iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012678

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase MARCH2; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; RING-type E3 ubiquitin transferase MARCH2

Genbank Nucleotide ID

BC109744

Gene Name

MARCH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000021036.2	ENSBTAT00000028017.2	ENSBTAP00000028017.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	93.09	3.00e-132	468.00	IUUC-Hsa-046263
E3 activity/RING/RING	25.24	2.00e-08	56.20	IUUC-Oin-080134

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.

Protein Sequence
(Fasta)

MTTGDCCHLP GSLCDCSDSP AFSKVVEATG LGPPQYVAQV TSRDGRLLST VIRALETPSD 60
GPFCRICHEG ANGESLLSPC GCSGTLGAVH KSCLERWLSS SNTSYCELCH TEFAVEKRSR 120

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Nucleotide Sequence
(Fasta)

AGAGCGGAGC TAGCGGCGCT GACGGGACCG GCCGGGCCGG GACCAGGGCC GGGGCGAGCG 60
GAGGGGCCTG CGCGGCCGCC CGGCCCGGCC GCGGATCAGG TGGGCACGGG CGGGAGGTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0254--Endocytosis
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0010008--C:endosome membrane
GO:0016021--C:integral component of membrane
GO:0005765--C:lysosomal membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0016567--P:protein ubiquitination

KEGG

bta:508949

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002189	Ailuropoda melanoleuca	93.90	2.00e-128	451.00
IUUC-Apl-004200	Anas platyrhynchos	79.50	1.00e-108	385.00
IUUC-Ame-010786	Astyanax mexicanus	76.42	6.00e-103	366.00
IUUC-Cja-019315	Callithrix jacchus	92.55	2.00e-100	357.00
IUUC-Cfa-020820	Canis familiaris	93.15	6.00e-133	466.00
IUUC-Cpo-021511	Cavia porcellus	90.24	8.00e-130	456.00
IUUC-Dre-028107	Danio rerio	79.00	4.00e-100	357.00
IUUC-Dno-029379	Dasypus novemcinctus	91.06	7.00e-120	422.00
IUUC-Dor-031059	Dipodomys ordii	91.46	3.00e-131	460.00
IUUC-Eca-034013	Equus caballus	90.24	4.00e-121	426.00
IUUC-Eeu-035139	Erinaceus europaeus	88.71	5.00e-61	225.00
IUUC-Fca-035894	Felis catus	93.09	4.00e-133	466.00
IUUC-Fal-037434	Ficedula albicollis	80.84	2.00e-100	358.00
IUUC-Gmo-039276	Gadus morhua	74.49	8.00e-102	362.00
IUUC-Gga-041224	Gallus gallus	77.24	1.00e-108	385.00
IUUC-Gac-042104	Gasterosteus aculeatus	73.39	7.00e-104	369.00
IUUC-Gma-043460	Glycine max	31.43	3.00e-10	58.90
IUUC-Ggo-045297	Gorilla gorilla	94.90	1.00e-107	381.00
IUUC-Hsa-046263	Homo sapiens	93.09	1.00e-133	468.00
IUUC-Itr-048963	Ictidomys tridecemlineatus	93.09	6.00e-133	466.00
IUUC-Lch-050103	Latimeria chalumnae	77.64	1.00e-105	375.00
IUUC-Lpe-051137	Leersia perrieri	24.24	9.00e-11	60.50
IUUC-Loc-052480	Lepisosteus oculatus	68.70	2.00e-97	348.00
IUUC-Laf-054410	Loxodonta africana	92.68	2.00e-133	468.00
IUUC-Mcc-054712	Macaca mulatta	93.50	3.00e-134	470.00
IUUC-Mga-060053	Meleagris gallopavo	78.05	4.00e-111	393.00
IUUC-Mdo-062010	Monodelphis domestica	77.64	4.00e-112	397.00
IUUC-Mmu-064040	Mus musculus	88.21	1.00e-126	445.00
IUUC-Mpu-066205	Mustela putorius furo	93.50	2.00e-133	468.00
IUUC-Mlu-067013	Myotis lucifugus	88.35	1.00e-123	435.00
IUUC-Opr-070698	Ochotona princeps	69.11	4.00e-83	300.00
IUUC-Ont-071768	Oreochromis niloticus	72.98	3.00e-102	364.00
IUUC-Oan-073269	Ornithorhynchus anatinus	62.10	3.00e-82	297.00
IUUC-Ocu-074212	Oryctolagus cuniculus	91.46	2.00e-130	457.00
IUUC-Oin-080134	Oryza indica	25.24	2.00e-09	56.60
IUUC-Ola-087137	Oryzias latipes	69.70	5.00e-90	323.00
IUUC-Oga-088712	Otolemur garnettii	93.50	3.00e-133	467.00
IUUC-Oar-090175	Ovis aries	98.37	3.00e-140	490.00
IUUC-Pan-092276	Papio anubis	93.90	6.00e-135	472.00
IUUC-Psi-094007	Pelodiscus sinensis	78.46	2.00e-111	394.00
IUUC-Pfo-097509	Poecilia formosa	75.69	7.00e-96	342.00
IUUC-Pca-100424	Procavia capensis	90.24	4.00e-130	456.00
IUUC-Pva-102806	Pteropus vampyrus	93.09	4.00e-134	469.00
IUUC-Rno-105029	Rattus norvegicus	91.46	6.00e-131	459.00
IUUC-Sha-106628	Sarcophilus harrisii	77.64	7.00e-112	395.00
IUUC-Sit-110468	Setaria italica	42.00	8.00e-10	57.40
IUUC-Sbi-114312	Sorghum bicolor	42.00	7.00e-10	57.80
IUUC-Ssc-115689	Sus scrofa	95.12	6.00e-137	479.00
IUUC-Tgu-116681	Taeniopygia guttata	77.24	9.00e-110	389.00
IUUC-Tru-118517	Takifugu rubripes	69.76	2.00e-91	328.00
IUUC-Tni-120353	Tetraodon nigroviridis	67.07	1.00e-93	335.00
IUUC-Ttr-128265	Tursiops truncatus	94.72	8.00e-136	475.00
IUUC-Xtr-132814	Xenopus tropicalis	78.07	4.00e-105	373.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence