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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046731
UUCD1 version UUC-HoS-01205
Ensembl Protein ID ENSP00000270225.6
UniProt Accession Q9UBE0; B2RDP5; B3KMQ2; F5GXX7; G3XAK6; O95717; Q9P020; SAE1_HUMAN
Genbank Protein ID AAD12785.2; AAD23902.2; AAD24433.1; AAF29104.1; AAP35954.1; BAG51064.1; BAG37992.1; EAW57461.1; EAW57463.1; AAH00344.1; AAH03611.1; AAH18271.1
Protein Name SUMO-activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A; SUMO-activating enzyme subunit 1, N-terminally processed
Genbank Nucleotide ID AF090385; AF046025; AF110956; AF161489; AL560234; AK021978; AK315624; AC008532; CH471126; BC000344; BC003611; BC018271
Gene Name SAE1; AOS1; SUA1; UBLE1A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000142230.11 ENST00000413379.7 ENSP00000416557.2
ENSG00000142230.11 ENST00000600706.5 ENSP00000468931.1
ENSG00000142230.11 ENST00000598840.5 ENSP00000470741.1
ENSG00000142230.11 ENST00000414294.6 ENSP00000398818.1
ENSG00000142230.11 ENST00000270225.11 ENSP00000270225.6
ENSG00000142230.11 ENST00000596995.1 ENSP00000473037.1
ENSG00000142230.11 ENST00000392776.3 ENSP00000440818.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDBSCOP
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E1 E1_ThiF 9920803; 20682785
Classification
Family E-value Score Start End
E1 2.30e-90 305.5 19 335
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E1
   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnvea 92
           YDRQirlwG eaq++l+ ++vllvG++glG+E++KnL+laGv+ +t++D+++v+ +++++qFL+r  +vg+++Ae+++e++++lnp+v+v++
   Q: 19   YDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKV 110
           ******************************************************************************************** PP
   S: 93   heesiteleeeivFfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaae 184
           ++e+i+++ e+  Ff++fd V+l++++r+   kv+++c+++++++++++++G++G++                       f +l+e++ ++e
   Q: 111  DTEDIEKKPES--FFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYT-----------------------FANLGEHEFVEE 177
           ***********..********************************************.......................************ PP
   S: 185  htiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtkskspfwvsf 276
           +t +        ++ e+g++++++klds+e++++k+kv                                                     f
   Q: 178  KTKVAK----VSQGVEDGPDTKRAKLDSSETTMVKKKV----------------------------------------------------VF 213
           ***955....89999**********************9....................................................8* PP
   S: 277  csnaealqvpekvekdeevvkasaplylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiepkldddlikeiagniipa 368
           c+++eal+v+++ ek ++++k++ + y+ll++l +f+++kgr+p++ ++e+d++ ++++ ++++     slgi+p   d l + ++++++++
   Q: 214  CPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVL----DSLGISP---DLLPEDFVRYCFSE 298
           ****************************************************************....*******...555555666899** PP
   S: 369  iattnavvgGlaaqEviKvvsgkfeplknfflfdaee 405
           +a+++avvgG++aqE++K++s++  p++nff+fd+++
   Q: 299  MAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMK 335
           **********************************985 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
 The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Protein Sequence
(Fasta)
MVEKEEAGGG ISEEEAAQYD RQIRLWGLEA QKRLRASRVL LVGLKGLGAE IAKNLILAGV 60
KGLTMLDHEQ VTPEDPGAQF LIRTGSVGRN RAEASLERAQ NLNPMVDVKV DTEDIEKKPE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046731|E1,E1_ThiF|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCCGAGGGG AGGCGGAAAT AGCCGAAAGG AGCTGAGCAG GAGCGAGGAG GCGACGGGGG 60
AGAGCCAGAA AGAGCTGAAG GTGGTGATAT GGGTGGGGCT AGAGAGAGCA TGAGAAACCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046731|E1,E1_ThiF|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0436--Ligase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR000011--UBQ/SUMO-activ_enz_E1-like
Pfam

PF00899--ThiF
PRINTS

PR01849--UBIQUITINACT
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031510--C:SUMO activating enzyme complex
GO:0043008--F:ATP-dependent protein binding
GO:0008047--F:enzyme activator activity
GO:0008022--F:protein C-terminus binding
GO:0046982--F:protein heterodimerization activity
GO:0004839--F:ubiquitin activating enzyme activity
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0016925--P:protein sumoylation
GO:0016567--P:protein ubiquitination
KEGG hsa:10055
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000695 Aegilops tauschii 30.81 1.00e-39 157.00
IUUC-Aml-001477 Ailuropoda melanoleuca 96.35 0.00e+00 656.00
IUUC-Atr-002536 Amborella trichopoda 31.86 2.00e-41 162.00
IUUC-Apl-003982 Anas platyrhynchos 72.90 2.00e-104 372.00
IUUC-Aca-004868 Anolis carolinensis 80.30 3.00e-154 537.00
IUUC-Aly-005588 Arabidopsis lyrata 32.28 1.00e-44 173.00
IUUC-Ath-006677 Arabidopsis thaliana 33.33 2.00e-45 176.00
IUUC-Ago-007891 Ashbya gossypii 33.04 3.00e-44 172.00
IUUC-Acl-008197 Aspergillus clavatus 35.39 4.00e-53 202.00
IUUC-Afl-008520 Aspergillus flavus 33.33 3.00e-52 199.00
IUUC-Afu-009107 Aspergillus fumigatus 32.04 2.00e-45 176.00
IUUC-Ani-009143 Aspergillus nidulans 32.37 1.00e-42 167.00
IUUC-Ang-009804 Aspergillus niger 34.73 9.00e-54 204.00
IUUC-Aor-010190 Aspergillus oryzae 33.33 3.00e-52 199.00
IUUC-Ame-011043 Astyanax mexicanus 69.28 1.00e-127 449.00
IUUC-Bgr-012084 Blumeria graminis 32.09 3.00e-46 179.00
IUUC-Bta-012723 Bos taurus 96.34 0.00e+00 657.00
IUUC-Bci-013809 Botrytis cinerea 33.62 3.00e-50 192.00
IUUC-Bdi-014800 Brachypodium distachyon 33.33 5.00e-45 174.00
IUUC-Bol-015744 Brassica oleracea 30.99 8.00e-41 160.00
IUUC-Bra-016683 Brassica rapa 31.58 5.00e-42 164.00
IUUC-Cel-018434 Caenorhabditis elegans 30.92 5.00e-39 154.00
IUUC-Cja-019815 Callithrix jacchus 98.27 0.00e+00 703.00
IUUC-Cfa-020329 Canis familiaris 96.05 0.00e+00 657.00
IUUC-Cpo-022208 Cavia porcellus 94.22 0.00e+00 668.00
IUUC-Csa-023592 Chlorocebus sabaeus 98.56 1.00e-162 565.00
IUUC-Cho-024345 Choloepus hoffmanni 86.59 4.00e-127 447.00
IUUC-Cin-025351 Ciona intestinalis 44.94 7.00e-85 307.00
IUUC-Cgl-026491 Colletotrichum gloeosporioides 32.49 7.00e-43 168.00
IUUC-Cne-026970 Cryptococcus neoformans 28.88 1.00e-24 107.00
IUUC-Dre-028263 Danio rerio 69.36 6.00e-132 463.00
IUUC-Dno-030055 Dasypus novemcinctus 94.53 0.00e+00 652.00
IUUC-Dor-030864 Dipodomys ordii 92.01 1.00e-173 601.00
IUUC-Dse-031565 Dothistroma septosporum 33.91 2.00e-49 189.00
IUUC-Dme-032011 Drosophila melanogaster 39.42 5.00e-59 221.00
IUUC-Ete-032982 Echinops telfairi 83.14 3.00e-165 574.00
IUUC-Eca-034164 Equus caballus 95.54 2.00e-180 624.00
IUUC-Eeu-035135 Erinaceus europaeus 79.82 1.00e-100 359.00
IUUC-Fca-035564 Felis catus 96.96 0.00e+00 660.00
IUUC-Fox-037928 Fusarium oxysporum 32.77 4.00e-47 182.00
IUUC-Fso-038404 Fusarium solani 32.87 2.00e-46 180.00
IUUC-Gmo-038867 Gadus morhua 67.54 4.00e-127 447.00
IUUC-Ggr-040068 Gaeumannomyces graminis 35.80 4.00e-51 195.00
IUUC-Gga-041197 Gallus gallus 74.47 5.00e-128 450.00
IUUC-Gac-042609 Gasterosteus aculeatus 67.34 4.00e-129 454.00
IUUC-Gma-044135 Glycine max 30.55 3.00e-44 172.00
IUUC-Ggo-044600 Gorilla gorilla 100.00 0.00e+00 679.00
IUUC-Itr-049038 Ictidomys tridecemlineatus 97.87 0.00e+00 668.00
IUUC-Kpa-049371 Komagataella pastoris 28.81 7.00e-34 137.00
IUUC-Lch-050045 Latimeria chalumnae 77.68 2.00e-155 541.00
IUUC-Lpe-051103 Leersia perrieri 32.08 3.00e-42 166.00
IUUC-Loc-051749 Lepisosteus oculatus 64.97 4.00e-125 441.00
IUUC-Lma-053150 Leptosphaeria maculans 36.24 1.00e-50 193.00
IUUC-Laf-053875 Loxodonta africana 95.74 0.00e+00 657.00
IUUC-Mcc-055107 Macaca mulatta 98.68 2.00e-179 621.00
IUUC-Meu-056076 Macropus eugenii 64.16 4.00e-123 434.00
IUUC-Mor-057029 Magnaporthe oryzae 35.26 3.00e-48 186.00
IUUC-Mtr-058633 Medicago truncatula 32.65 5.00e-43 168.00
IUUC-Mvi-060367 Microbotryum violaceum 33.71 4.00e-52 198.00
IUUC-Mmr-061294 Microcebus murinus 95.05 2.00e-173 601.00
IUUC-Mdo-062827 Monodelphis domestica 87.32 0.00e+00 632.00
IUUC-Mmu-063568 Mus musculus 93.01 6.00e-177 613.00
IUUC-Mac-064495 Musa acuminata 29.74 3.00e-41 162.00
IUUC-Mpu-065826 Mustela putorius furo 95.44 0.00e+00 653.00
IUUC-Mlu-067751 Myotis lucifugus 94.27 5.00e-178 616.00
IUUC-Nfi-068597 Neosartorya fischeri 34.84 4.00e-55 208.00
IUUC-Ncr-068768 Neurospora crassa 32.80 4.00e-46 179.00
IUUC-Nle-069882 Nomascus leucogenys 100.00 4.00e-93 333.00
IUUC-Opr-071077 Ochotona princeps 66.87 7.00e-122 430.00
IUUC-Ont-072576 Oreochromis niloticus 69.65 2.00e-123 435.00
IUUC-Oan-073560 Ornithorhynchus anatinus 84.82 7.00e-158 549.00
IUUC-Ocu-074732 Oryctolagus cuniculus 87.43 2.00e-170 591.00
IUUC-Oba-075956 Oryza barthii 31.85 3.00e-44 172.00
IUUC-Obr-076004 Oryza brachyantha 31.25 8.00e-42 164.00
IUUC-Ogu-078335 Oryza glumaepatula 31.85 5.00e-44 171.00
IUUC-Oin-079177 Oryza indica 31.85 9.00e-45 174.00
IUUC-Olo-080537 Oryza longistaminata 29.64 9.00e-37 147.00
IUUC-Ome-081880 Oryza meridionalis 31.85 9.00e-45 174.00
IUUC-Oni-082688 Oryza nivara 32.14 1.00e-45 176.00
IUUC-Opu-083231 Oryza punctata 32.67 3.00e-48 185.00
IUUC-Oru-084759 Oryza rufipogon 31.85 9.00e-45 174.00
IUUC-Osa-085601 Oryza sativa 31.55 2.00e-44 172.00
IUUC-Ola-086496 Oryzias latipes 69.16 8.00e-124 436.00
IUUC-Oga-089005 Otolemur garnettii 88.82 4.00e-175 607.00
IUUC-Oar-089611 Ovis aries 96.34 0.00e+00 657.00
IUUC-Ptr-091337 Pan troglodytes 100.00 0.00e+00 679.00
IUUC-Pan-092401 Papio anubis 92.40 0.00e+00 625.00
IUUC-Pma-094210 Petromyzon marinus 59.88 7.00e-120 423.00
IUUC-Pno-094975 Phaeosphaeria nodorum 34.86 5.00e-49 188.00
IUUC-Ppa-095925 Physcomitrella patens 35.65 2.00e-53 202.00
IUUC-Pfo-096890 Poecilia formosa 68.21 1.00e-128 452.00
IUUC-Pab-098173 Pongo abelii 100.00 0.00e+00 680.00
IUUC-Pop-099145 Populus trichocarpa 33.14 2.00e-46 179.00
IUUC-Pca-100899 Procavia capensis 78.42 5.00e-140 490.00
IUUC-Ppe-101274 Prunus persica 30.22 7.00e-32 130.00
IUUC-Pva-102625 Pteropus vampyrus 93.92 0.00e+00 646.00
IUUC-Pgr-103426 Puccinia graminis 36.63 6.00e-55 208.00
IUUC-Pte-104082 Pyrenophora teres 35.90 2.00e-48 186.00
IUUC-Pyt-104818 Pyrenophora triticirepentis 35.51 1.00e-47 183.00
IUUC-Rno-106129 Rattus norvegicus 92.15 0.00e+00 644.00
IUUC-Sce-106370 Saccharomyces cerevisiae 34.02 6.00e-44 171.00
IUUC-Sha-107120 Sarcophilus harrisii 85.40 2.00e-157 548.00
IUUC-Sja-107996 Schizosaccharomyces japonicus 31.29 4.00e-39 155.00
IUUC-Spo-108321 Schizosaccharomyces pombe 29.22 2.00e-31 129.00
IUUC-Ssl-108608 Sclerotinia sclerotiorum 34.21 3.00e-49 188.00
IUUC-Smo-109539 Selaginella moellendorffii 29.91 6.00e-35 141.00
IUUC-Sit-110166 Setaria italica 32.86 3.00e-47 182.00
IUUC-Sly-111116 Solanum lycopersicum 31.83 2.00e-42 166.00
IUUC-Stu-112397 Solanum tuberosum 32.13 3.00e-42 165.00
IUUC-Sar-113506 Sorex araneus 84.10 8.00e-172 596.00
IUUC-Sbi-114548 Sorghum bicolor 33.72 2.00e-47 182.00
IUUC-Ssc-115891 Sus scrofa 96.66 0.00e+00 661.00
IUUC-Tru-118469 Takifugu rubripes 64.74 8.00e-123 433.00
IUUC-Tsy-119304 Tarsius syrichta 86.58 9.00e-158 549.00
IUUC-Tni-119803 Tetraodon nigroviridis 59.83 5.00e-118 417.00
IUUC-Tca-121747 Theobroma cacao 33.04 6.00e-46 178.00
IUUC-Tre-122060 Trichoderma reesei 33.33 2.00e-45 176.00
IUUC-Tvi-122324 Trichoderma virens 33.62 6.00e-47 181.00
IUUC-Tae-123512 Triticum aestivum 32.14 1.00e-44 173.00
IUUC-Tur-126224 Triticum urartu 32.46 2.00e-43 169.00
IUUC-Tme-126939 Tuber melanosporum 34.84 2.00e-52 199.00
IUUC-Tbe-127982 Tupaia belangeri 85.71 1.00e-168 585.00
IUUC-Ttr-128758 Tursiops truncatus 96.05 0.00e+00 660.00
IUUC-Vda-129664 Verticillium dahliae 32.30 7.00e-43 168.00
IUUC-Vpa-130778 Vicugna pacos 80.60 3.00e-136 477.00
IUUC-Vvi-131399 Vitis vinifera 32.36 1.00e-44 173.00
IUUC-Xtr-131919 Xenopus tropicalis 73.49 6.00e-144 503.00
IUUC-Xma-133482 Xiphophorus maculatus 69.36 4.00e-126 444.00
IUUC-Yli-134596 Yarrowia lipolytica 28.92 1.00e-34 140.00
IUUC-Zma-135688 Zea mays 33.14 6.00e-47 181.00
Created Date 25-Jun-2017

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