iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066331

Ensembl Protein ID

ENSMPUP00000018888.1

UniProt Accession

M3Z5M6; M3Z5M6_MUSPF

Genbank Protein ID

ENSMPUP00000018888

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AEYP01047350

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000019010.1	ENSMPUT00000019162.1	ENSMPUP00000018888.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	37.30	3.00e-40	162.00	IUUC-Ath-007192

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mustela putorius furo

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

LRRPLKGAPS SVPGDLREAR FRAAAAARRV PSVSVSVSVS ALVPGPGPGP GPGPARRRGG 60
GDGAARVSLE PGCEAQRRPP EMKRQCPAAL PPGAATCNPP QRLPSLAGTT VPNSDLASLF 120

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Nucleotide Sequence
(Fasta)

CTGAGGCGAC CGTTAAAAGG CGCGCCCTCG AGCGTCCCAG GCGACCTTCG AGAGGCACGT 60
TTTCGAGCGG CGGCGGCGGC CCGGCGTGTC CCGTCGGTGT CGGTGTCGGT GTCGGTGTCG 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006522	Arabidopsis lyrata	37.70	5.00e-42	164.00
IUUC-Ath-007192	Arabidopsis thaliana	37.30	2.00e-41	162.00
IUUC-Mac-065014	Musa acuminata	36.46	1.00e-42	166.00
IUUC-Smo-109412	Selaginella moellendorffii	35.71	1.00e-39	156.00
IUUC-Sly-111259	Solanum lycopersicum	36.40	1.00e-41	163.00
IUUC-Stu-112571	Solanum tuberosum	36.40	1.00e-41	163.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence