris gallopavo	45.78	4.00e-166	577.00
IUUC-Mvi-060537	Microbotryum violaceum	40.58	2.00e-137	481.00
IUUC-Mmr-060676	Microcebus murinus	46.11	2.00e-163	569.00
IUUC-Mdo-062967	Monodelphis domestica	44.73	4.00e-157	547.00
IUUC-Mmu-063217	Mus musculus	45.60	2.00e-162	565.00
IUUC-Mac-065527	Musa acuminata	63.05	0.00e+00	828.00
IUUC-Mpu-066417	Mustela putorius furo	45.05	1.00e-159	556.00
IUUC-Mlu-067195	Myotis lucifugus	45.17	3.00e-164	571.00
IUUC-Nfi-068576	Neosartorya fischeri	38.08	2.00e-132	465.00
IUUC-Ncr-068867	Neurospora crassa	40.63	6.00e-144	503.00
IUUC-Nle-069447	Nomascus leucogenys	53.11	1.00e-96	345.00
IUUC-Opr-070737	Ochotona princeps	45.16	5.00e-151	527.00
IUUC-Ont-071260	Oreochromis niloticus	44.09	3.00e-160	558.00
IUUC-Oan-073622	Ornithorhynchus anatinus	45.14	4.00e-112	397.00
IUUC-Ocu-074584	Oryctolagus cuniculus	46.11	1.00e-168	585.00
IUUC-Oba-075483	Oryza barthii	47.38	2.00e-159	556.00
IUUC-Obr-076786	Oryza brachyantha	48.18	1.00e-169	589.00
IUUC-Ogl-077388	Oryza glaberrima	46.95	5.00e-157	548.00
IUUC-Ogu-078618	Oryza glumaepatula	47.68	6.00e-165	574.00
IUUC-Oin-080007	Oryza indica	47.83	5.00e-161	561.00
IUUC-Olo-080994	Oryza longistaminata	46.97	4.00e-150	525.00
IUUC-Ome-081735	Oryza meridionalis	47.68	1.00e-160	559.00
IUUC-Oni-082153	Oryza nivara	47.83	2.00e-160	559.00
IUUC-Opu-083146	Oryza punctata	47.83	2.00e-157	549.00
IUUC-Oru-084919	Oryza rufipogon	47.83	5.00e-161	561.00
IUUC-Osa-086182	Oryza sativa	47.61	3.00e-160	558.00
IUUC-Ola-086441	Oryzias latipes	45.17	3.00e-164	571.00
IUUC-Olu-087664	Ostreococcus lucimarinus	41.94	1.00e-143	503.00
IUUC-Oga-089074	Otolemur garnettii	46.71	4.00e-156	544.00
IUUC-Oar-090159	Ovis aries	45.39	1.00e-155	542.00
IUUC-Ptr-091105	Pan troglodytes	47.79	1.00e-143	502.00
IUUC-Pan-092446	Papio anubis	45.97	1.00e-164	572.00
IUUC-Psi-093372	Pelodiscus sinensis	44.88	1.00e-155	543.00
IUUC-Pma-094661	Petromyzon marinus	42.93	1.00e-134	472.00
IUUC-Pno-094813	Phaeosphaeria nodorum	37.20	8.00e-109	387.00
IUUC-Ppa-095224	Physcomitrella patens	53.51	0.00e+00	686.00
IUUC-Pfo-096565	Poecilia formosa	45.86	2.00e-158	552.00
IUUC-Pop-099702	Populus trichocarpa	69.46	0.00e+00	988.00
IUUC-Pca-100324	Procavia capensis	32.27	7.00e-92	330.00
IUUC-Ppe-101416	Prunus persica	71.26	0.00e+00	961.00
IUUC-Pva-102589	Pteropus vampyrus	43.04	3.00e-146	511.00
IUUC-Pgr-103497	Puccinia graminis	41.80	1.00e-149	523.00
IUUC-Ptt-103718	Puccinia triticina	40.79	7.00e-142	497.00
IUUC-Pte-104206	Pyrenophora teres	38.37	1.00e-102	366.00
IUUC-Pyt-104767	Pyrenophora triticirepentis	37.04	4.00e-118	418.00
IUUC-Rno-105911	Rattus norvegicus	46.03	8.00e-164	570.00
IUUC-Sce-106413	Saccharomyces cerevisiae	38.51	8.00e-122	430.00
IUUC-Sha-106679	Sarcophilus harrisii	45.38	2.00e-160	558.00
IUUC-Sja-107928	Schizosaccharomyces japonicus	37.84	4.00e-123	434.00
IUUC-Spo-108107	Schizosaccharomyces pombe	39.91	2.00e-124	439.00
IUUC-Ssl-108570	Sclerotinia sclerotiorum	40.55	5.00e-143	500.00
IUUC-Smo-109677	Selaginella moellendorffii	51.19	0.00e+00	644.00
IUUC-Sit-110319	Setaria italica	43.63	2.00e-137	483.00
IUUC-Sly-111215	Solanum lycopersicum	70.20	0.00e+00	957.00
IUUC-Stu-112442	Solanum tuberosum	71.16	0.00e+00	968.00
IUUC-Sar-113370	Sorex araneus	50.75	2.00e-103	369.00
IUUC-Sbi-114261	Sorghum bicolor	44.46	4.00e-144	505.00
IUUC-Sre-114997	Sporisorium reilianum	40.72	1.00e-146	512.00
IUUC-Ssc-115304	Sus scrofa	45.64	5.00e-158	550.00
IUUC-Tgu-117235	Taeniopygia guttata	45.83	6.00e-163	566.00
IUUC-Tru-118374	Takifugu rubripes	45.34	8.00e-161	560.00
IUUC-Tsy-118966	Tarsius syrichta	39.28	1.00e-124	439.00
IUUC-Tni-120269	Tetraodon nigroviridis	44.51	4.00e-145	507.00
IUUC-Tca-121245	Theobroma cacao	70.46	0.00e+00	1017.00
IUUC-Tre-121966	Trichoderma reesei	41.05	7.00e-139	486.00
IUUC-Tvi-122360	Trichoderma virens	40.98	3.00e-134	471.00
IUUC-Tae-125251	Triticum aestivum	47.20	4.00e-167	581.00
IUUC-Tur-126294	Triticum urartu	47.20	8.00e-162	563.00
IUUC-Tme-127117	Tuber melanosporum	41.52	2.00e-138	485.00
IUUC-Tbe-127662	Tupaia belangeri	47.50	3.00e-43	169.00
IUUC-Ttr-129054	Tursiops truncatus	45.39	1.00e-160	559.00
IUUC-Uma-129526	Ustilago maydis	38.80	6.00e-145	507.00
IUUC-Vda-129878	Verticillium dahliae	39.97	3.00e-141	494.00
IUUC-Vpa-130264	Vicugna pacos	40.52	2.00e-87	315.00
IUUC-Vvi-131163	Vitis vinifera	72.31	0.00e+00	1011.00
IUUC-Xtr-132328	Xenopus tropicalis	34.74	1.00e-94	340.00
IUUC-Xma-133015	Xiphophorus maculatus	44.59	1.00e-147	516.00
IUUC-Yli-134468	Yarrowia lipolytica	35.85	1.00e-112	399.00
IUUC-Zma-134871	Zea mays	48.00	4.00e-166	578.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence