iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.90e-24	86.9	667	812

Active Site

Position(s)	Description	Evidence
748	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk..ifhPnvyenGkvClsilk.....eeekW 92
           +++e ++le++ p++i +++ +e  ++ ++++++G ++tpY++g+F ++i +p++YP +PP v++ +   +++Pn+ye+G+vCls+l+      +e W
   Q: 667  VQQEWSNLEANLPNTIYVRVCEE-RMDLLRAALVGAPGTPYHDGLFFFDIMLPPQYPHEPPMVHYHSGgmRLNPNLYESGRVCLSLLNtwsgsGTEVW 763
           799********************.5*****************************************9999*****************87888889*** PP
   S: 93   sp.alsvesvllsiqsll..aepnpesplneeaa..ellkknreeykkk 136
           ++  +s+ + lls q+l+  ++p+++++ ++++    + +kn  +y+++
   Q: 764  NAgSSSILQLLLSFQALVlnEKPYFNEAGYDKQLgrAEGEKNSVSYNEN 812
           *98899***********98777*****9998887334445555566665 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Mediates PHO1 degradation through multivesicular body-mediated vacuolar proteolysis in response to inorganic phosphate (Pi) availability (PubMed:22634761). Negatively regulates the protein abundance of PHF1 and PHT1s under Pi-sufficient conditions by facilitating the degradation of PHT1 proteins at the endomembrane (PubMed:24122829).

Protein Sequence
(Fasta)

MEMSLTDSDW DSSSDSGSSE HEEVEFSYGG RAQNIFSNLE ETIGKIDEFL SFERGFMYGD 60
IVRSATEPSG QSGRVINIDM FVNLESTHGK IMKEVDTKRL QKLRSISLSD YVINGPWVGR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTGGGTTGG AAAAGGAAAG AGGAAGAGAG AAAAAAGGGA GGAAGAAAAG GAGTGATGTA 60
GAGTTGTGTG TGTGTGGGAT ACTGAGATAC TGTTGGTATA TTCTCTTCTT CTCCACCGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0436--Ligase
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0005524--F:ATP binding
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0044257--P:cellular protein catabolic process
GO:0016036--P:cellular response to phosphate starvation
GO:0055062--P:phosphate ion homeostasis
GO:0006817--P:phosphate ion transport
GO:2000185--P:regulation of phosphate transmembrane transport

KEGG

ath:AT2G33770

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000866	Aegilops tauschii	44.23	0.00e+00	642.00
IUUC-Aly-005447	Arabidopsis lyrata	92.68	0.00e+00	1649.00
IUUC-Bdi-014823	Brachypodium distachyon	45.32	0.00e+00	681.00
IUUC-Bol-015113	Brassica oleracea	79.82	0.00e+00	1381.00
IUUC-Bra-017538	Brassica rapa	80.93	0.00e+00	1397.00
IUUC-Gma-043816	Glycine max	48.90	0.00e+00	829.00
IUUC-Hvu-047271	Hordeum vulgare	44.48	0.00e+00	650.00
IUUC-Lpe-051011	Leersia perrieri	45.25	0.00e+00	693.00
IUUC-Mtr-058547	Medicago truncatula	50.56	0.00e+00	832.00
IUUC-Mac-064763	Musa acuminata	45.46	0.00e+00	737.00
IUUC-Oba-075343	Oryza barthii	45.38	0.00e+00	689.00
IUUC-Obr-076056	Oryza brachyantha	46.12	0.00e+00	717.00
IUUC-Ogl-076992	Oryza glaberrima	45.38	0.00e+00	690.00
IUUC-Ogu-078577	Oryza glumaepatula	45.38	0.00e+00	689.00
IUUC-Oin-080041	Oryza indica	45.38	0.00e+00	691.00
IUUC-Olo-080416	Oryza longistaminata	44.85	0.00e+00	627.00
IUUC-Ome-081223	Oryza meridionalis	45.38	0.00e+00	696.00
IUUC-Oni-082698	Oryza nivara	45.83	0.00e+00	691.00
IUUC-Opu-083990	Oryza punctata	45.16	0.00e+00	712.00
IUUC-Oru-085168	Oryza rufipogon	45.38	0.00e+00	689.00
IUUC-Pop-099296	Populus trichocarpa	50.33	0.00e+00	791.00
IUUC-Ppe-101182	Prunus persica	53.56	0.00e+00	858.00
IUUC-Sit-110593	Setaria italica	45.58	0.00e+00	676.00
IUUC-Sly-111703	Solanum lycopersicum	47.58	0.00e+00	822.00
IUUC-Stu-112096	Solanum tuberosum	47.97	0.00e+00	798.00
IUUC-Sbi-114682	Sorghum bicolor	44.30	0.00e+00	686.00
IUUC-Tca-121300	Theobroma cacao	55.18	0.00e+00	887.00
IUUC-Tae-124228	Triticum aestivum	44.33	0.00e+00	648.00
IUUC-Tur-126140	Triticum urartu	43.72	0.00e+00	641.00
IUUC-Vvi-131407	Vitis vinifera	51.50	0.00e+00	845.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence