• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046527
Ensembl Protein ID ENSP00000377936.1
UniProt Accession Q00005; A6NEJ2; A8K102; B3KPD0; B7Z2F2; B7Z304; D3DQF7; D3DQF8; G3V149; 2ABB_HUMAN
Genbank Protein ID AAA36493.1; BAG51642.1; BAF82406.1; BAH11838.1; BAH12040.1; EAW61829.1; EAW61831.1; EAW61832.1; EAW61833.1; EAW61834.1; EAW61835.1; AAH31790.1; ENSP00000336591
Protein Name Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; PP2A subunit B isoform B55-beta; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform R2-beta; PP2A subunit B isoform beta
Genbank Nucleotide ID M64930; AK056192; AK289717; AK294659; AK295347; AC008728; CH471062; CH471062; CH471062; CH471062; CH471062; BC031790; BI490027
Gene Name PPP2R2B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000156475.18 ENST00000508545.6 ENSP00000431320.1
ENSG00000156475.18 ENST00000394414.5 ENSP00000377936.1
ENSG00000156475.18 ENST00000336640.10 ENSP00000336591.6
ENSG00000156475.18 ENST00000504198.5 ENSP00000421396.1
ENSG00000156475.18 ENST00000394413.7 ENSP00000377935.4
ENSG00000156475.18 ENST00000512639.5 ENSP00000426599.1
ENSG00000156475.18 ENST00000512984.1 ENSP00000425828.1
ENSG00000156475.18 ENST00000515880.5 ENSP00000421577.1
ENSG00000156475.18 ENST00000512011.5 ENSP00000424409.1
ENSG00000156475.18 ENST00000508267.5 ENSP00000421224.1
ENSG00000156475.18 ENST00000504565.1 ENSP00000425413.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPMSZDB
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.60e-11 45.6 157 186
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 5    svtclaf...sd.tllvsGsdDgtikvWDl 30
           +++ +++   ++  +++ +++D+t+k+W +
   Q: 157  KINKIRWlpqQNaAYFLLSTNDKTVKLWKV 186
           79999***986678899999********97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity).
 The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity).
Protein Sequence
(Fasta)
MLLSLPALHL QTSEHHPFFQ LPHRRLGPWC SPTGSPAPLS CETGCGEGSW ILVCRLLVPT 60
QVSLLSMEED IDTRKINNSF LRDHSYATEA DIISTVEFNH TGELLATGDK GGRVVIFQRE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046527|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTGGACCAAG TGATCTCCAA GGGCTGACCA GATTCAGAAG TTGTCTATTC CATGAGCCTA 60
GAGATAAGAT ACATGCATGC CATCTGCGGG CTGTGCTTCC AACCATTCAG TAGGTGAGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046527|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0472--Membrane
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-0523--Neurodegeneration
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0950--Spinocerebellar ataxia
KW-0853--WD repeat
Interpro

IPR000009--PP2A_PR55
IPR018067--PP2A_PR55_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS01024--PR55_1
PS01025--PR55_2
PS00678--WD_REPEATS_1
PRINTS

PR00600--PP2APR55
SMART

SM00320--WD40
Gene Ontology

GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0000159--C:protein phosphatase type 2A complex
GO:0019888--F:protein phosphatase regulator activity
GO:0006915--P:apoptotic process
GO:0032502--P:developmental process
GO:0000278--P:mitotic cell cycle
GO:0070262--P:peptidyl-serine dephosphorylation
KEGG hsa:5521
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001169 Aegilops tauschii 50.74 5.00e-125 441.00
IUUC-Aml-001777 Ailuropoda melanoleuca 98.58 0.00e+00 850.00
IUUC-Apl-004114 Anas platyrhynchos 98.57 0.00e+00 840.00
IUUC-Aca-004308 Anolis carolinensis 98.87 0.00e+00 890.00
IUUC-Ago-007825 Ashbya gossypii 54.34 5.00e-132 464.00
IUUC-Ame-011491 Astyanax mexicanus 93.84 0.00e+00 813.00
IUUC-Bgr-012221 Blumeria graminis 54.63 4.00e-138 484.00
IUUC-Bta-012662 Bos taurus 100.00 0.00e+00 899.00
IUUC-Cja-018822 Callithrix jacchus 99.41 0.00e+00 1037.00
IUUC-Cfa-020968 Canis familiaris 99.38 0.00e+00 984.00
IUUC-Cpo-022045 Cavia porcellus 99.21 0.00e+00 1032.00
IUUC-Cho-024810 Choloepus hoffmanni 100.00 0.00e+00 849.00
IUUC-Cne-026887 Cryptococcus neoformans 62.98 4.00e-149 521.00
IUUC-Cme-027332 Cyanidioschyzon merolae 47.64 1.00e-115 410.00
IUUC-Dre-027721 Danio rerio 93.23 0.00e+00 851.00
IUUC-Dno-029502 Dasypus novemcinctus 100.00 0.00e+00 899.00
IUUC-Ete-032410 Echinops telfairi 77.57 3.00e-174 604.00
IUUC-Eca-033882 Equus caballus 100.00 0.00e+00 899.00
IUUC-Fca-035978 Felis catus 99.76 0.00e+00 855.00
IUUC-Fal-037489 Ficedula albicollis 97.17 0.00e+00 840.00
IUUC-Gmo-039536 Gadus morhua 89.62 0.00e+00 822.00
IUUC-Gga-041033 Gallus gallus 98.10 0.00e+00 839.00
IUUC-Gac-041573 Gasterosteus aculeatus 89.62 0.00e+00 821.00
IUUC-Ggo-045529 Gorilla gorilla 85.27 0.00e+00 849.00
IUUC-Hvu-047813 Hordeum vulgare 51.84 2.00e-129 455.00
IUUC-Kpa-049100 Komagataella pastoris 54.09 5.00e-133 468.00
IUUC-Lch-050157 Latimeria chalumnae 96.67 0.00e+00 833.00
IUUC-Lpe-050866 Leersia perrieri 53.61 5.00e-132 464.00
IUUC-Loc-052619 Lepisosteus oculatus 94.13 0.00e+00 862.00
IUUC-Laf-053989 Loxodonta africana 99.41 0.00e+00 1036.00
IUUC-Mcc-055718 Macaca mulatta 98.20 0.00e+00 997.00
IUUC-Meu-056450 Macropus eugenii 80.55 0.00e+00 795.00
IUUC-Mmr-061080 Microcebus murinus 99.41 0.00e+00 1036.00
IUUC-Mdo-062231 Monodelphis domestica 96.07 0.00e+00 991.00
IUUC-Mmu-064059 Mus musculus 100.00 0.00e+00 854.00
IUUC-Mpu-066201 Mustela putorius furo 98.00 0.00e+00 994.00
IUUC-Mlu-067042 Myotis lucifugus 91.92 0.00e+00 785.00
IUUC-Nle-069840 Nomascus leucogenys 100.00 0.00e+00 1042.00
IUUC-Opr-070857 Ochotona princeps 99.21 0.00e+00 1028.00
IUUC-Ont-071958 Oreochromis niloticus 90.07 0.00e+00 823.00
IUUC-Ocu-074693 Oryctolagus cuniculus 100.00 0.00e+00 852.00
IUUC-Oba-075019 Oryza barthii 52.70 7.00e-132 464.00
IUUC-Ogu-078671 Oryza glumaepatula 52.70 3.00e-132 465.00
IUUC-Olo-080800 Oryza longistaminata 52.93 3.00e-132 465.00
IUUC-Ome-081334 Oryza meridionalis 52.70 4.00e-132 464.00
IUUC-Opu-084074 Oryza punctata 52.38 3.00e-133 468.00
IUUC-Osa-085954 Oryza sativa 52.70 3.00e-132 465.00
IUUC-Oga-088363 Otolemur garnettii 100.00 0.00e+00 899.00
IUUC-Oar-090213 Ovis aries 99.38 0.00e+00 986.00
IUUC-Ptr-090700 Pan troglodytes 99.76 0.00e+00 853.00
IUUC-Pan-092915 Papio anubis 98.59 0.00e+00 856.00
IUUC-Psi-093137 Pelodiscus sinensis 98.42 0.00e+00 887.00
IUUC-Pfo-096432 Poecilia formosa 90.28 0.00e+00 785.00
IUUC-Pab-097563 Pongo abelii 100.00 0.00e+00 989.00
IUUC-Pva-102279 Pteropus vampyrus 99.21 0.00e+00 1033.00
IUUC-Pgr-103671 Puccinia graminis 52.38 2.00e-117 416.00
IUUC-Rno-106071 Rattus norvegicus 92.31 0.00e+00 837.00
IUUC-Sha-106616 Sarcophilus harrisii 99.32 0.00e+00 893.00
IUUC-Sja-107757 Schizosaccharomyces japonicus 58.81 6.00e-138 484.00
IUUC-Sit-110793 Setaria italica 51.84 4.00e-132 464.00
IUUC-Stu-111973 Solanum tuberosum 49.89 5.00e-122 431.00
IUUC-Sre-115166 Sporisorium reilianum 61.33 6.00e-146 510.00
IUUC-Ssc-115334 Sus scrofa 93.92 0.00e+00 830.00
IUUC-Tgu-116646 Taeniopygia guttata 98.10 0.00e+00 837.00
IUUC-Tru-118603 Takifugu rubripes 86.74 0.00e+00 819.00
IUUC-Tni-120319 Tetraodon nigroviridis 88.94 0.00e+00 816.00
IUUC-Tur-126274 Triticum urartu 51.84 2.00e-125 443.00
IUUC-Tme-127130 Tuber melanosporum 60.66 7.00e-140 490.00
IUUC-Tbe-128016 Tupaia belangeri 92.91 0.00e+00 776.00
IUUC-Uma-129346 Ustilago maydis 61.33 8.00e-146 510.00
IUUC-Xtr-132662 Xenopus tropicalis 90.35 0.00e+00 819.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved