iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049504

Ensembl Protein ID

ENSLACP00000016416.1

UniProt Accession

H3B3E5; H3B3E5_LATCH

Genbank Protein ID

ENSLACP00000016416

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AFYH01092501

Gene Name

SIAH1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000014463.1	ENSLACT00000016530.1	ENSLACP00000016416.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	82.35	5.00e-126	447.00	IUUC-Dme-031700
E3 activity/RING/RING	98.94	1.00e-167	586.00	IUUC-Hsa-046357
E3 activity/RING/RING	98.58	5.00e-167	583.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Latimeria chalumnae

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSRQTATTLP TGTSKCAPSQ RVPALTGTTA SNNDLASLFE CPVCFDYVLP PILQCQSGHL 60
VCSNCRPKLT CCPTCRGPLG SIRNLAMEKV ANSVLFPCKY ASSGCEITLP HTEKTDHEEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTCGTC AGACTGCTAC AACGCTTCCA ACAGGTACCT CAAAATGTGC ACCATCCCAG 60
CGAGTGCCAG CACTGACGGG CACTACAGCT TCCAACAATG ATTTGGCCAG TCTTTTTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	37.36	1.00e-44	172.00
IUUC-Aml-001186	Ailuropoda melanoleuca	98.94	5.00e-169	586.00
IUUC-Atr-002857	Amborella trichopoda	36.06	1.00e-44	172.00
IUUC-Apl-003813	Anas platyrhynchos	98.94	5.00e-169	586.00
IUUC-Aca-005014	Anolis carolinensis	98.94	4.00e-169	586.00
IUUC-Aly-006522	Arabidopsis lyrata	37.35	3.00e-41	162.00
IUUC-Ath-007049	Arabidopsis thaliana	33.45	7.00e-42	164.00
IUUC-Ame-011196	Astyanax mexicanus	96.81	3.00e-167	580.00
IUUC-Bta-012887	Bos taurus	99.29	2.00e-169	587.00
IUUC-Bdi-014200	Brachypodium distachyon	37.73	3.00e-45	175.00
IUUC-Bol-015523	Brassica oleracea	36.36	6.00e-42	164.00
IUUC-Bra-016910	Brassica rapa	36.82	2.00e-41	162.00
IUUC-Cel-018320	Caenorhabditis elegans	68.23	5.00e-116	410.00
IUUC-Cja-019796	Callithrix jacchus	98.94	1.00e-168	585.00
IUUC-Cfa-020642	Canis familiaris	98.94	6.00e-170	589.00
IUUC-Cpo-022348	Cavia porcellus	98.94	9.00e-169	585.00
IUUC-Csa-023974	Chlorocebus sabaeus	98.94	5.00e-169	586.00
IUUC-Cin-025674	Ciona intestinalis	78.01	7.00e-135	472.00
IUUC-Csv-026233	Ciona savignyi	84.25	4.00e-132	463.00
IUUC-Dre-028041	Danio rerio	96.45	1.00e-166	578.00
IUUC-Dno-029764	Dasypus novemcinctus	98.94	5.00e-169	586.00
IUUC-Dme-031700	Drosophila melanogaster	84.27	7.00e-120	423.00
IUUC-Ete-032423	Echinops telfairi	98.50	3.00e-158	551.00
IUUC-Eca-033536	Equus caballus	98.94	5.00e-169	586.00
IUUC-Eeu-035314	Erinaceus europaeus	98.50	2.00e-158	551.00
IUUC-Fca-035362	Felis catus	98.94	3.00e-169	587.00
IUUC-Fal-037487	Ficedula albicollis	98.94	5.00e-169	586.00
IUUC-Gga-040269	Gallus gallus	98.94	5.00e-169	586.00
IUUC-Gac-042282	Gasterosteus aculeatus	97.16	1.00e-166	578.00
IUUC-Gma-042926	Glycine max	34.04	1.00e-40	159.00
IUUC-Ggo-045444	Gorilla gorilla	98.94	5.00e-169	586.00
IUUC-Hsa-046357	Homo sapiens	98.94	5.00e-169	586.00
IUUC-Hvu-047574	Hordeum vulgare	37.36	5.00e-45	174.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	98.94	9.00e-169	585.00
IUUC-Lpe-050879	Leersia perrieri	40.25	1.00e-42	166.00
IUUC-Loc-052191	Lepisosteus oculatus	98.94	8.00e-169	585.00
IUUC-Laf-053668	Loxodonta africana	98.94	5.00e-169	586.00
IUUC-Mcc-054640	Macaca mulatta	98.94	5.00e-169	586.00
IUUC-Mtr-058747	Medicago truncatula	34.81	4.00e-42	165.00
IUUC-Mga-059503	Meleagris gallopavo	98.94	3.00e-169	587.00
IUUC-Mmr-060794	Microcebus murinus	98.94	9.00e-169	585.00
IUUC-Mmu-064129	Mus musculus	98.58	3.00e-168	583.00
IUUC-Mac-065670	Musa acuminata	36.07	2.00e-42	165.00
IUUC-Mpu-066488	Mustela putorius furo	98.94	7.00e-169	585.00
IUUC-Mlu-067207	Myotis lucifugus	98.94	2.00e-169	587.00
IUUC-Nle-069706	Nomascus leucogenys	98.94	8.00e-169	585.00
IUUC-Ont-071849	Oreochromis niloticus	97.16	4.00e-167	579.00
IUUC-Ocu-074876	Oryctolagus cuniculus	98.94	1.00e-168	585.00
IUUC-Oba-075454	Oryza barthii	40.66	9.00e-43	166.00
IUUC-Obr-076037	Oryza brachyantha	35.43	2.00e-40	159.00
IUUC-Ogl-077712	Oryza glaberrima	40.66	9.00e-43	166.00
IUUC-Ogu-078910	Oryza glumaepatula	40.83	2.00e-42	166.00
IUUC-Oin-079749	Oryza indica	40.66	9.00e-43	166.00
IUUC-Olo-080244	Oryza longistaminata	35.43	2.00e-40	160.00
IUUC-Ome-081318	Oryza meridionalis	40.66	1.00e-42	166.00
IUUC-Oni-083109	Oryza nivara	40.66	9.00e-43	166.00
IUUC-Opu-084065	Oryza punctata	41.08	5.00e-43	167.00
IUUC-Oru-084785	Oryza rufipogon	40.66	9.00e-43	166.00
IUUC-Osa-085610	Oryza sativa	40.66	9.00e-43	166.00
IUUC-Ola-086814	Oryzias latipes	97.16	1.00e-166	578.00
IUUC-Oga-088399	Otolemur garnettii	98.94	9.00e-169	585.00
IUUC-Oar-089323	Ovis aries	99.29	2.00e-169	587.00
IUUC-Ptr-090692	Pan troglodytes	98.94	7.00e-169	585.00
IUUC-Pan-092012	Papio anubis	98.94	5.00e-169	586.00
IUUC-Psi-093687	Pelodiscus sinensis	98.94	2.00e-169	587.00
IUUC-Pma-094387	Petromyzon marinus	93.64	7.00e-160	555.00
IUUC-Ppa-095212	Physcomitrella patens	36.19	5.00e-41	161.00
IUUC-Pfo-097134	Poecilia formosa	97.16	1.00e-166	578.00
IUUC-Pab-097555	Pongo abelii	98.94	5.00e-169	586.00
IUUC-Pop-099970	Populus trichocarpa	34.90	3.00e-44	171.00
IUUC-Ppe-101760	Prunus persica	36.67	8.00e-44	170.00
IUUC-Rno-104866	Rattus norvegicus	98.58	3.00e-168	583.00
IUUC-Sha-106547	Sarcophilus harrisii	98.94	3.00e-169	587.00
IUUC-Smo-109412	Selaginella moellendorffii	34.69	4.00e-39	154.00
IUUC-Sit-110595	Setaria italica	37.45	1.00e-41	163.00
IUUC-Sly-111259	Solanum lycopersicum	36.76	2.00e-41	162.00
IUUC-Stu-112571	Solanum tuberosum	36.76	2.00e-41	162.00
IUUC-Sbi-114090	Sorghum bicolor	37.11	2.00e-42	165.00
IUUC-Tgu-116579	Taeniopygia guttata	98.94	5.00e-169	586.00
IUUC-Tru-118250	Takifugu rubripes	93.26	3.00e-159	553.00
IUUC-Tni-120488	Tetraodon nigroviridis	96.81	3.00e-163	566.00
IUUC-Tca-121228	Theobroma cacao	35.50	3.00e-41	162.00
IUUC-Tae-123647	Triticum aestivum	37.36	1.00e-44	172.00
IUUC-Tur-126049	Triticum urartu	35.04	8.00e-39	154.00
IUUC-Ttr-129166	Tursiops truncatus	98.76	1.00e-142	499.00
IUUC-Vvi-131233	Vitis vinifera	35.56	8.00e-42	164.00
IUUC-Xtr-132553	Xenopus tropicalis	98.23	2.00e-168	583.00
IUUC-Xma-133670	Xiphophorus maculatus	97.16	1.00e-166	578.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence