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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046488
UUCD1 version UUC-HoS-00345
Ensembl Protein ID ENSP00000405574.1
UniProt Accession Q9BZK7; D3DNQ9; Q14DC3; Q9H2I1; Q9H9A1; TBL1R_HUMAN
Genbank Protein ID AAK00301.1; AAG44736.1; BAB14331.1; EAW78438.1; AAH60320.1; AAI13422.1
Protein Name F-box-like/WD repeat-containing protein TBL1XR1; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1
Genbank Nucleotide ID AF314544; AF268193; AK022956; CH471052; BC060320; BC113421
Gene Name TBL1XR1; IRA1; TBLR1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000177565.16 ENST00000430069.5 ENSP00000405574.1
ENSG00000177565.16 ENST00000637659.1 ENSP00000490514.1
ENSG00000177565.16 ENST00000631253.2 ENSP00000486324.1
ENSG00000177565.16 ENST00000626758.1 ENSP00000486622.1
ENSG00000177565.16 ENST00000630796.2 ENSP00000486235.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 20547759; 19759827
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 20547759; 19759827
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.70e-53 177.8 347 385
UBD/Beta-Prp 1.90e-65 222.6 312 513
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt++v+++++ ++ +ll+s+sdD t+k+W+++++++++
   Q: 347  GHTNEVNAIKWdPTgNLLASCSDDMTLKIWSMKQDNCVH 385
           8***********778*********************987 PP
   

   UBD/Beta-Prp
   S: 14   tcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp. 104
            +v++ ++++ +a+ s+d +i v ++ +   +++++gh++ev+a+k++p+g++l+++s+D+t+k+w++++  cvh l++h+++++++++sp 
   Q: 312  LDVDW-QSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPt 402
           44555.66777777777777777777777777777777777777777777777777777777777777777777777777777777777775 PP
   S: 105  .......sg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsf 188
                  +    l+s+s d+t+r+wd++ g c++ tl++h++ v +v+++pdg++l+sGs D++v +W+ +tg l++  +g  t+ +  + +
   Q: 403  gpgtnnpNAnLMLASASFDSTVRLWDVDRGICIH-TLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG--TGGIFEVCW 491
           5555444222467777777777777777777777.7777777777777777777777777777777777777777777776..777777777 PP
   S: 189  dsngkelvsgsldgtvklwdlq 210
           +  g  + + + dg+v + dl+
   Q: 492  NAAGDKVGASASDGSVCVLDLR 513
           7777777777777777776665 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
 F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
Protein Sequence
(Fasta)
MSISSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GALVPPAALI SIIQKGLQYV 60
EAEVSINEDG TLFDGRPIES LSLIDAVMPD VVQTRQQAYR DKLAQQQAAA AAAAAAAASQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046488|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGTTGCAGTG AGCTGAGATT GCACCATTGT GCTCCAATCT GGGCAACAAG AGCAAGACTC 60
TGTCTCAAAA ACAACAACAA CAAAAAAAAG TGATGTGACT GGCAGCACCC TATGCCTTAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046488|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0991--Mental retardation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08513--LisH
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00667--LisH
SM00320--WD40
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005876--C:spindle microtubule
GO:0017053--C:transcriptional repressor complex
GO:0008013--F:beta-catenin binding
GO:0042393--F:histone binding
GO:0047485--F:protein N-terminus binding
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0044255--P:cellular lipid metabolic process
GO:0060613--P:fat pad development
GO:0016575--P:histone deacetylation
GO:0016042--P:lipid catabolic process
GO:0035264--P:multicellular organism growth
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030814--P:regulation of cAMP metabolic process
GO:0090207--P:regulation of triglyceride metabolic process
GO:0002021--P:response to dietary excess
GO:0006351--P:transcription, DNA-templated
GO:0050872--P:white fat cell differentiation
KEGG hsa:79718
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000916 Aegilops tauschii 60.71 6.00e-55 206.00
IUUC-Aml-001717 Ailuropoda melanoleuca 98.83 0.00e+00 956.00
IUUC-Atr-002514 Amborella trichopoda 65.38 5.00e-145 508.00
IUUC-Apl-003708 Anas platyrhynchos 95.75 0.00e+00 911.00
IUUC-Aca-004611 Anolis carolinensis 95.91 0.00e+00 952.00
IUUC-Aly-005622 Arabidopsis lyrata 58.40 1.00e-119 424.00
IUUC-Ath-007137 Arabidopsis thaliana 59.50 4.00e-121 428.00
IUUC-Ago-007869 Ashbya gossypii 28.27 1.00e-32 134.00
IUUC-Ame-011601 Astyanax mexicanus 92.22 0.00e+00 904.00
IUUC-Bta-012418 Bos taurus 99.22 0.00e+00 980.00
IUUC-Bdi-014315 Brachypodium distachyon 60.42 1.00e-134 473.00
IUUC-Bol-016277 Brassica oleracea 57.25 5.00e-127 448.00
IUUC-Bra-016944 Brassica rapa 60.56 2.00e-126 446.00
IUUC-Cja-018832 Callithrix jacchus 99.81 0.00e+00 958.00
IUUC-Cfa-020029 Canis familiaris 99.03 0.00e+00 958.00
IUUC-Cpo-022080 Cavia porcellus 93.20 0.00e+00 913.00
IUUC-Cre-022979 Chlamydomonas reinhardtii 60.38 2.00e-130 459.00
IUUC-Csa-024075 Chlorocebus sabaeus 100.00 0.00e+00 958.00
IUUC-Cho-024872 Choloepus hoffmanni 99.15 5.00e-111 394.00
IUUC-Cin-025704 Ciona intestinalis 71.38 0.00e+00 790.00
IUUC-Csv-026257 Ciona savignyi 69.96 0.00e+00 759.00
IUUC-Cne-026946 Cryptococcus neoformans 38.01 2.00e-30 127.00
IUUC-Cme-027258 Cyanidioschyzon merolae 40.35 7.00e-106 377.00
IUUC-Dre-028075 Danio rerio 93.19 0.00e+00 924.00
IUUC-Dno-029196 Dasypus novemcinctus 99.61 0.00e+00 959.00
IUUC-Dor-030732 Dipodomys ordii 99.45 0.00e+00 732.00
IUUC-Eeu-034952 Erinaceus europaeus 89.61 0.00e+00 825.00
IUUC-Fca-035734 Felis catus 99.22 0.00e+00 958.00
IUUC-Fal-037185 Ficedula albicollis 96.11 0.00e+00 952.00
IUUC-Gmo-038870 Gadus morhua 90.47 0.00e+00 927.00
IUUC-Gga-041161 Gallus gallus 96.11 0.00e+00 953.00
IUUC-Gac-041844 Gasterosteus aculeatus 92.23 0.00e+00 954.00
IUUC-Gma-044208 Glycine max 48.34 3.00e-153 535.00
IUUC-Ggo-044882 Gorilla gorilla 100.00 0.00e+00 958.00
IUUC-Itr-047958 Ictidomys tridecemlineatus 100.00 0.00e+00 740.00
IUUC-Kpa-049338 Komagataella pastoris 28.91 9.00e-32 131.00
IUUC-Lch-050672 Latimeria chalumnae 96.70 0.00e+00 971.00
IUUC-Lpe-051084 Leersia perrieri 62.64 2.00e-136 479.00
IUUC-Loc-052030 Lepisosteus oculatus 95.95 0.00e+00 959.00
IUUC-Laf-054280 Loxodonta africana 98.83 0.00e+00 980.00
IUUC-Mcc-055203 Macaca mulatta 100.00 0.00e+00 957.00
IUUC-Meu-056563 Macropus eugenii 98.32 9.00e-135 473.00
IUUC-Mga-059660 Meleagris gallopavo 96.11 0.00e+00 953.00
IUUC-Mmr-060925 Microcebus murinus 97.80 0.00e+00 918.00
IUUC-Mdo-062078 Monodelphis domestica 98.25 0.00e+00 950.00
IUUC-Mmu-063603 Mus musculus 99.03 0.00e+00 954.00
IUUC-Mac-065508 Musa acuminata 61.80 3.00e-93 335.00
IUUC-Mpu-066741 Mustela putorius furo 99.03 0.00e+00 958.00
IUUC-Mlu-068152 Myotis lucifugus 99.42 0.00e+00 951.00
IUUC-Nle-069229 Nomascus leucogenys 100.00 0.00e+00 958.00
IUUC-Opr-070277 Ochotona princeps 88.56 0.00e+00 812.00
IUUC-Ont-072623 Oreochromis niloticus 92.43 0.00e+00 955.00
IUUC-Ocu-074280 Oryctolagus cuniculus 97.51 0.00e+00 949.00
IUUC-Obr-076718 Oryza brachyantha 62.91 7.00e-137 481.00
IUUC-Olo-080427 Oryza longistaminata 63.32 6.00e-132 464.00
IUUC-Ola-087365 Oryzias latipes 95.53 0.00e+00 952.00
IUUC-Oga-088357 Otolemur garnettii 94.36 0.00e+00 901.00
IUUC-Oar-089214 Ovis aries 99.42 0.00e+00 984.00
IUUC-Ptr-091532 Pan troglodytes 100.00 0.00e+00 958.00
IUUC-Pan-091927 Papio anubis 100.00 0.00e+00 958.00
IUUC-Psi-093941 Pelodiscus sinensis 92.60 0.00e+00 940.00
IUUC-Ppa-095868 Physcomitrella patens 65.16 9.00e-140 490.00
IUUC-Pfo-096158 Poecilia formosa 92.43 0.00e+00 954.00
IUUC-Pab-098705 Pongo abelii 100.00 0.00e+00 958.00
IUUC-Pop-098989 Populus trichocarpa 61.54 9.00e-128 450.00
IUUC-Pca-100256 Procavia capensis 99.02 0.00e+00 944.00
IUUC-Pva-102616 Pteropus vampyrus 99.01 0.00e+00 937.00
IUUC-Rno-105411 Rattus norvegicus 99.22 0.00e+00 957.00
IUUC-Sce-106132 Saccharomyces cerevisiae 24.78 2.00e-42 167.00
IUUC-Sha-106636 Sarcophilus harrisii 98.06 0.00e+00 950.00
IUUC-Smo-109301 Selaginella moellendorffii 63.49 9.00e-143 500.00
IUUC-Sit-110710 Setaria italica 63.71 2.00e-142 499.00
IUUC-Sly-111042 Solanum lycopersicum 50.68 4.00e-150 525.00
IUUC-Stu-112744 Solanum tuberosum 49.90 2.00e-141 496.00
IUUC-Sar-112971 Sorex araneus 90.20 0.00e+00 866.00
IUUC-Sbi-114420 Sorghum bicolor 63.19 3.00e-142 498.00
IUUC-Sre-115175 Sporisorium reilianum 37.92 1.00e-57 218.00
IUUC-Ssc-115695 Sus scrofa 97.67 0.00e+00 936.00
IUUC-Tgu-117009 Taeniopygia guttata 96.05 0.00e+00 936.00
IUUC-Tru-118581 Takifugu rubripes 95.34 0.00e+00 956.00
IUUC-Tsy-119424 Tarsius syrichta 82.05 0.00e+00 725.00
IUUC-Tni-119986 Tetraodon nigroviridis 95.53 0.00e+00 956.00
IUUC-Tca-121739 Theobroma cacao 54.08 7.00e-125 441.00
IUUC-Tme-127126 Tuber melanosporum 38.42 3.00e-58 219.00
IUUC-Tbe-127665 Tupaia belangeri 82.46 0.00e+00 820.00
IUUC-Vpa-130768 Vicugna pacos 99.61 0.00e+00 944.00
IUUC-Xtr-132842 Xenopus tropicalis 89.96 0.00e+00 902.00
IUUC-Xma-134020 Xiphophorus maculatus 92.43 0.00e+00 954.00
Created Date 25-Jun-2017

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