iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-036107

Ensembl Protein ID

ENSFCAP00000005424.1

UniProt Accession

M3W4T2; M3W4T2_FELCA

Genbank Protein ID

ENSFCAP00000005424

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

AANG02047605

Gene Name

URM1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000005842.1	ENSFCAT00000005844.1	ENSFCAP00000005424.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	42.42	9.00e-17	79.30	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Felis catus

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MAAPLSVEVE FGGGAELLFD GIKKHQVTLP GQEEPWDIRN LLVWIKKNLL KERPELFIQG 60
DSVRPGILVL VNDADWELLG ELDYQLQDQD NILFISTLHG G 101

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Nucleotide Sequence
(Fasta)

ATGGCAGCGC CCTTGTCGGT GGAGGTGGAG TTCGGGTGAG TCACAGAGCT GGGGCACTGT 60
GGGGATGGAT TGAAGTCGTC GGGCCCGGAA CTCCCCTCCC TCTGCTTTGG GGCCTGTCAC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016783--F:sulfurtransferase activity
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

KEGG

fca:101100256

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	98.02	1.00e-53	200.00
IUUC-Atr-003089	Amborella trichopoda	56.57	5.00e-30	121.00
IUUC-Apl-003382	Anas platyrhynchos	86.81	1.00e-43	166.00
IUUC-Aca-004981	Anolis carolinensis	83.17	2.00e-48	182.00
IUUC-Aly-005517	Arabidopsis lyrata	55.43	1.00e-27	113.00
IUUC-Ath-006718	Arabidopsis thaliana	55.95	4.00e-24	102.00
IUUC-Ago-007917	Ashbya gossypii	41.41	1.00e-19	87.00
IUUC-Acl-008054	Aspergillus clavatus	68.00	1.00e-15	73.90
IUUC-Afl-008704	Aspergillus flavus	56.18	4.00e-21	92.00
IUUC-Aor-009890	Aspergillus oryzae	58.42	1.00e-25	108.00
IUUC-Bta-012448	Bos taurus	96.04	6.00e-53	198.00
IUUC-Bci-013865	Botrytis cinerea	47.52	4.00e-22	95.90
IUUC-Bdi-014980	Brachypodium distachyon	61.04	7.00e-24	101.00
IUUC-Bol-016055	Brassica oleracea	57.50	4.00e-24	102.00
IUUC-Bra-016845	Brassica rapa	57.50	4.00e-24	102.00
IUUC-Cel-018485	Caenorhabditis elegans	33.98	1.00e-11	60.50
IUUC-Cja-019587	Callithrix jacchus	96.04	3.00e-53	199.00
IUUC-Cfa-020653	Canis familiaris	97.03	4.00e-53	198.00
IUUC-Cpo-021622	Cavia porcellus	96.04	3.00e-53	199.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	51.02	5.00e-25	105.00
IUUC-Csa-023756	Chlorocebus sabaeus	98.73	6.00e-41	159.00
IUUC-Cgl-026518	Colletotrichum gloeosporioides	46.53	2.00e-21	93.60
IUUC-Cne-026953	Cryptococcus neoformans	56.31	1.00e-27	115.00
IUUC-Cme-027314	Cyanidioschyzon merolae	44.33	5.00e-18	82.00
IUUC-Dre-027884	Danio rerio	76.24	1.00e-44	170.00
IUUC-Dno-029262	Dasypus novemcinctus	93.83	1.00e-39	155.00
IUUC-Dor-030601	Dipodomys ordii	64.36	2.00e-27	113.00
IUUC-Dme-031893	Drosophila melanogaster	63.73	6.00e-33	131.00
IUUC-Ete-032773	Echinops telfairi	88.12	1.00e-47	180.00
IUUC-Eca-034187	Equus caballus	97.03	2.00e-53	199.00
IUUC-Eeu-034808	Erinaceus europaeus	96.04	3.00e-52	196.00
IUUC-Fal-036607	Ficedula albicollis	85.71	4.00e-43	164.00
IUUC-Fox-037698	Fusarium oxysporum	48.08	1.00e-23	100.00
IUUC-Gmo-039492	Gadus morhua	74.26	6.00e-44	167.00
IUUC-Ggr-039965	Gaeumannomyces graminis	49.04	4.00e-21	93.60
IUUC-Gga-041268	Gallus gallus	86.14	4.00e-49	185.00
IUUC-Gac-042111	Gasterosteus aculeatus	78.22	1.00e-46	177.00
IUUC-Gma-043240	Glycine max	53.57	1.00e-22	97.40
IUUC-Ggo-045176	Gorilla gorilla	96.20	3.00e-32	130.00
IUUC-Hsa-046077	Homo sapiens	95.05	8.00e-45	171.00
IUUC-Itr-048111	Ictidomys tridecemlineatus	93.26	1.00e-37	147.00
IUUC-Kpa-049157	Komagataella pastoris	47.47	1.00e-19	87.40
IUUC-Lch-049889	Latimeria chalumnae	81.19	2.00e-46	176.00
IUUC-Lpe-050783	Leersia perrieri	56.63	1.00e-22	97.40
IUUC-Loc-052400	Lepisosteus oculatus	77.23	3.00e-45	172.00
IUUC-Lma-053259	Leptosphaeria maculans	45.54	6.00e-21	92.00
IUUC-Laf-053596	Loxodonta africana	93.20	3.00e-51	192.00
IUUC-Mcc-054845	Macaca mulatta	90.82	5.00e-47	178.00
IUUC-Meu-055968	Macropus eugenii	92.08	1.00e-51	193.00
IUUC-Mor-057126	Magnaporthe oryzae	45.19	1.00e-19	88.60
IUUC-Mpo-057311	Magnaporthe poae	50.50	3.00e-22	97.10
IUUC-Mtr-058266	Medicago truncatula	51.16	2.00e-22	96.70
IUUC-Mla-058847	Melampsora laricipopulina	41.75	6.00e-13	65.90
IUUC-Mga-059468	Meleagris gallopavo	86.81	1.00e-43	166.00
IUUC-Mvi-060235	Microbotryum violaceum	36.42	2.00e-19	88.20
IUUC-Mdo-061948	Monodelphis domestica	89.11	1.00e-50	190.00
IUUC-Mmu-063946	Mus musculus	94.06	5.00e-52	194.00
IUUC-Mac-064812	Musa acuminata	63.89	3.00e-25	105.00
IUUC-Mpu-066763	Mustela putorius furo	95.05	7.00e-52	194.00
IUUC-Mlu-066970	Myotis lucifugus	97.47	9.00e-41	157.00
IUUC-Ncr-068824	Neurospora crassa	45.54	4.00e-20	89.40
IUUC-Nle-069849	Nomascus leucogenys	97.47	2.00e-40	157.00
IUUC-Opr-070227	Ochotona princeps	96.04	3.00e-53	199.00
IUUC-Ont-072530	Oreochromis niloticus	79.21	2.00e-46	176.00
IUUC-Oan-073191	Ornithorhynchus anatinus	81.44	2.00e-42	162.00
IUUC-Ocu-074460	Oryctolagus cuniculus	98.98	5.00e-52	194.00
IUUC-Oba-075499	Oryza barthii	64.06	3.00e-22	97.40
IUUC-Obr-076896	Oryza brachyantha	54.32	2.00e-21	95.50
IUUC-Ogl-077834	Oryza glaberrima	64.06	1.00e-22	97.80
IUUC-Ogu-078622	Oryza glumaepatula	64.06	1.00e-22	97.80
IUUC-Oin-079358	Oryza indica	64.06	3.00e-22	98.20
IUUC-Olo-081035	Oryza longistaminata	49.51	3.00e-23	100.00
IUUC-Oni-082425	Oryza nivara	64.06	1.00e-22	97.80
IUUC-Opu-083461	Oryza punctata	63.49	6.00e-22	96.30
IUUC-Oru-084875	Oryza rufipogon	57.75	1.00e-20	90.50
IUUC-Oga-089128	Otolemur garnettii	97.03	2.00e-53	199.00
IUUC-Oar-089896	Ovis aries	96.04	6.00e-53	198.00
IUUC-Ptr-091618	Pan troglodytes	96.20	3.00e-32	130.00
IUUC-Pan-092238	Papio anubis	98.73	6.00e-41	159.00
IUUC-Psi-093879	Pelodiscus sinensis	86.14	1.00e-48	183.00
IUUC-Pma-094484	Petromyzon marinus	78.22	3.00e-35	139.00
IUUC-Ppa-095801	Physcomitrella patens	55.56	2.00e-22	96.30
IUUC-Pfo-097192	Poecilia formosa	80.20	1.00e-46	176.00
IUUC-Pab-098203	Pongo abelii	94.06	2.00e-44	169.00
IUUC-Pop-099614	Populus trichocarpa	55.95	1.00e-23	100.00
IUUC-Pca-100507	Procavia capensis	98.73	6.00e-41	157.00
IUUC-Ppe-101174	Prunus persica	54.55	2.00e-28	116.00
IUUC-Pva-102735	Pteropus vampyrus	94.06	2.00e-49	186.00
IUUC-Pgr-103510	Puccinia graminis	40.78	1.00e-12	65.10
IUUC-Ptt-103918	Puccinia triticina	36.89	7.00e-11	58.90
IUUC-Pte-104173	Pyrenophora teres	47.57	3.00e-23	99.40
IUUC-Pyt-104806	Pyrenophora triticirepentis	47.57	4.00e-23	99.40
IUUC-Rno-105820	Rattus norvegicus	95.05	2.00e-52	196.00
IUUC-Sce-106366	Saccharomyces cerevisiae	42.42	3.00e-17	79.30
IUUC-Sja-107727	Schizosaccharomyces japonicus	42.71	5.00e-17	79.30
IUUC-Spo-108074	Schizosaccharomyces pombe	39.80	2.00e-09	53.90
IUUC-Smo-108944	Selaginella moellendorffii	57.30	1.00e-25	107.00
IUUC-Sit-110277	Setaria italica	54.76	2.00e-23	100.00
IUUC-Sly-111505	Solanum lycopersicum	54.76	7.00e-25	104.00
IUUC-Stu-112076	Solanum tuberosum	55.95	2.00e-25	106.00
IUUC-Sbi-114274	Sorghum bicolor	58.44	9.00e-24	101.00
IUUC-Sre-114953	Sporisorium reilianum	57.84	3.00e-27	112.00
IUUC-Ssc-115418	Sus scrofa	95.05	8.00e-53	197.00
IUUC-Tgu-117311	Taeniopygia guttata	85.71	5.00e-43	164.00
IUUC-Tru-118598	Takifugu rubripes	80.90	7.00e-41	157.00
IUUC-Tni-120109	Tetraodon nigroviridis	76.47	3.00e-43	166.00
IUUC-Tca-120942	Theobroma cacao	54.22	6.00e-23	98.60
IUUC-Tre-122099	Trichoderma reesei	48.94	2.00e-16	77.00
IUUC-Tvi-122285	Trichoderma virens	52.88	3.00e-21	93.20
IUUC-Tae-125193	Triticum aestivum	55.42	7.00e-23	98.20
IUUC-Tur-126677	Triticum urartu	48.42	2.00e-20	90.10
IUUC-Tme-127120	Tuber melanosporum	48.08	1.00e-23	101.00
IUUC-Tbe-128050	Tupaia belangeri	68.32	3.00e-33	132.00
IUUC-Ttr-129019	Tursiops truncatus	93.07	9.00e-50	187.00
IUUC-Uma-129483	Ustilago maydis	55.88	4.00e-25	105.00
IUUC-Vda-129690	Verticillium dahliae	41.96	3.00e-17	79.70
IUUC-Vvi-131174	Vitis vinifera	57.83	3.00e-24	102.00
IUUC-Xma-133862	Xiphophorus maculatus	80.20	1.00e-46	176.00
IUUC-Yli-134398	Yarrowia lipolytica	46.46	4.00e-19	85.90
IUUC-Zma-134964	Zea mays	56.10	3.00e-22	95.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence