iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.70e-08	35.4	169	213

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 4    ClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           C +C++++ +   ++eC++C   fH +Clk++  +e+p+ + wiC+ C+
   Q: 169  CQICFKSDTN--IMIECDDCLGGFHLKCLKPP-LKEVPEGD-WICQFCE 213
           9*****9996..5*******************.*******7.******7 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Essential protein required for ovules fertilization (PubMed:15634699, PubMed:19171893). Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication (By similarity). H3K4me3 effector that regulates positively the transcription of a subset of genes (PubMed:19171893).

Protein Sequence
(Fasta)

MASTPRAKTF KSPTKTPSNI YRKSYLSPSS TSHTPQTPET HTPLRRSARH VSRKIDLGND 60
PIDAPGNDPI EGMNLIRKRE RAPRKPTTDV VPSKSKKTET PKKKKKIDSF TPVSPIRSET 120

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Nucleotide Sequence
(Fasta)

TAAGCCCAAT ATTCGGCCCA AAGTTAAACC CTTTTCTCGC AAACTCTTGT CTGATGCGAA 60
GAAGAAGAAG TGTCCGCCAC CTTTTCCCGC CAACTTTCTC TCTCTACCTC CTTCTTCATC 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0235--DNA replication
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003593--AAA+_ATPase
IPR003959--ATPase_AAA_core
IPR001025--BAH_dom
IPR027417--P-loop_NTPase
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51038--BAH
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00004--AAA
PF01426--BAH
PF00628--PHD

SMART

SM00382--AAA
SM00439--BAH
SM00249--PHD

Gene Ontology

GO:0005634--C:nucleus
GO:0000808--C:origin recognition complex
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0010385--F:double-stranded methylated DNA binding
GO:0008270--F:zinc ion binding
GO:0006260--P:DNA replication
GO:0009567--P:double fertilization forming a zygote and endosperm
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

ath:AT4G12620

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005695	Arabidopsis lyrata	94.38	0.00e+00	1390.00
IUUC-Bol-016257	Brassica oleracea	77.42	0.00e+00	1178.00
IUUC-Bra-017118	Brassica rapa	79.08	0.00e+00	1189.00
IUUC-Cel-018523	Caenorhabditis elegans	49.02	4.00e-11	63.90
IUUC-Kpa-049245	Komagataella pastoris	38.18	1.00e-05	45.80
IUUC-Ppe-102108	Prunus persica	71.95	0.00e+00	966.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence