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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046868
Ensembl Protein ID ENSP00000402140.2
UniProt Accession Q8IVI9; A8K2I9; B3KSF5; E7EPT9; Q27HG3; Q53S62; Q96CJ9; NOSTN_HUMAN
Genbank Protein ID CAD58724.1; ABD62889.1; BAE46614.1; BAG52717.1; BAF82943.1; AAY24097.1; AAH14189.1; AAH93072.1; ENSP00000318921
Protein Name Nostrin; BM247 homolog; Nitric oxide synthase traffic inducer; Nitric oxide synthase trafficker; eNOS-trafficking inducer
Genbank Nucleotide ID AJ532842; DQ402497; AK002203; AK093444; AK290254; AC069137; AC009475; BC093072; AL550371
Gene Name NOSTRIN
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000163072.15 ENST00000458381.6 ENSP00000402140.2
ENSG00000163072.15 ENST00000317647.11 ENSP00000318921.7
ENSG00000163072.15 ENST00000439509.5 ENSP00000415337.1
ENSG00000163072.15 ENST00000397209.6 ENSP00000380392.2
ENSG00000163072.15 ENST00000427068.1 ENSP00000388597.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmicroRNA
TRANSFACRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 5.60e-17 63.1 497 552
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
            +++++ly+++a +ddeL+l+kGd+v +  +e++++gW+ g   l+gk+G fP+ +ve+l
   Q: 497  SRLCKALYSFQARQDDELNLEKGDIVII--HEKKEGGWWFG--SLNGKKGHFPAAYVEEL 552
           578***********************98..69*********..9**************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.
 Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.
Protein Sequence
(Fasta)
MRDPLTDCPY NKVYKNLKEF SQNGENFCKQ VTSVLQQRAN LEISYAKGLQ KLASKLSKAL 60
QNTRKSCVSS AWAWASEGMK STADLHQKLG KAIELEAIKP TYQVLNVQEK KRKSLDNEVE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046868|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGCATGCAG CCCTTCCCAA GCACTGGTAG GGCACTGGGC ATGCAGACAG CCCACCAGAA 60
GGGAAGAATC AGGAGAAAAG GGATGCAAGA TCCCAGAGGT ATGCCAATAT ATAAAACCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046868|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR031160--F_BAR
IPR001060--FCH_dom
IPR011072--HR1_rho-bd
IPR001452--SH3_domain
PROSITE

PS51741--F_BAR
PS50002--SH3
Pfam

PF00611--FCH
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00326--SH3
Gene Ontology

GO:0005856--C:cytoskeleton
GO:0030666--C:endocytic vesicle membrane
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0003677--F:DNA binding
GO:0006897--P:endocytosis
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0050999--P:regulation of nitric-oxide synthase activity
GO:0007165--P:signal transduction
KEGG hsa:115677
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001403 Ailuropoda melanoleuca 75.81 0.00e+00 759.00
IUUC-Aca-005138 Anolis carolinensis 44.11 1.00e-127 449.00
IUUC-Bta-012680 Bos taurus 71.94 0.00e+00 748.00
IUUC-Cja-019985 Callithrix jacchus 84.90 0.00e+00 866.00
IUUC-Cfa-020888 Canis familiaris 76.41 0.00e+00 768.00
IUUC-Cpo-021852 Cavia porcellus 75.54 0.00e+00 724.00
IUUC-Csa-023196 Chlorocebus sabaeus 86.15 0.00e+00 861.00
IUUC-Dre-027969 Danio rerio 42.06 4.00e-63 235.00
IUUC-Dno-029703 Dasypus novemcinctus 71.23 0.00e+00 701.00
IUUC-Dor-030928 Dipodomys ordii 74.60 0.00e+00 721.00
IUUC-Ete-033034 Echinops telfairi 54.51 2.00e-137 482.00
IUUC-Eca-034165 Equus caballus 74.42 0.00e+00 791.00
IUUC-Eeu-034697 Erinaceus europaeus 72.04 0.00e+00 773.00
IUUC-Fca-035811 Felis catus 71.02 0.00e+00 723.00
IUUC-Gac-041751 Gasterosteus aculeatus 40.79 5.00e-118 418.00
IUUC-Itr-049056 Ictidomys tridecemlineatus 78.72 0.00e+00 825.00
IUUC-Lch-050314 Latimeria chalumnae 50.88 6.00e-152 531.00
IUUC-Loc-051803 Lepisosteus oculatus 42.98 6.00e-127 447.00
IUUC-Laf-053672 Loxodonta africana 71.71 0.00e+00 719.00
IUUC-Mcc-054984 Macaca mulatta 95.74 0.00e+00 1005.00
IUUC-Mmr-061250 Microcebus murinus 78.86 0.00e+00 819.00
IUUC-Mdo-062278 Monodelphis domestica 64.18 0.00e+00 655.00
IUUC-Mmu-063360 Mus musculus 72.65 0.00e+00 699.00
IUUC-Mpu-065954 Mustela putorius furo 72.33 0.00e+00 711.00
IUUC-Mlu-066993 Myotis lucifugus 71.10 0.00e+00 723.00
IUUC-Nle-069744 Nomascus leucogenys 91.83 0.00e+00 925.00
IUUC-Ont-072001 Oreochromis niloticus 40.13 2.00e-122 432.00
IUUC-Oan-072971 Ornithorhynchus anatinus 57.12 4.00e-158 551.00
IUUC-Ocu-074140 Oryctolagus cuniculus 76.51 0.00e+00 764.00
IUUC-Ola-086827 Oryzias latipes 40.36 7.00e-110 391.00
IUUC-Oga-088144 Otolemur garnettii 78.69 0.00e+00 801.00
IUUC-Oar-090280 Ovis aries 72.29 0.00e+00 726.00
IUUC-Ptr-091508 Pan troglodytes 87.92 0.00e+00 869.00
IUUC-Pan-092649 Papio anubis 84.93 0.00e+00 811.00
IUUC-Pfo-097405 Poecilia formosa 35.82 3.00e-92 332.00
IUUC-Pab-097751 Pongo abelii 87.03 0.00e+00 860.00
IUUC-Pca-100878 Procavia capensis 71.05 0.00e+00 719.00
IUUC-Pva-102337 Pteropus vampyrus 71.96 0.00e+00 743.00
IUUC-Rno-105255 Rattus norvegicus 72.17 0.00e+00 689.00
IUUC-Sha-106635 Sarcophilus harrisii 52.02 3.00e-141 494.00
IUUC-Sly-111123 Solanum lycopersicum 32.29 9.00e-10 57.80
IUUC-Ssc-116156 Sus scrofa 71.00 0.00e+00 755.00
IUUC-Tru-118662 Takifugu rubripes 40.97 3.00e-124 438.00
IUUC-Tbe-127388 Tupaia belangeri 77.70 0.00e+00 801.00
IUUC-Ttr-128767 Tursiops truncatus 72.29 0.00e+00 718.00
IUUC-Xtr-132443 Xenopus tropicalis 51.91 1.00e-137 483.00
Created Date 25-Jun-2017

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