iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sit-110608

Ensembl Protein ID

Si000310m

UniProt Accession

K3XEJ3; K3XEJ3_SETIT

Genbank Protein ID

KQL03316.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

CM003532

Gene Name

LOC101785125; SETIT_000310mg

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Si000310m.g	Si000310m	Si000310m

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.40e-54	183.8	348	827
UBD/Alpha-Helix/UBA	1.40e-13	51.5	647	686

Active Site

Position(s)	Description	Evidence
357	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
790	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw........kskkkavsprellkalkkeaeefsgyeqqD 91
           tGl NlgN+CYm S++Q++++++++ + ++e +  ++  + +p +p+ +l ++++kl + l+        k+ ++ + pr++++++++ ++efs+++qqD
   Q: 348  TGLANLGNSCYMASIMQVMFSTHPFISRYFEkQSLKAAFAAAPADPTVDLNMQMTKLGHGLLsgkysartKEGQEGIRPRMFKSVIAANHPEFSSMRQQD 447
           7************************998888344444455678999***************65555555577888************************* PP
   S: 92   aqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke...... 185
           a +f+ +l+d++e++                           + +++ ++    F++ ++++++c++ + vs  + + + lsl +p +e t+ke      
   Q: 448  ALDFFLHLIDRVEQAN--------------------------PGNHELNPC-SGFKFIIEERVQCPSGK-VSYNKRSDYILSLGIPLHEATNKEeleafn 519
           *************988..........................444455554.57***********9865.55555566777777777777777778**** PP
   S: 186  .......................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
                                   l+ cL++f+ +ee+ +   +y++  ++k++a+k+ +++++P++L+lh+ +f + e++++++k+  ++++p+++d+s
   Q: 520  ekkaamdldgkevsneeivrprvPLEACLANFAGPEEIPD---FYSTALNSKTTATKTAGFNTFPDYLVLHMRKF-VMEAGWVPKKLYVYIDVPDTIDIS 615
           **************************************97...********************************.77889******************* PP
   S: 263  pfcts......................................................................................peekqke.. 274
           ++ ++                                                                                      +     e  
   Q: 616  HMRSKgvqpgeellpegasgdnkaepalpvasedivsqlasmgfnylhclkaaintsntgveeamnwllshmddrdindpiskdsrasesvD-----Eas 710
           99999899888888888888888888888888777777777777777777777777777777766666666666666666665555555550.....055 PP
   S: 275  ...........................................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskV 314
                                                                      + +Y+L+a v+H+G s+++GHYva+v   +g+W  f+DskV
   Q: 711  vqtlisfgfpeeiatmalkasggniekatdwifsqasssasadsstsnvnaddtyvpdgCGIYKLMAFVSHMGtSTNCGHYVAHVLV-DGRWTIFNDSKV 809
           55566666666666666666666666666666666666667777778888999999999****************************.9*********** PP
   S: 315  tevkeeevleetgstaYvlfYkr 337
            ++   +  +   + +Y++f++r
   Q: 810  AAS--VDLPK---DMGYLYFFQR 827
           999..68888...999**99997 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           +ed++ ql +MGF+  ++l+a  ++ n  +e+A+++Ll++
   Q: 647  SEDIVSQLASMGFNYLHCLKAAINTsNTGVEEAMNWLLSH 686
           79************************************97 PP

Organism

Setaria italica

Protein Sequence
(Fasta)

MRFSSGLHPI FFQLITHSSS LSSLSSNPKT LDATLRRRRS PPPAAMDLLR WHLHKVRFPE 60
PTNRIHKDEC CVSFDTPRSE GGLYVDMSSF LGFGREHVEW NFEKTGNPVY LHIVQRRKPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCGTTTTT CATCCGGGCT GCACCCAATT TTCTTCCAAC TAATCACCCA TTCTTCCTCC 60
CTCTCATCTC TCTCCTCCAA CCCCAAAACC CTAGACGCGA CCCTCCGCCG GCGCCGCTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence