iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071671

Ensembl Protein ID

ENSONIP00000015569.1

UniProt Accession

I3K374; I3K374_ORENI

Genbank Protein ID

ENSONIP00000015569

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01019475

Gene Name

uba1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000012360.1	ENSONIT00000015582.1	ENSONIP00000015569.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	6.60e-220	730.8	452	930

Active Site

Position(s)	Description	Evidence
632	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkeln 85
           YD+Qi+++G + q+ l +++++lvGag++GcEllKn++++G+    g++ v+Dmdt+e+snlnrqFLfr++dv k K+++aa+a+k +n
   Q: 452  YDGQIAVFGTKMQDLLAKQRYFLVGAGAIGCELLKNFAMIGLatgeGEVIVTDMDTIEKSNLNRQFLFRPWDVTKMKSDTAAAAVKLMN 540
           ***************************************************************************************** PP
   S: 86   pdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkti 171
           p ++++ h++++ +++e+i+   Ff+ +d+V++aldn++ar++++r+c+++r+pl+esgtlG++G+v+v+i+ lte+ys+s+dpp+k+i
   Q: 541  PAIKITGHQNRVGPDTERIYdddFFESLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSI 629
           ***************************************************************************************** PP
   S: 172  Pfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakt 248
           P+ctlk++pna+eht++wa            + + ++l +++++ e++ kl  +++ e++++v ++l++  ++n+++++++a+++++ +
   Q: 630  PICTLKNFPNAIEHTLQWArdefeglfkqppENAMQYL-TDPKFMERTLKLPGAQPAEVLEAVYKSLVTDCPQNWADCVAWARNHWQCQ 717
           *******************************9999999.78888899999*************************************** PP
   S: 249  tinsikqllksfecdivtkskspfwv..............................................................s 275
           ++n+i+qll++f++d++t+s++pfw+                                                              +
   Q: 718  YSNNIRQLLHNFPPDQLTSSGAPFWSgpkrcphplefstsnelhmdyvvaaanlfaqtyglqgstdragvikilqdvkvppftprsgvK 806
           *****************************************999999999999999999999999999888888777555533332221 PP
   S: 276  fcsnaealqvpekvekdeevvkasap....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddli 358
                        +++d+e +  +++    +  +l+a+    +  + k ++++fekddd   ++d++ aa+nlrae+++i+p  d+++ 
   Q: 807  ------------IHVSDQELQNNNSSiddtKLEELKAMLPSPESFQFKLTSIDFEKDDDTnfHMDFIVAASNLRAENYDIPP-TDRHKS 882
           ............3333333333333333443333333333334444556679******************************.****** PP
   S: 359  keiagniipaiattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           k iag+iipaiatt+a+v Gl+++E++K+++g  k e +kn f+++a+
   Q: 883  KLIAGKIIPAIATTTAAVVGLVCLELFKIIKGhkKLESYKNGFMNLAL 930
           ********************************99999******99875 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MSSSPLSKKR RLSGTETKTG SHCSSSNSVR TDLSHTPANG MAKNGNDAEI DEGLYSRQLY 60
VLGHEAMKRM QNSNVLISGM RGLGVEIAKN VILGGVRSVT IHDEGVAEWR DLSSQFYLRE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACTTCGGTT TAGTCCATGG TTGTAAGGCT ACGGGGGTAA CAAAAGTAGT CTTGTTTCTA 60
AATATACAAC TAAACCACAG AGCAGTGTAA TATTCAGTAC GCTTTATCTT GTGGATGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0007409--P:axonogenesis
GO:0006464--P:cellular protein modification process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000456	Aegilops tauschii	45.95	0.00e+00	900.00
IUUC-Aml-001311	Ailuropoda melanoleuca	77.70	0.00e+00	1734.00
IUUC-Atr-002684	Amborella trichopoda	44.36	0.00e+00	893.00
IUUC-Aca-004620	Anolis carolinensis	78.45	0.00e+00	1721.00
IUUC-Aly-005515	Arabidopsis lyrata	44.21	0.00e+00	911.00
IUUC-Ath-006891	Arabidopsis thaliana	44.92	0.00e+00	917.00
IUUC-Ago-007873	Ashbya gossypii	53.30	0.00e+00	1030.00
IUUC-Acl-008181	Aspergillus clavatus	55.57	0.00e+00	1070.00
IUUC-Afl-008455	Aspergillus flavus	54.47	0.00e+00	1018.00
IUUC-Afu-009065	Aspergillus fumigatus	55.27	0.00e+00	1085.00
IUUC-Ani-009371	Aspergillus nidulans	54.15	0.00e+00	1054.00
IUUC-Ang-009737	Aspergillus niger	55.05	0.00e+00	1062.00
IUUC-Aor-010007	Aspergillus oryzae	54.47	0.00e+00	1018.00
IUUC-Ate-010466	Aspergillus terreus	54.40	0.00e+00	1084.00
IUUC-Ame-010933	Astyanax mexicanus	88.47	0.00e+00	1877.00
IUUC-Bgr-012281	Blumeria graminis	53.47	0.00e+00	1055.00
IUUC-Bta-012767	Bos taurus	78.75	0.00e+00	1754.00
IUUC-Bci-013721	Botrytis cinerea	55.85	0.00e+00	1035.00
IUUC-Bdi-014335	Brachypodium distachyon	44.37	0.00e+00	895.00
IUUC-Bol-015665	Brassica oleracea	44.27	0.00e+00	895.00
IUUC-Bra-017252	Brassica rapa	43.30	0.00e+00	905.00
IUUC-Cel-018260	Caenorhabditis elegans	49.25	0.00e+00	959.00
IUUC-Cja-019152	Callithrix jacchus	78.38	0.00e+00	1741.00
IUUC-Cfa-020622	Canis familiaris	76.86	0.00e+00	1678.00
IUUC-Cpo-022526	Cavia porcellus	77.62	0.00e+00	1725.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	45.60	0.00e+00	867.00
IUUC-Csa-023780	Chlorocebus sabaeus	78.56	0.00e+00	1751.00
IUUC-Cin-025790	Ciona intestinalis	63.61	0.00e+00	1349.00
IUUC-Csv-026084	Ciona savignyi	60.20	0.00e+00	1328.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	55.03	0.00e+00	1095.00
IUUC-Cne-026960	Cryptococcus neoformans	57.58	0.00e+00	1119.00
IUUC-Cme-027290	Cyanidioschyzon merolae	44.75	0.00e+00	830.00
IUUC-Dre-028149	Danio rerio	87.52	0.00e+00	1894.00
IUUC-Dno-028884	Dasypus novemcinctus	78.38	0.00e+00	1748.00
IUUC-Dor-030229	Dipodomys ordii	74.79	0.00e+00	1656.00
IUUC-Dse-031524	Dothistroma septosporum	53.55	0.00e+00	1050.00
IUUC-Dme-032045	Drosophila melanogaster	60.10	0.00e+00	1290.00
IUUC-Ete-032544	Echinops telfairi	65.97	0.00e+00	702.00
IUUC-Eca-033330	Equus caballus	78.19	0.00e+00	1749.00
IUUC-Eeu-034717	Erinaceus europaeus	42.22	7.00e-163	568.00
IUUC-Fca-036255	Felis catus	78.56	0.00e+00	1740.00
IUUC-Fal-037445	Ficedula albicollis	47.49	0.00e+00	850.00
IUUC-Fox-038007	Fusarium oxysporum	55.20	4.00e-164	571.00
IUUC-Fso-038339	Fusarium solani	55.32	0.00e+00	1058.00
IUUC-Gmo-039338	Gadus morhua	84.78	0.00e+00	1791.00
IUUC-Ggr-039823	Gaeumannomyces graminis	54.09	0.00e+00	1105.00
IUUC-Gga-040365	Gallus gallus	45.84	0.00e+00	781.00
IUUC-Gac-041773	Gasterosteus aculeatus	89.85	0.00e+00	1896.00
IUUC-Gma-043198	Glycine max	44.03	0.00e+00	870.00
IUUC-Ggo-045336	Gorilla gorilla	78.19	0.00e+00	1734.00
IUUC-Hsa-045982	Homo sapiens	78.00	0.00e+00	1728.00
IUUC-Hvu-047418	Hordeum vulgare	45.44	0.00e+00	876.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	78.38	0.00e+00	1751.00
IUUC-Kpa-049112	Komagataella pastoris	52.21	0.00e+00	1005.00
IUUC-Lch-050371	Latimeria chalumnae	82.15	0.00e+00	1804.00
IUUC-Lpe-051299	Leersia perrieri	43.60	0.00e+00	866.00
IUUC-Loc-052936	Lepisosteus oculatus	86.87	0.00e+00	1890.00
IUUC-Lma-053315	Leptosphaeria maculans	54.51	0.00e+00	1098.00
IUUC-Laf-053948	Loxodonta africana	76.39	0.00e+00	1684.00
IUUC-Mcc-055843	Macaca mulatta	78.56	0.00e+00	1753.00
IUUC-Meu-056258	Macropus eugenii	76.96	0.00e+00	1702.00
IUUC-Mor-057269	Magnaporthe oryzae	54.95	0.00e+00	1089.00
IUUC-Mpo-057435	Magnaporthe poae	55.06	0.00e+00	1088.00
IUUC-Mtr-058572	Medicago truncatula	44.25	0.00e+00	850.00
IUUC-Mla-059176	Melampsora laricipopulina	56.54	0.00e+00	1092.00
IUUC-Mvi-060437	Microbotryum violaceum	54.61	0.00e+00	1073.00
IUUC-Mmr-061405	Microcebus murinus	76.30	0.00e+00	1687.00
IUUC-Mdo-062032	Monodelphis domestica	75.75	0.00e+00	1675.00
IUUC-Mmu-063280	Mus musculus	77.81	0.00e+00	1724.00
IUUC-Mac-065505	Musa acuminata	45.62	0.00e+00	885.00
IUUC-Mpu-066409	Mustela putorius furo	78.47	0.00e+00	1752.00
IUUC-Mlu-067217	Myotis lucifugus	78.00	0.00e+00	1731.00
IUUC-Nfi-068407	Neosartorya fischeri	55.08	0.00e+00	1064.00
IUUC-Ncr-068698	Neurospora crassa	55.44	0.00e+00	1102.00
IUUC-Nle-070072	Nomascus leucogenys	75.12	0.00e+00	1622.00
IUUC-Opr-070715	Ochotona princeps	41.41	0.00e+00	740.00
IUUC-Oan-073306	Ornithorhynchus anatinus	47.24	0.00e+00	709.00
IUUC-Ocu-074544	Oryctolagus cuniculus	78.85	0.00e+00	1758.00
IUUC-Oba-075120	Oryza barthii	44.50	0.00e+00	866.00
IUUC-Obr-076557	Oryza brachyantha	45.99	0.00e+00	856.00
IUUC-Ogl-077887	Oryza glaberrima	44.59	0.00e+00	869.00
IUUC-Ogu-078305	Oryza glumaepatula	43.94	0.00e+00	870.00
IUUC-Oin-079370	Oryza indica	43.50	0.00e+00	848.00
IUUC-Olo-081089	Oryza longistaminata	43.65	0.00e+00	868.00
IUUC-Ome-081942	Oryza meridionalis	44.50	0.00e+00	866.00
IUUC-Oni-082365	Oryza nivara	44.50	0.00e+00	867.00
IUUC-Opu-083301	Oryza punctata	44.59	0.00e+00	870.00
IUUC-Oru-084469	Oryza rufipogon	43.85	0.00e+00	872.00
IUUC-Osa-085949	Oryza sativa	44.50	0.00e+00	874.00
IUUC-Ola-087002	Oryzias latipes	90.42	0.00e+00	1951.00
IUUC-Olu-087687	Ostreococcus lucimarinus	45.43	0.00e+00	836.00
IUUC-Oga-088594	Otolemur garnettii	77.74	0.00e+00	1718.00
IUUC-Oar-090068	Ovis aries	78.49	0.00e+00	1749.00
IUUC-Ptr-090581	Pan troglodytes	43.53	0.00e+00	740.00
IUUC-Pan-092114	Papio anubis	78.66	0.00e+00	1755.00
IUUC-Pma-094214	Petromyzon marinus	60.95	1.00e-54	205.00
IUUC-Pno-095154	Phaeosphaeria nodorum	53.73	0.00e+00	1091.00
IUUC-Ppa-095227	Physcomitrella patens	44.99	0.00e+00	892.00
IUUC-Pfo-097184	Poecilia formosa	90.52	0.00e+00	1948.00
IUUC-Pab-097861	Pongo abelii	78.00	0.00e+00	1719.00
IUUC-Pop-098934	Populus trichocarpa	43.99	0.00e+00	912.00
IUUC-Pca-100347	Procavia capensis	75.31	0.00e+00	1383.00
IUUC-Ppe-102012	Prunus persica	44.08	0.00e+00	882.00
IUUC-Pva-102584	Pteropus vampyrus	78.38	0.00e+00	1768.00
IUUC-Pgr-103336	Puccinia graminis	54.20	0.00e+00	1056.00
IUUC-Ptt-103939	Puccinia triticina	53.83	0.00e+00	1048.00
IUUC-Pte-104200	Pyrenophora teres	52.97	0.00e+00	1095.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	53.06	0.00e+00	1084.00
IUUC-Rno-105462	Rattus norvegicus	77.90	0.00e+00	1716.00
IUUC-Sce-106245	Saccharomyces cerevisiae	51.52	0.00e+00	1037.00
IUUC-Sha-107142	Sarcophilus harrisii	77.34	0.00e+00	1720.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	55.01	0.00e+00	1113.00
IUUC-Spo-108034	Schizosaccharomyces pombe	54.69	0.00e+00	1078.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	56.04	0.00e+00	1061.00
IUUC-Smo-109211	Selaginella moellendorffii	44.87	0.00e+00	879.00
IUUC-Sit-110281	Setaria italica	45.01	0.00e+00	890.00
IUUC-Sly-110914	Solanum lycopersicum	45.19	0.00e+00	900.00
IUUC-Stu-112109	Solanum tuberosum	44.70	0.00e+00	896.00
IUUC-Sar-113737	Sorex araneus	78.38	0.00e+00	1737.00
IUUC-Sbi-114089	Sorghum bicolor	45.01	0.00e+00	890.00
IUUC-Sre-115148	Sporisorium reilianum	54.39	0.00e+00	1061.00
IUUC-Ssc-115777	Sus scrofa	78.49	0.00e+00	1746.00
IUUC-Tru-118742	Takifugu rubripes	91.76	0.00e+00	1911.00
IUUC-Tni-120401	Tetraodon nigroviridis	91.95	0.00e+00	1917.00
IUUC-Tca-121672	Theobroma cacao	44.86	0.00e+00	899.00
IUUC-Tre-122009	Trichoderma reesei	53.96	0.00e+00	1044.00
IUUC-Tvi-122259	Trichoderma virens	54.49	0.00e+00	1036.00
IUUC-Tae-125113	Triticum aestivum	45.56	0.00e+00	858.00
IUUC-Tur-126330	Triticum urartu	45.95	0.00e+00	900.00
IUUC-Tme-127055	Tuber melanosporum	53.27	0.00e+00	989.00
IUUC-Tbe-127487	Tupaia belangeri	73.93	0.00e+00	835.00
IUUC-Ttr-128331	Tursiops truncatus	77.90	0.00e+00	1724.00
IUUC-Uma-129387	Ustilago maydis	55.21	0.00e+00	1057.00
IUUC-Vda-129977	Verticillium dahliae	53.99	0.00e+00	1000.00
IUUC-Vvi-130857	Vitis vinifera	43.76	0.00e+00	881.00
IUUC-Xtr-132026	Xenopus tropicalis	64.79	0.00e+00	1282.00
IUUC-Xma-133805	Xiphophorus maculatus	90.42	0.00e+00	1921.00
IUUC-Yli-134547	Yarrowia lipolytica	53.48	0.00e+00	1083.00
IUUC-Zma-135052	Zea mays	45.25	0.00e+00	891.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence