iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-006798

Ensembl Protein ID

AT5G18650.1

UniProt Accession

Q8VZK0; MIEL1_ARATH

Genbank Protein ID

AED92594.1; AAL36416.1; AAM20011.1

Protein Name

E3 ubiquitin-protein ligase MIEL1; MYB30-interacting E3 ligase 1; RING-type E3 ubiquitin transferase MIEL1

Genbank Nucleotide ID

AC051627; AY064060; AY096370

Gene Name

MIEL1; At5g18650; T1A4.30

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT5G18650	AT5G18650.1	AT5G18650.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	23403577

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	6.70e-06	27.4	153	195

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf....kdgplvlpCgHvfhadCl.qkwpglknssskefrCPlC 45
           C+iC+e +    kd + v+ CgH++h +C  +++      ++ +f CP+C
   Q: 153  CPICYEYLfdslKD-TNVMKCGHTMHVECYnEMI------KRDKFCCPIC 195
           ****9999444455.66899*********84444......999******* PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase that acts as a regulator of cell death and defense. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Attenuates the activation of defense and related cell death responses in the absence of pathogens by mediating ubiquitination and subsequent proteasomal degradation of MYB30.

Protein Sequence
(Fasta)

MEASPNDRLH FGKMGFGCKH YKRRCQIRAP CCNEVFDCRH CHNESTSTLR NIYDRHDLVR 60
QDVKQVICSV CDTEQPAAQV CSNCGVNMGE YFCSICIFYD DDTEKQQFHC DDCGICRVGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTACAACAA AAATAAATGT ATTAAAGAAA GTGTTGGGAA ATAAATAGAA ATGTCTCTAA 60
AAGATAACGA TCTAGAATTG TGATTGGTCA ATAAATCGGC GCTCTCTGTT TTACGGTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0611--Plant defense
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR031109--Rinc_finger_CHY_Zinc_plant
IPR004039--Rubredoxin-type_fold
IPR018957--Znf_C3HC4_RING-type
IPR008913--Znf_CHY
IPR017921--Znf_CTCHY
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51266--ZF_CHY
PS51270--ZF_CTCHY
PS50089--ZF_RING_2

Pfam

PF00097--zf-C3HC4
PF05495--zf-CHY

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0008134--F:transcription factor binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006952--P:defense response
GO:1900425--P:negative regulation of defense response to bacterium
GO:1901485--P:positive regulation of transcription factor catabolic process
GO:0016567--P:protein ubiquitination

KEGG

ath:AT5G18650

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002810	Amborella trichopoda	70.52	4.00e-113	399.00
IUUC-Aly-005693	Arabidopsis lyrata	97.38	2.00e-156	543.00
IUUC-Bdi-014453	Brachypodium distachyon	65.08	4.00e-99	353.00
IUUC-Bol-015451	Brassica oleracea	91.39	4.00e-148	516.00
IUUC-Bra-017136	Brassica rapa	92.13	1.00e-149	521.00
IUUC-Cin-025667	Ciona intestinalis	46.37	1.00e-65	242.00
IUUC-Csv-025807	Ciona savignyi	44.22	1.00e-64	238.00
IUUC-Dme-031649	Drosophila melanogaster	43.27	1.00e-51	196.00
IUUC-Eeu-034769	Erinaceus europaeus	37.14	9.00e-24	103.00
IUUC-Gma-044156	Glycine max	82.40	8.00e-137	478.00
IUUC-Hvu-047085	Hordeum vulgare	65.87	3.00e-100	357.00
IUUC-Lch-050661	Latimeria chalumnae	45.27	2.00e-62	231.00
IUUC-Lpe-051107	Leersia perrieri	67.61	5.00e-101	359.00
IUUC-Mtr-057867	Medicago truncatula	80.90	2.00e-133	467.00
IUUC-Mac-065603	Musa acuminata	74.63	1.00e-119	421.00
IUUC-Mpu-065859	Mustela putorius furo	43.59	5.00e-24	102.00
IUUC-Oba-075296	Oryza barthii	66.80	1.00e-102	365.00
IUUC-Obr-076751	Oryza brachyantha	67.89	2.00e-100	358.00
IUUC-Ogl-077845	Oryza glaberrima	66.80	1.00e-102	365.00
IUUC-Ogu-078026	Oryza glumaepatula	62.50	3.00e-96	343.00
IUUC-Oin-079551	Oryza indica	63.16	3.00e-98	350.00
IUUC-Olo-080782	Oryza longistaminata	67.21	5.00e-100	357.00
IUUC-Ome-081602	Oryza meridionalis	66.80	5.00e-102	363.00
IUUC-Oni-082797	Oryza nivara	67.19	6.00e-103	366.00
IUUC-Opu-083572	Oryza punctata	66.80	4.00e-102	363.00
IUUC-Oru-085188	Oryza rufipogon	67.19	3.00e-104	371.00
IUUC-Osa-085573	Oryza sativa	67.19	6.00e-103	366.00
IUUC-Oar-089298	Ovis aries	45.83	1.00e-60	225.00
IUUC-Pop-099126	Populus trichocarpa	80.67	3.00e-133	466.00
IUUC-Ppe-101325	Prunus persica	82.40	8.00e-136	475.00
IUUC-Sit-110031	Setaria italica	64.73	7.00e-103	366.00
IUUC-Sly-111421	Solanum lycopersicum	83.90	1.00e-135	474.00
IUUC-Stu-112471	Solanum tuberosum	81.65	5.00e-133	466.00
IUUC-Sbi-114253	Sorghum bicolor	66.00	2.00e-100	358.00
IUUC-Tca-121199	Theobroma cacao	84.80	1.00e-129	454.00
IUUC-Tae-125231	Triticum aestivum	66.40	2.00e-99	354.00
IUUC-Tbe-127598	Tupaia belangeri	37.55	1.00e-34	139.00
IUUC-Vvi-131409	Vitis vinifera	80.52	1.00e-132	464.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence