iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044606

UUCD1 version

UUC-GoG-00292

Ensembl Protein ID

ENSGGOP00000006994.2

UniProt Accession

G3QW46; G3QW46_GORGO

Protein Name

Uncharacterized protein

Gene Name

TRAF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000007150.2	ENSGGOT00000007180.2	ENSGGOP00000006994.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	91.22	0.00e+00	936.00	IUUC-Hsa-046952

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MAAASVTPPG SLELLQPGFS KTLLGTKLEA KYLCSACRNV LRRPFQAQCG HRYCSFCLAS 60
ILSSGPQNCA ACVHEGIYEE GISILESSSA FPDNAARREV ESLPAVCPSD GCTWKGTLKE 120

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Nucleotide Sequence
(Fasta)

TTAGGGCTTT GTTGTTCACG GGGGTCACAG CTCTCATGGC TGCAGCTAGC GTGACCCCCC 60
CTGGCTCCCT GGAGTTGCTA CAGCCCGGCT TCTCCAAGAC CCTCCTGGGG ACCAAGCTGG 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027133--TRAF2
IPR032070--TRAF_BIRC3-bd
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF16673--TRAF_BIRC3_bd
PF00097--zf-C3HC4
PF02176--zf-TRAF

SMART

SM00184--RING

Gene Ontology

GO:1990597--C:AIP1-IRE1 complex
GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:1990604--C:IRE1-TRAF2-ASK1 complex
GO:0045121--C:membrane raft
GO:0097057--C:TRAF2-GSTP1 complex
GO:0000151--C:ubiquitin ligase complex
GO:0012506--C:vesicle membrane
GO:0046625--F:sphingolipid binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0043623--P:cellular protein complex assembly
GO:0071732--P:cellular response to nitric oxide
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:1903721--P:positive regulation of I-kappaB phosphorylation
GO:0032743--P:positive regulation of interleukin-2 production
GO:0043507--P:positive regulation of JUN kinase activity
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0090073--P:positive regulation of protein homodimerization activity
GO:0002726--P:positive regulation of T cell cytokine production
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0097300--P:programmed necrotic cell death
GO:0051865--P:protein autoubiquitination
GO:0030163--P:protein catabolic process
GO:0070207--P:protein homotrimerization
GO:0070534--P:protein K63-linked ubiquitination
GO:0051023--P:regulation of immunoglobulin secretion
GO:0033209--P:tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000744	Aegilops tauschii	27.12	3.00e-06	47.80
IUUC-Aml-002344	Ailuropoda melanoleuca	78.97	0.00e+00	815.00
IUUC-Apl-004202	Anas platyrhynchos	67.54	0.00e+00	740.00
IUUC-Aca-005029	Anolis carolinensis	51.21	5.00e-121	427.00
IUUC-Ame-011841	Astyanax mexicanus	46.85	4.00e-149	521.00
IUUC-Bta-013180	Bos taurus	79.49	0.00e+00	804.00
IUUC-Bdi-014617	Brachypodium distachyon	25.42	5.00e-05	43.90
IUUC-Cja-019813	Callithrix jacchus	89.62	0.00e+00	925.00
IUUC-Cfa-021205	Canis familiaris	83.23	0.00e+00	832.00
IUUC-Cpo-021346	Cavia porcellus	82.04	0.00e+00	835.00
IUUC-Csa-023809	Chlorocebus sabaeus	88.71	0.00e+00	808.00
IUUC-Dre-027669	Danio rerio	52.58	9.00e-154	536.00
IUUC-Dno-029458	Dasypus novemcinctus	76.98	0.00e+00	806.00
IUUC-Dor-030338	Dipodomys ordii	79.64	0.00e+00	744.00
IUUC-Eca-034401	Equus caballus	83.17	0.00e+00	855.00
IUUC-Eeu-034668	Erinaceus europaeus	61.25	6.00e-81	294.00
IUUC-Fca-036057	Felis catus	79.73	0.00e+00	841.00
IUUC-Fal-037560	Ficedula albicollis	65.35	0.00e+00	644.00
IUUC-Gmo-038964	Gadus morhua	56.06	4.00e-167	580.00
IUUC-Gga-040425	Gallus gallus	68.31	0.00e+00	739.00
IUUC-Gac-041908	Gasterosteus aculeatus	57.14	1.00e-171	595.00
IUUC-Gma-043859	Glycine max	29.66	7.00e-06	47.00
IUUC-Hsa-046952	Homo sapiens	91.22	0.00e+00	936.00
IUUC-Hvu-047095	Hordeum vulgare	26.27	1.00e-05	46.20
IUUC-Itr-049016	Ictidomys tridecemlineatus	69.31	0.00e+00	688.00
IUUC-Lch-049571	Latimeria chalumnae	53.10	1.00e-179	622.00
IUUC-Loc-051973	Lepisosteus oculatus	56.94	4.00e-159	554.00
IUUC-Laf-053815	Loxodonta africana	76.62	0.00e+00	764.00
IUUC-Mcc-054888	Macaca mulatta	90.42	0.00e+00	929.00
IUUC-Meu-056547	Macropus eugenii	65.30	4.00e-166	577.00
IUUC-Mga-059819	Meleagris gallopavo	67.81	0.00e+00	696.00
IUUC-Mdo-062570	Monodelphis domestica	75.10	0.00e+00	766.00
IUUC-Mmu-063133	Mus musculus	79.64	0.00e+00	783.00
IUUC-Mac-064547	Musa acuminata	32.65	2.00e-06	48.50
IUUC-Mpu-065802	Mustela putorius furo	80.66	0.00e+00	838.00
IUUC-Nle-070155	Nomascus leucogenys	91.22	0.00e+00	938.00
IUUC-Opr-070856	Ochotona princeps	74.76	6.00e-87	314.00
IUUC-Ont-071930	Oreochromis niloticus	57.79	0.00e+00	628.00
IUUC-Ola-087397	Oryzias latipes	54.93	7.00e-175	606.00
IUUC-Oga-088109	Otolemur garnettii	87.23	0.00e+00	902.00
IUUC-Oar-090310	Ovis aries	70.17	0.00e+00	707.00
IUUC-Ptr-090643	Pan troglodytes	91.82	0.00e+00	942.00
IUUC-Pan-091933	Papio anubis	90.22	0.00e+00	926.00
IUUC-Psi-093681	Pelodiscus sinensis	66.47	0.00e+00	698.00
IUUC-Pfo-096148	Poecilia formosa	54.38	6.00e-176	610.00
IUUC-Pab-098631	Pongo abelii	91.62	0.00e+00	942.00
IUUC-Pca-100582	Procavia capensis	82.67	4.00e-72	265.00
IUUC-Pva-102396	Pteropus vampyrus	67.66	0.00e+00	652.00
IUUC-Rno-106120	Rattus norvegicus	77.25	0.00e+00	771.00
IUUC-Sha-106493	Sarcophilus harrisii	75.10	0.00e+00	789.00
IUUC-Sit-110103	Setaria italica	26.27	2.00e-05	45.40
IUUC-Sar-113570	Sorex araneus	72.93	2.00e-72	266.00
IUUC-Ssc-115843	Sus scrofa	78.27	0.00e+00	828.00
IUUC-Tgu-117144	Taeniopygia guttata	62.80	7.00e-177	613.00
IUUC-Tru-117853	Takifugu rubripes	55.73	8.00e-175	606.00
IUUC-Tni-120256	Tetraodon nigroviridis	58.48	0.00e+00	634.00
IUUC-Tae-123531	Triticum aestivum	27.12	4.00e-06	47.80
IUUC-Tur-126325	Triticum urartu	26.27	1.00e-05	46.20
IUUC-Tbe-127943	Tupaia belangeri	53.87	3.00e-73	268.00
IUUC-Ttr-129246	Tursiops truncatus	82.34	0.00e+00	818.00
IUUC-Xtr-132279	Xenopus tropicalis	53.28	7.00e-148	516.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence