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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Cel-018355
UUCD1 version UUC-CaE-00340
Ensembl Protein ID C14B1.4
UniProt Accession Q17963; WDR51_CAEEL
Genbank Protein ID CAA85487.1
Protein Name WD repeat-containing protein wdr-5.1
Genbank Nucleotide ID Z37139
Gene Name wdr-5.1; swd-3.1; tag-125; C14B1.4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00006474 C14B1.4 C14B1.4
Annotation
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.90e-50 165.6 169 208
UBD/Beta-Prp 2.60e-78 263.5 80 373
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
    gH++ v+c++f + l+vsGs D ++++WD++tg ++k+
   Q: 169 GHNNYVFCCNFnPQsSLVVSGSFDESVRIWDVKTGMCIKT 208
    8**********955599*******************9985 PP
   


   UBD/Beta-Prp

   S: 2    iktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsf 102
    ++tl+gh k i++ kfsp +++l t+s+d+t+k+w+++ + + r+l gh+ +v+++ +s+d+ v++s+D+t+k++++ t+ ++ tlkgh+++v +++f
   Q: 80 MCTLEGHTK-SISSAKFSPCGKYLGTSSADKTVKIWNMDHMICERTLTGHKLGVNDIAWSSDSRCVVSASDDKTLKIFEIVTSRMTKTLKGHNNYVFCCNF 179
    689999988.5666*************************************************************************************** PP
   S: 103 spsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgt 203
    +p+++ +vsGs d+ +r+wd++tg c++ tl h++ v+ v+++ dg+l++sGs+D+ vr+Wd ++g++++tl + +++v ++f++ngk++++ ld+t
   Q: 180 NPQSSLVVSGSFDESVRIWDVKTGMCIK-TLPAHSDPVSAVSFNRDGSLIASGSYDGLVRIWDTANGQCIKTLVDDENPPVAFVKFSPNGKYILASNLDST 279
    ****************************.********************************************999************************* PP
   S: 204 vklwdlqtgecvrtlnghtdnvksvrfs...pnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgse..dskvniwk 293
    +klwd+++g+++++++gh++ +++ + +++++sgs+D i+iW+l++++++++l++h + v ++++ ++ +n++++g+ d+k++iw
   Q: 280 LKLWDFSKGKTLKQYTGHENSKYCIFANfsvTGGKWIISGSEDCKIYIWNLQTREIVQCLEGHTQPVLASDC-HPVQNIIASGALepDNKIHIWR 373
    ************************98887899****************************************.9*********999********7 PP
   

Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description



     Contributes to histone modification (PubMed:16710447, PubMed:17967446, PubMed:20188723, PubMed:20555324, PubMed:21455483, PubMed:22012258). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:21455483). Required for di- and trimethylation, particularly for the trimethylation at 'Lys-4' of histone H3 (PubMed:20555324, PubMed:21455483, PubMed:24682813). Not required for demethylation of histone H3 'Lys-27' (PubMed:21455483). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, germline establishment, maintenance and function (PubMed:21455483). Required for RNA interference with probable antagonistic role against hpl-2 function (PubMed:17967446). Regulates longevity by limiting lifespan (PubMed:17967446, PubMed:20555324, PubMed:22012258). Plays a role in vulval cell fate specification by acting in the synthetic multivulva pathway independent of set-2 (PubMed:17967446). Sex determining protein required in the germline to promote the spermatogenesis to oogenesis switch during the late larval stages of development (PubMed:24682813). Acts with the sex determining factor tra-1, and redundantly with wdr-5.2, to regulate fog-3 expression, which in turn determines germ cell fate (PubMed:24682813). Cooperates with jmjd-3.1, egl-27 and unc-3 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development (PubMed:25124442).
Contributes to histone modification (PubMed:16710447, PubMed:17967446, PubMed:20188723, PubMed:20555324, PubMed:21455483, PubMed:22012258). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:21455483). Required for di- and trimethylation, particularly for the trimethylation at 'Lys-4' of histone H3 (PubMed:20555324, PubMed:21455483, PubMed:24682813). Not required for demethylation of histone H3 'Lys-27' (PubMed:21455483). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, germline establishment, maintenance and function (PubMed:21455483). Required for RNA interference with probable antagonistic role against hpl-2 function (PubMed:17967446). Regulates longevity by limiting lifespan (PubMed:17967446, PubMed:20555324, PubMed:22012258). Plays a role in vulval cell fate specification by acting in the synthetic multivulva pathway independent of set-2 (PubMed:17967446). Sex determining protein required in the germline to promote the spermatogenesis to oogenesis switch during the late larval stages of development (PubMed:24682813). Acts with the sex determining factor tra-1, and redundantly with wdr-5.2, to regulate fog-3 expression, which in turn determines germ cell fate (PubMed:24682813). Cooperates with jmjd-3.1, egl-27 and unc-3 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development (PubMed:25124442).
Protein Sequence
(Fasta)
MDTSENAASA AEQQPTQQID QLTVPNAPDG GSSAPAPSTS PNSISPSNPT GTPAPGASAQ 60
TPNPNAAGAS ASGSANYKLM CTLEGHTKSI SSAKFSPCGK YLGTSSADKT VKIWNMDHMI 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Cel-018355|E3,WD_repeat;UBD,Beta-Prp|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATTTTTGCT GTGATTTCAG ATATGGATAC CAGCGAAAAT GCTGCTTCAG CTGCCGAGCA 60
ACAGCCAACA CAACAAATCG ATCAATTAAC AGTACCAAAT GCTCCGGATG GAGGTTCTTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Cel-018355|E3,WD_repeat;UBD,Beta-Prp|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0943--RNA-mediated gene silencing
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0044666--C:MLL3/4 complex
GO:0005634--C:nucleus
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0008340--P:determination of adult lifespan
GO:0031047--P:gene silencing by RNA
GO:0051568--P:histone H3-K4 methylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0060290--P:transdifferentiation

KEGG cel:CELE_C14B1.4
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000502 Aegilops tauschii 47.32 1.00e-76 278.00
IUUC-Aml-002420 Ailuropoda melanoleuca 68.52 8.00e-134 468.00
IUUC-Atr-002439 Amborella trichopoda 63.18 5.00e-115 405.00
IUUC-Apl-003436 Anas platyrhynchos 66.00 1.00e-119 421.00
IUUC-Aca-004259 Anolis carolinensis 72.33 6.00e-133 465.00
IUUC-Aly-005723 Arabidopsis lyrata 58.45 4.00e-106 376.00
IUUC-Ath-007308 Arabidopsis thaliana 57.77 3.00e-104 370.00
IUUC-Ago-007915 Ashbya gossypii 37.46 1.00e-49 188.00
IUUC-Acl-008045 Aspergillus clavatus 40.52 5.00e-72 263.00
IUUC-Afl-008596 Aspergillus flavus 41.84 1.00e-69 256.00
IUUC-Afu-009074 Aspergillus fumigatus 41.31 6.00e-72 263.00
IUUC-Ani-009318 Aspergillus nidulans 43.86 1.00e-71 262.00
IUUC-Ang-009775 Aspergillus niger 40.33 5.00e-71 260.00
IUUC-Aor-010222 Aspergillus oryzae 41.84 1.00e-69 256.00
IUUC-Ate-010583 Aspergillus terreus 41.84 2.00e-69 255.00
IUUC-Ame-011349 Astyanax mexicanus 72.33 3.00e-133 466.00
IUUC-Bgr-011968 Blumeria graminis 42.47 6.00e-72 263.00
IUUC-Bta-013016 Bos taurus 72.33 6.00e-133 465.00
IUUC-Bci-013948 Botrytis cinerea 43.85 4.00e-70 257.00
IUUC-Bdi-014263 Brachypodium distachyon 55.33 4.00e-107 379.00
IUUC-Bol-015900 Brassica oleracea 57.09 4.00e-103 366.00
IUUC-Bra-017143 Brassica rapa 56.42 4.00e-103 366.00
IUUC-Cja-019936 Callithrix jacchus 68.52 8.00e-134 468.00
IUUC-Cfa-020596 Canis familiaris 68.52 8.00e-134 468.00
IUUC-Cpo-021318 Cavia porcellus 68.52 8.00e-134 468.00
IUUC-Csa-023053 Chlorocebus sabaeus 68.52 8.00e-134 468.00
IUUC-Cho-024642 Choloepus hoffmanni 67.67 2.00e-117 414.00
IUUC-Cin-025495 Ciona intestinalis 71.67 2.00e-131 460.00
IUUC-Csv-025988 Ciona savignyi 72.11 1.00e-129 454.00
IUUC-Cgl-026771 Colletotrichum gloeosporioides 32.69 1.00e-41 164.00
IUUC-Cme-027119 Cyanidioschyzon merolae 49.06 1.00e-89 322.00
IUUC-Dre-027521 Danio rerio 72.33 1.00e-133 468.00
IUUC-Dno-029739 Dasypus novemcinctus 72.33 6.00e-133 465.00
IUUC-Dor-030966 Dipodomys ordii 72.33 6.00e-133 465.00
IUUC-Dse-031189 Dothistroma septosporum 45.10 3.00e-75 274.00
IUUC-Dme-031613 Drosophila melanogaster 65.07 2.00e-134 470.00
IUUC-Ete-033098 Echinops telfairi 68.00 1.00e-123 434.00
IUUC-Eca-033790 Equus caballus 68.52 8.00e-134 468.00
IUUC-Eeu-034805 Erinaceus europaeus 58.88 4.00e-114 402.00
IUUC-Fca-035901 Felis catus 68.52 8.00e-134 468.00
IUUC-Fal-037413 Ficedula albicollis 72.33 3.00e-133 466.00
IUUC-Fox-037876 Fusarium oxysporum 45.19 9.00e-55 205.00
IUUC-Gmo-039131 Gadus morhua 72.33 3.00e-133 466.00
IUUC-Ggr-040071 Gaeumannomyces graminis 36.09 8.00e-56 210.00
IUUC-Gga-040789 Gallus gallus 72.33 3.00e-133 466.00
IUUC-Gac-042634 Gasterosteus aculeatus 72.33 1.00e-133 467.00
IUUC-Gma-043987 Glycine max 60.46 9.00e-111 391.00
IUUC-Ggo-044443 Gorilla gorilla 68.52 8.00e-134 468.00
IUUC-Hsa-046290 Homo sapiens 68.52 8.00e-134 468.00
IUUC-Hvu-047077 Hordeum vulgare 52.40 7.00e-69 251.00
IUUC-Itr-048954 Ictidomys tridecemlineatus 68.52 8.00e-134 468.00
IUUC-Kpa-049404 Komagataella pastoris 39.86 6.00e-60 223.00
IUUC-Lch-049539 Latimeria chalumnae 68.52 2.00e-133 467.00
IUUC-Lpe-051082 Leersia perrieri 56.04 1.00e-106 378.00
IUUC-Loc-051743 Lepisosteus oculatus 72.33 3.00e-133 466.00
IUUC-Lma-053188 Leptosphaeria maculans 41.88 9.00e-75 272.00
IUUC-Laf-054432 Loxodonta africana 65.29 2.00e-130 456.00
IUUC-Mcc-055603 Macaca mulatta 68.52 8.00e-134 468.00
IUUC-Meu-056440 Macropus eugenii 69.33 4.00e-117 412.00
IUUC-Mor-056965 Magnaporthe oryzae 33.51 3.00e-60 225.00
IUUC-Mpo-057333 Magnaporthe poae 38.13 7.00e-55 207.00
IUUC-Mtr-057951 Medicago truncatula 58.03 1.00e-107 381.00
IUUC-Mla-058896 Melampsora laricipopulina 42.46 3.00e-70 257.00
IUUC-Mga-060046 Meleagris gallopavo 72.00 5.00e-133 465.00
IUUC-Mvi-060453 Microbotryum violaceum 46.20 6.00e-82 296.00
IUUC-Mmr-061020 Microcebus murinus 63.13 5.00e-124 435.00
IUUC-Mdo-062204 Monodelphis domestica 70.67 4.00e-131 459.00
IUUC-Mmu-063917 Mus musculus 68.52 8.00e-134 468.00
IUUC-Mac-065310 Musa acuminata 57.09 1.00e-106 378.00
IUUC-Mpu-066072 Mustela putorius furo 68.52 8.00e-134 468.00
IUUC-Mlu-068209 Myotis lucifugus 68.52 8.00e-134 468.00
IUUC-Nfi-068538 Neosartorya fischeri 40.66 1.00e-70 259.00
IUUC-Ncr-068651 Neurospora crassa 38.85 5.00e-62 230.00
IUUC-Nle-069383 Nomascus leucogenys 66.67 1.00e-116 411.00
IUUC-Opr-070937 Ochotona princeps 64.16 6.00e-110 388.00
IUUC-Ont-071458 Oreochromis niloticus 72.33 1.00e-133 468.00
IUUC-Oan-073597 Ornithorhynchus anatinus 72.33 4.00e-133 466.00
IUUC-Oba-075292 Oryza barthii 51.35 6.00e-88 315.00
IUUC-Obr-076723 Oryza brachyantha 48.69 2.00e-83 300.00
IUUC-Ogl-077251 Oryza glaberrima 54.22 9.00e-105 371.00
IUUC-Ogu-078143 Oryza glumaepatula 48.09 4.00e-86 310.00
IUUC-Oin-079601 Oryza indica 48.83 5.00e-100 356.00
IUUC-Olo-080976 Oryza longistaminata 58.96 6.00e-94 335.00
IUUC-Ome-081430 Oryza meridionalis 54.58 5.00e-105 372.00
IUUC-Oni-082216 Oryza nivara 48.09 4.00e-86 310.00
IUUC-Opu-083880 Oryza punctata 55.23 4.00e-106 376.00
IUUC-Oru-084935 Oryza rufipogon 48.25 2.00e-86 311.00
IUUC-Osa-085706 Oryza sativa 54.22 9.00e-105 371.00
IUUC-Ola-087134 Oryzias latipes 72.33 1.00e-133 468.00
IUUC-Oga-088672 Otolemur garnettii 72.33 2.00e-133 466.00
IUUC-Oar-089860 Ovis aries 66.22 8.00e-116 408.00
IUUC-Ptr-091513 Pan troglodytes 68.52 8.00e-134 468.00
IUUC-Pan-092046 Papio anubis 68.52 8.00e-134 468.00
IUUC-Psi-093192 Pelodiscus sinensis 72.33 3.00e-133 466.00
IUUC-Pno-094881 Phaeosphaeria nodorum 44.44 2.00e-79 287.00
IUUC-Ppa-095367 Physcomitrella patens 66.56 4.00e-120 422.00
IUUC-Pfo-097434 Poecilia formosa 72.33 2.00e-133 467.00
IUUC-Pab-098758 Pongo abelii 67.33 9.00e-118 414.00
IUUC-Pop-099778 Populus trichocarpa 60.00 2.00e-110 390.00
IUUC-Pca-100281 Procavia capensis 58.58 2.00e-86 310.00
IUUC-Ppe-101341 Prunus persica 59.80 2.00e-109 387.00
IUUC-Pva-103020 Pteropus vampyrus 68.21 8.00e-134 468.00
IUUC-Pgr-103589 Puccinia graminis 36.34 1.00e-64 239.00
IUUC-Ptt-103745 Puccinia triticina 32.35 6.00e-33 133.00
IUUC-Pte-104153 Pyrenophora teres 45.60 4.00e-80 290.00
IUUC-Pyt-104712 Pyrenophora triticirepentis 46.01 2.00e-67 247.00
IUUC-Rno-105858 Rattus norvegicus 68.52 8.00e-134 468.00
IUUC-Sce-106243 Saccharomyces cerevisiae 33.33 8.00e-41 159.00
IUUC-Sha-107101 Sarcophilus harrisii 72.33 2.00e-133 466.00
IUUC-Sja-107858 Schizosaccharomyces japonicus 47.42 1.00e-62 231.00
IUUC-Spo-108117 Schizosaccharomyces pombe 44.64 6.00e-61 226.00
IUUC-Smo-109155 Selaginella moellendorffii 64.19 4.00e-116 409.00
IUUC-Sit-110688 Setaria italica 55.00 8.00e-107 378.00
IUUC-Sly-110891 Solanum lycopersicum 60.47 9.00e-111 391.00
IUUC-Stu-112365 Solanum tuberosum 60.14 1.00e-110 391.00
IUUC-Sbi-114284 Sorghum bicolor 55.00 4.00e-106 376.00
IUUC-Ssc-116204 Sus scrofa 72.33 4.00e-133 466.00
IUUC-Tgu-117172 Taeniopygia guttata 72.33 3.00e-133 466.00
IUUC-Tru-118320 Takifugu rubripes 72.33 3.00e-133 466.00
IUUC-Tni-120660 Tetraodon nigroviridis 71.96 9.00e-81 291.00
IUUC-Tca-121051 Theobroma cacao 60.60 2.00e-110 390.00
IUUC-Tre-122237 Trichoderma reesei 41.42 3.00e-74 270.00
IUUC-Tvi-122635 Trichoderma virens 43.25 4.00e-73 266.00
IUUC-Tae-125819 Triticum aestivum 55.00 1.00e-105 375.00
IUUC-Tur-126217 Triticum urartu 51.95 2.00e-70 256.00
IUUC-Tme-127061 Tuber melanosporum 50.67 7.00e-95 338.00
IUUC-Tbe-127488 Tupaia belangeri 68.00 5.00e-119 419.00
IUUC-Ttr-129309 Tursiops truncatus 63.27 2.00e-120 423.00
IUUC-Uma-129585 Ustilago maydis 40.33 1.00e-73 268.00
IUUC-Vda-129907 Verticillium dahliae 40.21 8.00e-67 246.00
IUUC-Vpa-130384 Vicugna pacos 67.00 1.00e-116 411.00
IUUC-Vvi-131269 Vitis vinifera 61.62 2.00e-107 380.00
IUUC-Xtr-131945 Xenopus tropicalis 71.67 5.00e-132 462.00
IUUC-Xma-132997 Xiphophorus maculatus 72.33 2.00e-133 467.00
IUUC-Yli-134418 Yarrowia lipolytica 43.25 3.00e-73 267.00
IUUC-Zma-135765 Zea mays 55.00 6.00e-106 375.00
Created Date 25-Jun-2017

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