iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mtr-057852

Ensembl Protein ID

AES81513

UniProt Accession

G7KWA3; G7KWA3_MEDTR

Genbank Protein ID

AES81513.1

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

CM001223

Gene Name

MTR_7g093600

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MTR_7g093600	AES81513	AES81513

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	31.23	8.00e-39	157.00	IUUC-Dme-031755

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Medicago truncatula

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MAPGGGIFKE VLESHLLTSD YETGKAKSEA KINSTLTKST SVGLNGKHGT SSKNGVHDLL 60
GCPVCKNLMY PPIYQCPNGH TLCSNCKIEV HNLCPTCHHD LGNIRCLALE KVAESLELPC 120

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Nucleotide Sequence
(Fasta)

GCAGAAACAA AAAAATTACC AAAAATTACT TTTTTGTTTC CAAAATTTCA GATTAAATTA 60
AATAAAAAAG AAGAAGAAGA GAGAGAAAGA TAAATAACTC AACGAAAGAA ACATAGCAGA 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mtr:MTR_7g093600

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006207	Arabidopsis lyrata	77.42	4.00e-147	513.00
IUUC-Ath-007049	Arabidopsis thaliana	77.74	4.00e-146	509.00
IUUC-Bol-016263	Brassica oleracea	78.39	7.00e-146	508.00
IUUC-Bra-016847	Brassica rapa	74.19	7.00e-139	485.00
IUUC-Dme-031755	Drosophila melanogaster	34.23	1.00e-39	156.00
IUUC-Pop-099563	Populus trichocarpa	66.77	8.00e-130	455.00
IUUC-Ppe-101760	Prunus persica	68.61	9.00e-131	458.00
IUUC-Sly-111117	Solanum lycopersicum	69.58	5.00e-131	459.00
IUUC-Stu-112714	Solanum tuberosum	69.68	2.00e-133	467.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence