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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046693
UUCD1 version UUC-HoS-01195
Ensembl Protein ID ENSP00000305826.6
UniProt Accession Q8N2K1; A8MYC7; Q504T9; Q96N26; Q96T84; UB2J2_HUMAN
Genbank Protein ID AAK52609.1; BAB71086.1; BAC11355.1; BAF84624.1; CAI23257.1; EAW56256.1; EAW56259.1; AAH94777.1; AAI04891.1; AAI13431.1; AAI43658.1; ENSP00000305826
Protein Name Ubiquitin-conjugating enzyme E2 J2; E2 ubiquitin-conjugating enzyme J2; Non-canonical ubiquitin-conjugating enzyme 2
Genbank Nucleotide ID AF296658; AK056065; AK075017; AK291935; AL162741; CH471183; CH471183; BC094777; BC104890; BC113430; BC143657; BM544827
Gene Name UBE2J2; NCUBE2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000160087.20 ENST00000349431.10 ENSP00000305826.6
ENSG00000160087.20 ENST00000464036.5 ENSP00000423880.1
ENSG00000160087.20 ENST00000400930.8 ENSP00000383719.4
ENSG00000160087.20 ENST00000477894.5 ENSP00000423480.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbGWAS Central
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UBC E2_UBC 19951915
Classification
Family E-value Score Start End
E2/UBC 6.70e-28 98.8 16 125
Active Site
Position(s) Description Evidence
94 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00388}
Domain Profile

   E2/UBC
   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk..ifhPnvyenGkvClsilk.ee 89
           Rlk+++ +++kdp+++i a+p  + ++ ew++++ Gpe tpYegg+++ ++ fp+++PfkPP++ ++t+  +f++    n+++Clsi + ++
   Q: 16   RLKQDYLRIKKDPVPYICAEPLPS-NILEWHYVVRGPEMTPYEGGYYHGKLIFPREFPFKPPSIYMITPngRFKC----NTRLCLSITDfHP 102
           99**********************.9*******************************************555555....59*******889* PP
   S: 90   ekWspalsvesvllsiqsllaep 112
           ++W+pa+sv+++l+++ s++ e 
   Q: 103  DTWNPAWSVSTILTGLLSFMVEK 125
           *******************9764 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).
 Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).
Protein Sequence
(Fasta)
MSSTSSKRAP TTATQRLKQD YLRIKKDPVP YICAEPLPSN ILEWHYVVRG PEMTPYEGGY 60
YHGKLIFPRE FPFKPPSIYM ITPNGRFKCN TRLCLSITDF HPDTWNPAWS VSTILTGLLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046693|E2,E2/UBC|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGACCGCGC ACCGGAAGCA GAAGCTAGGC TGGTTCCGCC CCGCGAGCGG CCATCTTGGA 60
GGCTGAGGCG GCGGCGGCGG CGCTGCGGCG GGTTCGGTGG GCCCAATCCC GGGGCGGTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046693|E2,E2/UBC|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0834--Unfolded protein response
Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0000209--P:protein polyubiquitination
GO:0006986--P:response to unfolded protein
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG hsa:118424
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002152 Ailuropoda melanoleuca 96.53 3.00e-134 470.00
IUUC-Atr-003156 Amborella trichopoda 54.82 5.00e-54 204.00
IUUC-Apl-004224 Anas platyrhynchos 91.89 3.00e-113 401.00
IUUC-Aca-005049 Anolis carolinensis 90.46 2.00e-129 454.00
IUUC-Aly-006195 Arabidopsis lyrata 54.43 4.00e-50 191.00
IUUC-Ath-006640 Arabidopsis thaliana 54.43 1.00e-50 192.00
IUUC-Ago-007987 Ashbya gossypii 52.02 4.00e-53 201.00
IUUC-Acl-008060 Aspergillus clavatus 55.63 5.00e-43 167.00
IUUC-Afl-008561 Aspergillus flavus 55.63 8.00e-43 167.00
IUUC-Afu-008860 Aspergillus fumigatus 55.63 9.00e-43 167.00
IUUC-Ani-009333 Aspergillus nidulans 54.23 4.00e-42 164.00
IUUC-Ang-009810 Aspergillus niger 56.34 3.00e-43 168.00
IUUC-Aor-010127 Aspergillus oryzae 55.63 8.00e-43 167.00
IUUC-Ate-010362 Aspergillus terreus 38.11 6.00e-43 167.00
IUUC-Ame-010627 Astyanax mexicanus 88.12 4.00e-128 450.00
IUUC-Bgr-012069 Blumeria graminis 50.70 2.00e-39 155.00
IUUC-Bta-012472 Bos taurus 95.37 2.00e-131 461.00
IUUC-Bci-013843 Botrytis cinerea 53.52 2.00e-40 159.00
IUUC-Bdi-014467 Brachypodium distachyon 51.93 9.00e-51 193.00
IUUC-Bol-016116 Brassica oleracea 54.43 8.00e-51 193.00
IUUC-Bra-017799 Brassica rapa 54.14 3.00e-50 191.00
IUUC-Cel-018278 Caenorhabditis elegans 60.23 8.00e-52 196.00
IUUC-Cja-018817 Callithrix jacchus 95.95 8.00e-120 422.00
IUUC-Cfa-020885 Canis familiaris 95.75 3.00e-133 467.00
IUUC-Cpo-022326 Cavia porcellus 96.14 2.00e-141 494.00
IUUC-Cre-022635 Chlamydomonas reinhardtii 58.23 8.00e-55 206.00
IUUC-Csa-023646 Chlorocebus sabaeus 98.84 3.00e-146 510.00
IUUC-Cho-025075 Choloepus hoffmanni 77.92 2.00e-64 237.00
IUUC-Cin-025389 Ciona intestinalis 73.74 2.00e-80 291.00
IUUC-Csv-026315 Ciona savignyi 58.00 5.00e-84 303.00
IUUC-Cgl-026602 Colletotrichum gloeosporioides 53.52 2.00e-42 166.00
IUUC-Cne-026808 Cryptococcus neoformans 52.11 1.00e-42 165.00
IUUC-Dre-028455 Danio rerio 88.03 1.00e-129 455.00
IUUC-Dno-029667 Dasypus novemcinctus 95.75 1.00e-139 488.00
IUUC-Dor-030747 Dipodomys ordii 81.09 8.00e-118 416.00
IUUC-Dse-031231 Dothistroma septosporum 50.00 3.00e-39 155.00
IUUC-Dme-031841 Drosophila melanogaster 51.76 3.00e-79 288.00
IUUC-Ete-032258 Echinops telfairi 85.45 9.00e-123 432.00
IUUC-Eca-033602 Equus caballus 72.97 3.00e-98 351.00
IUUC-Eeu-034443 Erinaceus europaeus 96.02 3.00e-106 377.00
IUUC-Fca-036167 Felis catus 90.80 5.00e-120 423.00
IUUC-Fal-037114 Ficedula albicollis 89.20 8.00e-98 349.00
IUUC-Fox-037957 Fusarium oxysporum 58.87 3.00e-40 158.00
IUUC-Fso-038277 Fusarium solani 54.93 5.00e-43 167.00
IUUC-Gmo-039501 Gadus morhua 82.38 2.00e-107 382.00
IUUC-Ggr-040010 Gaeumannomyces graminis 56.34 6.00e-43 167.00
IUUC-Gga-041257 Gallus gallus 91.51 4.00e-111 394.00
IUUC-Gac-041433 Gasterosteus aculeatus 83.52 1.00e-108 385.00
IUUC-Gma-043529 Glycine max 48.72 1.00e-53 202.00
IUUC-Ggo-044437 Gorilla gorilla 94.78 7.00e-122 429.00
IUUC-Itr-048477 Ictidomys tridecemlineatus 96.91 1.00e-134 472.00
IUUC-Kpa-049391 Komagataella pastoris 54.72 1.00e-41 163.00
IUUC-Lch-049617 Latimeria chalumnae 91.51 1.00e-120 425.00
IUUC-Lpe-050949 Leersia perrieri 51.50 7.00e-49 187.00
IUUC-Loc-052157 Lepisosteus oculatus 88.93 7.00e-120 423.00
IUUC-Lma-053128 Leptosphaeria maculans 55.07 2.00e-41 162.00
IUUC-Laf-054455 Loxodonta africana 93.82 2.00e-122 431.00
IUUC-Mcc-054756 Macaca mulatta 98.84 3.00e-146 510.00
IUUC-Meu-056106 Macropus eugenii 78.10 4.00e-101 360.00
IUUC-Mor-057202 Magnaporthe oryzae 54.93 2.00e-42 166.00
IUUC-Mpo-057349 Magnaporthe poae 55.63 2.00e-42 166.00
IUUC-Mtr-058271 Medicago truncatula 50.29 4.00e-49 187.00
IUUC-Mla-058894 Melampsora laricipopulina 52.45 2.00e-43 167.00
IUUC-Mga-059493 Meleagris gallopavo 91.51 4.00e-111 394.00
IUUC-Mvi-060232 Microbotryum violaceum 48.67 6.00e-42 164.00
IUUC-Mmr-060957 Microcebus murinus 96.14 3.00e-141 493.00
IUUC-Mdo-062141 Monodelphis domestica 93.82 2.00e-128 451.00
IUUC-Mmu-063882 Mus musculus 94.21 1.00e-128 452.00
IUUC-Mac-064530 Musa acuminata 48.50 5.00e-51 194.00
IUUC-Mpu-065902 Mustela putorius furo 96.53 2.00e-134 471.00
IUUC-Mlu-068008 Myotis lucifugus 94.59 2.00e-130 458.00
IUUC-Nfi-068515 Neosartorya fischeri 55.63 6.00e-43 167.00
IUUC-Ncr-068755 Neurospora crassa 53.52 4.00e-41 161.00
IUUC-Opr-071201 Ochotona princeps 91.04 1.00e-87 315.00
IUUC-Ont-071311 Oreochromis niloticus 83.52 5.00e-107 380.00
IUUC-Oan-073310 Ornithorhynchus anatinus 91.12 8.00e-130 456.00
IUUC-Ocu-074514 Oryctolagus cuniculus 95.37 5.00e-139 486.00
IUUC-Oba-075200 Oryza barthii 52.33 1.00e-49 189.00
IUUC-Obr-076396 Oryza brachyantha 50.83 2.00e-50 192.00
IUUC-Ogl-077398 Oryza glaberrima 52.33 1.00e-49 189.00
IUUC-Ogu-078362 Oryza glumaepatula 52.33 1.00e-49 189.00
IUUC-Oin-079625 Oryza indica 52.33 1.00e-49 189.00
IUUC-Olo-080620 Oryza longistaminata 45.71 7.00e-30 124.00
IUUC-Ome-081187 Oryza meridionalis 52.33 2.00e-49 189.00
IUUC-Oni-082271 Oryza nivara 52.33 2.00e-49 188.00
IUUC-Opu-083487 Oryza punctata 51.74 9.00e-49 186.00
IUUC-Oru-085263 Oryza rufipogon 52.33 1.00e-49 189.00
IUUC-Osa-085694 Oryza sativa 52.33 1.00e-49 189.00
IUUC-Ola-086450 Oryzias latipes 84.94 1.00e-116 412.00
IUUC-Olu-087733 Ostreococcus lucimarinus 41.27 2.00e-25 108.00
IUUC-Oga-088054 Otolemur garnettii 92.00 2.00e-128 451.00
IUUC-Oar-089486 Ovis aries 95.37 2.00e-131 461.00
IUUC-Pan-092633 Papio anubis 98.84 3.00e-146 510.00
IUUC-Psi-093165 Pelodiscus sinensis 88.41 4.00e-38 149.00
IUUC-Pno-095025 Phaeosphaeria nodorum 55.80 1.00e-42 166.00
IUUC-Ppa-095641 Physcomitrella patens 57.59 1.00e-54 206.00
IUUC-Pfo-096423 Poecilia formosa 86.36 6.00e-105 373.00
IUUC-Pab-097771 Pongo abelii 99.23 1.00e-146 512.00
IUUC-Pop-099714 Populus trichocarpa 53.49 1.00e-54 206.00
IUUC-Pca-100493 Procavia capensis 83.26 9.00e-80 289.00
IUUC-Ppe-102054 Prunus persica 51.16 1.00e-52 199.00
IUUC-Pva-102224 Pteropus vampyrus 93.05 6.00e-128 449.00
IUUC-Pgr-103530 Puccinia graminis 51.28 5.00e-47 180.00
IUUC-Ptt-103776 Puccinia triticina 50.65 1.00e-45 176.00
IUUC-Pte-104166 Pyrenophora teres 53.62 2.00e-41 162.00
IUUC-Pyt-104570 Pyrenophora triticirepentis 53.62 3.00e-41 161.00
IUUC-Rno-105593 Rattus norvegicus 94.98 5.00e-130 456.00
IUUC-Sce-106212 Saccharomyces cerevisiae 58.49 2.00e-52 199.00
IUUC-Sha-106767 Sarcophilus harrisii 93.05 6.00e-128 449.00
IUUC-Sja-107907 Schizosaccharomyces japonicus 48.81 3.00e-48 185.00
IUUC-Spo-108094 Schizosaccharomyces pombe 53.80 2.00e-48 185.00
IUUC-Ssl-108556 Sclerotinia sclerotiorum 53.52 1.00e-40 159.00
IUUC-Smo-108965 Selaginella moellendorffii 53.49 5.00e-55 207.00
IUUC-Sit-110407 Setaria italica 56.10 8.00e-52 196.00
IUUC-Sly-111642 Solanum lycopersicum 53.18 1.00e-48 186.00
IUUC-Stu-112336 Solanum tuberosum 49.21 3.00e-48 184.00
IUUC-Sbi-114327 Sorghum bicolor 56.10 2.00e-51 195.00
IUUC-Sre-115170 Sporisorium reilianum 54.78 1.00e-42 166.00
IUUC-Ssc-116385 Sus scrofa 95.37 4.00e-132 463.00
IUUC-Tgu-117041 Taeniopygia guttata 88.80 4.00e-104 370.00
IUUC-Tru-117697 Takifugu rubripes 84.35 7.00e-111 393.00
IUUC-Tsy-119024 Tarsius syrichta 86.87 4.00e-128 450.00
IUUC-Tni-120466 Tetraodon nigroviridis 83.40 3.00e-109 387.00
IUUC-Tca-121569 Theobroma cacao 46.46 2.00e-51 195.00
IUUC-Tre-121882 Trichoderma reesei 55.63 2.00e-42 166.00
IUUC-Tvi-122466 Trichoderma virens 54.93 4.00e-42 164.00
IUUC-Tae-124797 Triticum aestivum 54.07 4.00e-51 194.00
IUUC-Tur-126536 Triticum urartu 54.44 7.00e-51 193.00
IUUC-Tme-127051 Tuber melanosporum 57.04 9.00e-45 173.00
IUUC-Tbe-128095 Tupaia belangeri 95.98 5.00e-97 346.00
IUUC-Ttr-128466 Tursiops truncatus 95.37 3.00e-132 463.00
IUUC-Uma-129383 Ustilago maydis 54.14 5.00e-42 164.00
IUUC-Vda-130013 Verticillium dahliae 55.22 1.00e-40 160.00
IUUC-Vvi-131251 Vitis vinifera 52.47 1.00e-47 183.00
IUUC-Xtr-132408 Xenopus tropicalis 90.35 1.00e-140 492.00
IUUC-Xma-133893 Xiphophorus maculatus 85.61 1.00e-104 372.00
IUUC-Yli-134618 Yarrowia lipolytica 59.46 7.00e-51 193.00
IUUC-Zma-135216 Zea mays 54.27 2.00e-50 192.00
Created Date 25-Jun-2017

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