iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068833

Ensembl Protein ID

EAA27491

UniProt Accession

Q96U88; Q1K5B1; ATG18_NEUCR

Genbank Protein ID

CAD11327.1; EAA27491.2

Protein Name

Autophagy-related protein 18

Genbank Nucleotide ID

AL390091; CM002237

Gene Name

apg-10; atg18; B12F1.070; NCU03441

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU03441	EAA27491	EAA27491

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.00e-06	26.5	189	225

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgt.ikvWDlrtgvl 35
           H+++ +++a+ +d  +l+++s  gt i+v++l +g +
   Q: 189  HKSPLCAIALnHDgSMLATASETGTiIRVFSLPQGQK 225
           9*********97789**********999***998876 PP

Organism

Neurospora crassa

Functional Description
(View)

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct apg-7/atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Protein Sequence
(Fasta)

MTGGTLNFIT FNQDYSCLAV GTSKGFRFYH TDPFSKIFSS DEGNVSIIEM LFSTSLVALI 60
LTPRQLEIQN TKRASVICEL TFPSAVLAVR LNRKRLAVVL ECQIYLYDVS NMNLVQTIDT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCAAACACC ACTCCCCTGC CATTGCCGCC TTGGGAGCTT CAAGTTACCA ACCTCTATTC 60
TTCTTTCTCT CTCCAGTCAC AACAACACTG CACTTCGGTT CCGTTCTTTT CAAAGAGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0967--Endosome
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0926--Vacuole
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

SMART

SM00320--WD40

Gene Ontology

GO:0010008--C:endosome membrane
GO:0000329--C:fungal-type vacuole membrane
GO:0005794--C:Golgi apparatus
GO:0034045--C:pre-autophagosomal structure membrane
GO:0016236--P:macroautophagy
GO:0015031--P:protein transport

KEGG

ncr:NCU03441

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000966	Aegilops tauschii	34.72	6.00e-41	159.00
IUUC-Aml-001842	Ailuropoda melanoleuca	34.83	3.00e-61	227.00
IUUC-Atr-002710	Amborella trichopoda	30.65	5.00e-41	159.00
IUUC-Apl-003390	Anas platyrhynchos	34.62	2.00e-61	227.00
IUUC-Aca-004975	Anolis carolinensis	34.80	5.00e-65	239.00
IUUC-Aly-006440	Arabidopsis lyrata	36.47	1.00e-35	142.00
IUUC-Ath-007660	Arabidopsis thaliana	34.72	2.00e-36	144.00
IUUC-Ago-007948	Ashbya gossypii	47.17	2.00e-42	165.00
IUUC-Acl-008148	Aspergillus clavatus	55.74	2.00e-130	456.00
IUUC-Afl-008562	Aspergillus flavus	56.97	2.00e-128	449.00
IUUC-Afu-008936	Aspergillus fumigatus	56.71	6.00e-133	465.00
IUUC-Ani-009254	Aspergillus nidulans	55.53	9.00e-133	464.00
IUUC-Ang-009798	Aspergillus niger	56.32	2.00e-130	456.00
IUUC-Aor-010066	Aspergillus oryzae	56.97	2.00e-128	449.00
IUUC-Ate-010266	Aspergillus terreus	55.53	1.00e-130	457.00
IUUC-Ame-010727	Astyanax mexicanus	35.75	3.00e-66	244.00
IUUC-Bta-012655	Bos taurus	35.25	1.00e-65	241.00
IUUC-Bci-013627	Botrytis cinerea	65.58	1.00e-152	530.00
IUUC-Bdi-014719	Brachypodium distachyon	35.74	8.00e-37	146.00
IUUC-Bol-015119	Brassica oleracea	35.19	5.00e-35	140.00
IUUC-Bra-017319	Brassica rapa	35.19	3.00e-35	140.00
IUUC-Cel-018503	Caenorhabditis elegans	30.11	7.00e-45	172.00
IUUC-Cja-018829	Callithrix jacchus	38.46	2.00e-49	188.00
IUUC-Cfa-020858	Canis familiaris	34.60	4.00e-61	226.00
IUUC-Cpo-022235	Cavia porcellus	41.51	9.00e-55	205.00
IUUC-Cre-022613	Chlamydomonas reinhardtii	35.93	5.00e-41	160.00
IUUC-Csa-023963	Chlorocebus sabaeus	31.28	2.00e-54	204.00
IUUC-Cho-024328	Choloepus hoffmanni	35.25	1.00e-57	215.00
IUUC-Cin-025343	Ciona intestinalis	32.95	1.00e-52	198.00
IUUC-Csv-025920	Ciona savignyi	34.52	6.00e-57	212.00
IUUC-Cgl-026425	Colletotrichum gloeosporioides	73.86	2.00e-56	211.00
IUUC-Cne-026947	Cryptococcus neoformans	46.14	2.00e-96	344.00
IUUC-Dre-027490	Danio rerio	35.75	3.00e-66	243.00
IUUC-Dno-030057	Dasypus novemcinctus	34.83	1.00e-61	228.00
IUUC-Dor-030472	Dipodomys ordii	41.95	6.00e-49	186.00
IUUC-Dse-031215	Dothistroma septosporum	45.62	2.00e-107	380.00
IUUC-Dme-031881	Drosophila melanogaster	32.04	5.00e-29	119.00
IUUC-Ete-032362	Echinops telfairi	32.29	7.00e-53	199.00
IUUC-Eca-034362	Equus caballus	34.60	5.00e-62	229.00
IUUC-Eeu-034479	Erinaceus europaeus	31.07	2.00e-18	83.60
IUUC-Fca-036230	Felis catus	34.92	4.00e-62	229.00
IUUC-Fal-036782	Ficedula albicollis	34.37	1.00e-61	228.00
IUUC-Fox-037797	Fusarium oxysporum	68.97	6.00e-143	498.00
IUUC-Fso-038174	Fusarium solani	67.71	1.00e-143	500.00
IUUC-Gmo-039706	Gadus morhua	33.26	3.00e-56	210.00
IUUC-Ggr-040113	Gaeumannomyces graminis	78.03	1.00e-114	404.00
IUUC-Gga-040690	Gallus gallus	35.12	8.00e-65	239.00
IUUC-Gac-041360	Gasterosteus aculeatus	35.50	2.00e-65	241.00
IUUC-Gma-043876	Glycine max	38.11	4.00e-48	183.00
IUUC-Ggo-045610	Gorilla gorilla	29.87	2.00e-30	124.00
IUUC-Hsa-046782	Homo sapiens	38.81	4.00e-52	196.00
IUUC-Hvu-047851	Hordeum vulgare	34.72	7.00e-41	159.00
IUUC-Itr-048693	Ictidomys tridecemlineatus	38.81	2.00e-52	197.00
IUUC-Kpa-049378	Komagataella pastoris	42.91	2.00e-69	254.00
IUUC-Lch-050413	Latimeria chalumnae	32.74	1.00e-59	222.00
IUUC-Lpe-051205	Leersia perrieri	28.90	4.00e-42	163.00
IUUC-Loc-052379	Lepisosteus oculatus	31.70	3.00e-33	133.00
IUUC-Lma-052948	Leptosphaeria maculans	52.61	1.00e-128	451.00
IUUC-Laf-054007	Loxodonta africana	35.32	2.00e-65	241.00
IUUC-Mcc-055829	Macaca mulatta	30.66	1.00e-32	131.00
IUUC-Meu-056020	Macropus eugenii	29.03	4.00e-26	110.00
IUUC-Mor-057125	Magnaporthe oryzae	66.31	5.00e-162	562.00
IUUC-Mpo-057416	Magnaporthe poae	28.52	3.00e-27	114.00
IUUC-Mtr-058536	Medicago truncatula	30.31	2.00e-42	164.00
IUUC-Mla-058885	Melampsora laricipopulina	25.19	4.00e-15	72.80
IUUC-Mga-059795	Meleagris gallopavo	34.62	3.00e-61	226.00
IUUC-Mvi-060219	Microbotryum violaceum	45.90	5.00e-96	342.00
IUUC-Mmr-061096	Microcebus murinus	33.85	9.00e-63	232.00
IUUC-Mdo-062881	Monodelphis domestica	34.51	1.00e-63	234.00
IUUC-Mmu-063787	Mus musculus	34.78	1.00e-64	238.00
IUUC-Mac-064838	Musa acuminata	29.52	1.00e-44	171.00
IUUC-Mpu-066019	Mustela putorius furo	33.41	3.00e-55	207.00
IUUC-Mlu-068016	Myotis lucifugus	35.48	4.00e-66	243.00
IUUC-Nfi-068424	Neosartorya fischeri	57.41	2.00e-134	470.00
IUUC-Nle-069047	Nomascus leucogenys	31.90	7.00e-36	142.00
IUUC-Opr-070933	Ochotona princeps	42.35	5.00e-34	136.00
IUUC-Ont-072495	Oreochromis niloticus	35.73	3.00e-66	243.00
IUUC-Oan-073084	Ornithorhynchus anatinus	35.13	4.00e-58	216.00
IUUC-Ocu-074689	Oryctolagus cuniculus	40.67	3.00e-54	204.00
IUUC-Oba-075601	Oryza barthii	35.12	3.00e-36	144.00
IUUC-Obr-076476	Oryza brachyantha	29.23	4.00e-42	163.00
IUUC-Ogl-077630	Oryza glaberrima	29.04	9.00e-43	166.00
IUUC-Ogu-078089	Oryza glumaepatula	35.12	3.00e-36	144.00
IUUC-Oin-079071	Oryza indica	35.12	3.00e-36	144.00
IUUC-Olo-080657	Oryza longistaminata	29.50	3.00e-41	162.00
IUUC-Ome-081702	Oryza meridionalis	34.72	4.00e-41	160.00
IUUC-Oni-083063	Oryza nivara	35.12	3.00e-36	144.00
IUUC-Opu-083356	Oryza punctata	34.78	5.00e-35	140.00
IUUC-Oru-084845	Oryza rufipogon	36.98	5.00e-36	143.00
IUUC-Osa-086113	Oryza sativa	35.12	3.00e-36	144.00
IUUC-Ola-086628	Oryzias latipes	33.93	8.00e-39	152.00
IUUC-Olu-087808	Ostreococcus lucimarinus	33.83	2.00e-42	164.00
IUUC-Oga-088894	Otolemur garnettii	38.81	2.00e-52	197.00
IUUC-Oar-089850	Ovis aries	34.60	2.00e-62	230.00
IUUC-Ptr-090456	Pan troglodytes	38.81	4.00e-52	197.00
IUUC-Pan-092111	Papio anubis	41.42	8.00e-56	209.00
IUUC-Psi-094095	Pelodiscus sinensis	34.61	8.00e-62	229.00
IUUC-Pma-094403	Petromyzon marinus	31.62	1.00e-31	128.00
IUUC-Pno-095015	Phaeosphaeria nodorum	52.63	7.00e-122	428.00
IUUC-Ppa-095480	Physcomitrella patens	31.40	4.00e-43	167.00
IUUC-Pfo-096987	Poecilia formosa	35.29	3.00e-65	240.00
IUUC-Pab-097754	Pongo abelii	41.11	1.00e-51	195.00
IUUC-Pop-099760	Populus trichocarpa	33.70	3.00e-38	150.00
IUUC-Pca-100176	Procavia capensis	27.61	6.00e-23	99.80
IUUC-Ppe-101963	Prunus persica	34.44	1.00e-32	131.00
IUUC-Pva-103047	Pteropus vampyrus	33.41	3.00e-61	227.00
IUUC-Pgr-103258	Puccinia graminis	24.36	2.00e-12	65.50
IUUC-Ptt-103915	Puccinia triticina	24.91	2.00e-17	82.00
IUUC-Pte-104139	Pyrenophora teres	52.71	3.00e-122	429.00
IUUC-Pyt-104488	Pyrenophora triticirepentis	52.13	1.00e-120	424.00
IUUC-Rno-105990	Rattus norvegicus	34.55	1.00e-64	238.00
IUUC-Sce-106327	Saccharomyces cerevisiae	34.94	2.00e-79	287.00
IUUC-Sha-106581	Sarcophilus harrisii	34.38	1.00e-60	225.00
IUUC-Sja-107913	Schizosaccharomyces japonicus	41.01	6.00e-80	289.00
IUUC-Spo-108068	Schizosaccharomyces pombe	49.81	7.00e-66	242.00
IUUC-Ssl-108418	Sclerotinia sclerotiorum	65.64	4.00e-160	555.00
IUUC-Smo-109446	Selaginella moellendorffii	30.34	4.00e-46	176.00
IUUC-Sit-110655	Setaria italica	35.86	3.00e-36	144.00
IUUC-Sly-111030	Solanum lycopersicum	34.33	4.00e-40	157.00
IUUC-Stu-112534	Solanum tuberosum	35.71	5.00e-38	150.00
IUUC-Sar-113276	Sorex araneus	31.07	2.00e-18	84.00
IUUC-Sbi-114057	Sorghum bicolor	34.78	1.00e-34	138.00
IUUC-Sre-115219	Sporisorium reilianum	45.88	3.00e-99	353.00
IUUC-Ssc-116360	Sus scrofa	35.48	6.00e-66	243.00
IUUC-Tgu-116951	Taeniopygia guttata	34.62	3.00e-61	227.00
IUUC-Tru-117889	Takifugu rubripes	33.63	1.00e-62	232.00
IUUC-Tsy-119533	Tarsius syrichta	42.35	2.00e-17	80.50
IUUC-Tni-119729	Tetraodon nigroviridis	32.71	4.00e-32	130.00
IUUC-Tca-121459	Theobroma cacao	32.49	4.00e-24	103.00
IUUC-Tre-121895	Trichoderma reesei	69.39	2.00e-162	563.00
IUUC-Tvi-122311	Trichoderma virens	67.11	1.00e-164	571.00
IUUC-Tae-124634	Triticum aestivum	33.90	1.00e-34	139.00
IUUC-Tur-126757	Triticum urartu	34.34	5.00e-40	156.00
IUUC-Ttr-128940	Tursiops truncatus	30.67	2.00e-26	110.00
IUUC-Uma-129438	Ustilago maydis	46.53	7.00e-93	332.00
IUUC-Vda-129782	Verticillium dahliae	62.17	1.00e-103	368.00
IUUC-Vvi-131674	Vitis vinifera	29.12	9.00e-44	169.00
IUUC-Xtr-131806	Xenopus tropicalis	32.62	2.00e-36	144.00
IUUC-Xma-133370	Xiphophorus maculatus	35.29	3.00e-65	240.00
IUUC-Yli-134337	Yarrowia lipolytica	47.44	1.00e-97	347.00
IUUC-Zma-135902	Zea mays	31.21	2.00e-37	147.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence