iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-61	202.0	159	195
UBD/Beta-Prp	1.30e-75	254.4	111	301

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gH+ +v c+++ +d ++l+sG+  g+i +WD+ tg +
   Q: 159  GHKQWVLCVSWaPDgKRLASGCKAGSIIIWDPETGQQ 195
           8***********999****************999865 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvn 141
           + +s+ gh ++v +++fspdg  l++gs D t+++wdl+t ++  t +gh++ vl++s+ p+g++l+sG +   i +wd etgq    +lsgh++ +n
   Q: 111  CTSSMPGHAEAVVSLNFSPDGAHLASGSGDTTVRLWDLNTETPHFTCTGHKQWVLCVSWAPDGKRLASGCKAGSIIIWDPETGQQKGRPLSGHKKHIN 208
           35667778888888888888888888888888888888888888888888888888888888888888888888888888888888778888888888 PP
   S: 142  cvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs 231
           c+++     +p+++ l+s+s D+ +r+Wd+k g++l    g ht++v+ + +   g  + + s+d+tvk+w    g   rt+ gh  +v+ +++s
   Q: 209  CLAWepyhrDPECRKLASASGDGDCRIWDVKLGQCLMNIAG-HTNAVTAVRWGGAG-LIYTSSKDRTVKMWRAADGILCRTFSGHAHWVNNIALS 301
           87773333345667788888888888888888888888877.88888888888865.77778888888888888888888888888888888777 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Plays a role in regulating Notch activity.

Protein Sequence
(Fasta)

MLAKKQKMQE TDTEQEATPH TIQARLVSDT GEEAGPPIDL PAGITTQQLG LICNALLKNE 60
EATPYLFFVG EDEIKKSLED TLDLASVDTE NVIDIVYQPQ AVFKVRPVTR CTSSMPGHAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCTCATCAC TAACGAACAA GTTGCGGCAC GTGTTTACTT TTGTTTTGAC CGCGAGAATG 60
TTGGCCAAAA AACAGAAAAT GCAGGAGACG GACACGGAGC AAGAGGCCAC GCCACATACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0914--Notch signaling pathway
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005840--C:ribosome
GO:0005112--F:Notch binding
GO:0007219--P:Notch signaling pathway
GO:0000027--P:ribosomal large subunit assembly

KEGG

dme:Dmel_CG2863

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	54.43	5.00e-153	533.00
IUUC-Aml-001793	Ailuropoda melanoleuca	59.39	9.00e-169	585.00
IUUC-Atr-002507	Amborella trichopoda	53.68	2.00e-148	518.00
IUUC-Apl-003964	Anas platyrhynchos	61.28	9.00e-168	582.00
IUUC-Aly-006396	Arabidopsis lyrata	53.32	1.00e-147	515.00
IUUC-Ath-007278	Arabidopsis thaliana	53.32	1.00e-147	515.00
IUUC-Ago-007951	Ashbya gossypii	44.14	2.00e-117	415.00
IUUC-Acl-008298	Aspergillus clavatus	44.47	7.00e-109	386.00
IUUC-Afl-008581	Aspergillus flavus	51.12	3.00e-99	353.00
IUUC-Afu-008906	Aspergillus fumigatus	43.70	4.00e-109	387.00
IUUC-Ani-009189	Aspergillus nidulans	43.93	2.00e-106	378.00
IUUC-Ang-009630	Aspergillus niger	46.29	2.00e-113	402.00
IUUC-Aor-010038	Aspergillus oryzae	45.06	5.00e-118	417.00
IUUC-Ate-010278	Aspergillus terreus	45.27	1.00e-110	392.00
IUUC-Ame-011890	Astyanax mexicanus	59.83	1.00e-164	571.00
IUUC-Bgr-012011	Blumeria graminis	49.51	3.00e-116	410.00
IUUC-Bta-012964	Bos taurus	59.17	3.00e-168	583.00
IUUC-Bci-013592	Botrytis cinerea	44.27	2.00e-106	378.00
IUUC-Bdi-015035	Brachypodium distachyon	54.49	1.00e-155	541.00
IUUC-Bol-015501	Brassica oleracea	53.42	6.00e-147	513.00
IUUC-Bra-017642	Brassica rapa	53.21	1.00e-146	512.00
IUUC-Cel-018430	Caenorhabditis elegans	52.61	1.00e-145	509.00
IUUC-Cja-019125	Callithrix jacchus	59.83	3.00e-168	583.00
IUUC-Cfa-021013	Canis familiaris	59.35	5.00e-159	553.00
IUUC-Cpo-021743	Cavia porcellus	58.26	6.00e-169	586.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	45.71	3.00e-124	437.00
IUUC-Csa-024270	Chlorocebus sabaeus	58.16	6.00e-169	586.00
IUUC-Cin-025795	Ciona intestinalis	55.65	6.00e-164	569.00
IUUC-Csv-025953	Ciona savignyi	55.49	3.00e-164	570.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	48.94	6.00e-97	347.00
IUUC-Cne-026901	Cryptococcus neoformans	41.80	3.00e-115	408.00
IUUC-Cme-027281	Cyanidioschyzon merolae	42.95	6.00e-105	374.00
IUUC-Dre-028515	Danio rerio	58.03	2.00e-162	564.00
IUUC-Dno-029596	Dasypus novemcinctus	59.61	3.00e-168	583.00
IUUC-Dor-030494	Dipodomys ordii	59.17	1.00e-166	578.00
IUUC-Dse-031538	Dothistroma septosporum	47.15	1.00e-119	422.00
IUUC-Ete-032948	Echinops telfairi	59.90	8.00e-70	256.00
IUUC-Eca-033399	Equus caballus	59.17	4.00e-168	583.00
IUUC-Eeu-035013	Erinaceus europaeus	58.25	9.00e-71	259.00
IUUC-Fca-035860	Felis catus	60.04	5.00e-170	590.00
IUUC-Fal-037069	Ficedula albicollis	59.44	5.00e-87	313.00
IUUC-Fox-038059	Fusarium oxysporum	44.18	1.00e-115	409.00
IUUC-Fso-038445	Fusarium solani	44.18	1.00e-114	405.00
IUUC-Gmo-039319	Gadus morhua	57.86	3.00e-149	521.00
IUUC-Ggr-040095	Gaeumannomyces graminis	44.44	1.00e-113	402.00
IUUC-Gga-040303	Gallus gallus	60.24	1.00e-87	315.00
IUUC-Gac-042267	Gasterosteus aculeatus	59.13	1.00e-155	541.00
IUUC-Gma-043974	Glycine max	55.11	7.00e-157	546.00
IUUC-Ggo-044637	Gorilla gorilla	59.61	2.00e-168	584.00
IUUC-Hsa-046128	Homo sapiens	58.40	2.00e-169	588.00
IUUC-Hvu-047373	Hordeum vulgare	53.53	2.00e-153	534.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	58.75	4.00e-168	583.00
IUUC-Kpa-049274	Komagataella pastoris	40.63	3.00e-112	397.00
IUUC-Lch-049907	Latimeria chalumnae	58.79	3.00e-160	557.00
IUUC-Lpe-050778	Leersia perrieri	48.96	3.00e-136	477.00
IUUC-Loc-051889	Lepisosteus oculatus	59.57	3.00e-165	574.00
IUUC-Lma-053041	Leptosphaeria maculans	43.89	4.00e-109	387.00
IUUC-Laf-053598	Loxodonta africana	58.16	2.00e-169	587.00
IUUC-Mcc-055660	Macaca mulatta	58.16	5.00e-169	586.00
IUUC-Meu-056197	Macropus eugenii	53.07	9.00e-143	499.00
IUUC-Mor-056949	Magnaporthe oryzae	44.42	2.00e-108	385.00
IUUC-Mpo-057571	Magnaporthe poae	50.68	4.00e-55	207.00
IUUC-Mtr-058530	Medicago truncatula	55.06	3.00e-148	517.00
IUUC-Mla-059133	Melampsora laricipopulina	44.35	1.00e-110	392.00
IUUC-Mga-059252	Meleagris gallopavo	61.88	9.00e-136	475.00
IUUC-Mvi-060522	Microbotryum violaceum	45.09	1.00e-118	419.00
IUUC-Mmr-061117	Microcebus murinus	57.83	2.00e-166	578.00
IUUC-Mdo-062892	Monodelphis domestica	59.83	5.00e-169	586.00
IUUC-Mmu-064108	Mus musculus	59.39	2.00e-163	568.00
IUUC-Mac-064430	Musa acuminata	55.20	1.00e-157	548.00
IUUC-Mpu-065882	Mustela putorius furo	59.17	3.00e-168	583.00
IUUC-Mlu-068123	Myotis lucifugus	59.83	2.00e-168	584.00
IUUC-Nfi-068484	Neosartorya fischeri	44.05	2.00e-109	388.00
IUUC-Ncr-068649	Neurospora crassa	43.08	1.00e-111	395.00
IUUC-Nle-069140	Nomascus leucogenys	59.83	1.00e-168	585.00
IUUC-Opr-070220	Ochotona princeps	52.73	4.00e-141	493.00
IUUC-Ont-072643	Oreochromis niloticus	59.22	2.00e-162	564.00
IUUC-Ocu-074007	Oryctolagus cuniculus	58.26	5.00e-164	570.00
IUUC-Oba-075904	Oryza barthii	53.53	2.00e-153	535.00
IUUC-Obr-076280	Oryza brachyantha	53.21	4.00e-153	533.00
IUUC-Ogl-077425	Oryza glaberrima	53.75	6.00e-154	536.00
IUUC-Ogu-078586	Oryza glumaepatula	52.82	3.00e-155	540.00
IUUC-Oin-079489	Oryza indica	51.82	4.00e-145	507.00
IUUC-Olo-080766	Oryza longistaminata	53.88	4.00e-153	533.00
IUUC-Ome-081905	Oryza meridionalis	53.75	2.00e-153	535.00
IUUC-Oni-083022	Oryza nivara	53.32	4.00e-153	533.00
IUUC-Opu-083615	Oryza punctata	53.75	1.00e-153	535.00
IUUC-Oru-085076	Oryza rufipogon	53.32	4.00e-153	533.00
IUUC-Osa-085516	Oryza sativa	53.32	4.00e-153	533.00
IUUC-Ola-087290	Oryzias latipes	56.52	5.00e-160	556.00
IUUC-Olu-087898	Ostreococcus lucimarinus	46.74	2.00e-133	468.00
IUUC-Oga-088980	Otolemur garnettii	59.61	7.00e-170	589.00
IUUC-Oar-089580	Ovis aries	57.32	3.00e-139	487.00
IUUC-Ptr-090845	Pan troglodytes	58.95	2.00e-165	574.00
IUUC-Pan-092836	Papio anubis	58.40	6.00e-169	586.00
IUUC-Pno-095052	Phaeosphaeria nodorum	43.84	1.00e-114	406.00
IUUC-Ppa-095432	Physcomitrella patens	53.88	4.00e-153	533.00
IUUC-Pfo-096963	Poecilia formosa	53.70	2.00e-140	491.00
IUUC-Pab-097716	Pongo abelii	56.33	3.00e-156	544.00
IUUC-Pop-099224	Populus trichocarpa	54.74	1.00e-153	535.00
IUUC-Pca-100682	Procavia capensis	59.15	2.00e-127	447.00
IUUC-Ppe-101819	Prunus persica	53.68	4.00e-151	527.00
IUUC-Pva-102338	Pteropus vampyrus	56.08	8.00e-119	419.00
IUUC-Pgr-103583	Puccinia graminis	50.74	9.00e-120	423.00
IUUC-Ptt-103737	Puccinia triticina	41.71	1.00e-90	326.00
IUUC-Pte-104150	Pyrenophora teres	43.84	2.00e-113	401.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	43.64	7.00e-113	400.00
IUUC-Rno-105987	Rattus norvegicus	59.39	9.00e-168	582.00
IUUC-Sce-106315	Saccharomyces cerevisiae	44.81	1.00e-113	402.00
IUUC-Sha-107273	Sarcophilus harrisii	60.04	1.00e-170	592.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	41.92	6.00e-106	377.00
IUUC-Spo-108092	Schizosaccharomyces pombe	45.79	4.00e-110	390.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	40.61	2.00e-101	362.00
IUUC-Smo-108855	Selaginella moellendorffii	52.25	3.00e-145	507.00
IUUC-Sit-110329	Setaria italica	53.85	4.00e-154	537.00
IUUC-Sly-111830	Solanum lycopersicum	54.91	2.00e-154	538.00
IUUC-Stu-112603	Solanum tuberosum	54.91	3.00e-154	537.00
IUUC-Sar-113504	Sorex araneus	56.08	1.00e-42	166.00
IUUC-Sbi-114560	Sorghum bicolor	53.10	3.00e-152	530.00
IUUC-Sre-115133	Sporisorium reilianum	38.61	4.00e-110	390.00
IUUC-Ssc-115903	Sus scrofa	58.77	7.00e-170	589.00
IUUC-Tgu-116798	Taeniopygia guttata	60.60	4.00e-170	590.00
IUUC-Tru-118361	Takifugu rubripes	58.44	3.00e-163	567.00
IUUC-Tsy-118849	Tarsius syrichta	58.40	5.00e-169	586.00
IUUC-Tni-120094	Tetraodon nigroviridis	56.47	4.00e-161	560.00
IUUC-Tca-121634	Theobroma cacao	54.70	1.00e-154	538.00
IUUC-Tre-122051	Trichoderma reesei	41.98	7.00e-107	380.00
IUUC-Tvi-122322	Trichoderma virens	43.00	8.00e-111	393.00
IUUC-Tae-125822	Triticum aestivum	54.08	3.00e-153	534.00
IUUC-Tur-126766	Triticum urartu	48.00	5.00e-144	503.00
IUUC-Tme-127175	Tuber melanosporum	44.95	6.00e-118	416.00
IUUC-Tbe-127779	Tupaia belangeri	60.89	8.00e-157	545.00
IUUC-Ttr-128224	Tursiops truncatus	57.83	2.00e-152	531.00
IUUC-Uma-129537	Ustilago maydis	43.71	6.00e-113	400.00
IUUC-Vda-129927	Verticillium dahliae	42.49	2.00e-104	372.00
IUUC-Vpa-130658	Vicugna pacos	56.88	9.00e-93	333.00
IUUC-Vvi-131659	Vitis vinifera	54.17	1.00e-155	542.00
IUUC-Xtr-132918	Xenopus tropicalis	57.63	1.00e-159	555.00
IUUC-Xma-133700	Xiphophorus maculatus	58.79	2.00e-161	561.00
IUUC-Yli-134478	Yarrowia lipolytica	46.40	1.00e-127	449.00
IUUC-Zma-135835	Zea mays	50.10	5.00e-147	513.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence