iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-036441

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin thioesterase

Genbank Nucleotide ID

AANG02046026

Gene Name

OTUB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000029184.1	ENSFCAT00000031276.1	ENSFCAP00000023949.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.00e-51	174.1	85	275

Active Site

Position(s)	Description	Evidence
92	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
95	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
269		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA+++s                                                          ll++f+d+s+sd
   Q: 85   YIRKTRPDGNCFYRAFGFShleallddskelqrfkavsakskedlvsqgfteftiedfhntfmdlieqvekqtsvadLLASFNDQSTSD 173
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           +lv++Lr+lts ylq+es+ff++fie+++++kefcq++vep++k +++ihi+aLaq+Ls++i+v+++d++e   gg+++p++fpe + +
   Q: 174  YLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKeSDHIHIIALAQALSVSIQVEYMDRGE---GGTTNPHIFPEGS-E 258
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlYr+gHYd+L++
   Q: 259  PKVYLLYRPGHYDILYK 275
           ***************96 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MLRAVRGCER PRCVPLRPAA FVSGVNCLAY DEAIMAQQDR IQQEIAVQNP LVSERLELSV 60
LYKEYAEDDN IYQQKIKDLH KKYSYIRKTR PDGNCFYRAF GFSHLEALLD DSKELQRFKA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNCCTTTTCC AGAGCAGTCT GCGCCCGGGA GGGCGTCGAG TTACGCCGGG CCGCGGAGCA 60
CAAAGGACTG GGCGGGCCGC TCGGGATGCT GCGGGCGGTC AGGGGTTGTG AGCGGCCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	97.32	7.00e-150	522.00
IUUC-Apl-003233	Anas platyrhynchos	58.46	8.00e-19	84.30
IUUC-Aca-004648	Anolis carolinensis	85.09	2.00e-135	474.00
IUUC-Aly-005710	Arabidopsis lyrata	42.22	2.00e-51	195.00
IUUC-Ath-007112	Arabidopsis thaliana	43.24	2.00e-50	192.00
IUUC-Afl-008439	Aspergillus flavus	34.18	3.00e-08	52.40
IUUC-Ame-010662	Astyanax mexicanus	85.04	5.00e-129	452.00
IUUC-Bta-013533	Bos taurus	98.81	3.00e-148	517.00
IUUC-Bol-016100	Brassica oleracea	42.21	5.00e-50	191.00
IUUC-Bra-017705	Brassica rapa	39.29	7.00e-45	174.00
IUUC-Cel-018295	Caenorhabditis elegans	35.78	7.00e-41	160.00
IUUC-Cja-019190	Callithrix jacchus	100.00	2.00e-149	521.00
IUUC-Cfa-020430	Canis familiaris	98.82	2.00e-149	521.00
IUUC-Cpo-022355	Cavia porcellus	99.60	1.00e-149	521.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	39.56	8.00e-46	177.00
IUUC-Csa-023286	Chlorocebus sabaeus	96.55	3.00e-147	513.00
IUUC-Cin-025507	Ciona intestinalis	43.33	2.00e-44	171.00
IUUC-Csv-026273	Ciona savignyi	48.43	7.00e-69	253.00
IUUC-Dre-027843	Danio rerio	82.54	7.00e-125	439.00
IUUC-Dno-029165	Dasypus novemcinctus	99.00	2.00e-117	414.00
IUUC-Dor-030943	Dipodomys ordii	99.60	1.00e-149	521.00
IUUC-Dme-031922	Drosophila melanogaster	56.40	4.00e-78	284.00
IUUC-Ete-032296	Echinops telfairi	96.23	3.00e-89	321.00
IUUC-Eca-033695	Equus caballus	98.03	8.00e-148	515.00
IUUC-Gmo-038908	Gadus morhua	81.89	1.00e-124	438.00
IUUC-Ggr-040020	Gaeumannomyces graminis	31.32	5.00e-33	135.00
IUUC-Gga-040460	Gallus gallus	81.23	5.00e-127	446.00
IUUC-Gac-042417	Gasterosteus aculeatus	81.20	3.00e-122	431.00
IUUC-Gma-043712	Glycine max	42.01	5.00e-51	194.00
IUUC-Ggo-044552	Gorilla gorilla	100.00	3.00e-92	331.00
IUUC-Hsa-046766	Homo sapiens	100.00	7.00e-150	522.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	99.60	1.00e-149	521.00
IUUC-Lch-050602	Latimeria chalumnae	80.00	1.00e-119	422.00
IUUC-Laf-053705	Loxodonta africana	99.60	1.00e-149	521.00
IUUC-Mcc-055745	Macaca mulatta	93.33	4.00e-146	510.00
IUUC-Meu-056569	Macropus eugenii	84.92	1.00e-124	438.00
IUUC-Mtr-057712	Medicago truncatula	43.12	2.00e-46	179.00
IUUC-Mvi-060358	Microbotryum violaceum	33.94	3.00e-15	75.50
IUUC-Mmr-061123	Microcebus murinus	99.53	1.00e-123	435.00
IUUC-Mdo-062613	Monodelphis domestica	88.05	1.00e-114	405.00
IUUC-Mmu-063658	Mus musculus	99.60	1.00e-149	521.00
IUUC-Mac-065274	Musa acuminata	37.60	6.00e-39	154.00
IUUC-Mpu-066172	Mustela putorius furo	100.00	7.00e-150	522.00
IUUC-Mlu-066966	Myotis lucifugus	99.60	3.00e-149	520.00
IUUC-Nle-069519	Nomascus leucogenys	88.17	5.00e-93	333.00
IUUC-Ont-071901	Oreochromis niloticus	82.47	1.00e-124	438.00
IUUC-Ola-087331	Oryzias latipes	80.90	8.00e-86	309.00
IUUC-Oga-088064	Otolemur garnettii	100.00	7.00e-150	522.00
IUUC-Oar-089251	Ovis aries	94.76	3.00e-147	513.00
IUUC-Ptr-091430	Pan troglodytes	100.00	2.00e-149	521.00
IUUC-Psi-093823	Pelodiscus sinensis	87.69	2.00e-133	468.00
IUUC-Pma-094366	Petromyzon marinus	75.81	8.00e-102	362.00
IUUC-Pfo-096734	Poecilia formosa	80.88	1.00e-113	402.00
IUUC-Pab-097919	Pongo abelii	100.00	1.00e-122	432.00
IUUC-Pop-099401	Populus trichocarpa	41.24	3.00e-48	184.00
IUUC-Ppe-101977	Prunus persica	42.38	2.00e-51	196.00
IUUC-Pva-102499	Pteropus vampyrus	100.00	7.00e-149	519.00
IUUC-Rno-105233	Rattus norvegicus	99.60	1.00e-149	521.00
IUUC-Sha-107081	Sarcophilus harrisii	98.41	7.00e-148	516.00
IUUC-Sly-111640	Solanum lycopersicum	42.01	5.00e-49	187.00
IUUC-Ssc-116202	Sus scrofa	100.00	7.00e-150	522.00
IUUC-Tru-117664	Takifugu rubripes	78.76	2.00e-120	424.00
IUUC-Tca-121467	Theobroma cacao	41.54	3.00e-50	191.00
IUUC-Tbe-128116	Tupaia belangeri	98.76	5.00e-93	333.00
IUUC-Ttr-128622	Tursiops truncatus	99.21	3.00e-147	513.00
IUUC-Vvi-131389	Vitis vinifera	43.75	1.00e-52	199.00
IUUC-Xma-134191	Xiphophorus maculatus	81.27	1.00e-114	405.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence