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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046305
UUCD1 version UUC-HoS-00635
Ensembl Protein ID ENSP00000308450.5
UniProt Accession Q12834; B2R6Z6; D3DPJ1; Q5JUY4; Q9BW56; Q9UQI9; CDC20_HUMAN
Genbank Protein ID AAA19017.1; AAD16405.1; BAG35643.1; AAP36052.1; ABE96834.1; CAB92757.1; EAX07101.1; EAX07102.1; AAH00624.1; AAH01088.1; AAH06272.1; AAH09425.1; AAH09426.1; AAH10044.1; AAH12803.1; AAH12827.1; AAH13303.1; AAH15998.1; AAH24257.1; AAH31294.1; AAI10322.1
Protein Name Cell division cycle protein 20 homolog; p55CDC
Genbank Nucleotide ID U05340; AF099644; AK312780; BT007388; DQ473545; AL139289; CH471059; CH471059; BC000624; BC001088; BC006272; BC009425; BC009426; BC010044; BC012803; BC012827; BC013303; BC015998; BC024257; BC031294; BC110321
Gene Name CDC20
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000117399.13 ENST00000310955.10 ENSP00000308450.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACmiRWalkTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/APC_C/CDC20 CDC20 18662541; 19339280; 19167333; 17908926; 17015473; 20937767; 21439932; 11742988
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/APC_C/CDC20 2.10e-147 491.9 172 478
E3 adaptor/Cullin RING/DCX/DWD 4.90e-28 97.6 307 336
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/APC_C/CDC20
   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkkvrt 91
           p+++ldape+r+d+ylnL+dWss nvlavaL++svylwsa++gd+ +l ++ +++++++sv+wi+eg++lavGt+++ev+++Dv+++k++r+
   Q: 172  PDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMeQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRN 263
           689************************************************899************************************** PP
   S: 92   ltghsarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdassse....Plkkfkehk 179
           +t+hsarvg+LsWn+++lssGsr+g+i+h+dvrv+e++++tl++h+qevCGl+w+ d+++LasGGnDn v+vw ++  e    Pl++f++h+
   Q: 264  MTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEggwvPLQTFTQHQ 355
           *****************************************************************************9999*********** PP
   S: 180  aavkaiawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvl 271
           +avka+aw+Pwq+++La+GGGt+Dr+i++wn+++ga+l+++d++sqvcs+lws+++kel+s+hGfa+n++++wkyp+++kvaelkgh++Rvl
   Q: 356  GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVL 447
           ******************************************************************************************** PP
   S: 272  slalspdgeaivtaagDetlrfwklfdkkka 302
           sl++spdg+++++aa+Detlr+w++f+ ++a
   Q: 448  SLTMSPDGATVASAAADETLRLWRCFELDPA 478
           **************************99876 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvW 28
           gH+ +v++l++ +d ++l+sG++D+ + vW
   Q: 307  GHSQEVCGLRWaPDgRHLASGGNDNLVNVW 336
           8***********999*************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
 Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Protein Sequence
(Fasta)
MAQFAFESDL HSLLQLDAPI PNAPPARWQR KAKEAAGPAP SPMRAANRSH SAGRTPGRTP 60
GKSSSKVQTT PSKPGGDRYI PHRSAAQMEV ASFLLSKENQ PENSQTPTKK EHQKAWALNL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046305|E3,CDC20;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGGCGTAAG CCAGGCGTGT TAAAGCCGGT CGGAACTGCT CCGGAGGGCA CGGTGAGAGG 60
TGGTGGGGCT GAGCCGAGGT GGGGCCGTGG CCAGGGGGAG GGGGTGCTAG GCCGGAAGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046305|E3,CDC20;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0221--Differentiation
KW-1017--Isopeptide bond
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR024977--Apc4_WD40_dom
IPR033187--CDC20
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0005819--C:spindle
GO:0000922--C:spindle pole
GO:0019899--F:enzyme binding
GO:0008022--F:protein C-terminus binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0007064--P:mitotic sister chromatid cohesion
GO:0090307--P:mitotic spindle assembly
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0008284--P:positive regulation of cell proliferation
GO:0090129--P:positive regulation of synapse maturation
GO:0031915--P:positive regulation of synaptic plasticity
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0050773--P:regulation of dendrite development
GO:0040020--P:regulation of meiotic nuclear division
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0007062--P:sister chromatid cohesion
KEGG hsa:991
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000638 Aegilops tauschii 46.77 2.00e-111 395.00
IUUC-Aml-001545 Ailuropoda melanoleuca 97.39 0.00e+00 947.00
IUUC-Atr-003103 Amborella trichopoda 46.92 2.00e-109 389.00
IUUC-Apl-003255 Anas platyrhynchos 80.23 0.00e+00 754.00
IUUC-Aca-004920 Anolis carolinensis 76.23 0.00e+00 778.00
IUUC-Aly-006012 Arabidopsis lyrata 49.02 2.00e-109 389.00
IUUC-Ath-006795 Arabidopsis thaliana 46.71 6.00e-108 384.00
IUUC-Ate-010479 Aspergillus terreus 50.78 3.00e-92 332.00
IUUC-Ame-010850 Astyanax mexicanus 60.70 3.00e-91 328.00
IUUC-Bgr-012059 Blumeria graminis 49.84 2.00e-95 343.00
IUUC-Bta-012625 Bos taurus 97.60 0.00e+00 951.00
IUUC-Bci-013607 Botrytis cinerea 47.95 6.00e-99 355.00
IUUC-Bdi-014344 Brachypodium distachyon 48.67 3.00e-110 392.00
IUUC-Bol-015368 Brassica oleracea 45.88 1.00e-106 381.00
IUUC-Bra-016738 Brassica rapa 46.36 5.00e-106 379.00
IUUC-Cja-019132 Callithrix jacchus 98.80 0.00e+00 964.00
IUUC-Cfa-020780 Canis familiaris 97.60 0.00e+00 947.00
IUUC-Cpo-022223 Cavia porcellus 97.19 0.00e+00 901.00
IUUC-Cre-022701 Chlamydomonas reinhardtii 50.00 2.00e-116 412.00
IUUC-Csa-023666 Chlorocebus sabaeus 99.60 0.00e+00 965.00
IUUC-Cho-024920 Choloepus hoffmanni 96.81 6.00e-161 560.00
IUUC-Cin-025675 Ciona intestinalis 51.39 5.00e-136 478.00
IUUC-Csv-026019 Ciona savignyi 51.13 2.00e-131 462.00
IUUC-Cgl-026465 Colletotrichum gloeosporioides 40.78 4.00e-97 348.00
IUUC-Cme-027234 Cyanidioschyzon merolae 51.91 1.00e-105 377.00
IUUC-Dre-028026 Danio rerio 59.96 0.00e+00 631.00
IUUC-Dno-028865 Dasypus novemcinctus 96.60 0.00e+00 935.00
IUUC-Dor-030958 Dipodomys ordii 96.19 0.00e+00 943.00
IUUC-Dse-031391 Dothistroma septosporum 49.40 5.00e-97 348.00
IUUC-Dme-031905 Drosophila melanogaster 49.44 1.00e-143 503.00
IUUC-Ete-032387 Echinops telfairi 91.98 0.00e+00 903.00
IUUC-Eca-033522 Equus caballus 87.58 0.00e+00 852.00
IUUC-Eeu-035059 Erinaceus europaeus 84.80 0.00e+00 796.00
IUUC-Fca-036346 Felis catus 98.19 0.00e+00 869.00
IUUC-Fal-037558 Ficedula albicollis 80.36 0.00e+00 800.00
IUUC-Fox-037850 Fusarium oxysporum 45.31 3.00e-98 352.00
IUUC-Fso-038375 Fusarium solani 44.56 5.00e-99 355.00
IUUC-Gmo-039284 Gadus morhua 62.30 0.00e+00 632.00
IUUC-Ggr-039864 Gaeumannomyces graminis 48.55 5.00e-99 355.00
IUUC-Gga-040790 Gallus gallus 79.96 0.00e+00 815.00
IUUC-Gac-041431 Gasterosteus aculeatus 61.43 9.00e-180 623.00
IUUC-Gma-043489 Glycine max 46.97 4.00e-107 381.00
IUUC-Ggo-045052 Gorilla gorilla 100.00 0.00e+00 967.00
IUUC-Hvu-047476 Hordeum vulgare 46.03 8.00e-111 394.00
IUUC-Itr-048461 Ictidomys tridecemlineatus 97.60 0.00e+00 905.00
IUUC-Lch-050174 Latimeria chalumnae 61.39 1.00e-173 602.00
IUUC-Lpe-050954 Leersia perrieri 48.29 1.00e-101 363.00
IUUC-Loc-052638 Lepisosteus oculatus 63.12 0.00e+00 634.00
IUUC-Lma-052998 Leptosphaeria maculans 43.50 8.00e-101 361.00
IUUC-Laf-053742 Loxodonta africana 97.80 0.00e+00 949.00
IUUC-Mcc-054948 Macaca mulatta 99.60 0.00e+00 965.00
IUUC-Meu-056013 Macropus eugenii 86.22 1.00e-142 499.00
IUUC-Mor-057277 Magnaporthe oryzae 45.93 2.00e-96 346.00
IUUC-Mpo-057624 Magnaporthe poae 51.47 5.00e-97 348.00
IUUC-Mtr-057725 Medicago truncatula 46.28 2.00e-100 359.00
IUUC-Mga-060102 Meleagris gallopavo 80.20 0.00e+00 817.00
IUUC-Mmr-061615 Microcebus murinus 98.96 0.00e+00 955.00
IUUC-Mdo-061982 Monodelphis domestica 89.12 0.00e+00 778.00
IUUC-Mmu-063864 Mus musculus 94.79 0.00e+00 934.00
IUUC-Mac-064861 Musa acuminata 47.70 1.00e-110 393.00
IUUC-Mpu-066502 Mustela putorius furo 97.60 0.00e+00 938.00
IUUC-Mlu-067277 Myotis lucifugus 89.62 0.00e+00 884.00
IUUC-Ncr-068951 Neurospora crassa 45.87 1.00e-95 343.00
IUUC-Nle-070149 Nomascus leucogenys 99.60 0.00e+00 961.00
IUUC-Opr-070778 Ochotona princeps 95.54 0.00e+00 689.00
IUUC-Ont-071660 Oreochromis niloticus 61.16 1.00e-178 619.00
IUUC-Oan-073677 Ornithorhynchus anatinus 77.49 0.00e+00 711.00
IUUC-Ocu-073797 Oryctolagus cuniculus 97.38 0.00e+00 947.00
IUUC-Oba-075514 Oryza barthii 48.52 2.00e-101 362.00
IUUC-Obr-076018 Oryza brachyantha 46.83 4.00e-109 388.00
IUUC-Ogl-077254 Oryza glaberrima 48.52 6.00e-102 364.00
IUUC-Ogu-078521 Oryza glumaepatula 48.40 9.00e-109 388.00
IUUC-Oin-080094 Oryza indica 48.52 6.00e-102 364.00
IUUC-Olo-080449 Oryza longistaminata 48.52 6.00e-102 364.00
IUUC-Ome-081186 Oryza meridionalis 48.16 1.00e-108 388.00
IUUC-Oni-082243 Oryza nivara 48.52 6.00e-102 364.00
IUUC-Opu-084007 Oryza punctata 48.29 1.00e-101 363.00
IUUC-Oru-084562 Oryza rufipogon 48.40 2.00e-108 387.00
IUUC-Osa-086094 Oryza sativa 48.29 1.00e-101 363.00
IUUC-Ola-086907 Oryzias latipes 60.83 3.00e-166 578.00
IUUC-Olu-087647 Ostreococcus lucimarinus 49.07 2.00e-119 422.00
IUUC-Oga-088184 Otolemur garnettii 97.40 0.00e+00 944.00
IUUC-Oar-090023 Ovis aries 92.28 0.00e+00 843.00
IUUC-Ptr-090935 Pan troglodytes 98.94 0.00e+00 899.00
IUUC-Pan-091845 Papio anubis 99.60 0.00e+00 965.00
IUUC-Psi-093188 Pelodiscus sinensis 80.93 0.00e+00 844.00
IUUC-Pma-094187 Petromyzon marinus 54.36 8.00e-149 520.00
IUUC-Pno-094809 Phaeosphaeria nodorum 41.39 2.00e-101 363.00
IUUC-Ppa-095457 Physcomitrella patens 47.22 6.00e-111 394.00
IUUC-Pfo-097429 Poecilia formosa 58.57 1.00e-160 559.00
IUUC-Pab-098603 Pongo abelii 99.80 0.00e+00 966.00
IUUC-Pop-099654 Populus trichocarpa 46.39 3.00e-103 369.00
IUUC-Pca-101062 Procavia capensis 96.79 0.00e+00 926.00
IUUC-Ppe-101865 Prunus persica 46.76 3.00e-97 348.00
IUUC-Pva-102925 Pteropus vampyrus 95.99 0.00e+00 969.00
IUUC-Pte-104142 Pyrenophora teres 42.64 6.00e-99 355.00
IUUC-Pyt-104693 Pyrenophora triticirepentis 42.48 7.00e-99 354.00
IUUC-Rno-106005 Rattus norvegicus 94.99 0.00e+00 933.00
IUUC-Sha-107472 Sarcophilus harrisii 89.60 0.00e+00 893.00
IUUC-Sja-107919 Schizosaccharomyces japonicus 42.82 2.00e-94 339.00
IUUC-Spo-108075 Schizosaccharomyces pombe 45.34 5.00e-97 348.00
IUUC-Ssl-108507 Sclerotinia sclerotiorum 49.27 3.00e-98 352.00
IUUC-Smo-108922 Selaginella moellendorffii 49.46 7.00e-124 437.00
IUUC-Sit-110732 Setaria italica 47.69 3.00e-110 392.00
IUUC-Sly-111202 Solanum lycopersicum 44.65 4.00e-106 378.00
IUUC-Stu-112676 Solanum tuberosum 45.32 1.00e-97 350.00
IUUC-Sar-113092 Sorex araneus 90.98 0.00e+00 879.00
IUUC-Sbi-114558 Sorghum bicolor 46.24 3.00e-110 392.00
IUUC-Ssc-115710 Sus scrofa 98.20 0.00e+00 955.00
IUUC-Tgu-117100 Taeniopygia guttata 79.56 0.00e+00 800.00
IUUC-Tru-118184 Takifugu rubripes 57.34 2.00e-139 489.00
IUUC-Tsy-118892 Tarsius syrichta 97.87 4.00e-164 570.00
IUUC-Tni-120474 Tetraodon nigroviridis 59.01 1.00e-168 585.00
IUUC-Tca-120949 Theobroma cacao 46.51 4.00e-107 381.00
IUUC-Tre-122211 Trichoderma reesei 40.94 1.00e-97 350.00
IUUC-Tvi-122531 Trichoderma virens 41.19 5.00e-98 352.00
IUUC-Tae-123017 Triticum aestivum 46.24 2.00e-111 395.00
IUUC-Tur-126193 Triticum urartu 46.24 5.00e-111 395.00
IUUC-Tbe-127384 Tupaia belangeri 98.99 1.00e-177 615.00
IUUC-Ttr-128511 Tursiops truncatus 97.60 0.00e+00 946.00
IUUC-Vda-129993 Verticillium dahliae 41.04 1.00e-98 354.00
IUUC-Vvi-131245 Vitis vinifera 47.17 1.00e-94 340.00
IUUC-Xtr-131993 Xenopus tropicalis 73.68 0.00e+00 759.00
IUUC-Xma-133332 Xiphophorus maculatus 61.74 3.00e-177 615.00
IUUC-Zma-135135 Zea mays 47.64 3.00e-108 385.00
Created Date 25-Jun-2017

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