iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012360

Ensembl Protein ID

ENSBTAP00000007100.4

UniProt Accession

Q3MQ24; Q3SZN7; ATG5_BOVIN

Genbank Protein ID

CAJ31263.1; AAI02771.1

Protein Name

Autophagy protein 5

Genbank Nucleotide ID

AM086994; BC102770

Gene Name

ATG5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000005400.4	ENSBTAT00000007100.4	ENSBTAP00000007100.4

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/Other	26.37	3.00e-05	42.70	IUUC-Sce-106216

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD (By similarity).

Protein Sequence
(Fasta)

MTDDKDVLRD VWFGRIPTCF TLYQDEITER EAEPYYLLLP RVSYLTLVTD KVKKHFQKVM 60
RQEDISEIWF EYEGTPLKWH YPIGLLFDLL ASSSALPWNI TVHFKSFPEK DLLHCPSKDV 120

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Nucleotide Sequence
(Fasta)

GGACTTGCGG TGGGCTTCCA GGGCTCCGCG GCGCTGCGGG CCGTCTTTGC TGGATACCGG 60
AGGGCGGAAG TGGAGCTGGG CTCTACTCCG ACCTCCGCGC AGGTGTCTTC TGCGGCTGCG 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0053--Apoptosis
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR007239--Atg5

Pfam

PF04106--APG5

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0005930--C:axoneme
GO:0034045--C:pre-autophagosomal structure membrane
GO:0006915--P:apoptotic process
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0006995--P:cellular response to nitrogen starvation
GO:0045087--P:innate immune response
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:1902017--P:regulation of cilium assembly

KEGG

bta:532686

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000583	Aegilops tauschii	33.79	1.00e-22	101.00
IUUC-Aml-002403	Ailuropoda melanoleuca	99.37	2.00e-87	315.00
IUUC-Atr-002645	Amborella trichopoda	35.06	3.00e-20	92.40
IUUC-Apl-003611	Anas platyrhynchos	93.71	4.00e-88	317.00
IUUC-Aca-004411	Anolis carolinensis	92.45	2.00e-87	315.00
IUUC-Aly-005636	Arabidopsis lyrata	33.12	1.00e-20	93.60
IUUC-Ath-006959	Arabidopsis thaliana	33.12	4.00e-20	92.00
IUUC-Ago-007978	Ashbya gossypii	35.00	1.00e-03	37.00
IUUC-Acl-008328	Aspergillus clavatus	34.78	2.00e-14	73.20
IUUC-Afl-008638	Aspergillus flavus	30.39	6.00e-21	94.70
IUUC-Afu-009042	Aspergillus fumigatus	31.67	4.00e-22	98.60
IUUC-Ani-009364	Aspergillus nidulans	32.00	1.00e-21	97.10
IUUC-Aor-009889	Aspergillus oryzae	30.39	6.00e-21	94.70
IUUC-Ate-010511	Aspergillus terreus	31.18	4.00e-10	56.20
IUUC-Ame-011644	Astyanax mexicanus	86.08	7.00e-38	147.00
IUUC-Bgr-012153	Blumeria graminis	29.25	5.00e-08	51.20
IUUC-Bci-013723	Botrytis cinerea	32.67	8.00e-09	53.90
IUUC-Bdi-014520	Brachypodium distachyon	35.51	3.00e-18	86.30
IUUC-Bol-016053	Brassica oleracea	32.92	1.00e-22	100.00
IUUC-Bra-017072	Brassica rapa	33.12	1.00e-22	100.00
IUUC-Cel-018529	Caenorhabditis elegans	36.02	1.00e-20	93.20
IUUC-Cja-019569	Callithrix jacchus	98.74	4.00e-87	313.00
IUUC-Cfa-020473	Canis familiaris	99.37	2.00e-87	315.00
IUUC-Cpo-021421	Cavia porcellus	97.48	2.00e-86	311.00
IUUC-Cre-022862	Chlamydomonas reinhardtii	31.17	3.00e-18	85.10
IUUC-Csa-024197	Chlorocebus sabaeus	98.74	5.00e-87	313.00
IUUC-Cho-024521	Choloepus hoffmanni	95.93	1.00e-61	229.00
IUUC-Cin-025119	Ciona intestinalis	49.68	1.00e-43	169.00
IUUC-Csv-026192	Ciona savignyi	48.41	1.00e-42	166.00
IUUC-Cgl-026686	Colletotrichum gloeosporioides	31.82	6.10e-02	31.20
IUUC-Dre-028466	Danio rerio	84.91	3.00e-80	291.00
IUUC-Dse-031228	Dothistroma septosporum	28.25	3.00e-19	89.00
IUUC-Dme-031703	Drosophila melanogaster	50.93	1.00e-45	176.00
IUUC-Ete-032482	Echinops telfairi	96.75	4.00e-63	234.00
IUUC-Eca-034036	Equus caballus	98.74	3.00e-87	314.00
IUUC-Eeu-035235	Erinaceus europaeus	98.11	1.00e-86	312.00
IUUC-Fca-036263	Felis catus	99.37	2.00e-87	315.00
IUUC-Fal-037064	Ficedula albicollis	93.08	9.00e-88	316.00
IUUC-Fox-037813	Fusarium oxysporum	27.63	1.00e-06	46.60
IUUC-Fso-038139	Fusarium solani	27.74	2.00e-07	48.90
IUUC-Gmo-039509	Gadus morhua	83.65	7.00e-80	289.00
IUUC-Gga-040517	Gallus gallus	92.45	3.00e-87	314.00
IUUC-Gac-042270	Gasterosteus aculeatus	84.28	4.00e-80	291.00
IUUC-Gma-044400	Glycine max	36.60	6.00e-22	97.40
IUUC-Ggo-045048	Gorilla gorilla	98.11	9.00e-86	309.00
IUUC-Hsa-046744	Homo sapiens	98.74	5.00e-87	313.00
IUUC-Kpa-049174	Komagataella pastoris	24.06	1.00e-07	50.40
IUUC-Lch-049475	Latimeria chalumnae	91.82	2.00e-86	311.00
IUUC-Lpe-051283	Leersia perrieri	37.29	5.00e-21	96.30
IUUC-Loc-052446	Lepisosteus oculatus	86.79	7.00e-83	300.00
IUUC-Lma-053278	Leptosphaeria maculans	32.26	1.00e-20	94.00
IUUC-Laf-054020	Loxodonta africana	98.11	1.00e-86	312.00
IUUC-Mcc-055176	Macaca mulatta	98.74	5.00e-87	313.00
IUUC-Mor-057164	Magnaporthe oryzae	30.47	3.00e-07	49.30
IUUC-Mtr-058424	Medicago truncatula	37.09	6.00e-22	97.80
IUUC-Mla-058872	Melampsora laricipopulina	35.33	1.00e-18	87.40
IUUC-Mga-059859	Meleagris gallopavo	92.45	3.00e-87	314.00
IUUC-Mmr-061482	Microcebus murinus	99.37	2.00e-87	315.00
IUUC-Mdo-062371	Monodelphis domestica	97.48	2.00e-91	328.00
IUUC-Mmu-063139	Mus musculus	97.48	9.00e-87	312.00
IUUC-Mac-065332	Musa acuminata	36.24	1.00e-23	103.00
IUUC-Mpu-066783	Mustela putorius furo	98.74	8.00e-87	313.00
IUUC-Mlu-068165	Myotis lucifugus	97.48	1.00e-85	309.00
IUUC-Nfi-068578	Neosartorya fischeri	32.22	1.00e-22	100.00
IUUC-Ncr-068636	Neurospora crassa	27.56	1.00e-03	37.40
IUUC-Nle-069740	Nomascus leucogenys	98.74	5.00e-87	313.00
IUUC-Opr-070802	Ochotona princeps	98.11	8.00e-86	310.00
IUUC-Ont-072222	Oreochromis niloticus	85.53	6.00e-81	293.00
IUUC-Oan-072760	Ornithorhynchus anatinus	96.86	3.00e-91	327.00
IUUC-Ocu-074844	Oryctolagus cuniculus	91.07	2.00e-26	111.00
IUUC-Oba-075834	Oryza barthii	34.42	3.00e-22	99.00
IUUC-Obr-076230	Oryza brachyantha	35.00	1.00e-11	63.90
IUUC-Ogl-077554	Oryza glaberrima	34.42	4.00e-22	99.00
IUUC-Ogu-078687	Oryza glumaepatula	34.42	3.00e-22	99.40
IUUC-Oin-079677	Oryza indica	35.06	1.00e-22	100.00
IUUC-Olo-081078	Oryza longistaminata	38.02	1.00e-22	100.00
IUUC-Ome-081548	Oryza meridionalis	35.76	7.00e-25	109.00
IUUC-Oni-082050	Oryza nivara	35.06	2.00e-22	100.00
IUUC-Opu-083609	Oryza punctata	34.84	2.00e-22	100.00
IUUC-Oru-085057	Oryza rufipogon	35.06	2.00e-22	100.00
IUUC-Osa-085917	Oryza sativa	35.06	2.00e-22	99.80
IUUC-Ola-087032	Oryzias latipes	81.13	2.00e-77	282.00
IUUC-Oga-088468	Otolemur garnettii	98.11	2.00e-91	328.00
IUUC-Oar-089751	Ovis aries	100.00	8.00e-88	316.00
IUUC-Ptr-091064	Pan troglodytes	98.74	5.00e-87	313.00
IUUC-Pan-092505	Papio anubis	98.74	5.00e-87	313.00
IUUC-Psi-093086	Pelodiscus sinensis	94.34	2.00e-89	322.00
IUUC-Pno-094825	Phaeosphaeria nodorum	32.90	2.00e-17	82.80
IUUC-Ppa-095419	Physcomitrella patens	35.14	6.00e-25	108.00
IUUC-Pfo-096224	Poecilia formosa	82.39	7.00e-79	286.00
IUUC-Pab-098501	Pongo abelii	98.11	7.00e-86	310.00
IUUC-Pop-099243	Populus trichocarpa	35.62	2.00e-20	92.80
IUUC-Ppe-101255	Prunus persica	35.44	6.00e-23	101.00
IUUC-Pva-102828	Pteropus vampyrus	98.11	2.00e-86	311.00
IUUC-Pgr-103672	Puccinia graminis	33.54	5.00e-15	75.50
IUUC-Ptt-104013	Puccinia triticina	32.93	1.00e-14	74.30
IUUC-Pyt-104615	Pyrenophora triticirepentis	30.98	4.00e-18	85.50
IUUC-Rno-106089	Rattus norvegicus	93.80	7.00e-65	239.00
IUUC-Sce-106216	Saccharomyces cerevisiae	28.57	3.00e-07	49.30
IUUC-Sha-106484	Sarcophilus harrisii	96.23	3.00e-90	324.00
IUUC-Sja-107699	Schizosaccharomyces japonicus	30.38	3.00e-17	81.60
IUUC-Spo-108177	Schizosaccharomyces pombe	29.71	5.00e-15	74.70
IUUC-Ssl-108475	Sclerotinia sclerotiorum	33.33	3.00e-09	55.50
IUUC-Smo-109473	Selaginella moellendorffii	32.28	2.00e-20	93.20
IUUC-Sit-110736	Setaria italica	35.76	3.00e-25	109.00
IUUC-Sly-111657	Solanum lycopersicum	37.09	1.00e-25	110.00
IUUC-Sar-113050	Sorex araneus	99.19	4.00e-64	237.00
IUUC-Sbi-114258	Sorghum bicolor	35.66	1.00e-22	100.00
IUUC-Sre-114902	Sporisorium reilianum	30.69	1.00e-19	91.30
IUUC-Ssc-116166	Sus scrofa	100.00	4.00e-88	317.00
IUUC-Tgu-116814	Taeniopygia guttata	93.08	1.00e-87	315.00
IUUC-Tru-118172	Takifugu rubripes	83.65	1.00e-80	292.00
IUUC-Tsy-119010	Tarsius syrichta	97.48	9.00e-91	326.00
IUUC-Tni-120397	Tetraodon nigroviridis	84.91	8.00e-82	296.00
IUUC-Tca-121283	Theobroma cacao	36.42	6.00e-23	101.00
IUUC-Tvi-122545	Trichoderma virens	28.85	1.00e-05	43.10
IUUC-Tae-122685	Triticum aestivum	32.21	2.00e-22	99.80
IUUC-Tur-126407	Triticum urartu	35.77	1.00e-21	97.40
IUUC-Tme-126913	Tuber melanosporum	30.86	4.00e-24	105.00
IUUC-Tbe-127738	Tupaia belangeri	96.25	9.00e-43	166.00
IUUC-Ttr-128528	Tursiops truncatus	100.00	8.00e-88	316.00
IUUC-Uma-129625	Ustilago maydis	27.27	3.00e-18	86.30
IUUC-Vda-129906	Verticillium dahliae	23.88	5.90e-02	31.20
IUUC-Vpa-130223	Vicugna pacos	100.00	7.00e-88	316.00
IUUC-Vvi-131617	Vitis vinifera	37.50	1.00e-23	103.00
IUUC-Xtr-132288	Xenopus tropicalis	91.19	5.00e-85	306.00
IUUC-Xma-134214	Xiphophorus maculatus	81.76	3.00e-78	283.00
IUUC-Yli-134377	Yarrowia lipolytica	21.18	1.00e+00	26.90
IUUC-Zma-135108	Zea mays	37.29	1.00e-21	97.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence